XLOC_004620 (ch25h)


Basic Information

Item Value
gene id XLOC_004620
gene name ch25h
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 17042754 ~ 17043874 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009155
ATCATTCAGATTTAGAACTGAAAAGAAATAGAAATGTTTGGACTACAGCACATCTGGGACTGCATTCTGCAGTACGAAGCACAGCTAAGGTCTCCATTTTTCCCAGTCCTCTTCTCAATTACAGTCTACCTAAGCTTCTGCCTGCCTTTTGTCCTTCTGGATGCCCTGTCTCCAAAGGTAGAACTGATAAGGAGATACAAGATCCAACAGAAAGCCAGCGTGTCTTGGACTATGATGTGGAGCTGCCTCGCACTCTCCCTCTACAACCACGTGGTGTACATCTTCCCGCTGAGTGTCCTGCACTGGTACTGGAGACCTGTCAGCTACCTAGCGGAGGCACCTGGGGTCTTGCGGGTCGTCTGGGATCTTGCTGCCTGCCTGCTTCTGTTTGACTTCCAGTACTTTGTGTGGCATCTTCTACATCACAAAGTGCCTTGGCTTTACCGGACTTTCCATAAGGTGCACCACAAATACACATCCACCTTCGCTCTGGCCACTGAGTACTCTGGGGCTTGGGAGACCCTGTCTTTGGGGTTCTTCGCTGCGGTGAATCCCATGTTGCTTGGGGTTCATCCTATGACAGAGATGCTCTTCCACATGCTGAACATGTGGCTGTCAGTTGAGGACCATTGTGGCTATGACCTGCCATGGGCCACGCACAGACTGATGCCTTTTGGACTTTACGGAGGAGCTCCACACCATGATGTCCACCATCAGAAGTTCAAGTCCAACTACGCTCCATACTTCACTCACTGGGACAAGCTCTTTGGGACACTGCACTTTGAATGAACAGAACATTTGAAACAGactcttttttttgtaaaaagttcTTTCTCATTCTGTGAATGAATACCTTTGACTCTAAAACTTTATAAAAGATTATTTATAATTCAGATCTGTTTGACCAATTTGTCTATTTATTGAGTGTCTGTATTTAAGAGTGACTGTAAAAACTGAGATGTAAGAAATGTATTATGTTaatcatattatatttattatttataagattgttgttttgcatttataagtttgtgttgttgttattactaaaTGTATTAACGTGGACCATGAAGAAATTCAACAAGCTAATTGCAATAAATCTGTGAAGTAGATAATATAAA

Function

symbol description
ch25h Predicted to enable C-4 methylsterol oxidase activity and cholesterol 25-hydroxylase activity. Acts upstream of or within defense response to virus. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gill; intestine; kidney; liver; and spleen. Orthologous to human CH25H (cholesterol 25-hydroxylase).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0016126 sterol biosynthetic process biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0006694 steroid biosynthetic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0051607 defense response to virus biological_process
GO:0035754 B cell chemotaxis biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0008395 steroid hydroxylase activity molecular_function
GO:0004497 monooxygenase activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0001567 cholesterol 25-hydroxylase activity molecular_function
GO:0000254 C-4 methylsterol oxidase activity molecular_function

KEGG:

id description
ko00120 Primary bile acid biosynthesis

ZFIN:

id description
ZDB-GENE-041212-81 Predicted to enable C-4 methylsterol oxidase activity and cholesterol 25-hydroxylase activity. Acts upstream of or within defense response to virus. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gill; intestine; kidney; liver; and spleen. Orthologous to human CH25H (cholesterol 25-hydroxylase).

Ensembl:

ensembl_id ENSDARG00000045190

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009155 True 1121 mRNA 0.43 1 17042754 17043874

Neighbor

gene id symbol gene type direction distance location
XLOC_004619 slc16a12b coding upstream 55786 16967715 ~ 16986968 (+)
XLOC_004617 pank1b coding upstream 77914 16953415 ~ 16964840 (+)
XLOC_004618 dre-mir-107a coding upstream 81973 16960693 ~ 16960781 (+)
XLOC_004616 zgc:174153 coding upstream 90903 16949391 ~ 16951851 (+)
XLOC_004615 NA coding upstream 168051 16742395 ~ 16874703 (+)
XLOC_004621 acta2 coding downstream 56147 17100021 ~ 17116481 (+)
XLOC_004622 ankrd22 coding downstream 110781 17154655 ~ 17158635 (+)
XLOC_004623 rnls coding downstream 157648 17201522 ~ 17323341 (+)
XLOC_004624 AL731788.1 coding downstream 301676 17345550 ~ 17345667 (+)
XLOC_004625 NA coding downstream 380557 17424431 ~ 17427380 (+)
XLOC_004614 NA non-coding upstream 457700 16583373 ~ 16585054 (+)
XLOC_004613 NA non-coding upstream 472710 16567854 ~ 16570044 (+)
XLOC_004612 NA non-coding upstream 550948 16490198 ~ 16491806 (+)
XLOC_004634 BX005075.1 non-coding downstream 1081784 18125658 ~ 18125774 (+)
XLOC_004635 NA non-coding downstream 1165997 18209871 ~ 18228004 (+)
XLOC_004644 AL772266.2 non-coding downstream 1554976 18598850 ~ 18598964 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000063_00811088_00811849 CH25H coding CI01000063 null 810881 ~ 812197 (+)
tiger barb (Puntius tetrazona) G86330 ch25h,LOC107753436,LOC107584143,LOC107669234,LOC107683723,LOC107758440,LOC107594211 non-coding NC_056710.1 CM032079.1 7615868 ~ 7617213 (-)