XLOC_004237 (tdo2b)


Basic Information

Item Value
gene id XLOC_004237
gene name tdo2b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 34084532 ~ 34097437 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008090
AGAACATTGTGACAACCTTCAGTAAGCAGACAGAGGAAAAAATCAATTCCTGTTGAACATTGCAAGGACAAAACATGAGTGGATGTCCATTTTTGGGAGGAACGCTTCAATTGTTGTCCAGTAACCCCAGGCAGGCGGAGGAAGAGGATGGATCCCAAGGAGGCGTCAACAAAGCCGCTAAAGGAGGAATCATCTACGGAGACTATTTACAGCTTGACAAGGTGCTGAATGCTCAAGTTTTGCAGAGTGAACAAAAAGGCAACAAAATCCATGATGAGCATCTCTTCATCGTTACTCACCAAGCGTACGAGTTGTGGTTTAAGCAGATATTGTGGGAGCTTGATTCAGTTCGTGAcctgttcattaaaaaacatGTTCGGGATGAGAGAAACATGCTGAAGGTGGTGAGCAGAATCCACAGGATAACCATGATCTTCAAGCTGCTGGTAGATCAGTTTGCTGTACTGGAGACTATGACTGCTCTGGACTTCTTTGATTTCAGGGAGTATCTGTCTCCAGCCTCGGGCTTCCAGAGTCTTCAGTTCCGTCTTCTGGAGCAAAAGATTGGTGTAGCGGATCATTTAAGAGTCCCGTACAATCGCAGACACTACAGAGACAACTTTCATGGAGAGGAGAGCGAGACGCTGCTGAGTTCAGAGCAGGAACCCACTCTCCTTCAGCTGGTGGAGCAATGGCTGGAGAGGACACCTGGACTTGAAAAAGATGGCTTTAATTTCTGGGGGAAACTGCAGGCTAACATCGAAGAGGGTCTCAAGAGGGAGAAGCACCAAGTGGAAAAAATGGAAGATACTGAGGTGAAGCAAGAGGTTCTGGAGGATCTAAACAAACAGATGGAGACCTTTACTGCCCTGTTTGACTCTAAACGCCACGAGCATCTGTTAAGCAAAGGTGAACGGAGACTTTCTTACAAGGCTCTTCAGGGAGCTCTAATGATCAATTTCTACAGGGAAGAGCCTCGATTCCAGGTACCTTTCCAGCTCCTGACTGCGCTGATGGAGATCGATACACTCATGACCAAGTGGAGATATAACCACGTGTGTATGGTGCACAGAATGATTGGCAGTAAAGCAGGAACGGGGGGATCTTCAGGATACCATTACTTGCGCTCAactgtcagTGACCGTTACAAAGTGTTTGTGGATTTGTTCAACCTCGCCACTTTCCTGGTTCCTCGTTCCTGGGTGCCCAAACTCAACCCAAACATCCATAAGTTCCCGTACACTGCCGAGTGTTACGACAGCTCGTACAATTCATGCAGCAGCGAGGATTCCGATTAGAAACATCAGACCTGTTTGTTTGTGAATAATGTTAAAGAATCCGGGATTAATGCCAGATATTGATACTCCTGTATTGATCAGCCAAAGTTTGTGCTTTTTGGACTATTTACTTGTTTGATTGAAGAGACTGAAAGTTTTTTTCCACCTTATATAAACGCAAAGATTTATTATAAAGTAATTGTGCACATATTAAAAATCTAAAGGAGTTCTCTACatactatttatattttaaacatatatgtaaaatataagtCTTTTGTACTAAGAATATATTTTTGAATGAGGCACATGATGTAGGTTTCTCTGGTTGTTTGTAAATATATGATACACTCTACTGGGTATGTATAGTATATATCCtaatataaaatgtcatttagacTGTACAGACAAGTGATGATACTATGTTccatattattaaacaaaatctttttttgtctttactaTATGCttcttacaaaaataaatgctaAACTCTTTCCTGAA
>TCONS_00008091
ACTTTGCAATGAAACACCCAGAACATTGTGACAACCTTCAGTAAGCAGACAGAGGAAAAAATCAATTCCTGTTGAACATTGCAAGGACAAAACATGAGTGGATGTCCATTTTTGGGAGGAACGCTTCATAACCCCAGGCAGGCGGAGGAAGAGGATGGATCCCAAGGAGGCGTCAACAAAGCCGCTAAAGGAGGAATCATCTACGGAGACTATTTACAGCTTGACAAGGTGCTGAATGCTCAAGTTTTGCAGAGTGAACAAAAAGGCAACAAAATCCATGATGAGCATCTCTTCATCGTTACTCACCAAGCGTACGAGTTGTGGTTTAAGCAGATATTGTGGGAGCTTGATTCAGTTCGTGAcctgttcattaaaaaacatGTTCGGGATGAGAGAAACATGCTGAAGGTGGTGAGCAGAATCCACAGGATAACCATGATCTTCAAGCTGCTGGTAGATCAGTTTGCTGTACTGGAGACTATGACTGCTCTGGACTTCTTTGATTTCAGGGAGTATCTGTCTCCAGCCTCGGGCTTCCAGAGTCTTCAGTTCCGTCTTCTGGAGCAAAAGATTGGTGTAGCGGATCATTTAAGAGTCCCGTACAATCGCAGACACTACAGAGACAACTTTCATGGAGAGGAGAGCGAGACGCTGCTGAGTTCAGAGCAGGAACCCACTCTCCTTCAGCTGGTGGA

Function

symbol description
tdo2b Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase).

GO:

id name namespace
GO:0051289 protein homotetramerization biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0019441 tryptophan catabolic process to kynurenine biological_process
GO:0019442 tryptophan catabolic process to acetyl-CoA biological_process
GO:0006569 tryptophan catabolic process biological_process
GO:0005575 cellular_component cellular_component
GO:0046872 metal ion binding molecular_function
GO:0004833 tryptophan 2,3-dioxygenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0051213 dioxygenase activity molecular_function
GO:0020037 heme binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030131-6014 Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase).

Ensembl:

ensembl_id ENSDARG00000023176

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008090 False 1781 mRNA 0.42 12 34084532 34097418
TCONS_00008091 True 695 mRNA 0.46 6 34091410 34097437

Neighbor

gene id symbol gene type direction distance location
XLOC_004236 col6a1 coding downstream 18814 33996526 ~ 34065718 (-)
XLOC_004235 NA coding downstream 91385 33992033 ~ 33993147 (-)
XLOC_004234 CR925698.1 coding downstream 118260 33966158 ~ 33966272 (-)
XLOC_004233 col6a2 coding downstream 124214 33921358 ~ 33960318 (-)
XLOC_004232 phka2 coding downstream 165223 33870357 ~ 33919309 (-)
XLOC_004238 atp13a3 coding upstream 19297 34116734 ~ 34147205 (-)
XLOC_004239 atp13a3 coding upstream 53740 34151177 ~ 34151487 (-)
XLOC_004240 atp13a3 coding upstream 57156 34154593 ~ 34188346 (-)
XLOC_004241 tmem44 coding upstream 103746 34201183 ~ 34219211 (-)
XLOC_004242 lsg1 coding upstream 122554 34219991 ~ 34232906 (-)
XLOC_004063 CR854846.1 misc downstream 17956854 16127382 ~ 16127678 (-)
XLOC_004019 CR450764.8 misc downstream 21392841 12691395 ~ 12691691 (-)
XLOC_004015 CR450764.4 misc downstream 21462765 12621518 ~ 12621767 (-)
XLOC_004013 CABZ01022569.1 misc downstream 21493236 12590999 ~ 12591296 (-)
XLOC_004008 BX000700.19 misc downstream 21571270 12512966 ~ 12513262 (-)
XLOC_004229 NA non-coding downstream 395583 33676834 ~ 33688949 (-)
XLOC_004227 NA non-coding downstream 683056 33305132 ~ 33401476 (-)
XLOC_004226 BX530032.2 non-coding downstream 885928 33190658 ~ 33198604 (-)
XLOC_004243 FO681390.1 non-coding upstream 152019 34249456 ~ 34255220 (-)
XLOC_004244 NA non-coding upstream 218088 34315525 ~ 34358689 (-)
XLOC_004245 BX548160.1 non-coding upstream 258107 34355544 ~ 34355662 (-)
XLOC_004247 BX548160.2 non-coding upstream 368958 34466395 ~ 34466513 (-)
XLOC_004249 NA non-coding upstream 453410 34550847 ~ 34577106 (-)

Expression


Co-expression Network