XLOC_004487 (scn4aa)


Basic Information

Item Value
gene id XLOC_004487
gene name scn4aa
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 4869248 ~ 4893492 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008965
ATGGCACGCCTGCTCCCTCCCACAGGCACCAGTGTGTTCCGCCGCTTCACCCCAGAGTCACTGGTGGAGATCGAGAGGCTCATCCAGGAGAAGAGCACCAGGGAGGAACTAGAGGGAGCCGAGGAGGAACCACAGGCACCGAGCAGCGATCTGGAGGCGGGAAAATGCCTGCCGATGATCTATGGCGACCCCCCCGGGGATCTCCTCAACACCCCTCTGGAAGACATCGACCCCTTTTATAAAACACAGAAAACTTTTATTGTCATAAGCAAGGGAAACACAATCTTCAGGTTCTCTTCTGAACCGGCGATGTTTTGCATCAGTCCTTTTAGTATTGTCAGAAGAGGAGCCATCAAAATTCTTATACATTCGTTATTTAGCATGTTCATCATGATCACCATCCTGTCCAATTGCGTGTTCATGACGATGAGTAACCCTCCAGCCTGGAGTAAAACTGTCGAGTATGTTTTTACTGGTATATATACCTTTGAAGCGACTGTCAAAGTTTTATCCCGAGGCTTCTGCATTGGACCTTTTACATTCCTCCGTGATCCATGGAACTGGCTTGATTTCATGGTGATCAGCATGGCGTACGTCACAGAGTTTGTAGACCTTGGCAATGTGTCAGCACTGAGGACATTTCGTGTGCTTCGAGCTCTCAAAACAATCACAGTTATTCCTGGTTTGAAAACCATTGTTGGGGCTTTGATTCAATCTGTCAAGAAGATGATAGACGTCATGATTTTGACCATCTTTGCACTGGCTGTATTTGCCCTCATTGGACTACAGCTGTTCATGGGAAATCTGCGCCAAAAGTGCATCCGTTGGCCCATTCTCAACAGCACCATCTTTGACGTCTACAACTCCAACATGGTCAATGACACCACCCTCAACGTTACCGATACTTTCGATTTCAAAGCTTACATAAGCAATGAAGAAAACCAATACTTTCTGGAAGGAAGTTTAGATGCTTTACTATGTGGCAACAGTTCTGATGCTGGGAGATGTCCAGAAGGATACACGTGTATGAAAGCTGGTCGAAACCCAAACTATGGCTATACAAGCTATGACAACTTTGGATGGGCCTTTCTCGCCCTCTTCAGACTCATGACCCAGGACTTTTGGGAGAATCTTTTCCAGCTGACCCTTCGTGCTGCTGGGAAGACTTACATGATCTTCTTCGTGGTGGTCATCTTCCTGGGCTCTTTCTACCTCATCAATCTGATCTTGGCTGTGGTTGCAATGGCATACGACGAGCAGAATGAGGCCACATTGGCCGAGGCTCGTGACAAAGAAGAGGAGTTTCAAAGATTACTTGAGCAGCTCAAGAACCAAGAGACAGGCAGTAAAGCATCTTTGGCCAGCCAGAAAACACAAAGTCGAGGGTCAAACCGGACAGGTTCCCTGCACGATCTTGCAGATGAAGATGTCATAAAGGACTGTAATGGCCGAATAGTACCTCGCCTTATTGTCAACAGAGTTTCCTCTAACAAAGAGTTATCAGCAGAAGAGGACCAGAAGTCTCTGAGTTCAAAACACAGCATGCAGTACTTGGACCAGCCCAAACTCTCCAAGAGAACAGCTAGTGCTCTCAGTGTACTCACTGCAACTATGGAGGGGTTGGAGGATGCCCAGAGGCCTTGTCCCCCTGGCTGGTATAAGTTTGCGGATATGTTCCTTAAATGGGACTGCTGCGCTCCCTGGATCTTGTTTAAGAAGTGGGTTCATTTTGTAGTGATGGACCCATTCGTTGACCTGGGTATCACCATCTGCATTGTGCTCAATACACTGTTCATGGCCATGGAGCATTACCCTATGAGTCCACATTTTGAACATGTCCTCTCAGTGGGCAACTTGGTGTTCACAGGAATCTTCACAGCTGAAATGGTGTTCAAGCTTATAGCTATGGACCCTTACTACTACTTCCAGGTGGGCTGGAACATTTTTGACAGCATCATTGTCACACTCAGCCTGGTGGAGTTGGGACTGGCCAACGTTCAGGGATTGTCCGTTCTAAGGTCCTTTCGTTTGCTACGTGTCTTCAAACTGGCTAAATCTTGGCCCACCCTTAACATGCTGATCAAGATCATCGGCAACTCAGTGGGTGCTCTAGGGAACCTAACACTTGTTCTGGCCATCATTGTCTTCATCTTTGCCGTGGTGGGCATGCAGCTTTTTGGAAAAAGCTACAAGGACTGCGTTTGTAAGATCTCTGAGGATTGCGAGCTGCCCCGCTGGCACATGAACGACTTCTTCCACTCATTCCTCATCGTCTTTCGGATCTTATGTGGAGAGTGGATTGAGACTATGTGGGACTGCATGGAGGTGGCAGGAGCTAGCATGTGTTTGATAGTCTTCATGATGGTCATGGTCATCGGAAACCTTGTGGTGCTGAATCTGTTTCTGGCCCTGCTGCTTAGCTCCTTCAGTGGAGATAACCTGTCTGGAGGTGATGATGATGGAGAGATGAACAACCTTCAGATTGCCATTGGCCGCATCACCAGGGGTATCGATTGGGTTAAAGCCTTAGTTGCCAGTATGGTGCAACGGATTCTGGGAAAGAAACCTGATAATACCAAAGAGGAAGGGGAGGGAGACATAGAACTGTACGCTTTAAATCACCTTGATGAAGGAAAAATGGCAGATGGTTTGACCAACTGTTTGTCTCCAACATTGACTGTACCTATTGCTCGTTGTGAGTCTGATGTGGAGGAAGATGAGGACTCTGAATCTTCTGATGAGGAAGACGCAAAGGCCACTCTTAATGATGGTGACTCTTCGGTTTGTAGCACAGTGGACTACCAGCCTCCAGAACCTGAGCCTGAACCTGAAGAGGTAGAAGAAGAGGAACCAGAACCTGAAGAACCAGAGGCCTGTTTCACAGAGGGCTGTATTAGGCGATGTGCATGTTTGAGTGTTGACATCACAGAAGGATGGGGTAAAAAATGGTGGAACCTCAGAAGGACATGCTTCACCATCGTTGAGCATGATTACTTTGAGACCTTCATCATCTTTATGATCCTCCTTAGCAGTGGAGCACTGGCTTTTGAGGATATCAACATTGAGAGGCGCAGAGTGATCAAGACCATTCTGGAGTATGCTGATAAAgtctttacatatatttttatagtgGAGATGTTACTGAAGTGGGTGGCATATGGCTTCAAGACCTACTTCACTAATGCATGGTGCTGGCTGGACTTCCTCATTGTGGATgtgtcTCTGGTCAGTTTAACGGCTAATTTAATGGGCTACTCTGAGCTGGGGGCAATCAAATCTCTCAGGACACTTAGAGCTCTTCGTCCACTTCGAGCCCTATCCAGATTTGAAGGAATGAGGGTGGTAGTGAATGCACTTGTAGGTGCCATTCCCTCTATTTTTAACGTGCTCCTGGTGTGTCTGATATTCTGGCTCATCTTCAGCATTATGGGGGTCAATCTGTTTGCCGGAAAATTCTACCACTGCATCAACACCACCACAGAGGAACGGATCCCCATGGATGTAGTCAACAACAAGAGTGACTGCATGGCACTGATGTACACCAACGAGGTGCGATGGGTCAATGTCAAGGTCAACTACGACAACGTGGGACTCGGCTACCTCTCTCTGCTGCAGATTGCCACATTCAAAGGCTGGATGGATATCATGTATGCTGCAGTGGATTCTAGAGAGGTGGATGAGCAGCCATCATATGAAATCAACCTTTACATGtacctttattttgttattttcatcATTTTTGGCTCCTTTTTTACTCTCAACCTCTTTATTGGTGTCATCATTGACAACTTCAATCAGCAAAAATCAAAGTTTGGAGGGAAAGACATTTTCATGACTGAGGAACAGAAAAAGTATTACAATGCCATGAAGAAGCTGGGTGCAAAGAAACGTCCAAAACCTATACCTCGACCATCaAATATTATCCAGGGTTTGGTGTTTGACTTCATATCAAAACAGTTCTTTGACATTTTTATCATGGTGCTAATCTGCCTCAACATGGTGACCATGATGATAGAGACGGATGACCAGAGTGCTGAGAAAGAATATGTCCTGTACCAGATCAATCTGGTCTTCATCGTCGTCTTCACAAGTGAATGTGTACTTAAATTATTTGCACTCAGACAGTACTTTTTCACTATTGGCTGGAACGTCTTTGATTTTGTTGTAGTCATCCTTTCTATTGCAGGTCTAATGTTATCAGACATCATTGAGAAGTACTTTGTGTCTCCTACTTTGTTTCGTGTCATCAGACTTGCAAGAATCGGCCGTGTGCTGCGTCTCATCAGAGGGGCGAAGGGCATTCGGACCCTTTTGTTTGCCTTGATGATGTCACTTCCTGCCCTTTTCAACATTGGACTGCTTCTGTTCCTGATCATGTTCATCTTCTCCATCTTTGGCATGTCTAACTTTGCCTATGTGAAAAAGCAGGCAGGCATCGATGACATCTTCAACTTTGAAACATTTGGTGGCAGCATTATCTGCCTGTTTGAGATCACAACCTCGGCAGGCTGGGACGGCCTTCTGCTGCCTATTCTAAACAGTGGCCCTCCTGATTGTGACCCTGACTTTGAAAACCCTGGTACAGATGTGCGGGGAAACTGCGGGAATCCTGGCATGGGCATCATGTTTTTCTGCAGTTACATCATCATGTCATTCCTGGTGGTCGTGAACATGTACATCGCCATCATTCTGGAGAACTTCAACAATGCTCAAGAGGAAAGTGGAGACCCGCTCTGTGAGGATGACTTTGATATGTTTGATGAAACATGGGAAAAGTTTGACGTCGATGCTACGCAGTTTATTGAATACGACCGCTTGTTTGACTTTGTCGATGCCCTGCAGGAGCCTTTACGAATTGCCAAACCCAACCGTCTCAAGCTGATCTCCATGGACATCCCCATTGTAAACGGCGACAAAATCCACTCTCAGGATATACTTTTAGCAGTGACCCGGGAAGTACTTGGCGACACTATTGAGATGGATGCCATGAAGGAGAGCATCGAAGCCAAGTTCATCATGAACAACCCCACATCTGCCTCGTTTGAGCCAATCATCACCACTCTCAGGAGGAAGGAGGAAGAGCGAGCAGCCATTGCGGTTCAAAGAATATACCGTAGGCATCTTCTCAAGCGTGCCATCCGCTATGCCTGCTTCATGCGCCAATCAAAGAGGAAAGTTAGGAATCCCAACGACAATGAACCTCCTGAAACTGAAGGGTTGATTGCAAGGAAGATGAATACCCTATATGGCAGCAATCCAGAACTTGCCATGGCTCTTGAATTGGAGACTAGGCCAATGCGGCCAAATTCACAGCCTCCTAAACCAAGCCAGGTCACACAGACCAGAGCATCAGTGACCTTCCCTAGGCCGCAAGGACAGCTCATCCTCCCAGTGGAGCTCACCAGTGAGGTGATCCTCCGGTCTGCACCCACTACACACAGCTTCAACAGTTCAGAGAATGCAACAACGATAAAGGAGTCAATAGTATAACTAGCAGACAATTCCTGTGGACTAAAAGACAATCCTTGTGGTGTTAAATGGAGTGTCATCTGAACAACA

Function

symbol description
scn4aa Predicted to enable voltage-gated sodium channel activity. Predicted to be involved in membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to act upstream of or within regulation of ion transmembrane transport; sodium ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in heart; musculature system; nervous system; pectoral fin; and testis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4).

GO:

id name namespace
GO:0019228 neuronal action potential biological_process
GO:0034765 regulation of ion transmembrane transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0086010 membrane depolarization during action potential biological_process
GO:0006811 ion transport biological_process
GO:0006814 sodium ion transport biological_process
GO:0035725 sodium ion transmembrane transport biological_process
GO:0030424 axon cellular_component
GO:0001518 voltage-gated sodium channel complex cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005216 ion channel activity molecular_function
GO:0005244 voltage-gated ion channel activity molecular_function
GO:0005248 voltage-gated sodium channel activity molecular_function
GO:0005261 cation channel activity molecular_function
GO:0005272 sodium channel activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-051201-2 Predicted to enable voltage-gated sodium channel activity. Predicted to be involved in membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to act upstream of or within regulation of ion transmembrane transport; sodium ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in heart; musculature system; nervous system; pectoral fin; and testis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4).

Ensembl:

ensembl_id ENSDARG00000098738

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008965 True 5559 mRNA 0.47 25 4869248 4893492

Neighbor

gene id symbol gene type direction distance location
XLOC_004486 ghrhr2 coding upstream 14693 4845448 ~ 4854555 (+)
XLOC_004485 NA coding upstream 33934 4834849 ~ 4835314 (+)
XLOC_004484 NA coding upstream 117396 4748571 ~ 4751852 (+)
XLOC_004483 NA coding upstream 134260 4729017 ~ 4734988 (+)
XLOC_004482 kansl1a coding upstream 143588 4686145 ~ 4725660 (+)
XLOC_004488 cd79b coding downstream 7489 4900981 ~ 4906924 (+)
XLOC_004489 plekhm1 coding downstream 26959 4920451 ~ 4963153 (+)
XLOC_004490 arhgap27 coding downstream 78023 4971515 ~ 5044931 (+)
XLOC_004491 kif22 coding downstream 154552 5048044 ~ 5071836 (+)
XLOC_004492 AL929469.5 coding downstream 158070 5051562 ~ 5051697 (+)
XLOC_004480 CABZ01030103.1 non-coding upstream 371769 4497364 ~ 4497479 (+)
XLOC_004479 NA non-coding upstream 396100 4428123 ~ 4473148 (+)
XLOC_004493 AL929469.4 non-coding downstream 158951 5052443 ~ 5052578 (+)
XLOC_004494 AL929469.2 non-coding downstream 163729 5057221 ~ 5057356 (+)
XLOC_004495 AL929469.1 non-coding downstream 168075 5061567 ~ 5061697 (+)
XLOC_004497 AL929469.3 non-coding downstream 196323 5089815 ~ 5089930 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000047_03271413_03302291 SCN4AA coding CI01000047 null 3269915 ~ 3302371 (-)