XLOC_037421 (cxcr2)


Basic Information

Item Value
gene id XLOC_037421
gene name cxcr2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007120.7
NCBI id CM002893.2
chromosome length 56459846
location 48108174 ~ 48109197 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00073613
CATGGAAACTGCTACTACAGAGTTCCCATTTACCCTTATGACTCCTTGCCCGGAGACCGTGAAGAACCTCAACAGCACGGTTTTGGTTGTAATCTACATCATAGTCTTTTGCCTGAGCTTGCTGGGAAACACCGTGGTCATATTTGTGGTTTTCTTCATGGACAACCGCAGGACGTCCACCGACCTTTACCTGATGCACCTGGCTGTGGCTGACCTGCTTTTTTCCCTCACTCTCCCCTTCTGGGTGGCGTACCTCCACGCCGGTCACTGGCCGTTCGGCACCATCATGTGCAAAATGATCTCTGGTGTGCAGGAGGTCAcattttactgcagcgttttcaTGCTAGCCTGCATTAGCATCGACCGCTACATGGCCATCGTAAAAGCAACGCAATTCCTCAACCGAAAGCTCCATCTGATTGGGTTTGTGTGTGCGTTGGTGTGGCTGTGCGCCGCCCTCTTATCTCTTCCGGTTATGGTGCACCGTGAAGCGATCACGTATGATGGTGTGGAGTATATATGTGAGGACAATGTGACTGCGGAGAGCACCGACAGCTGGAGGATGAGCCTTCGCATTATCCGTCATACTCTGGGATTCTTCCTGCCGCTCACCGTGATGATGTTCTGCTACGGTTTCACCATGTTCACTTTATGTCACACGCGCAACAGCCAAAAGCAGAAGGCCATGCGGGTCATCTTGAGCGTGGTGCTGGCTTTTATCATCTGCTGGTTGCCTCATAACATCATAGAGTTCACAGACATCCTGATGCGAGCCGGACAGGTGGAGGAAACATGCCAGCTGAGAGACAACATAGACGTGGCTTTGTATGCGACGCAGGTGATGGCGTTCGCACACTGCGCAATAAACCCCATCCTGTACGCCTTCATCGGGAAGAAATTTCGTAACCAGTTGCTGATTTCTCTCTTTAAGAAAGGCCTGTTTGGGAGAAACATGCTGTCCAGATATGGAGCGGGATCCTTTCAGAGCTCTGGAAGCACTCGGCAAATGTCAGTGACGCTGTAG

Function

symbol description
cxcr2 Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within defense response to bacterium; leukocyte migration; and neutrophil activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; human immunodeficiency virus infectious disease; pyelonephritis (multiple); and urinary tract infection. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0002523 leukocyte migration involved in inflammatory response biological_process
GO:0042119 neutrophil activation biological_process
GO:0006935 chemotaxis biological_process
GO:0042742 defense response to bacterium biological_process
GO:1990266 neutrophil migration biological_process
GO:0007165 signal transduction biological_process
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0016494 C-X-C chemokine receptor activity molecular_function
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0051916 granulocyte colony-stimulating factor binding molecular_function

KEGG:

id description
ko04072 Phospholipase D signaling pathway
ko04060 Cytokine-cytokine receptor interaction
ko04061 Viral protein interaction with cytokine and cytokine receptor
ko04144 Endocytosis
ko04062 Chemokine signaling pathway
ko05163 Human cytomegalovirus infection
ko05120 Epithelial cell signaling in Helicobacter pylori infection
ko04030 G protein-coupled receptors
ko04050 Cytokine receptors
ko04090 CD molecules

ZFIN:

id description
ZDB-GENE-100414-1 Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within defense response to bacterium; leukocyte migration; and neutrophil activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; human immunodeficiency virus infectious disease; pyelonephritis (multiple); and urinary tract infection. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2).

Ensembl:

ensembl_id ENSDARG00000054975

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00073613 True 1024 mRNA 0.51 1 48108174 48109197

Neighbor

gene id symbol gene type direction distance location
XLOC_037420 cxcr1 coding upstream 16433 48085039 ~ 48091741 (+)
XLOC_037419 zgc:92380 coding upstream 68210 48007081 ~ 48039964 (+)
XLOC_037418 gpbar1 coding upstream 137414 47961482 ~ 47970760 (+)
XLOC_037417 NA coding upstream 785210 46854545 ~ 47322964 (+)
XLOC_037416 NA coding upstream 1267785 46838646 ~ 46840389 (+)
XLOC_037422 mettl5 coding downstream 13805 48123002 ~ 48135809 (+)
XLOC_037423 ccdc173 coding downstream 109914 48219111 ~ 48231775 (+)
XLOC_037424 fastkd1 coding downstream 123374 48232571 ~ 48267646 (+)
XLOC_037425 NA coding downstream 271658 48380855 ~ 48381572 (+)
XLOC_037426 lrp2a coding downstream 305846 48415043 ~ 48672254 (+)
XLOC_037413 NA non-coding upstream 1492141 46482929 ~ 46616033 (+)
XLOC_037412 NA non-coding upstream 1676878 46415158 ~ 46431296 (+)
XLOC_037411 NA non-coding upstream 1712770 46378709 ~ 46395404 (+)
XLOC_037427 BX927361.2 non-coding downstream 573578 48682775 ~ 48687885 (+)
XLOC_037428 NA non-coding downstream 584235 48693432 ~ 48817119 (+)
XLOC_037430 NA non-coding downstream 736381 48845578 ~ 48858403 (+)
XLOC_037431 NA non-coding downstream 760699 48869896 ~ 48877349 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000009_15680573_15681601 NA coding CI01000009 null 15680573 ~ 15681976 (+)