XLOC_004819 (aldh18a1)


Basic Information

Item Value
gene id XLOC_004819
gene name aldh18a1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 30788912 ~ 30810171 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009523
GTCAACATGGCTGAACCCATGCGAGCAGCTGTTGAGAGTTGATGTGGCATCGAAGAACAGCAGTGGCAGTGAACTTGAGCtgaattattcatatttattgcaCAGATTAAGATCAGATCACCATGTCTCTCCAGAGGATGTTCTCCTGTTCGCGGCTTTTAGCAAGACCAAATGCTCTGCAAACATTCAGGCGAGCAGCTTCACAGGGCAAAATGCCGCTGGCACGGGCGCATGGTAAGTCATTCGCTCACCGGAGCGAGCTGCGCCAGGCCAAGAGAATCGTCGTCAAGTTGGGAAGTGCTGTCGTAACCCGAGGTGATGAGTGTGGCCTCGCTTTGGGCCGACTCGCTTCAATCGTAGAGCAGGTGGCCATGCTTCAGAATCAGGGTAGGGAAATGATGATCGTGACCAGTGGCGCTGTGGCATTTGGAAAACAAAGGCTGAGGCATGAAATACTTCTCTCACAGAGTGTCAGACAAGCCCTGCATTCAGGCCAGAATCAGCTCAAAGACATGTCATTGCCGGTTCTAGAGGCGAGAGCTTGTGCCGCTGCAGGACAGAGTGGCCTTATGGCTCTGTATGAGGCAATGTTCACTCAGTACAGCACTTGCACGGCCCAGATCCTGGTAACAAACCTAGACTTCCACGACGAACAGAAAAGACGAAACTTGAATAGCACTCTGTACGAGCTGCTGCGAATGAACATCGTTCCCATCATCAACACCAACGATGCCGTGGTGCCTCCCCCAGAACCCAACAGCGACCTACAGGGGGTAAATGTTATCAGCATTAAGGATAATGACAGTCTTGCTGCAAGGCTTGCTGTGGAAATGAGGGCAGATCTCCTTATTGCTCTCTCTGATGTAGAGGGCCTTTATGACAGTCCACCAGGGTCAGATGATGCCAAGCTTTTGGACACATTTTACCCTGGAGACCAGCAATCAATAACCTATGGCACAAAGTCTAGGGTCGGCATCGGAGGAATGGAAGCCAAGGTAAAAGCTGCTCTCTGGGCTCTCCAAGGAGGAACGTCTGTGGTCATTGCTAACGGTACACACCCCAAAGTCACAGGTCATGTGATCACTGATATTGTTGAGGGCAAGAAAGTGGGAACCTTCTTCTCAGAGGTCAAGCCAGCAGGCCCCACGGTGGAGCAGCAGACAGAAATGGCTCGCTCTGCTGGCAGGACTCTTGCTTCCCTTGAACCAGAGCAGAGAAGTGACATCATCTGTGCATTGGCTGACCTTCTCACAGAGAGGAAAGAAGAAATCCTGTCTGCCAACAAGAAGGACATGGAGAACGCTGTCAACACGGGTCGCCTGTCTCCAGCTATGCTGAAGCGGCTTAGTTTGTCATCGTCTAAGCTGAACAGTCTGTCCATCGGTCTGCGTCAGATCGCGGTGTCCTCTCAGGACAGTGTTGGCAGGGTTTTGCGCAGGACTCGTGTTGCAAACAACCTGGAGCTGGAGCAGATCACTGTGCCCATAGGAGTACTGCTGGTCATCTTTGAGTCACGGCCAGACTGCCTGCCTCAGGTTTCTGCATTAGCCATTGCCAGTGGAAATGCTCTTTTGCTGAAAGGTGGCAAAGAGGCGGCCAACACCAATCGCATCCTGCATGAGCTTGCACAGGAAGCCCTGTCTATACATGGAGTCAAAGATGCCATCCAACTGGTGAGCACTCGTGAAGAGGTGGAGGATCTGTGTCGTCTGGAGAAGATGATTGATCTGATCATTCCCCGTGGCTCCTCGCAGCTGGTCAGAGATATTCAGCGAGCAGCTAAAGGCATCCCTGTGCTTGGCCACAGTGAGGGGATCTGCCATGTCTATGTTGACCACGAGGCCAGTATTGACAAAGCCATCAAAATCATCCGAGACTCTAAATGTGACTACCCTGCTGCCTGCAACGCAATGGAAACTCTGTTGGTGCATCGAGATCTTCTCAGAACTCCAGTATTTGATCAAATCATTGATATGCTGAGAACAGAACAAGTCAAGATTCACGCTGGCCCTAAGTTTGCATCCTATCTAACCTTTAGTCCATCAGAAGTGAAGTCTTTGCGTACAGAGTATGGAGATCTGGAGTGCTGTATCGAGGTGGTGGACAGCATGCAGGAGGCTATAGATCACATCCATAAATATGGCAGCTCACACACTGATGTTATCGTCACTGAGAACGAGAACACAGCTGAGCAGTTCCTCCAGCAGTTGGACAGTGCCTGTGTCTTCTGGAATGCCAGCTCACGGTTTGCTGATGGATATCGGTTTGGCCTAGGTGCGGAGGTTGGCATCAGCACTGCCCGTATTCATGCCCGTGGTCCTGtggggctggaagggcttctCACGACTAAGTGGGTGTTGCGGGGTGAAGGCCACACAGTGGCAGATTTCTCGGAGCATGGCAGCATGACGTATCTGCATGAAAATCTACCGGTGGCACAGCTCCTTCCTGGATACAGAACCACCAGCTAGAGTTGAGAAGTAAATGCTTCTACGCTCAAGGATCAAATGCATATCACCTACTTAAATCCCATTTAAAGACTCCTGTCAGGCAGTGTGTTTGGAAAATCAAATGTGAATGGGCAGTCAAACCGATgtattttaagggatagttctccaaaaaaaaaaaaaagtaatttattctCCCTCAGGCCATTCAAGATGTAGGGGACTTTTTGTTTAGTTGCTgatcaaataaattataatactaaatgcattaaaaatacatataataaatacaataaattatataattatttgagcTGAAATTGAAAGTGCTAGCAGCCATTGATTTATATTAATCTTCCCATAGTTAAAGACATGCAGGCACAACAAAATTAATACCCATTGTTTCTGATGGTACGTTGAGGTCTAatccatttaaaataattagtctaTTCAAGGAACTGAGCATTATTTGCAAAACTTTCATTTATTCACACGATTTTGCAAGCACTCTTGAGCATTTATAATGATGGGCAATGGACAGATGCAAACAAGTTGTTAGCAATGGAAAGAAAGGTCGTGTGAGTACATATGCTGAAACTTGTTGAAAGTTAAACACCTGCACACATCCTTACAATCATTATGACTGTACTCTGGACTATTTTCTGCACCTACTATTTTAATAATGCTCAGATGCATCATTTTGCTTCATCAGATTTAAGTGCATCGTCAGGAGCCACGGGTACTAGTTTAGTTTTGCCTGTGTGTGGTATTTAACTCTGAAAATGCCAACTAATCGTTTAATgttctactaaagaaaaaaaCTCACCTACATTACATATTGAATTTCCTGAGGGTAAAATagtagcatttattttttatttttggaggtGTTCTATCCCTTTAAGAAGCCTTTAAAGCATAAGTCTCAAACACAATTCCTGGacggccacagctctgcacagttttactcCGACCCTGATTAAACAGCTGATCCCACTAATGAATGTGTTCAAGACTCTTTTTAAACGcctcgattatttggatcagctgagtttgattagagttggaacaaaactgtgcagagctacggccctccaggaattgttTGAGACTTCTGCTTTAAAGGCTTCTGTTTGTCCCGTACTTTAGATTCTCTCAAGGGCCAAAGAGATCACCTCAACTTATTGTTAAATGTGTCTTGTTTTCTTTGTAAATCGGTTGAACCTAGCTACTAAACACAGTTAATGGTACACAGATGGATAAGGGATTTTAGTGCTGGCTATGCTCATGTTGTCATTTTATGATTTGTGCATATTTTCCTTTAAGTATCCAAATGTATCATGATCACGATGAATGCAATGACACTTCCCGACCTCCAGAATTGCCAAtgttatatttatgtaatatttaagaATAAAATGTGGTACAATAATCCTTTACAGTACAATAATCCTTCAAATCatagcattaaataaaatgtgtattacAAGTATGGCAACATTGTGTACCCAACTTCAGGTTTAGAGagtaaagtatttttttcatatggTATAGTGATCTCAAATAGAATATAACATGAGTACTAACTGAAAAAGGTAACCATAGAAGAAAATAGTCATGTTACCATAGTGTTCAACCTATCCAATTCAACATGGGAAAACTGTATTATTAGCTTAAATCATCTGTATGCTGCttttgaaaagaaaacgaatggaAAATCAGTTTTCCTGTGCATCACTTCTCTCATTTTGCGTAGTTCTTTAGCTTTTTAATCACAAATACTGTGCAAATCATTTCCCTGCTGTAAAATTCACCCGGGACGGGCACATTTTGTCCTGAACTGCTGCAGAAATCCTCATTATCTGTACTTAAAAGTGCTGTATCGCTTCACTAAATAGTGATGCTCGCAGTGTTCTGAAGATGTTCACAATTTTTGTATGTAGAATAAATGTCTTTTTGTACTTTCAAA
>TCONS_00009524
ATCAGATCACCATGTCTCTCCAGAGGATGTTCTCCTGTTCGCGGCTTTTAGCAAGACCAAATGCTCTGCAAACATTCAGGCGAGCAGCTTCACAGGGCAAAATGCCGCTGGCACGGGCGCATGGTAAGTCATTCGCTCACCGGAGCGAGCTGCGCCAGGCCAAGAGAATCGTCGTCAAGTTGGGAAGTGCTGTCGTAACCCGAGGTGATGAGTGTGGCCTCGCTTTGGGCCGACTCGCTTCAATCGTAGAGCAGGTGGCCATGCTTCAGAATCAGGGTAGGGAAATGATGATCGTGACCAGTGGCGCTGTGGCATTTGGAAAACAAAGGCTGAGGCATGAAATACTTCTCTCACAGAGTGTCAGACAAGCCCTGCATTCAGGCCAGAATCAGCTCAAAGACATGTCATTGCCGGTTCTAGAGGCGAGAGCTTGTGCCGCTGCAGGACAGAGTGGCCTTATGGCTCTGTATGAGGCAATGTTCACTCAGTACAGCACTTGCACGGCCCAGATCCTGGTAACAAACCTAGACTTCCACGACGAACAGAAAAGACGAAACTTGAATAGCACTCTGTACGAGCTGCTGCGAATGAACATCGTTCCCATCATCAACACCAACGATGCCGTGGTGCCTCCCCCAGAACCCAACAGCGACCTACAGGGGGTAAATGTTATCAGCATTAAGGATAATGACAGTCTTGCTGCAAGGCTTGCTGTGGAAATGAGGGCAGATCTCCTTATTGCTCTCTCTGATGTAGAGGGCCTTTATGACAGTCCACCAGGGTCAGATGATGCCAAGCTTTTGGACACATTTTACCCTGGAGACCAGCAATCAATAACCTATGGCACAAAGTCTAGGGTCGGCATCGGAGGAATGGAAGCCAAGGTAAAAGCTGCTCTCTGGGCTCTCCAAGGAGGAACGTCTGTGGTCATTGCTAACGGTACACACCCCAAAGTCACAGGTCATGTGATCACTGATATTGTTGAGGGCAAGAAAGTGGGAACCTTCTTCTCAGAGGTCAAGCCAGCAGGCCCCACGGTGGAGCAGCAGACAGAAATGGCTCGCTCTGCTGGCAGGACTCTTGCTTCCCTTGAACCAGAGCAGAGAAGTGACATCATCTGTGCATTGGCTGACCTTCTCACAGAGAGGAAAGAAGAAATCCTGTCTGCCAACAAGAAGGACATGGAGAACGCTGTCAACACGGGTCGCCTGTCTCCAGCTATGCTGAAGCGGCTTAGTTTGTCATCGTCTAAGCTGAACAGTCTGTCCATCGGTCTGCGTCAGATCGCGGTGTCCTCTCAGGACAGTGTTGGCAGGGTTTTGCGCAGGACTCGTGTTGCAAACAACCTGGAGCTGGAGCAGATCACTGTGCCCATAGGAGTACTGCTGGTCATCTTTGAGTCACGGCCAGACTGCCTGCCTCAGGTTTCTGCATTAGCCATTGCCAGTGGAAATGCTCTTTTGCTGAAAGGTGGCAAAGAGGCGGCCAACACCAATCGCATCCTGCATGAGCTTGCACAGGAAGCCCTGTCTATACATGGAGTCAAAGATGCCATCCAACTGGTGAGCACTCGTGAAGAGGTGGAGGATCTGTGTCGTCTGGAGAAGATGATTGATCTGATCATTCCCCGTGGCTCCTCGCAGCTGGTCAGAGATATTCAGCGAGCAGCTAAAGGCATCCCTGTGCTTGGCCACAGTGAGGGGATCTGCCATGTCTATGTTGACCACGAGGCCAGTATTGACAAAGCCATCAAAATCATCCGAGACTCTAAATGTGACTACCCTGCTGCCTGCAACGCAATGGAAACTCTGTTGGTGCATCGAGATCTTCTCAGAACTCCAGTATTTGATCAAATCATTGATATGCTGAGAACAGAACAAGTCAAGATTCACGCTGGCCCTAAGTTTGCATCCTATCTAACCTTTAGTCCATCAGAAGTGAAGTCTTTGCGTACAGAGTATGGAGATCTGGAGTGCTGTATCGAGGTGGTGGACAGCATGCAGGAGGCTATAGATCACATCCATAAATATGGCAGCTCACACACTGATGTTATCGTCACTGAGAACGAGAACACAGCTGAGCAGTTCCTCCAGCAGTTGGACAGTGCCTGTGTCTTCTGGAATGCCAGCTCACGGTTTGCTGATGGATATCGGTTTGGCCTAGGTGCGGAGGTTGGCATCAGCACTGCCCGTATTCATGCCCGTGGTCCTGtggggctggaagggcttctCACGACTAAGTGGGTGTTGCGGGGTGAAGGCCACACAGTGGCAGATTTCTCGGAGCATGGCAGCATGACGTATCTGCATGAAAATCTACCGGTGGCACAGCTCCTTCCTGGATACAGAACCACCAGCTAGAGTTGAGAAGTAAATGCTTCTACGCTCAAGGATCAAATGCATATCACCTACTTAAATCCCATTTAAAGACTCCTGTCAGGCAGTGTGTTTGGAAAATCAAATGTGAATGGGCAGTCAAACCGATgtattttaagggatagttctccaaaaaaaaaaaaaagtaatttattctCCCTCAGGCCATTCAAGATGTAGGGGACTTTTTGTTTAGTTGCTgatcaaataaattataatactaaatgcattaaaaatacatataataaatacaataaattatataattatttgagcTGAAATTGAAAGTGCTAGCAGCCATTGATTTATATTAATCTTCCCATAGTTAAAGACATGCAGGCACAACAAAATTAATACCCATTGTTTCTGATGGTACGTTGAGGTCTAatccatttaaaataattagtctaTTCAAGGAACTGAGCATTATTTGCAAAACTTTCATTTATTCACACGATTTTGCAAGCACTCTTGAGCATTTATAATGATGGGCAATGGACAGATGCAAACAAGTTGTTAGCAATGGAAAGAAAGGTCGTGTGAGTACATATGCTGAAACTTGTTGAAAGTTAAACACCTGCACACATCCTTACAATCATTATGACTGTACTCTGGACTATTTTCTGCACCTACTATTTTAATAATGCTCAGATGCATCATTTTGCTTCATCAGATTTAAGTGCATCGTCAGGAGCCACGGGTACTAGTTTAGTTTTGCCTGTGTGTGGTATTTAACTCTGAAAATGCCAACTAATCGTTTAATgttctactaaagaaaaaaaCTCACCTACATTACATATTGAATTTCCTGAGGGTAAAATagtagcatttattttttatttttggaggtGTTCTATCCCTTTAAGAAGCCTTTAAAGCATAAGTCTCAAACACAATTCCTGGacggccacagctctgcacagttttactcCGACCCTGATTAAACAGCTGATCCCACTAATGAATGTGTTCAAGACTCTTTTTAAACGcctcgattatttggatcagctgagtttgattagagttggaacaaaactgtgcagagctacggccctccaggaattgttTGAGACTTCTGCTTTAAAGGCTTCTGTTTGTCCCGTACTTTAGATTCTCTCAAGGGCCAAAGAGATCACCTCAACTTATTGTTAAATGTGTCTTGTTTTCTTTGTAAATCGGTTGAACCTAGCTACTAAACACAGTTAATGGTACACAGATGGATAAGGGATTTTAGTGCTGGCTATGCTCATGTTGTCATTTTATGATTTGTGCATATTTTCCTTTAAGTATCCAAATGTATCATGATCACGATGAATGCAATGACACTTCCCGACCTCCAGAATTGCCAAtgttatatttatgtaatatttaagaATAAAATGTGGTACAATAATCCTTTACAGTACAATAATCCTTCAAATCatagcattaaataaaatgtgtattacAAGTATGGCAACATTGTGTACCCAACTTCAGGTTTAGAGagtaaagtatttttttcatatggTATAGTGATCTCAAATAGAATATAACATGAGTACTAACTGAAAAAGGTAACCATAGAAGAAAATAGTCATGTTACCATAGTGTTCAACCTATCCAATTCAACATGGGAAAACTGTATTATTAGCTTAAATCATCTGTATGCTGCttttgaaaagaaaacgaatggaAAATCAGTTTTCCTGTGCATCACTTCTCTCATTTTGCGTAGTTCTTTAGCTTTTTAATCACAAATACTGTGCAAATCATTTCCCTGCTGTAAAATTCACCCGGGACGGGCACATTTTGTCCTGAACTGCTGCAGAAATCCTCATTATCTGTACTTAAAAGTGCTGTATCGCTTCACTAAATAGTGATGCTCGCAGTGTTCTGAAGATGTTCACAATTTTTGTATGTAGAATAAATGTCTTTTTGTACTTTCAAACAGCTTCTGGATGCATGATTCGATGCACAAAGACCTGAAAGTTTAATTTGTACCTGAAAGATGTTTGGAGAAGCCGACAAGTATCCGGGGCCGTTCTGAACTTGATTAACAATCTTTCGTAAGTGCAGTTCTGTGTTGGAAACATCAAGAGGCTGTTCTGTAGGGATAGAAAGAGACTTGCCAAGCACTAAGTGGGACATGGAAAAGTGAAAACAATACTACAGAGGATTAATTATGTTGCTATTAGGAAAGAAGAGACTGTGAGAAGACTGAAGCTTGCCATGAAAGTGCCAGTGCCTTTTGACTCACAAATTCGTTTTATTCTCCAAAATGTGCGGTTCGCGCTCAATGAGCCTTCATCAGGAACTAAAAAGATCCAGAGATGAAGAGAAACAGAGTCTTATTCATGTGTTATTGTGTTCCAACTTTGCTGCGTAAGATCTATGATCAATGGCTGTTTGGGATGAAAGAGGTTAAAAATGCTCAAATGAGGAGAATGTTACTGCCAAAACAGAAGACGAAAATACAGGTGCTGCTCTATGAAAGGGAAATTATTACTAATGTACAAAGCAAAGGTTATCTtgattttcagaattttttttgtcCTATTGGCATGCAAGCGTTGACCCCAATACTGTAATTTACTTTGCCAATGCAGTTTTGATGTTAGGACTGCTAAATAATGATTTggtattattagggaccgagcaccgaaacggtgcgtaggccctattggaattgctccgttttttattattattattattattattattattattattattattagggaccgagcaccgaaacggtgcgtaggccctattggaattgctccgttttttattattattattattagggaccgagcaccgaaacggtgcgtaggccctattggaattgctccgttttttattattattattattattattattattattattattattattattattattccgcccccaatcggggcacttttgagggtctaaacatgcccgaaaactcacgaaaatttgcacacacaccaaacgcggtgtaaatggcTGGGTTTTAGgggtttcggaagtgggcgtggcaaaatgactcgacagcgccacctagaaaatttaaaaggacgagcccccgatccacgaatcacacacatgcacgaaaattggcacacacctcaaacatgccaaaacatacgaaaaagtctcttggagccatatctcaaacccaacaggaagtcg

Function

symbol description
aldh18a1 Predicted to enable glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within phosphorylation and proline biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including central nervous system; endocrine system; eye; immature eye; and tail bud. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1).

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0055129 L-proline biosynthetic process biological_process
GO:0008652 cellular amino acid biosynthetic process biological_process
GO:0016310 phosphorylation biological_process
GO:0006561 proline biosynthetic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004349 glutamate 5-kinase activity molecular_function
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity molecular_function
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function
GO:0016301 kinase activity molecular_function
GO:0003824 catalytic activity molecular_function

KEGG:

id description
ko00330 Arginine and proline metabolism

ZFIN:

id description
ZDB-GENE-030131-5602 Predicted to enable glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within phosphorylation and proline biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including central nervous system; endocrine system; eye; immature eye; and tail bud. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1).

Ensembl:

ensembl_id ENSDARG00000099579

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009523 False 4416 mRNA 0.44 18 30788912 30808933
TCONS_00009524 True 5543 mRNA 0.43 17 30789611 30810171

Neighbor

gene id symbol gene type direction distance location
XLOC_004818 slc35f3a coding upstream 32327 30723178 ~ 30756585 (+)
XLOC_004817 kcnk1a coding upstream 76801 30705769 ~ 30712111 (+)
XLOC_004816 thbs2b coding upstream 106985 30653047 ~ 30681927 (+)
XLOC_004815 NA coding upstream 137886 30636385 ~ 30651026 (+)
XLOC_004813 NA coding upstream 155910 30630019 ~ 30633002 (+)
XLOC_004820 CR751608.1 coding downstream 123680 30933851 ~ 30952692 (+)
XLOC_004821 CR456684.1 coding downstream 385655 31195826 ~ 31195950 (+)
XLOC_004822 CR456684.3 coding downstream 398265 31208436 ~ 31208551 (+)
XLOC_004823 NA coding downstream 465588 31275759 ~ 31276339 (+)
XLOC_004824 zdhhc6 coding downstream 612386 31422557 ~ 31438582 (+)
XLOC_004814 NA non-coding upstream 156536 30631796 ~ 30632376 (+)
XLOC_004810 CU695011.1 non-coding upstream 279513 30509283 ~ 30509399 (+)
XLOC_004807 NA non-coding upstream 313760 30470981 ~ 30475152 (+)
XLOC_004828 NA non-coding downstream 758017 31568188 ~ 31568526 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) AMCG00003264 aldh18a1,LOC107081732 coding CM030139.1 CM030139.1 16914965 ~ 16930855 (+)