XLOC_003685 (aldh4a1)


Basic Information

Item Value
gene id XLOC_003685
gene name aldh4a1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 41936435 ~ 41960276 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007154
AGTATCAAAATTCCACCTCAGCGCCGTGGTTCCTCAACTGGAGGATATTTCtgaattgtatatatataaataatatctcTGTGCTTCCCTGTACGGCCAAATCAACGATGCTGCGAGTGAGGTCTGCCGTCAGTCAGTCGTGGAAAGGGTTCAAAACTTTCTCGTGTGCAGCGGTGGAGGTGAAGAATGAGCCCGTTCTGGGGTTTAAAGAGGGCAGTAAAGAGAGAGCAGAACTGGAGGagGCGTTACGAAACCTGAAGGGAAAAACAGAAGAAATTCCATGTGTGATCGGGAATGAAGAAGTGTGGACCAAAGACATCCGATTCCAGCTGTCTCCCTTCAACCATTCTCACCAAGTTGCAAAGTTCTGCTATGCTGACAAGGATCTTCTAAATAAAGCCATTGAGGCTTCAGTCGCTGCTCGGAGGGAATGGGATCTTAAACCGGTCTCAGATCGAGCCCAGATCTTCTTCAAAGCTGCCGACATCATCAGTGGGCCCAAGAGAGCAGAAGTACTGGCCAAGACAATGATCGGACAGGGTAAGACTGTGGTTCAGGCGGAAATCGACGCAGCTCCAGAACTCATTGACTTCTTCAGGTTTAATGCCAAACATGCAATTGAGCTTGAAGACCAGCAGCCGCTGGACAGTGACGGCAGCACAAACACCATGCTGTACCGCGGCCTAGAGGGATTCGTTGCTGCTGTTGCTCCATTTAACTTCACAGCGATTGGTGGAAACCTGGCCGGCACTCCTGCTCTTATGGGTAACGTTGTGCTGTGGAAACCCAGTGATACCGCCATGTCTGCCAGTTATGCTGTCTATAAGATCCTGAGAGAGTCTGGATTGCCACCGAACATCATTCAGTTTGTCCCGGCAGATGGGCCAGTGTTTGGAGACACAGTTACGTCCTCTGAGCACCTCGCCGGCATCAACTTCACCGGCAGCGTCCCAACGTTTAAGCGGTTGTGGAAGCAGGTCGCCCAGAATCTGGACATCTACAGGAATTTCCCTCGCGTTGCTGGAGagtgtGGTGGGAAGAACTTCCACTTTGTGCACAAGTCTGCAGACGTCCGCAGTGTGGTGACCGGCACCATCCGCTCTGCGTTTGAGTACGGAGGACAGAAATGTTCTGCCTGCTCTCGTATGTACGTCCCAGACTCTCTCTGGCCTCAGATCAGACAGGGCCTCCTGGACGTCCACAAACAGATCAAAGTTGGAGACccaGTGGAAGATTTCAGCACTTTCTTCTCAGCGGTGATTGATGACAAGTCTTTCTCCAGGATTAAAGGCTGGCTTGAACACGCCAGATCTTCTCCACATCTGAAGATCATCGCTGGAGGAAACTGCGACGATAAGAAGGGCTATTTCGTGGAGCCCACAATAATCGAGACCACCGACCCACAGGAGAAGATCATGAATGAGGAGATCTTCGGACCCGTCCTGACAGTCTACGTTTACCCTGAAAACGACTACAAGAAAGTCCTGCACTTAATAGACAACACTTCTCCATACGCCCTAACAGGAGCCATCTTCTCCCAAGACAAATCTGTTATAGAGGAGGCCGGAAAAGCTTTAAGAAATGCTGCAGGAAATTATTATATCAATGATAAATCGACAGGATCAATCGTGGCCCAGCAGCCTTTTGGTGGCGCCAGAGCGTCAGGCACCAACGACAAACCCGGCGGCCCCCATTACGTCCTGCGCTGGACGTCCCCTCAGGTGGTCAAGCAGACACACGTCCCACTCACAGAATGGAAATATCCTTACATGAGCTAAAAGACCGCTTCATTTCTCTAAAATCCTTCCTAAAAGACTCTTCTTACCGTCCCAAAACCGCAGACAAAGTGTGGTAATGATGAAGAGCAACAGTAAAAAGCAGACCAGACTGAATGTATCCCCGAAGATTTCTCTGCAAACATCACTGGATTATTAATACAAGCTATTAATTCAGC

Function

symbol description
aldh4a1 Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to act upstream of or within proline catabolic process to glutamate. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).

GO:

id name namespace
GO:0010133 proline catabolic process to glutamate biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0006560 proline metabolic process biological_process
GO:0005759 mitochondrial matrix cellular_component
GO:0005739 mitochondrion cellular_component
GO:0016491 oxidoreductase activity molecular_function
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040426-1179 Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to act upstream of or within proline catabolic process to glutamate. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).

Ensembl:

ensembl_id ENSDARG00000038207

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007154 True 1954 mRNA 0.49 15 41936435 41960276

Neighbor

gene id symbol gene type direction distance location
XLOC_003684 NA coding upstream 1816 41933100 ~ 41934619 (+)
XLOC_003683 iffo2b coding upstream 6929 41858807 ~ 41929506 (+)
XLOC_003682 akr7a3 coding upstream 86349 41838036 ~ 41850086 (+)
XLOC_003681 kcnab2a coding upstream 236531 41540862 ~ 41699904 (+)
XLOC_003679 park7 coding upstream 460440 41459408 ~ 41475995 (+)
XLOC_003686 her15.1 coding downstream 21683 41981959 ~ 41984487 (+)
XLOC_003687 NA coding downstream 53727 42014003 ~ 42018127 (+)
XLOC_003688 NA coding downstream 75511 42035787 ~ 42036989 (+)
XLOC_003689 NA coding downstream 82283 42042559 ~ 42069664 (+)
XLOC_003690 NA coding downstream 92975 42053251 ~ 42054601 (+)
XLOC_003369 CR854846.2 misc upstream 25813353 16122786 ~ 16123082 (+)
XLOC_003318 CR450764.6 misc upstream 29224439 12711700 ~ 12711996 (+)
XLOC_003317 CR450764.16 misc upstream 29242172 12693967 ~ 12694263 (+)
XLOC_003316 CR450764.11 misc upstream 29250836 12685304 ~ 12685599 (+)
XLOC_003315 CR450764.18 misc upstream 29256407 12679732 ~ 12680028 (+)
XLOC_003680 BX571706.1 non-coding upstream 471199 41465107 ~ 41465236 (+)
XLOC_003677 CABZ01087025.1 non-coding upstream 701345 41223485 ~ 41235090 (+)
XLOC_003676 CABZ01087025.2 non-coding upstream 735163 41192329 ~ 41201272 (+)
XLOC_003671 NA non-coding upstream 980312 40891681 ~ 40956123 (+)
XLOC_003691 NA non-coding downstream 137771 42098047 ~ 42098291 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000057_00388747_00398161 ALDH4A1 coding CI01000057 null 388306 ~ 398819 (+)