Gene
RNA
| Item | Value |
|---|---|
| gene id | ptenb |
| gene name | pten |
| gene type | coding |
| species | eurasian perch (Perca fluviatilis) |
| category of species | economic fish |
| Item | Value |
|---|---|
| chromosome id | NC_053132.1 |
| NCBI id | CM020929.1 |
| chromosome length | 33651559 |
| location | 1181045 ~ 1193221 (+) |
| genome version | GENO_Pfluv_1.0_2020_eurasian_perch_Genome |
| symbol | description |
|---|---|
| pten | Enables several functions, including PDZ domain binding activity; anaphase-promoting complex binding activity; and phosphatase activity. Involved in several processes, including dephosphorylation; negative regulation of cell migration; and regulation of cellular protein metabolic process. Acts upstream of or within negative regulation of protein kinase B signaling. Located in several cellular components, including apical plasma membrane; cytoplasmic side of plasma membrane; and nucleoplasm. Implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including PTEN hamartoma tumor syndrome; gastrointestinal system cancer (multiple); in situ carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). |
| description |
|---|
| PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 |
| id | name | namespace |
|---|---|---|
| GO:0046855 | inositol phosphate dephosphorylation | biological_process |
| GO:0046856 | phosphatidylinositol dephosphorylation | biological_process |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | biological_process |
| GO:0031647 | regulation of protein stability | biological_process |
| GO:0008285 | negative regulation of cell population proliferation | biological_process |
| GO:0051895 | negative regulation of focal adhesion assembly | biological_process |
| GO:0051898 | negative regulation of protein kinase B signaling | biological_process |
| GO:0030336 | negative regulation of cell migration | biological_process |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | molecular_function |
| GO:0030165 | PDZ domain binding | molecular_function |
| GO:0051800 | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | molecular_function |
| GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | molecular_function |
| GO:0004725 | protein tyrosine phosphatase activity | molecular_function |
| GO:0000287 | magnesium ion binding | molecular_function |
| id | description |
|---|---|
| K01110 | PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
| RNA id | representative | length | rna type | GC content | exon number | start site | end site |
|---|---|---|---|---|---|---|---|
| XM_039788822.1 | True | 1898 | mRNA | 0.54 | 9 | 1181045 | 1193221 |
| gene id | symbol | gene type | direction | distance | location |
|---|---|---|---|---|---|
| LOC120551414 | NA | coding | upstream | 91885 | 1043694 ~ 1089160 (+) |
| LOC120551421 | NA | coding | upstream | 131435 | 1043672 ~ 1049610 (+) |
| LOC120551430 | atad1 | coding | upstream | 162155 | 1015297 ~ 1018890 (+) |
| LOC120551425 | NA | coding | upstream | 198307 | 977736 ~ 982738 (+) |
| LOC120551418 | NA | coding | upstream | 223412 | 953123 ~ 957633 (+) |
| LOC120551397 | NA | coding | downstream | 104806 | 1298027 ~ 1303083 (+) |
| LOC120551407 | NA | coding | downstream | 185430 | 1378651 ~ 1380831 (+) |
| LOC120551423 | NA | coding | downstream | 192142 | 1385363 ~ 1398958 (+) |
| LOC120551406 | NA | coding | downstream | 220567 | 1413788 ~ 1427061 (+) |
| LOC120551410 | NA | coding | downstream | 237251 | 1430472 ~ 1437585 (+) |
| G208853 | minpp1 | non-coding | upstream | 80197 | 1099315 ~ 1100848 (+) |
| G208841 | NA | non-coding | upstream | 87300 | 1015928 ~ 1093745 (+) |
| LOC120551440 | NA | non-coding | upstream | 97611 | 1071580 ~ 1083434 (+) |
| G208850 | NA | non-coding | upstream | 122617 | 1056886 ~ 1058428 (+) |
| G208784 | NA | non-coding | upstream | 131417 | 1039125 ~ 1049628 (+) |
| LOC120551437 | NA | non-coding | downstream | 5701 | 1198922 ~ 1200173 (+) |
| G208864 | NA | non-coding | downstream | 16202 | 1209423 ~ 1226685 (+) |
| G208885 | NA | non-coding | downstream | 118835 | 1312056 ~ 1335340 (+) |
| G208886 | NA | non-coding | downstream | 135917 | 1329138 ~ 1383544 (+) |
| G208887 | acta2,LOC107594158,LOC105896556,LOC101064889,LOC103374497 | non-coding | downstream | 139525 | 1332746 ~ 1333550 (+) |
| G208852 | minpp1 | other | upstream | 87448 | 1090547 ~ 1093597 (+) |
| G208851 | minpp1,LOC102795090 | other | upstream | 121605 | 1058842 ~ 1059440 (+) |
| LOC120551422 | NA | other | upstream | 141676 | 1027301 ~ 1039369 (+) |
| G208768 | NA | other | upstream | 525825 | 654899 ~ 655220 (+) |
| LOC120551434 | LOC101484734,LOC101161619,LOC103361136 | other | upstream | 533823 | 584120 ~ 647222 (+) |
| G208867 | NA | other | downstream | 11369 | 1204590 ~ 1205248 (+) |
| stambpl1 | NA | other | downstream | 119980 | 1313201 ~ 1328029 (+) |
| G208777 | NA | other | downstream | 237288 | 1430509 ~ 1493181 (+) |
| G208911 | NA | other | downstream | 272797 | 1466018 ~ 1571837 (+) |
| LOC120550772 | NA | other | downstream | 305226 | 1498447 ~ 1577370 (+) |
