XLOC_036880 (nfe2l2a)


Basic Information

Item Value
gene id XLOC_036880
gene name nfe2l2a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007120.7
NCBI id CM002893.2
chromosome length 56459846
location 1654284 ~ 1683368 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00072638
ACTCCACAGACAGCGTTTCCTTCGCAAGTGCAGCGTCCAGCAAAGACAATCCGACGTATTTATTTGAAGCCTCATTTAATTTCTCGGTGAAGGATTACAGGAGGTGCACCACATTAGGAGTTACGCTGAATATAAAGAGGAGATTATCTCTGAGACATGATGGAGATTGAAATGTCTAAAATGCAGCCAAGCCAAcagGACATGGATCTGATCGATATCCTGTGGCGGCAGGATGTGGATCTGGGCGCGGGCCGTGAGGTGTTCGACTTCAGCTACCGGCAGAAGGAGGTGGAGCTGCGCAGGCGGAGGGAGCAGGAGGAGCAGGAGCTGCAGGAGCGTCTGCAGGAGCAGGAGAAGACACTGCTGGCTCAGCTGCAGCTCGACGAGGAGACCGGAGAGTTCCTGCCGCGCAGCacaccgctcacacacacacctgaagcagACGGAGGAGGAGCGGGAGAAATCACACagAATGGGGCTTTTGCAGAACAGGAGGCCGATCCCATGTCATTCGATGAGTGCATGCAGCTCCTGGCTGAAACCTTTCCACTAACAGAGCCGGCTGAGTCGGCTCCGCCTTGCCTGAACACCTCCGCTCCACCTTCCACTGATCTCATGATGCCCGCAGACGTCCCGGCGTTTACCCAGAATCCTTTGCTGCCAGGATCTCTGGATCAGGCCTGGATGGAGCTGCTGTCACTCCCAGAGTTGCAGCAGTGCCTCAACATGCAAATGCAGGAGACGTTGGATATGAATGCATTCATGAAACCTTCCACAGAAGCACCAACCCAAAACTACGGCCAATATCTACCCGGGATGGACCATCTCGGCTCGGCTCAAACAGAAGTGTGTCCTCCTGAATTCACCAACACCTATAATGGATCCTTCAACACTATGGTGTCACCCAACATGAATCAACTGAGTCTGAACGTCCCGGATGTGGGAGCCGAGTTTGGCCCTGAAGAATTTAACGAGCTGTTTTATCCAGAGATGGAGGTAAAAGTGAACAACCCTCCGATTACATCAGATGGCGGAAATATGGTCGGCGATCCTCCTGTAAACCCAATAGATCTACAGAGCTtctcaccgggagatttcagctCAGGGAAACCAGATCCAATCGTGGAGTTTCAAGATTCTGACTCGGGTTTGTCCCTAGATGCAAGTCCTCACATGAGCTCTCCGGGGAAGTCCATAACTCAAGACGGATCATTCGGATTTAGTGATTCTGACTCGGAGGAGATGGAAGGAAGTCCGGGAAGCATGGAGTCAGATTACAATGAGATATTCCCATTGGTGTACCTCAACGATGGCTCCCAGACTCCACTCTCTGAGAAATCCTCGACGGAGAAACAAGAGATGAAACTGAAAAACCCAAAGATGGAGCCGGCGGAGGCTAGCGGACACTCCAAACCTCCGTTCACCAAAGACAAGCTGAAGAAGCGCTCCGAGGCGCGGCTCTCCCGTGACGAACAGAGAGCGAAAGCCTTGCAGATACCGTTTACCGTGGATATGATCATCAATCTGCCCGTAGACGACTTTAACGAGATGATGTCCAAACACCAGCTCAACGAAGCCCAGCTAGCGCTCGTTCGGGATATCCGCCGACGAGGCAAGAACAAAGTGGCGGCGCAGAACTGCCGCAAGCGCAAGCTGGAGAACATCGTGGGATTGGAGTACGAGCTGGACTCGCTGAAGGAGGAAAAAGAGCGTCTGATGAAGGAAAAGAGCGAACGCAGCAGCAACCTGAAAGAGATGAAGCAGCAGCTGAGCACGCTCTATCAGGAGGTTTTCGGGATGCTTCGAGATGAGAACGGAAAGGCTTTCTCGCCTAACGAATTCTCCCTTCAGCACACCGCGGACGGCACTGTTTTCCTAGTTCCTCGCCTTAAAAAGACTCTTGTGAAGAATATCTAGCTTTGTCCTTCCTCCTTCTCTCTTCCTCTACACTTTGCTTCTGTTTTTTTGGTACTGCTTTTCTCTTGCTAACACTGTGTCCTGATCAGAAGTGATATGAATGCAATAAAGCGTCAAAATCGGCGACAAAATTGGACGAACACTAACACGGGTTTTTTCAAAAACGCACTTTTTTtcgaaaaaaattaaaaaaaataaaaagtcattatCGCCGCCTGTTGGTTCGGAGGCTCTTAACATCGTTTGTAAAAATACCCATGtaagtgtggacatggcctaaaaCAACATCTTATTatagttttgcgcttgagcgcctccaagtgctgttgccacaaaagtggcaatctgattggtggagaaggttttgcacgttggtgtgcatgatcagATTGGTGCCCTTTATTTAGTAAAGAGGCAATAAACATCGACGGAAAACACGAGCAAAAAACGTcttggtgtgcacgggccttaactTTCGCAATGCAGCAGGTGATCGTAAGGTGATTACGATTGTAGCTTGTCAGAATTTACGAACATGATACAAATATCTCACCATAACATATCAATAGTTATAATATGAGAATCAAGTTGAGTCAAAAACGAATGAGTTAAACCTCATGTGATAGGTTTATTAAcccattttctaaaataatagttaattacaaatgtaaacaatttGAAGCATTAATTACGAAATAAATAATCCCGATAAGAGGAATACAATTGTAGCTTGTCAGAATCTCCGAACATGATACACACCTTAAAATAGCAGTTGTCATAATATACGACAATCTGAGTTGAGTTTAACGTAATCTGTAATATGTTTAGTATTCCTAAATCTTTCTTAACTGCTAATGTAAACAATTTGTAGTGTGAATTTCTAAATTTTCCAGTGGTGCTTTAAAGTTATTGCGATAATGGTAATACAATTGTAGCTTGTCAGAATGTATGAACATGACACAAATGTTACAATGTAAGATATCATTGATCGCAGATGAAGAAATTGTAAAAACTATGAAACATGCTTGGTGATTCTCCACTAGGTGGCGATCTGAGTCAATTGGTATTATCGCCCGCTAGTGGAGAACCATACAATTTTAGAGATGTTTTGAAACCGTTATGACGTAATGCAGACTCATTTAATGACATCATGTGATCTTGCAAAATTAATACACGATTCGAACCACTGACTCGAAACAAAAgattcataaaagtttgaaagtAGTCGCATGCAGTGCgaaaaaatgaaactgaaatgacACTAAACTGCAAGCGTAAACTATTCGTAGCATTATTTTTGAAATTTCTCAGTGGTGCTTTGACGTGTTTGCAATTTCTGCCTCATGACGTTTTGCACTTCTATTGGTTCTTGGTTTTATCGTTATCGTAGTTGATGTCACACTGCAGACATGTGTCTGAAAACTTCTGACAATGCCAGAATTTCATTGTTTAACAAATTATCGCATTAATCAGCTGTTGGTGAACATTTCAAACCAATGATCAAAGAACACAGATTTTAGAATAGGATTTAGTCATCTTAGGATTTCCAAAATTGTAAAAACTTTGAAACATGTTCAGTGATACTCCACTAGGTGGCGATCTAAGTGAAATGGAATCATCACCCGCTAGTGGACAACCATTAAATTTTTGAACTTTCATAACAGTTATGACGTAACGAAGACTCGCTTAATGAAATCAAGTGATCTTGCCAATTTAATATGCGATTCGACCACAGACTCGAAACAAAagattcataaaagtttaaaagtagtCGCATGCAGTGCTTAGAGAAAAATGAAATTGAAATGACACTCAACTGCAAGCGTAAACTATTCGTAGCATTATTTTTGAAATTTCTCAGTGGTGTTTTGACGTGTTTGCAATTTCTGCCTCATGACGTTTTGCGCTTCTATTGGTTCTTGGTTTTATCGTTATCGTAGTTGATGTCACACTGCAGACATGTGTCTGAAAACTTCTGACAATGCCAGAATTTTATTGTTGAACAAATTATCGCATTAATCAGCTGTTGGTGAACATTTCAAACCAATGATCAAAGAACACAGATTTTAGAATAGGATTTAGTCATCTTAGGATTTCCAAAATTGATCACCGATGAAGAAATTGTAAAAACTTTGAAACATGTTCAGTGATTCTCCACTAGGTGGCGATCTAAGTGAAATGGAATCATCACCCGCTAGTGGACAACCATTAAATTTTCGAACTTTCGTAACAGTTATGACAAAACGAAGACTCGCTTAATGAAATCAAGTGATCTTGCCAATTTAATATGCGATTCGACCACAGACTCGAAACAAAAgattcataaaagtttgaaagtAGCCATCACCAGTCGCATGCAAtgattagagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaatcgcaactGGTTTGGACACAGTGTACATCTTACGCAAAGGAAACAACTAAATAGGAGCGTATTTTGCTTATACAACGACTGTTGAAACGGCAGAACTATTATATACGTTTTGCGTATTCTACTTTCCTAACATTCTTAACCTCCGTTGGATTTTGTACTCCTTTATATTTTTCTCTGAGATTCTTTTACCTGTATggtttgtaaatacatttatactTTATTTGCTATCGAGATAGGAATAAacgtactgtatatatatatatattaaaagaaaagAGATCACGTTttagtaagctaaaattgttgtGATCATTTTAAGTCTGCACTTAAGTCGGTTTTTTATATCTTAATTTACTATTCTACTGCTGTTTTACCTCTTGACTCTATGGCtttatatgataaataaataaatatttaaaccag

Function

symbol description
nfe2l2a Enables protein heterodimerization activity and transcription cis-regulatory region binding activity. Contributes to DNA-binding transcription factor activity. Acts upstream of or within several processes, including cellular response to oxidative stress; cellular response to prostaglandin stimulus; and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0006979 response to oxidative stress biological_process
GO:0071379 cellular response to prostaglandin stimulus biological_process
GO:0045893 positive regulation of transcription, DNA-templated biological_process
GO:0034599 cellular response to oxidative stress biological_process
GO:0071466 cellular response to xenobiotic stimulus biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription regulator complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030723-2 Enables protein heterodimerization activity and transcription cis-regulatory region binding activity. Contributes to DNA-binding transcription factor activity. Acts upstream of or within several processes, including cellular response to oxidative stress; cellular response to prostaglandin stimulus; and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).

Ensembl:

ensembl_id ENSDARG00000042824

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00072638 True 4739 mRNA 0.42 5 1654284 1683368
Loading

Neighbor

gene id symbol gene type direction distance location
XLOC_036879 BX004991.1 coding upstream 74240 1575420 ~ 1580044 (+)
XLOC_036878 pde11a coding upstream 79898 1505206 ~ 1574386 (+)
XLOC_036877 FP102120.1 coding upstream 277824 1372946 ~ 1376460 (+)
XLOC_036875 prkra coding upstream 282765 1365747 ~ 1371519 (+)
XLOC_036876 NA coding upstream 284977 1368954 ~ 1369307 (+)
XLOC_036881 NA coding downstream 140951 1824319 ~ 1883661 (+)
XLOC_036882 NA coding downstream 241940 1925308 ~ 1926531 (+)
XLOC_036883 NA coding downstream 256515 1939883 ~ 1940095 (+)
XLOC_036884 evx2 coding downstream 319333 2002701 ~ 2007106 (+)
XLOC_036885 lnpa coding downstream 337299 2020667 ~ 2037625 (+)
XLOC_036874 NA non-coding upstream 319812 1332785 ~ 1334472 (+)
XLOC_036873 FP102120.2 non-coding upstream 328416 1325704 ~ 1325868 (+)
XLOC_036887 NA non-coding downstream 446095 2129463 ~ 2130990 (+)
XLOC_036888 BX255915.2 non-coding downstream 593949 2277317 ~ 2341127 (+)

Expression

Expression of XLOC_036880(nfe2l2a) in the Zebrafish Sample from each Developmental Stage of PRJEB12982

Boxplot with 18 boxes. Box plot charts are typically used to display groups of statistical data. Each data point in the chart can have up to 5 values: minimum, lower quartile, median, upper quartile, and maximum.
The chart has 1 X axis displaying categories.
The chart has 1 Y axis displaying Expression. Range: 0 to 60.
End of interactive chart.

Expression of XLOC_036880(nfe2l2a) in the Zebrafish Sample of PRJEB12982

Bar chart with 360 bars.
The chart has 1 X axis displaying categories.
The chart has 1 Y axis displaying Expression. Range: 0 to 60.
End of interactive chart.

Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000353_00565944_00573619 NFE2L2A coding CI01000353 null 565853 ~ 573619 (-)
bowfin (Amia calva) AMCG00016661 nfe2l1 coding CM030122.1 CM030122.1 26977195 ~ 26990313 (+)