XLOC_000488 (lrpap1)


Basic Information

Item Value
gene id XLOC_000488
gene name lrpap1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007112.7
NCBI id CM002885.2
chromosome length 59578282
location 41131481 ~ 41141446 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00000852
TGTTTTGAAAGCTACAAACTACAATACCCACAATGCAAAGCGCACAGGCATGTGAACGCCGTATGATTCCAGTAGCGCTTCCTGGATAGCGCTGCAGATGCTCTACGAAACGGTTTATTTAGGTTTTCATAACTAATTTGCTTCTGTTGCCACAATTAAAATGCAGCTTCTAATTTTGGTTTCGTTGTTCGCTGTCGGTGCAATGGCGGGAAAGTActcaaaagaaatgaatgaaaaaaatgcgTCTGATAAAAGCAACAGCCAGGTGGAATTTAGGATTGCCAAACTAAATCAGGTTTGGGAAAAGGCGATAAGGATGCAGCTTGCACCGGTCCGTCTGTCAGAACTACACAGTGACTTGAAAATCCAAGAAAAAGATGAACTTCAATGGAAAAAACTCAAAGCAGAAGGGATGGACGAAGATGGAGAGAGAGAAGCCAAGCTCAGGCGAAATTTTAATATTATTCTTGCAAAGTATGGAATGGATGGGAAAAAAGACACCCGAACATTGGACAGCAACAGACTGAAAGATCATGAAGTTAAAGTTGGAGACACATTTGATGACCCAAAGTTGGACAAGCTGTGGAATAAGGCCAGAACTTCTGGAAAATTCTCTGATGAGGAACTCCAGACCTTACATAGAGAATTCCAGCATCACAAAGACAAGATCCATGAGTATAACATTGTCATGGACACTGTCAGCCGGACTGAAGAGATCCATAAGAACGTGATCAGTCCTCTGGAGGGGGATGTGAAGGAGAACGTTCTTCATCAGAAACACACAGATCTGAAGCAGAGAATGAGGGATCTAAACCAGGGCTTTGAGCGTCTCCGCAAGATCACCCACGAGGGCTACACTGATGACAGCGAATTTAGGGAGCCACGAGTCATTGAGCTGTGGGAGATGGCAAAAAGATCCAACCTCAGCAAAGATGAACTTGATTCTCttaaaGAGGAACTCCGACACTTTGAAACAAAGGTGGAGAAGCACCAGCACTATCAGGAGCAGCTGGAACTGTCTCATCAGAAACTGAAGCATGTGGAGGCTCTGGGAGATGAGGATCACATTATGAGAAACAAAGAGAAATACAACACTCTGGCTGAGAAAGCACGGGAGATGGGATACAAGATGAAGAAGCACTTGCAGGATTTAACGAACAAGCTTTCCAAAAATGGATTACAACACAATGAACTCTGAGCACTCTTTTCCTCAGCATGGCAGCACTACAGTTAGTTATGATCACATATGGAGTGTTATTCCACACTGATTGGCTGGGGTTATGAAGGTAAGGTGCACAGCATTTCCACTGGAAAGTCAAACCAATTATTaaataatgagatttttttttacggTACGGAGCAGTGAACAGTTCTGTGCATTCTGTTCATTATCCATGTTCTATTTGTTGTGgccaaatttgtatgaatttcaTGATACTTGctaaaaaatgaactgaaacacgTGTAGCTTCCCACAAACATGTGGGTGCAATAGAACTTCACAACAAAACCACACAAGAAGGCTCGCAAAGTTTTCAATGTAAACTTTTAAGCTTCCATTTGAGCAATCTCCTAAAGCTGAGCATCTTAACATTTAAAGAAAGGCTCAATTGAACTCTGCCATGAAAAACGGTGCCATCCCAATGCAGGTTTGATGTTATATCCAGATAACCTCTGTTACGAGCTAAACCTGGCAGATTGAGGACAATAGATGTGCTTTAATGGAAAAAGCTGCAGTGAAATGGAGAACCAGAAGCTAAGGCCAGGCACAAAAGTAAAGCAGGTCTTGAATCAGCCGTTATATTTACCAAACAGCATTGAGTGCAGATATTATCAACATGATTGACAGCTTTGTCCAGAGTTAGACTTGAATCATCCTGACTTTTAGATATTTAAAGATTTGTTACAAAAATTCAAACTACAAACTGATTCTATTATATGACAATGTAATTACTCAATCGACAGAATTTTGTGATTTTGTGTAGAACACATGCTATAATCCAGTATTGTAATTCATGATCAGGAATGTGTTGTCTGTTAATAATAGGATCTCTTTTGTATAAGTCTGTTTTGTATATGTCAGTCGCACATTtcataataaaacaaactaacCATTTTTTCAA

Function

symbol description
lrpap1 Predicted to enable lipase binding activity; lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in negative regulation of receptor internalization and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in endoplasmic reticulum. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in neural tube; otic placode; and pronephric duct. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1).

GO:

id name namespace
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance biological_process
GO:0048259 regulation of receptor-mediated endocytosis biological_process
GO:0002091 negative regulation of receptor internalization biological_process
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment cellular_component
GO:0005801 cis-Golgi network cellular_component
GO:0048237 rough endoplasmic reticulum lumen cellular_component
GO:0005886 plasma membrane cellular_component
GO:0012505 endomembrane system cellular_component
GO:0008201 heparin binding molecular_function
GO:0070326 very-low-density lipoprotein particle receptor binding molecular_function
GO:0050750 low-density lipoprotein particle receptor binding molecular_function
GO:0048019 receptor antagonist activity molecular_function
GO:0035473 lipase binding molecular_function

KEGG:

id description
ko04979 Cholesterol metabolism

ZFIN:

id description
ZDB-GENE-030131-5871 Predicted to enable lipase binding activity; lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to be involved in negative regulation of receptor internalization and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in endoplasmic reticulum. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in neural tube; otic placode; and pronephric duct. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1).

Ensembl:

ensembl_id ENSDARG00000033604

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00000852 True 2123 mRNA 0.40 8 41131481 41141446

Neighbor

gene id symbol gene type direction distance location
XLOC_000487 BX511116.1 coding upstream 6079 41125286 ~ 41125402 (+)
XLOC_000486 NA coding upstream 78908 40837105 ~ 41052573 (+)
XLOC_000485 cpz coding upstream 312581 40801448 ~ 40818900 (+)
XLOC_000484 gpr78a coding upstream 331625 40760448 ~ 40799856 (+)
XLOC_000483 htra3a coding upstream 371852 40740951 ~ 40759629 (+)
XLOC_000489 AL954671.1 coding downstream 128327 41269773 ~ 41269887 (+)
XLOC_000490 CR974461.1 coding downstream 176795 41318241 ~ 41331772 (+)
XLOC_000491 si:ch211-89o9.4 coding downstream 312764 41454210 ~ 41464007 (+)
XLOC_000492 paip2b coding downstream 324325 41465771 ~ 41472087 (+)
XLOC_000493 dok1a coding downstream 336899 41478345 ~ 41484861 (+)
XLOC_000481 CABZ01072532.1 non-coding upstream 407847 40716379 ~ 40723634 (+)
XLOC_000480 FO681323.1 non-coding upstream 426295 40693323 ~ 40705186 (+)
XLOC_000479 FO834828.2 non-coding upstream 438763 40683491 ~ 40692718 (+)
XLOC_000500 NA non-coding downstream 624170 41765616 ~ 41797116 (+)
XLOC_000502 NA non-coding downstream 736997 41878443 ~ 41878892 (+)
XLOC_000504 NA non-coding downstream 807857 41949303 ~ 41950349 (+)

Expression

Expression of XLOC_000488(lrpap1) in the Zebrafish Sample from each Developmental Stage of PRJEB12982

Boxplot with 18 boxes. Box plot charts are typically used to display groups of statistical data. Each data point in the chart can have up to 5 values: minimum, lower quartile, median, upper quartile, and maximum.
The chart has 1 X axis displaying categories.
The chart has 1 Y axis displaying Expression. Range: 0 to 150.
End of interactive chart.

Expression of XLOC_000488(lrpap1) in the Zebrafish Sample of PRJEB12982

Bar chart with 360 bars.
The chart has 1 X axis displaying categories.
The chart has 1 Y axis displaying Expression. Range: 0 to 150.
End of interactive chart.

Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000049_07441504_07445621 LRPAP1 coding CI01000049 null 7441357 ~ 7445621 (+)