XLOC_003679 (park7)


Basic Information

Item Value
gene id XLOC_003679
gene name park7
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 41459408 ~ 41475995 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007148
gacttattaaaataaattaaagcaacataaaatatttgttgtcttgaatttttgtcatattttagtgTAGAAGTTACAATGTACTGTTACAAACAGTGACACATTAATTTTATTTGGAATAAGAACGTTACGAGGGATTAAAATTAATAGCATATTAAGCACAACATAAACACTccactaaataaacaaattaaaatttaagaaaaaaatatacccAAGTTTGACGTGGAATCAATCTCCGTTTACAGATGATTCAGTAatcaaaataaaatctgttatcttttaatgccttttttttctttgaaaaaagaaaaaaaaagaaaaacaacaacaaacgaCCATAGAATAGCTCCTTACAAGaagaaaacttttattttgcctGGTAGTTCCCCATAACCCACCTACTCCCGGAAACGCCTTCCATAATAAAAGTACATGAGTGAGGTTGCATTGCAGACACGCACAGGTTATTAGACGCACGGTTATTATGGCCGGTAAAAGAGCGTTAGTGATTCTTGCGAAAGGAGCGGAGGAGATGGAGACTGTAATCCCGGTGGATGTGATGCGCAGAGCGGGGATCGCTGTTACTGTCGCAGGTCTGGCAGGTAAAGAGCCGGTTCAGTGCAGCCGTGAGGTCATGATCTGCCCAGACTCCAGCCTGGAGGACGCACACAAACAGGGTCCATATGACGTTGTTCTTCTGCCTGGAGGTTTGCTTGGAGCCCAGAACCTTTCTGAGtCTCCTGCTGTGAAAGAGGTGTTGAAGGACCAGGAGGGCAGGAAGGGTCTGATCGCTGCAATCTGTGCAGGCCCGACGGCACTGTTGGCTCATGGCATTGCATATGGCAGCACAGTTACTACTCATCCTGGTGCCAAGGACAAGATGATGGCTGGTGATCATTATAAATATTCAGAGGCTCGAGTTCAGAAGGATGGTAACGTGATCACCAGCAGAGGGCCAGGAACCAGCTTTGAGTTTGCCTTGACTATAGTGGAGGAGCTCATGGGTGCTGAGGTCGCTGCGCAAGTCAAAGCCCCGCTCATCCTGAAAGACTAATCTGTGAAGATCTGCACTGTGTAAAGATGCATTTACAATCGCACCGCTCTGTCAGTCTGAAAGACCCTCTATTTAATTGGTTTGGAATTTGCCTTGAGTGTATaggaaaattaatatttaatgaaattaCTTCAAGAGAGTTGATGTAGACTGACAAATTGATAAAGCTTTTAATGCTTTCTGTGATGTCAGATATCAAGTTCTCCAGCTTTGCACTTAATAACTTCTGTACCAGAATAAAACAGTTGTGCACTAAACTCTCAAAAGCCTCCTCATAATTTCTGCATTAACactgaagggacagttcacccccaaaagtgaacatttactaaattttctctttttaatgCGGTCCAGATGATTGAGTTTCTTTACTGTTGAAAAATCTGAAACTgttaaaagctgaaaacctgtaaccattgattttaatagtagTAATCATTGTGCACTAAACTCACAAAAGCCTCCTCATAATTTCTGCATTaacattaaaggggtagttcaccccaaaagTGAATATTTACTCAGTTTTCTCATCCTAATGTGGTTCCTGATGATTTAGATTCTTTACTGttgaaaaagctgaaaacctgtaaccattgacttccatagtagaaaaactatagggaagtcaatagttactggtttaaTGTTGTTGCAAACTGACAAATTggtaatttactttattttctcaCCCTAATGTGGTtctatataataataagtttCTTTACTgttgaaaagaagatattttgaagtaagctgaaaacctgtaaccattgacttccatagaataatactactactactactactactactaataataataataataataataataataataatatggaagtcaatggttgcagggtTTATGTTGTTGCAGACTGACAAATTGGTAATGTAAAGCTTTCTGTGATGTCAGATATTCAGTTCTCCAAATTTGCACTTCTGTACCAGAATAAAACAGTTGTGCACTAAACTCACAAAAGCCTCCTAATAATTTCTGCATTAagattaaatggatagttcactctaaaagttaacatttacttcattttccCACCCGATGTGGTTCCAGATGATTATAAGTTTCTTTACTGttgaaaaagctgaaaacctgtaaccattgatttccatagtagaaaaaaataatattaaagtcaatggttcaAGTTTATATGTTGTTGCAGATTGACAAATTGGTAATGTAAAGCGTTCTATGATGTCAGATATTCAGTTCTCCAACTTTGCACTTAATAACTTCTGTACCAAAATAAAATTGTGCACTAAACTCAAAAAAGTCTTCTTATAATTTCCTCCTAAGCCTCCTAATAAAGGGATAGATAACCCCAAATATTAAATGTACTCAATTTTCTAATGTACAGGGTTCAtatggtcatggaaaacctgtaaaagtcatgtaatttttgacatggcattttacAGGCCTGGAATAGTTTTggaaaaagtcatggaaaacagatatctgtatacTTAAATATAGGTTATTtccttcttttctgtccttgctcaatcacacactctcacattattagtccgtgtaagcattatctaaatcagtTTTGAATAGATCTAAATATgatttgaaactaaatacattgctctgttttaaaatatgctgtaataaataaaaacatgcacagTTCTTCCTGTTACCACccatatgtagacattgcatgaaacattggatcatgaaaatttacttgaaagtcttggaaaaatcatggaaaagtcagggaattttaatagtaaaaatggGTATGAACCCTGAATGTGGTTGCATTTGTGGTGGTTAAAGCCAAAATATGATGTTTTGAagtaagctgaaaacctgtaaccattgacttgcatagcaggaaaaacaaataccatggttacaggttttcagtctGCTTCAAAACATCATTTGGGTTTAACAGTAAAATGAACTCATCAAGGTCTGGAACCACATTAGAAAATTGAGTACATTAAACTCAATTTGAGTAACTGAGTAATTAACATCTTAacatatggaagtcaatggttacaggcttccaaatgtttttgtattcaacagaaaaaaactcgTAATA
>TCONS_00008422
TGAGGTTGCATTGCAGACACGCACAGGTTATTAGACGCACGGTTATTATGGCCGGTAAAAGAGCGTTAGTGATTCTTGCGAAAGGAGCGGAGGAGATGGAGACTGTAATCCCGGTGGATGTGATGCGCAGAGCGGGGATCGCTGTTACTGTCGCAGGTCTGGCAGGTAAAGAGCCGGTTCAGTGCAGCCGTGAGGTCATGATCTGCCCAGACTCCAGCCTGGAGGACGCACACAAACAGGGTCCATATGACGTTGTTCTTCTGCCTGGAGGTTTGCTTGGAGCCCAGAACCTTTCTGAGGTACAAATCTGTTTTAATTATGCATGTTTTACAGTAGAGTGAGTTCCATAGGAGAGCTCTTACGCCATTCGAGTCTTACATAAGGTTATGAGTGTTCCTCAAATCAACAGAAAACATCTTTGAGTCATCTGCCGAGGTTAGAAACACGGTCGCATTGTGAAACGCAAACATTGCGCAATTATGTAAATTGAAGCAGTGTTGTGACAGTTGTTTCTGTAGTGCGTCATAtacatataagtgtgtgtgtgcatgtgtgtgttgtagtCTCCTGCTGTGAAAGAGGTGTTGAAGGACCAGGAGGGCAGGAAGGGTCTGATCGCTGCAATCTGTGCAGGCCCGACGGCACTGTTGGCTCATGGCATTGCATATGGCAGCACAGTTACTACTCATCCTGGTGCCAAGGACAAGATGATGGCTGGTGATCATT

Function

symbol description
park7 Predicted to enable several functions, including hydro-lyase activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).

GO:

id name namespace
GO:0006914 autophagy biological_process
GO:1903427 negative regulation of reactive oxygen species biosynthetic process biological_process
GO:0006954 inflammatory response biological_process
GO:0070301 cellular response to hydrogen peroxide biological_process
GO:0006979 response to oxidative stress biological_process
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity biological_process
GO:0007338 single fertilization biological_process
GO:0106045 guanine deglycation, methylglyoxal removal biological_process
GO:0106046 guanine deglycation, glyoxal removal biological_process
GO:0042593 glucose homeostasis biological_process
GO:0006508 proteolysis biological_process
GO:0034599 cellular response to oxidative stress biological_process
GO:0006517 protein deglycosylation biological_process
GO:0060548 negative regulation of cell death biological_process
GO:0050821 protein stabilization biological_process
GO:0030073 insulin secretion biological_process
GO:0043523 regulation of neuron apoptotic process biological_process
GO:0036529 protein deglycation, glyoxal removal biological_process
GO:0006281 DNA repair biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0045121 membrane raft cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005634 nucleus cellular_component
GO:0016020 membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:1990422 glyoxalase (glycolic acid-forming) activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0003723 RNA binding molecular_function
GO:0003729 mRNA binding molecular_function
GO:0036524 protein deglycase activity molecular_function

KEGG:

id description
ko05012 Parkinson disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko01002 Peptidases and inhibitors
ko04147 Exosome

ZFIN:

id description
ZDB-GENE-041010-5 Predicted to enable several functions, including hydro-lyase activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).

Ensembl:

ensembl_id ENSDARG00000116835

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007148 False 3156 mRNA 0.36 6 41459408 41475995
TCONS_00008422 True 726 lncRNA 0.49 5 41459848 41473741

Neighbor

gene id symbol gene type direction distance location
XLOC_003678 pax7a coding upstream 86460 41242644 ~ 41372948 (+)
XLOC_003677 CABZ01087025.1 coding upstream 224318 41223485 ~ 41235090 (+)
XLOC_003676 CABZ01087025.2 coding upstream 258136 41192329 ~ 41201272 (+)
XLOC_003675 camta1 coding upstream 301454 41110669 ~ 41157954 (+)
XLOC_003674 phf13 coding upstream 353776 41089574 ~ 41105632 (+)
XLOC_003681 kcnab2a coding downstream 64867 41540862 ~ 41699904 (+)
XLOC_003682 akr7a3 coding downstream 362041 41838036 ~ 41850086 (+)
XLOC_003683 iffo2b coding downstream 382812 41858807 ~ 41929506 (+)
XLOC_003684 NA coding downstream 457105 41933100 ~ 41934619 (+)
XLOC_003685 aldh4a1 coding downstream 460440 41936435 ~ 41960276 (+)
XLOC_003369 CR854846.2 misc upstream 25336326 16122786 ~ 16123082 (+)
XLOC_003318 CR450764.6 misc upstream 28747412 12711700 ~ 12711996 (+)
XLOC_003317 CR450764.16 misc upstream 28765145 12693967 ~ 12694263 (+)
XLOC_003316 CR450764.11 misc upstream 28773809 12685304 ~ 12685599 (+)
XLOC_003315 CR450764.18 misc upstream 28779380 12679732 ~ 12680028 (+)
XLOC_003671 NA non-coding upstream 503285 40891681 ~ 40956123 (+)
XLOC_003672 CABZ01044764.1 non-coding upstream 559519 40897326 ~ 40899889 (+)
XLOC_003670 CABZ01044767.1 non-coding upstream 570114 40889180 ~ 40889294 (+)
XLOC_003687 NA non-coding downstream 538008 42014003 ~ 42018127 (+)
XLOC_003688 NA non-coding downstream 559792 42035787 ~ 42036989 (+)
XLOC_003689 NA non-coding downstream 566564 42042559 ~ 42069664 (+)
XLOC_003690 NA non-coding downstream 577256 42053251 ~ 42054601 (+)

Expression


Co-expression Network