XLOC_004192 (nr0b1)


Basic Information

Item Value
gene id XLOC_004192
gene name nr0b1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 29682909 ~ 29685853 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008024
AAACTATTTGCCATTTGGGTGGACGGTAACACAGACCTCAGCCGTGCATGGACATCTCCAAGCGTGCAGCTCAGCACAGTTTCAGCAACGAAACATAAGCAGCTCTGCGAGGATGGCTTACTTTGACAGCGGCTGCCACTGCAGCAGCGAGCGGCGGCAGAACAGCATCTTATACAGCATCTTAAAGAACGACAGTCAGTCTGCGCAACTTGGGAACCAGCCGCGCGCCCCGAGGCTAGCCGTGTCCATGCGCGCCTGTGCCTGCGGCTCCAAGAGGAAAGTGTCCCTCCGTTCTCCTCAAACCACATGCAAAGCCGCCTCCGCCGTCCTGGTCAAGACCCTGAAGTTCGTGAAGAACGTCCCGTGCTTCCGCGAACTGCCAGCGGATGATCAGCACACGCTGGTGCGAAGCGGCTGGGCACCGCTGCTGGTGCTCGGTATGGCGCAGGACAGGATCGACTTCGAGACTTCGGAGACGCAGGAGCCCAGCATGCTGCAGCGGATTTTAACGAGCGGACAGGACAAGCAGGACAACCAGAGCCATAACGGCGGAGTGGCGTTGACCGACGTGCAGGGTATTAAAATGTTTCTGAGGAAATGCTGGGGACTGGACATAAGCACTAAGGAGTACGCGTACTTGAAAGGGGCCATTCTGTTCAACCCAGATGTTGCTGGGCTGCAGTGTCAACATTACATCCAGGCCCTGCAGAGCGAGGCGAACCAGGCACTTAATGAATATGTCAAAATGATTCACCGCGGGGACAGTGCGAGATTCGCCAAACTCTTCCTCGCTCTCTCCATGCTGAGATCCATCAACGCCAATGTAGTGGCTGGGCTCTTCTTCAAACCCGTCATTGGCGCGGTCAACATGGAGGAACTTCTTCTGGAGATGTTTTATGGAAAATAAACTTTGAAAAAAACTGGGAGAGAATTATCAGACTTGGAAAGAGCGACAGTCACTGTTGGAGGGACAGATTTTGAAAATGACTGATTCCTTTTTACACATGCTATTTTTGTACAATATATAAGAGCTCTCCTTTTTGCCTTCTGAGTTGAACTCATCACTGAATCCAAAGTTGATGACAATATTTTTCCCATTTGGGGAAAGAGCTTTATAACTTTGTtctgattgttttttgtttacttgCTTATTATCTGTAATGTCTTGttgcattttgaagaatgtttatttgattctgggagacactttataataactttcTTAAGGAAATCATTtacaaacattcatttaaatatgtgCTCCGTTTaagaaatacattgaaatgtaattatatttgatgtaaatatattacatttaataatagcCTAATATATGATCTTATGTTTCCTGATATTATTTGTTATCTCATGAACTGttttgcattattaaatgtaatgattttgttgttgtaaatgaaagttattataaagtgtaagctatttttgaaaatttgaaa

Function

symbol description
nr0b1 Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of male gonad development and water homeostasis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; interrenal primordium; and reproductive system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1).

GO:

id name namespace
GO:0030104 water homeostasis biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:2000019 negative regulation of male gonad development biological_process
GO:0043433 negative regulation of DNA-binding transcription factor activity biological_process
GO:0030325 adrenal gland development biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0008134 transcription factor binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003707 steroid hormone receptor activity molecular_function
GO:0003714 transcription corepressor activity molecular_function

KEGG:

id description
ko04927 Cortisol synthesis and secretion
ko03000 Transcription factors
ko03310 Nuclear receptors

ZFIN:

id description
ZDB-GENE-070130-1 Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of male gonad development and water homeostasis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; interrenal primordium; and reproductive system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1).

Ensembl:

ensembl_id ENSDARG00000056541

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008024 True 1457 mRNA 0.45 2 29682909 29685853

Neighbor

gene id symbol gene type direction distance location
XLOC_004191 chd5 coding downstream 24513 29574743 ~ 29658396 (-)
XLOC_004189 arhgef10la coding downstream 119472 29331142 ~ 29563437 (-)
XLOC_004190 NA coding downstream 137920 29537982 ~ 29544989 (-)
XLOC_004188 NA coding downstream 362990 29099927 ~ 29319919 (-)
XLOC_004187 NA coding downstream 594283 29085366 ~ 29088626 (-)
XLOC_004193 NA coding upstream 48725 29734578 ~ 29737247 (-)
XLOC_004194 plekha3 coding upstream 71007 29756860 ~ 29768054 (-)
XLOC_004195 cybb coding upstream 109302 29795155 ~ 29833698 (-)
XLOC_004196 vegfd coding upstream 203975 29889828 ~ 29916607 (-)
XLOC_004197 pir coding upstream 231760 29917613 ~ 29946927 (-)
XLOC_004063 CR854846.1 misc downstream 13555231 16127382 ~ 16127678 (-)
XLOC_004019 CR450764.8 misc downstream 16991218 12691395 ~ 12691691 (-)
XLOC_004015 CR450764.4 misc downstream 17061142 12621518 ~ 12621767 (-)
XLOC_004013 CABZ01022569.1 misc downstream 17091613 12590999 ~ 12591296 (-)
XLOC_004008 BX000700.19 misc downstream 17169647 12512966 ~ 12513262 (-)
XLOC_004183 BX649345.1 non-coding downstream 1157413 28522364 ~ 28525496 (-)
XLOC_004182 NA non-coding downstream 1160565 28513742 ~ 28522344 (-)
XLOC_004198 CU652893.1 non-coding upstream 275261 29961114 ~ 29961901 (-)
XLOC_004200 CR318645.1 non-coding upstream 415289 30101142 ~ 30101257 (-)
XLOC_004211 NA non-coding upstream 1514366 31200219 ~ 31202839 (-)
XLOC_004212 NA non-coding upstream 1519072 31204925 ~ 31211308 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000306_05476895_05478400 NR0B1 coding CI01000306 null 5476396 ~ 5478565 (-)