nkx2.5 (nkx2-5)


Basic Information

Item Value
gene id nkx2.5
gene name nkx2-5
gene type coding
species eurasian perch (Perca fluviatilis)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_053121.1
NCBI id CM020918.1
chromosome length 40300294
location 14898308 ~ 14901290 (-)
genome version GENO_Pfluv_1.0_2020_eurasian_perch_Genome

Sequence

>XM_039813865.1
AGTTTGGAGACAGAGTTGACATTCAAAATGCACACTTCACTCAAGATCAGTCTGCTATGCCAAACTAATACTTAAATCCAGTAAATATTACCAGGAAGGAGAGGGAGTTTGttgacctcttttttttttgttacctcCACATGACAGGTTAATAGGTTTCTTTTTCAGTTCTTGGCAATGTTTCCCAGCCCCAGCACGTCCACTCCCTTCTCTGTAAAGGATATATTAAACCTGGAGCAGAGTCATGACGTTATGGTGTCTTCTCTGGACGTTTCTTCTCGTATGGACTGCTGCACCGTGCCGACCTCGtcctcctactcctcctcctcctcctgcatgCTGGCCCGCCTGAAGCAGGAGCCTCTGCGGGACATGTCCGCCGCCGCCTCGCTGTTTGGAGAAGACCTCCACGACTCCAGAGCCGGCAGAGGCAATGCCCTCAACTATGCTACCTTTTATGGGAAATCCCTCATGGAGATGGATGTAGTTAAGGATGGGAAATCAGACGCGTTTGAGGGGAAACGCAGAAAAGAGGACTTCAGCCCTCCGACCGAGCCTGCGGACGACATAAAAACAGAGGACGCAGGGCGACCCAAGCCCCGGAGACGCAGGAAGCCGCGGGTCCTGTTCTCCCAGGCGCAGGTGTACGAGCTGGAGCGCCGCTTCAAGCAGCAGAGATACCTGTCCGCGCCGGAGAGAGACCACCTCGCCGGGGTGCTAAAACTCACCCCGACCCAGGTGAAGATCTGGTTCCAGAACAGGAGGTACAAGTGCAAGCGGCAGCGGCAGGACCAGAGCCTGGAGATGGTGTCTCTGCCGCCGCCCAGGAGGGTGTCGGTGCCGGTGCTGGTGCGGGATGGGAAGCCTTGCCTGGCGGCAGACACAGCCGCTTACAACCCCTCCTACAGTATGGGTCACATCAACCATTTCACCTATAACAACTATCCAGCTTTCAGTAACTACACCAGCCccggctgcaacacaaactaTGCGTGTAACTACCCTGCAGCCACAATGCAAACTATGCAAGGGTCATCCAACAACGGGAATTACATGAACTTTGGGGTGGGGGACCTGAATAATGTCCAGAACACATTTCCCTCCAGTAATGGGGTGTCTTCGTTACATGGCATTAGGACATGGTAAACTCAACATCCAGCAGTGTTACCTATTCAGTTTATAACGGGATTATTTGcatgcattttaaatgtgtcaaGACTTTGTCGAGCTTGTGTAACTTCTTATATTTAATTACCTACTCACTTTTGGTAGTTTTTCGTTttcagcacgtttttttttgtttttttaattaatttccgTGGCATGAGCGAACAGGCGCGTGCCATTTGAgcggaaataaaaaaaaataacatgttgCAACCACAGTTCGTTAATGTTATTCTAAATTTTCCCTCTCATTTTTCTATCtccatgttatttattttttttgacaccATGAGGTGGATTGCTAAATGTTCTTACCTACAAAAATGGGCCAAGAtgggaaaacacaaaataaaattgtaataactttggttaTGGAAAATGATTACTTCTATAGGCTATTCTAattattattgtaattgttAATATTACTGGCATGCAATTATTTGATTAGAAATGCTCAAAGTTGTTTAATGTGATTATTGGCTCTGGCTATAATCCCTGAATCatttaaaaatacacacaaaaaaaccccaaaacaacaaaaaaaaaaaccagcaaTATTAAGTCTCCATTATGTAATAGTGAACTATAGTTATGGCAGTATATAATCCATGGCTGTGGGTCACATGGTTGAACTGGTTGAACAGTCGATCCACATTAAAAGGACCCCAACATGTGTACACCCCTCATATGGTTTGTGTCTGGTTGAAGTGTTCAAGTGGCTATTAGGAAGCTTCCTTCTATAAGCTCAAACAAGGTGAAAAGGTTGTTAAAAGTTTACACTTTTTACAAGCCGCTGTCGGCCACGTGCACTCACGTTTACATTTGTTGGGACAGAGATCGCTGGGAGCCATAACCTTGACCTGTATTAAGCGTTATTATAAATCGTGTTTCTGCAAGGAAATGTGGTTTTAAAGTCATTACAATTTTGATTTTTCAATAATTGTACTGTGTGTACAAGTATTCTGTGTACAGCCTGTCAAAAGCCACACTGAAAGTCAATGGCTTTTGTCTGTACTTGTAAAATATGAGGACAAATCCAAGATGTTACCTGATCCACGATAGCACTCAGTGTACTTGATTATTAAAAGACGTTctttctgaaa

Function

symbol description
nkx2-5 Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; negative regulation of cardiac muscle cell apoptotic process; and regulation of transcription by RNA polymerase II. Acts upstream of or within cardiac conduction system development. Located in nucleus. Part of RNA polymerase II transcription regulator complex and protein-DNA complex. Implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5.

NR:

description
PREDICTED: homeobox protein Nkx-2.5

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0055007 cardiac muscle cell differentiation biological_process
GO:0060038 cardiac muscle cell proliferation biological_process
GO:0001947 heart looping biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function

KEGG:

id description
K09345 NKX2-5; homeobox protein Nkx-2.5

RNA

RNA id representative length rna type GC content exon number start site end site
XM_039813865.1 True 2273 mRNA 0.44 2 14898308 14901290

Neighbor

gene id symbol gene type direction distance location
ppp2r2ba ppp2r2b,LOC107086445,LOC104946885,LOC100708080 coding downstream 15492 14834054 ~ 14882816 (-)
gpr151 gpr151 coding downstream 64472 14829320 ~ 14833836 (-)
rab33ba LOC103374601,LOC106911658 coding downstream 132113 14761945 ~ 14766195 (-)
trnaa-ugc_8 NA coding downstream 194205 14704032 ~ 14704103 (-)
mmp17b LOC104951499,LOC101483571 coding downstream 201028 14685137 ~ 14697280 (-)
drd1a drd1,LOC103470866,LOC103144507,LOC106953475 coding upstream 127618 15028908 ~ 15032268 (-)
nek12 NA coding upstream 148846 15050136 ~ 15053250 (-)
LOC120567479 NA coding upstream 226608 15127898 ~ 15132154 (-)
sncb sncb coding upstream 233836 15135126 ~ 15149929 (-)
ctnna1 ctnna1 coding upstream 540129 15441419 ~ 15516760 (-)
G105001 NA non-coding downstream 6797 14890593 ~ 14891511 (-)
G104999 NA non-coding downstream 10101 14883859 ~ 14888207 (-)
G104962 hspa9 non-coding downstream 119567 14778207 ~ 14778741 (-)
G104924 NA non-coding downstream 260863 14635107 ~ 14637445 (-)
G104867 NA non-coding downstream 516246 14381645 ~ 14382062 (-)
LOC120567075 NA non-coding upstream 47103 14948393 ~ 14953055 (-)
G105040 NA non-coding upstream 123726 15025016 ~ 15025409 (-)
G105049 NA non-coding upstream 127060 15028350 ~ 15028866 (-)
LOC120567002 NA non-coding upstream 303843 15205133 ~ 15436933 (-)
G105096 NA non-coding upstream 373265 15274555 ~ 15274923 (-)
LOC120567441 LOC100697283,LOC102197909,LOC102314576 other downstream 158815 14735192 ~ 14739493 (-)
uvssa uvssa,LOC104961899,LOC106533076 other downstream 324815 14537100 ~ 14573493 (-)
G104837 NA other downstream 642267 14150492 ~ 14256041 (-)
G104656 NA other downstream 2754564 12142700 ~ 12143744 (-)
G104610 immt,LOC102797104 other downstream 2905630 11964979 ~ 11992678 (-)
rnf44 rnf44 other upstream 188114 15089404 ~ 15108598 (-)
G105086 NA other upstream 232240 15133530 ~ 15134736 (-)
tspan17 tspan17,LOC103361971 other upstream 697053 15598343 ~ 15619108 (-)
hnrnph1 hnrnph1,LOC102791917 other upstream 964770 15866060 ~ 15871949 (-)
unc5a unc5a,LOC102788949 other upstream 1058907 15960197 ~ 16103794 (-)

Expression


Co-expression Network