XLOC_004729 (gch2)


Basic Information

Item Value
gene id XLOC_004729
gene name gch2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 25085751 ~ 25092570 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009369
GAGCGCGTGCTCACGCTGAAAGCCGAGGTGCTCAATTGGACACAGTGATAGTGGAAGGCTCCTATAAAAGCCACCGAGTGGGAGACAGAATCTGAGTCAGCTCCACGACGATCAACAGGCTACCCAAGCACCGGCTGCAGTTCTGAAGCAACATCTGCTCGACTTCCAATATAAATAACAggcttgaaattattattatcttcTAAATAGTCAATCATTAGTCAGTATGGAATACCAAAAGGCAGCAGAACTGAACAGTTTGTGCAATGGCAAAATCGTCACAGAGTATCTCTGCCGCAATGGCTTTAGCGACCTGACGGTCGACACGAAAAAAGTCGCTGTCCAGCACAAAAACGAGACATCCCGGAAAGAGGAGGAGGATGAGTCGCGGTTACCTGCTCTGGAGGCGGCATACACCACTATACTGCGTGGACTGGGGGAAAACACCGACCGACAGGGTCTCCTCAAAACCCCTCTCCGTGCTGCCAAAGCCATGCAGTTTCTGACTAAGGGATACCACGAGACCATCTACGATATCCTTAACGATGCCATATTTGATGAAGACCATGAAGAGCTAGTCATTGTGAAAGACATTGACATGTTTTCACTTTGTGAACATCATCTAGTACCATTCTTTGGCAAGGTTCACATAGGATATCTGCCAAGCAAAAAGGTTGTTGGCCTCAGTAAGCTTGCAAGGATTGTTGAAATCTACAGTCGCAGACTTCAAGTTCAAGAGCGTCTAACAAAGCAAATAGCGATGGCAATCTCTGAAGCCCTGCAGCCTGTTGGTGTGGCAGTTGTCATTGAAGCAGCTCACATGTGCATGGTCATGCGTGGAGTGCAGAAGATGAACAGCCGTACCGTGACCAGTGCGATGCTGGGTGTGTTCAGAGAGGATCCAAAGGCCCGAGAGGAGTTCCTGGCCCTGGCCAAAAGCGCGCAGTGATCACACTTCCATCCCTTAAGTCCATCAGTGTGTTTACAGCCAAACAGGTCAACGATTGTTCCTGAAAAGCTCCATGGTGCTATTAGTGAATCTCACTGAGCCAGAGCTGTAGATCGTTTTTTTTCCACCAGCAACAGCTCAGGGGTCTTCACTGTTTGcgtatatttaaatattcaatgTGAATATATGAAGGATCAGTGTTACTATTTTGAAGCCATTATTGAATGTCCAAACATTCACAGAGCTGCCTTAAAATTGAATTTATGTGTCATTTCTACTGTTAACAATtactaaattcatattttttcctTATATACACTTGTCTAACCTTATGAgtttttacaaaaatgaaaacaattaattattttgtatacaactttcatattttataataagGTCTGATTAATTAGCaccagttaatgcatttactaacaatgaacagtacatttgttgcagtatttattcatctttgttaacgttggttattttaaatatagtaatTAATAAGTCGTTCTTGGTTAGTTTGTTTTATTATCTCAGGTTTAGTAAATATTAACATATACCACTTTTGATTTTAATTCAAATCTTTTGTTTGATATTGATATTTAGAAGTGCTTCAGAAAAGAGTAtttttcattgttagttcatgttaactaatccTAACTTATTGGAAAGTTTatccacaacttttttttttaaaaccaaaaacgTATTTTTGTCAAATGCTCTGATTAGAAAATATTCAAAGTGCCAAAatgcaaatacaataaaatatatattttttgttgttgtgcaaGTAAATGATTAGGTTCCTCTGGATATATCTGTGTGGCATCATTTGTATgcagttaaaaatgtttatttaaaataaaagcactGCCATTGTcacatttttatattatgtaCAGCTCTGCATTGTACAAACAGAAATGAAAGATGTCATTCACACCATCTTCAACAATAAAGCATCATTGTGAAATCCA

Function

symbol description
gch2 Predicted to enable GTP binding activity; GTP cyclohydrolase I activity; and zinc ion binding activity. Acts upstream of or within xanthophore differentiation. Predicted to be active in cytoplasm. Is expressed in head; neural crest; pigment cell; trunk; and xanthoblast. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia B; bipolar disorder; dystonia; and dystonia 5. Orthologous to human GCH1 (GTP cyclohydrolase 1).

GO:

id name namespace
GO:0050936 xanthophore differentiation biological_process
GO:0006729 tetrahydrobiopterin biosynthetic process biological_process
GO:0046654 tetrahydrofolate biosynthetic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0003934 GTP cyclohydrolase I activity molecular_function
GO:0005525 GTP binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008270 zinc ion binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-001205-3 Predicted to enable GTP binding activity; GTP cyclohydrolase I activity; and zinc ion binding activity. Acts upstream of or within xanthophore differentiation. Predicted to be active in cytoplasm. Is expressed in head; neural crest; pigment cell; trunk; and xanthoblast. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia B; bipolar disorder; dystonia; and dystonia 5. Orthologous to human GCH1 (GTP cyclohydrolase 1).

Ensembl:

ensembl_id ENSDARG00000099101

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009369 True 1932 mRNA 0.39 6 25085751 25092570

Neighbor

gene id symbol gene type direction distance location
XLOC_004728 CR385067.1 coding upstream 10631 25073305 ~ 25075120 (+)
XLOC_004727 calm3a coding upstream 126959 24952902 ~ 24958792 (+)
XLOC_004726 NA coding upstream 141247 24944172 ~ 24944504 (+)
XLOC_004725 fshr coding upstream 315561 24738962 ~ 24770190 (+)
XLOC_004724 BX255907.1 coding upstream 520159 24565478 ~ 24565592 (+)
XLOC_004730 pigf coding downstream 5184 25097754 ~ 25110974 (+)
XLOC_004731 CR848736.1 coding downstream 108973 25201543 ~ 25214727 (+)
XLOC_004732 mta3 coding downstream 131229 25223799 ~ 25284510 (+)
XLOC_004733 CR932077.1 coding downstream 219448 25312018 ~ 25430371 (+)
XLOC_004734 ppm1bb coding downstream 340056 25432626 ~ 25487244 (+)
XLOC_004723 BX255907.2 non-coding upstream 667411 24418224 ~ 24418340 (+)
XLOC_004721 AL928656.1 non-coding upstream 871234 24214401 ~ 24214517 (+)
XLOC_004735 NA non-coding downstream 409836 25502406 ~ 25504380 (+)
XLOC_004738 CR932018.1 non-coding downstream 555557 25648127 ~ 25648243 (+)
XLOC_004744 NA non-coding downstream 1396783 26489353 ~ 26491973 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000063_05183819_05187667 GCH2, GCH1 coding CI01000063 null 5183619 ~ 5188349 (+)