mthfd1b (mthfd1)


Basic Information

Item Value
gene id mthfd1b
gene name mthfd1
gene type coding
species eurasian perch (Perca fluviatilis)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_053131.1
NCBI id CM020928.1
chromosome length 36057207
location 22722780 ~ 22735027 (-)
genome version GENO_Pfluv_1.0_2020_eurasian_perch_Genome

Sequence

>XM_039786076.1
CACGTTCTACGTTTGACGCTATTCCTGAAAGTTAATGCGATGATTTTAAACCTTAGTGCTGGATTTGTGAATAGAGCCTGCGCCATCCCCTTAAGTCCCAACGCTTTTTGACAAACTTTAGTTTTTGGCAGTACTCACCGCAGTGCACTCCTCTTCTTGTCAGGCTCCTCGTGTCCAGGCGACACCATTAGAACACGGACTATCAGTACCAAAAGATGTCAGCTCAAATCATAAGCGGGAAAGAGGTTTCAGGGCAGGTGAGGGAGCGTCTGAAGAAGGATGTGGAGCAGATGAAGCTTCAGGACCCAAACTTCAGACCCGGTCTAGTGGTTTTACAGGTTGGAGACCGCGACGATTCAAATCTGTACATCAGCATGAAGTTGAAGGCAGCAGCAGAGATCGGAATAAATGCCACACATATGAGACTTCCCAAGACTGCgacagaggaggagGTTCTTCACAGCATCACAGAGGTGAATGAGAACTCGTCTGTCCACGGCCTCATCGTGCAGCTGCCCTTAGATTCAAACCACAAGATGGACACAGAGAAGGTCACCAACGCCGTGGCCCCAGAGAAGGATGTAGATGGACTGACCAGCATCAATGCAGGGAAGTTGTCTCGTGGGGACCTGGGCGACTGCTTCATCCCCTGCACACCAAACGGCTGCATGGAGTTGATCAGACAGACTGGTGTGTCCGTGGCAGGAAAGAGAGCGGTAGTGATTGGTCGCAGTAAGATTGTGGGCGCACCGATGCACGACCTGCTGCTGTGGAACCACGCCACCGTCACCACCTGCCACTCTAAAACCGCTGATCTGCCTGGAGAGGTGGGCAAAGCAGACATCCTGGTTGTCGGCATCGGGAAAGCGGAGATGGTGAAAGGAGAGTGGATCAAGAAGGGAGCAGTGGTCATCGACTGTGGCATCAACCACATTCCAGATGAGACTAAAGCAAGTGGGAAGCGGGTGGTGGGTGATGTCCACTACACCTCAGCCAAGGAGCAAGCCGGCTTCATCACTCCTGTGCCTGGTGGCGTGGGACCCATGACTGTGGCCATGCTGATGGCGaaCACAGTGTTGAGTGCAAAGCGTTTCCTGGAGAGCCACAGACCAGGGAAGTGGAACATTTCTTACACCAAACTCAACCTCCGGAAGCCCGTGCCAAGCGACATTGTGATTTCTCGCTCCTGCGTGCCCAAGCCTATCGACTGTCTGGCAAGAGAGGTGGGCCTGCTGTCAGATGAGGTGGAGCTTTATGGCAAAACTAAGGCCAAGGTCCAGCTGAGTATCATGAAACGCCTGCAGGCCCAGCCAGATGGCAAATATGTGGTGGTCACCGGTATTACACCCACCCCTCTGGGTGAAGGAAAGAGCACCACCACCATCGGCCTGGTCCAGGCCCTTGGAGCCCACTTAAAGCtcaatgtgtttgcttgtgtcCGACAGCCTTCTCAGGGACCCACCTTTGGTATCAAAGGCGGTGCTGCAGGAGGTGGATATTCTCAAGTCATTCCAATGGAAGAGTTCAACCTCCATCTTACCGGCGACATCCACGCCATCACAGCTGCCAACAACTTGGTGGCTGCTGCCATCGATGCTCGCATGTTCCACGAGTCTACACAAACTGACAAGGCTCTGTATAATCGCTTGGTCCCGCTCAATGGAGAACAGAGGAATTTCTCCCCCATCCAGATCAACAGACTGAAAAAATTGGGCATAGAAAAGACAGATCCCTCTACTTTGACCGAAGAAGAGATTACTCGCTTTGCCCGCCTGGACATGGACCCAAGCTCTGTCACCTGGCAGAGAGTGTTGGATACCAATGATCGGTTCCTGAGGAAGATCACGATCGGACAGTCGCCAACTGAAAAGGGATACACGAGAGAGGCCCAGTTTGACATCACAGTGGCCAGTGAAATCATGGCGGTGCTCGCCCTCACCACCAGCCTGCAGGACATGCGTCAGCGCCTGGCCAAGATGGTCGTGGCCACCAGCCGCAGCGGACAGCCCATCACCACCGAGGACCTGGGCGTGAGTGGTGCTCTAACTGTGCTAATGAAAGATGCCATCAAGCCAAACCTGATGCAGACCTTGGAGGGAAACCCTGTGTTTGTCCATGCCGGCCCGTTTGCCAACATCGCCCATGGCAACTCCTCCATTCTGGCTGATAAAATAGCTTTGAAGCTGGTTGGACCCGATGGCTTTGTAGTGACCGAGGCAGGCTTTGGTGCTGACATTGGCATGGAGAAGTTCTTCAACATCAAGTGTCGCTACTCAGGCCTGAGACCCCACGTGGTGGTGCTGGTGGCCACCGTCCGAGCCCTGAAGATGCACGGAGGAGGACCAACAGTCACTGCTGGGATGCCACTGCCTAAGGAATACATTGAGGAGAACCTACAGCTGCTGGAGAAGGGCTGCAGCAACATGAGGAAGCAGATAGAGAATGCACAGCACTTTGGCGTGCCAGTGGTGGTGGCTGTCAATGGTTTCAAGACAGACACCGATGCTGAGCTGGACCTGGTCTGCAGCATGGCCAAAGCTGCCGGAGCCTTCGACGCCGTGCGCTGCTCCCACTGGGCCGAAGGTGGAGCCGGTGCTGTGGCCCTGGGTCAGGCGGTCCAGAGGGCCTCTGAGTCCCCCAGCAAATTCCAATTCCTCTATGATTTGGAGCTCCCTATTGCTGATAAGATTCGAATAATCGCCCAGAAGATCTATGGAGCGGATGATATTGAGCTTCTTCCAGATGCTCAACACAAGGTGGAGCTGTACACCAAACAGGGTTTTAGCAATCTGCCAATCTGCATGGCGAAGACTCACCTGTCGCTCTCTCACGAGGCAGACAGGAAGGGTGTGCCCACAGGGTTCATCCTGCCAATCAGAGACATCCGAGCCAGTGTGGGCTCTGGCTTTCTGTTCCCACTGGTCGGCACGATGCCCACGATCCCTGGTCTGCCCACCAGGCCTTGTTTCTATGACATTGACCTGGACCCTGAGACTGAACAGGTCAACGGGCTCTTCTGAAGCACATAGTAAGGAAGGTAGTTGAGAACTACAGATGCCAACCTCACACTGCAGACACTGAGCCTTACATGTGATGGACTAATAATTGGAGCTGGTCTGCTGGAgctgtttgttgtttttcactCAGACACTGACATCTGTAAATAATTGATTTGCTTTTCCCTGAAGGCTGCAGATGGGTAATTCAAGAAACCTAATTAATCATAGAACAGTTTATCCCCCTGAGATTGTCAGTCTGTGATATACTTTTTGCAAGAGGGAATTGTCCTATTGACAATTCTTTCAGTTACATTGCTCGCTGCACATAAACAAGCGCTGCTTGTATTTCACATCCCAGAACCTCTTATGAAAATAATAAGCCGAGACTCTTAAGTGGCAGATTTGGATTCTTGTGTAAACtacttgtgtattttgtgtgaacTACACCAGGAGCATCCCCTCCAGGCCACTGTATTTAACAATTGTGTCCGTCTTTGAGATGCATACATTTCTTGAGATACATAAAAACaaccttttgttttatttttgagcAATCTTGTGACTATTGTCCTATTTTTGTCTGTCCTGTATTCTAATTAATATTTCTAACATTGCTGGAGAAAATAGATGTTGTAAATTAGTGGTTTCAACTTTTCTGTCaggaaaaaaatctaataaagtGTCCTTGATGGAAA
>XM_039786077.1
CGGTGTCGCTCAAAACACAGAATCTACTCTCCATTGCTCTCTGTATTTCTTCATGTCTTACGTCGGAGTTAAAGCCAGATGTGCTCCTCGTGTCCAGGCGACACCATTAGAACACGGACTATCAGTACCAAAAGATGTCAGCTCAAATCATAAGCGGGAAAGAGGTTTCAGGGCAGGTGAGGGAGCGTCTGAAGAAGGATGTGGAGCAGATGAAGCTTCAGGACCCAAACTTCAGACCCGGTCTAGTGGTTTTACAGGTTGGAGACCGCGACGATTCAAATCTGTACATCAGCATGAAGTTGAAGGCAGCAGCAGAGATCGGAATAAATGCCACACATATGAGACTTCCCAAGACTGCgacagaggaggagGTTCTTCACAGCATCACAGAGGTGAATGAGAACTCGTCTGTCCACGGCCTCATCGTGCAGCTGCCCTTAGATTCAAACCACAAGATGGACACAGAGAAGGTCACCAACGCCGTGGCCCCAGAGAAGGATGTAGATGGACTGACCAGCATCAATGCAGGGAAGTTGTCTCGTGGGGACCTGGGCGACTGCTTCATCCCCTGCACACCAAACGGCTGCATGGAGTTGATCAGACAGACTGGTGTGTCCGTGGCAGGAAAGAGAGCGGTAGTGATTGGTCGCAGTAAGATTGTGGGCGCACCGATGCACGACCTGCTGCTGTGGAACCACGCCACCGTCACCACCTGCCACTCTAAAACCGCTGATCTGCCTGGAGAGGTGGGCAAAGCAGACATCCTGGTTGTCGGCATCGGGAAAGCGGAGATGGTGAAAGGAGAGTGGATCAAGAAGGGAGCAGTGGTCATCGACTGTGGCATCAACCACATTCCAGATGAGACTAAAGCAAGTGGGAAGCGGGTGGTGGGTGATGTCCACTACACCTCAGCCAAGGAGCAAGCCGGCTTCATCACTCCTGTGCCTGGTGGCGTGGGACCCATGACTGTGGCCATGCTGATGGCGaaCACAGTGTTGAGTGCAAAGCGTTTCCTGGAGAGCCACAGACCAGGGAAGTGGAACATTTCTTACACCAAACTCAACCTCCGGAAGCCCGTGCCAAGCGACATTGTGATTTCTCGCTCCTGCGTGCCCAAGCCTATCGACTGTCTGGCAAGAGAGGTGGGCCTGCTGTCAGATGAGGTGGAGCTTTATGGCAAAACTAAGGCCAAGGTCCAGCTGAGTATCATGAAACGCCTGCAGGCCCAGCCAGATGGCAAATATGTGGTGGTCACCGGTATTACACCCACCCCTCTGGGTGAAGGAAAGAGCACCACCACCATCGGCCTGGTCCAGGCCCTTGGAGCCCACTTAAAGCtcaatgtgtttgcttgtgtcCGACAGCCTTCTCAGGGACCCACCTTTGGTATCAAAGGCGGTGCTGCAGGAGGTGGATATTCTCAAGTCATTCCAATGGAAGAGTTCAACCTCCATCTTACCGGCGACATCCACGCCATCACAGCTGCCAACAACTTGGTGGCTGCTGCCATCGATGCTCGCATGTTCCACGAGTCTACACAAACTGACAAGGCTCTGTATAATCGCTTGGTCCCGCTCAATGGAGAACAGAGGAATTTCTCCCCCATCCAGATCAACAGACTGAAAAAATTGGGCATAGAAAAGACAGATCCCTCTACTTTGACCGAAGAAGAGATTACTCGCTTTGCCCGCCTGGACATGGACCCAAGCTCTGTCACCTGGCAGAGAGTGTTGGATACCAATGATCGGTTCCTGAGGAAGATCACGATCGGACAGTCGCCAACTGAAAAGGGATACACGAGAGAGGCCCAGTTTGACATCACAGTGGCCAGTGAAATCATGGCGGTGCTCGCCCTCACCACCAGCCTGCAGGACATGCGTCAGCGCCTGGCCAAGATGGTCGTGGCCACCAGCCGCAGCGGACAGCCCATCACCACCGAGGACCTGGGCGTGAGTGGTGCTCTAACTGTGCTAATGAAAGATGCCATCAAGCCAAACCTGATGCAGACCTTGGAGGGAAACCCTGTGTTTGTCCATGCCGGCCCGTTTGCCAACATCGCCCATGGCAACTCCTCCATTCTGGCTGATAAAATAGCTTTGAAGCTGGTTGGACCCGATGGCTTTGTAGTGACCGAGGCAGGCTTTGGTGCTGACATTGGCATGGAGAAGTTCTTCAACATCAAGTGTCGCTACTCAGGCCTGAGACCCCACGTGGTGGTGCTGGTGGCCACCGTCCGAGCCCTGAAGATGCACGGAGGAGGACCAACAGTCACTGCTGGGATGCCACTGCCTAAGGAATACATTGAGGAGAACCTACAGCTGCTGGAGAAGGGCTGCAGCAACATGAGGAAGCAGATAGAGAATGCACAGCACTTTGGCGTGCCAGTGGTGGTGGCTGTCAATGGTTTCAAGACAGACACCGATGCTGAGCTGGACCTGGTCTGCAGCATGGCCAAAGCTGCCGGAGCCTTCGACGCCGTGCGCTGCTCCCACTGGGCCGAAGGTGGAGCCGGTGCTGTGGCCCTGGGTCAGGCGGTCCAGAGGGCCTCTGAGTCCCCCAGCAAATTCCAATTCCTCTATGATTTGGAGCTCCCTATTGCTGATAAGATTCGAATAATCGCCCAGAAGATCTATGGAGCGGATGATATTGAGCTTCTTCCAGATGCTCAACACAAGGTGGAGCTGTACACCAAACAGGGTTTTAGCAATCTGCCAATCTGCATGGCGAAGACTCACCTGTCGCTCTCTCACGAGGCAGACAGGAAGGGTGTGCCCACAGGGTTCATCCTGCCAATCAGAGACATCCGAGCCAGTGTGGGCTCTGGCTTTCTGTTCCCACTGGTCGGCACGATGCCCACGATCCCTGGTCTGCCCACCAGGCCTTGTTTCTATGACATTGACCTGGACCCTGAGACTGAACAGGTCAACGGGCTCTTCTGAAGCACATAGTAAGGAAGGTAGTTGAGAACTACAGATGCCAACCTCACACTGCAGACACTGAGCCTTACATGTGATGGACTAATAATTGGAGCTGGTCTGCTGGAgctgtttgttgtttttcactCAGACACTGACATCTGTAAATAATTGATTTGCTTTTCCCTGAAGGCTGCAGATGGGTAATTCAAGAAACCTAATTAATCATAGAACAGTTTATCCCCCTGAGATTGTCAGTCTGTGATATACTTTTTGCAAGAGGGAATTGTCCTATTGACAATTCTTTCAGTTACATTGCTCGCTGCACATAAACAAGCGCTGCTTGTATTTCACATCCCAGAACCTCTTATGAAAATAATAAGCCGAGACTCTTAAGTGGCAGATTTGGATTCTTGTGTAAACtacttgtgtattttgtgtgaacTACACCAGGAGCATCCCCTCCAGGCCACTGTATTTAACAATTGTGTCCGTCTTTGAGATGCATACATTTCTTGAGATACATAAAAACaaccttttgttttatttttgagcAATCTTGTGACTATTGTCCTATTTTTGTCTGTCCTGTATTCTAATTAATATTTCTAACATTGCTGGAGAAAATAGATGTTGTAAATTAGTGGTTTCAACTTTTCTGTCaggaaaaaaatctaataaagtGTCCTTGATGGAAA

Function

symbol description
mthfd1 Enables formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Involved in carboxylic acid biosynthetic process and tetrahydrofolate interconversion. Located in cytosol. Implicated in several diseases, including Down syndrome; cleft lip; developmental cardiac valvular defect; neural tube defect (multiple); and tetralogy of Fallot. Biomarker of Down syndrome.

NR:

description
C-1-tetrahydrofolate synthase, cytoplasmic

GO:

id name namespace
GO:0009396 folic acid-containing compound biosynthetic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0004329 formate-tetrahydrofolate ligase activity molecular_function

KEGG:

id description
K00288 MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_039786076.1 True 3694 mRNA 0.51 27 22722780 22734603
XM_039786077.1 False 3613 mRNA 0.51 28 22722780 22735027

Neighbor

gene id symbol gene type direction distance location
LOC120549245 NA coding downstream 24548 22681322 ~ 22698232 (-)
plcb2 plcb2 coding downstream 56066 22648288 ~ 22666714 (-)
LOC120548817 ankrd63 coding downstream 92425 22628336 ~ 22630355 (-)
zfyve19 zfyve19 coding downstream 122525 22589199 ~ 22600255 (-)
spint1a NA coding downstream 137850 22576769 ~ 22584930 (-)
LOC120549277 klhl28,LOC102787432 coding upstream 2810 22737837 ~ 22747538 (-)
ccdc28b ccdc28b,LOC103357048,LOC102303603,LOC100707625,LOC104924809 coding upstream 29818 22764845 ~ 22772062 (-)
tmem39b tmem39b coding upstream 37861 22772888 ~ 22776944 (-)
zbtb8os zbtb8os coding upstream 50458 22785485 ~ 22788583 (-)
LOC120548822 NA coding upstream 59574 22794601 ~ 22799993 (-)
G205297 NA non-coding downstream 3368 22705717 ~ 22719412 (-)
G205242 NA non-coding downstream 87318 22635201 ~ 22635462 (-)
G205219 NA non-coding downstream 195694 22524966 ~ 22527086 (-)
G205212 cep170b non-coding downstream 211375 22508455 ~ 22511405 (-)
G205205 NA non-coding downstream 229145 22493283 ~ 22493635 (-)
LOC120548708 NA non-coding upstream 153617 22888644 ~ 22895642 (-)
LOC120549686 NA non-coding upstream 174945 22909972 ~ 22920458 (-)
LOC120549687 NA non-coding upstream 215200 22950227 ~ 22951060 (-)
LOC120548728 NA non-coding upstream 400558 23135585 ~ 23150231 (-)
LOC120548729 NA non-coding upstream 520851 23255878 ~ 23266654 (-)
zbtb42 zbtb42,LOC102793331 other downstream 274837 22440729 ~ 22447943 (-)
chrm5a LOC103374637,LOC108232519,LOC106520150 other downstream 791514 21920885 ~ 21931266 (-)
LOC120549141 max,LOC103363129,LOC100701192,LOC101485218,LOC108232653,LOC102777802 other downstream 965185 21752386 ~ 21757595 (-)
LOC120549379 LOC100705232,LOC102305635,LOC102778868,LOC104921326,LOC101482755 other downstream 1019010 21656220 ~ 21703770 (-)
LOC120548683 NA other downstream 1730092 20990937 ~ 20992688 (-)
LOC120549283 khdrbs1 other upstream 42978 22778005 ~ 22783472 (-)
G205380 NA other upstream 175080 22910107 ~ 22937857 (-)
LOC120549684 NA other upstream 209910 22944937 ~ 22947810 (-)
arid1b LOC103368034,LOC102292653,LOC101481705,LOC102196556 other upstream 289134 23024161 ~ 23234798 (-)
LOC120548654 LOC106573685,LOC106610772 other upstream 972962 23707989 ~ 23710861 (-)

Expression


Co-expression Network