XLOC_004475 (itgam)


Basic Information

Item Value
gene id XLOC_004475
gene name itgam
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 4160804 ~ 4167750 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008955
CCCACACCTCACCCTCAAATACCCATATGGATTTTCATTCAGGAGATTCACATTGAAACAGGGCAGAGTAGAGTGTTCATCTCTGGATGGAGAGCAAGGGGTTCGACTGGGAGAAACTGAATGCGCCATCAGTAAACCCATCCTCAAGGATAATACAACGGTTGTGTTTGAGATTACGTACAGTATCAATAGAGAAGTTACACTGGGCCAAAACGTGACATTCAGTGCTTCAGTCAAGAGTGGGAATGACCAACACTCAAACCACAGTGAGTCATTCAAAGAGAAAAGCATTGATGTGAAATATGGCATCTACGTCACATTGATCCGGCATGAAAATTCCACCATCTACATTAACTTTACTTCAGGGAAGAAGGATCTTTCAAAACATGTGCAGCAGACAATAAAGATTGAAAATGACCTCAGACCATTAGCTTTCACAGCTTTCGTCAGAGTACCAGTGAAACTTGGTGATACCAACATCTGGAAAAATTCTACTTTGCAGGTTTCTGACTGTGTGAACAATACAGAGGAGAAACCTAATAGCACAAATTTCATGGACGTTATTAAAAAACATCATGTGCTGaactGCAGTGTGGCGGTGTGTGCCGTGTTCAGCTGTGATGTGAACCTCATAAAGAATGAAAGGAAGCTCTATAATATAACTGGCAATGTGAGCTCTGCGTGGATTGAGCAG

Function

symbol description
itgam Enables heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Located in cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.

GO:

id name namespace
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007155 cell adhesion biological_process
GO:0008305 integrin complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component

KEGG:

id description
ko04015 Rap1 signaling pathway
ko04514 Cell adhesion molecules
ko04145 Phagosome
ko04810 Regulation of actin cytoskeleton
ko04640 Hematopoietic cell lineage
ko04610 Complement and coagulation cascades
ko04613 Neutrophil extracellular trap formation
ko04670 Leukocyte transendothelial migration
ko05202 Transcriptional misregulation in cancer
ko05221 Acute myeloid leukemia
ko05133 Pertussis
ko05134 Legionellosis
ko05150 Staphylococcus aureus infection
ko05152 Tuberculosis
ko05146 Amoebiasis
ko05140 Leishmaniasis
ko04131 Membrane trafficking
ko04147 Exosome
ko04515 Cell adhesion molecules
ko04090 CD molecules
ko00536 Glycosaminoglycan binding proteins

ZFIN:

id description
ZDB-GENE-110510-4 Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).

Ensembl:

ensembl_id ENSDARG00000096587

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008955 True 694 mRNA 0.42 8 4160804 4167750

Neighbor

gene id symbol gene type direction distance location
XLOC_004474 itgam coding upstream 3564 4147714 ~ 4157240 (+)
XLOC_004473 si:dkey-32n7.4 coding upstream 15771 4114401 ~ 4145033 (+)
XLOC_004472 NA coding upstream 54394 4103788 ~ 4106410 (+)
XLOC_004471 NA coding upstream 67231 4092452 ~ 4093573 (+)
XLOC_004470 zgc:123217 coding upstream 116672 4036409 ~ 4044132 (+)
XLOC_004476 mapk7 coding downstream 52603 4220353 ~ 4238827 (+)
XLOC_004477 mmp25b coding downstream 93029 4260779 ~ 4278329 (+)
XLOC_004478 NA coding downstream 240909 4408659 ~ 4450452 (+)
XLOC_004479 NA coding downstream 260373 4428123 ~ 4473148 (+)
XLOC_004480 CABZ01030103.1 coding downstream 329614 4497364 ~ 4497479 (+)
XLOC_004469 NA non-coding upstream 169381 3986079 ~ 3991423 (+)
XLOC_004456 NA non-coding upstream 1388414 2769565 ~ 2772390 (+)
XLOC_004450 NA non-coding upstream 1553772 2578020 ~ 2607032 (+)
XLOC_004483 NA non-coding downstream 561267 4729017 ~ 4734988 (+)
XLOC_004484 NA non-coding downstream 580821 4748571 ~ 4751852 (+)

Expression


Co-expression Network