LOC120553419 (timp3,LOC103152565)


Basic Information

Item Value
gene id LOC120553419
gene name timp3,LOC103152565
gene type coding
species eurasian perch (Perca fluviatilis)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_053134.1
NCBI id CM020931.1
chromosome length 29109922
location 19983479 ~ 20000522 (-)
genome version GENO_Pfluv_1.0_2020_eurasian_perch_Genome

Sequence

>XM_039791791.1
CTCTCCGGGATCAGGGAGAAACGCTCAAGCGAGTCGAGAAGCAACAGCCAGAGCAGAGACTTGGACATTACATACCGCCTaacctactactactactactactactactacagcgGACCCGGCCGGACTCCATACACACTTTATCCCAGCAGCATAGAGGAGTGGAAAAGTTTGGAGAAATGCAGTCAGTGTACCAGCACCTGATCAGCCTGCTGTTTGTcttcagcagcctgcaggttatCCAGCTGACGGAGGGCTGCTCGTGCGCTCTGACGCACCCGCAAGACGCCTTCTGCAACTCCGACATAGTGATTCGGGCTAAAGTCGTGGGCAAGAAGCTCCTGAGAGATGGACCTTTCGGAACGATGCGCTACACAGTCAAGCAAATGAAGATGTACAAAGGATTCGACAAAGTCCAGCACGTGCAGCACATTTACACGGACGCTTCAGAGAGTTTGTGTGGTGTGAAGTTTGACATCAACAAGTACCAGTACCTGATCACAGGTCGAGTGTACGATGGCAAGGTCTACACGGGGCTGTGCAACTTCAACGAGCGGTGGGAGCGCCTCTCATTGGCCCAGAAGAAAGGCATCAACCATCGCTACCAGCTGGGCTGCAACTGCAGGATTAAGCCCTGCCACTACCTGCCATGCTTCGTGACCTCAAAGAACGAGTGCCTATGGACGGACATGCTGTCCCACTTCGGCTATCCCGGCTACCAGTCCCGGCACTACGCCTGCATCCAGCAGAAGGAGGGCTACTGCAGCTGGTACCGGGGCATGGCCGCACGCGACAAAACCACCATCAACGCCACCGACCCCTGAACCCCAAACGCACCCTGCCCCAAATCCACTGCCGCCTCCCTGACTGCGTCCTATCCCGATATCTTCTAGAGTATTACAGGACTCTTTAAGCTCACTGGCCAGGGTGTCAGCCTCTTTAAAAGGggcaaaaaaaggagaaaagaacAAATCCATTACAGTGCCTGTTTCGTAGCACTTCTGATTGAAaacaatacctttttttttgttgtgcagATCGCCCTGTTTAACTTTAATTTCCGCAAATCAAATTCCTTGCACCAAACCTTCTCTTCAGGGTCCAGTGGttaaaagacagatatttataAGGCCAATAAGAAGTGGAAGACCTTGATAAACCTCTATTGGATattcagatttctttttttaaccgaACTGACCTctaaacaattaaaagtatttaATTGGTGTTAATTAGTGACCTGCAGTTAGCCTACTGCTAACCTAGTATTATGGTCATTTTGTGCATTGAGGCAGTTTCTTCTGAAAAGCAAGGACTGAAGGTCAGATGAATTTCAATCAATGAAAAACGAACAGCCAATGATCTCTATGTACATTTAGATGTTAGATTGCTACACTTGCTAGCATTACAACATAACAAACTTCTGCAGTTCTACACATCAACAATACAGATGGAGTGCCAATGTGAGGTTTGACCTCGCATAAGTTAATATCCCTTATATTTTTTTGGAAAATGGTATTGTTTTACAGTGAAGTATACATAGATTATCTTCACAGTTTTTACTGTAACGTGTCTTTATGGATAGTAGTATCTCTGCTTACCTGAATGTTTGCAATGTAACTCATTTTGCAGTTATATCACAAACGACGTCCTTTCTGTTGAGCACTGTTGAATATCAGAGAAGAGCTAGAAATCTCTGTGTTACAGTGCTAACGCAGGGACGAGCTCACTTCTTGCAGAGAtggtgatattttattttttgctgtatATAACATAAGCTACAGAAATGAACTATCAACTCAGCTGAAACCTctgtaatacatttatttatgtttattggATGACACAGTAACTATGTGGTattatctgcaaaaaaaaagaagaacaaaatatataataacagtACATTGCGACAACCATCAAATCCTGTGCAACCTTCCAGAATGAAGGACCAGCATTTCCAGTGGTATGGTACTTGTGGTACTTCTGTTTGTTAGTTTGATCATAGTTCCCCTGACTGGTACTCTACATCAATCCAATGAAAGACAAGTATAAGCAGAGGTTTCAGACATTGAGATATTTTTTAAGTGTATATTCAATCTTTTTGTATTTAACTATTTCAAAtggacattatatatatatatatatatatatatatatatatatatatatatatgaaagtaACAATATTGTCACTAAATTCATTTTTCATCACCTGTTCCTATCTAGggttttttcttattttctttcccAGTGCCATACCTTCAGTCCATTCCATGAACAGACACAGATTTGTTTCAAAGGGAGTAACATCCCCTTCATCACTGACACTGAGAAAATATTAGATCGCTAATGCACTGTGGCTTTGACCAAGTTGGTTGTTTTCAAAagagtagtttgacattttgggaaatatgcttatttgctttcttgcttggAGCTAGATGAGCGTTTTTCctttacatggtacctgctcgactcaacTCGAGTCTACTctcctttttttggttttccatta

Function

symbol description
timp3 Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of TRAIL-activated apoptotic signaling pathway. Located in nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); preretinal fibrosis; reproductive organ cancer (multiple); thoracic aortic aneurysm; and type 2 diabetes mellitus.

NR:

description
PREDICTED: metalloproteinase inhibitor 3

GO:

id name namespace
GO:0010951 negative regulation of endopeptidase activity biological_process
GO:0005576 extracellular region cellular_component
GO:0008191 metalloendopeptidase inhibitor activity molecular_function

KEGG:

id description
K16866 TIMP3; metalloproteinase inhibitor 3

RNA

RNA id representative length rna type GC content exon number start site end site
XM_039791791.1 True 2521 mRNA 0.42 5 19983479 20000522

Neighbor

gene id symbol gene type direction distance location
LOC120553212 fam19a2,LOC103364248 coding downstream 176724 19733066 ~ 19806755 (-)
lrig3 lrig3 coding downstream 414422 19546626 ~ 19569057 (-)
rpap3 NA coding downstream 479173 19495419 ~ 19504306 (-)
trnal-cag_24 NA coding downstream 530451 19452946 ~ 19453028 (-)
trnal-cag_23 NA coding downstream 530929 19452469 ~ 19452550 (-)
cep83 cep83 coding upstream 259503 20260025 ~ 20272144 (-)
hcfc2 hcfc2 coding upstream 272004 20272526 ~ 20286587 (-)
mcm10 mcm10,LOC102783079 coding upstream 393544 20394066 ~ 20409676 (-)
optn optn coding upstream 409673 20410195 ~ 20430496 (-)
camk1da camk1d coding upstream 455153 20455675 ~ 20530744 (-)
G228946 LOC103364246,LOC103152567,LOC106913527,LOC103459763,LOC106945279 non-coding downstream 77536 19852964 ~ 19905943 (-)
G228947 LOC103152567,LOC106913527,LOC106945279,LOC106922717,LOC102300237 non-coding downstream 101400 19877097 ~ 19882079 (-)
G228949 NA non-coding downstream 124616 19858103 ~ 19858863 (-)
LOC120553214 NA non-coding downstream 265067 19717222 ~ 19718412 (-)
G228885 NA non-coding downstream 414120 19550617 ~ 19569359 (-)
G229062 NA non-coding upstream 355114 20355636 ~ 20357563 (-)
G229071 NA non-coding upstream 381943 20382465 ~ 20391508 (-)
G229076 ccdc3,LOC102778083 non-coding upstream 433633 20434155 ~ 20437536 (-)
G229079 NA non-coding upstream 441798 20442320 ~ 20450128 (-)
G229095 NA non-coding upstream 534763 20535285 ~ 20535597 (-)
etv6 etv6 other downstream 144129 19806814 ~ 19839350 (-)
G228934 fam19a2,LOC103364248 other downstream 176381 19733102 ~ 19807098 (-)
sox5 sox5 other downstream 713143 19028609 ~ 19270336 (-)
LOC120553633 slc2a13,LOC103369283 other downstream 1160389 18738396 ~ 18823090 (-)
gramd4a gramd4,LOC103376144 other downstream 1562072 18363259 ~ 18421407 (-)
rerg rerg other upstream 66373 20066895 ~ 20122393 (-)
cdk17 LOC104930593 other upstream 300570 20301092 ~ 20354627 (-)
G229199 NA other upstream 957135 20957657 ~ 20958220 (-)
ptprz1b NA other upstream 1063169 21063691 ~ 21145533 (-)
slc38a2 slc38a2 other upstream 1460554 21461076 ~ 21474602 (-)

Expression


Co-expression Network