XLOC_005281 (ptenb)


Basic Information

Item Value
gene id XLOC_005281
gene name ptenb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 17399852 ~ 17424174 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00010143
GAGAGTGTAACAGGCAGTGGAGCAGTGGAGGATAAGGACAGAACCGGAGGTGTCTCTTACGCCACATTTAAATATCGAGTTTTTCATTTCTTGGTGGAGGCTGTCACATTTTGTTTCATGTGTTGGAACCTGGTCATCGCGGATTGTCGTAGAGTTTAATGGCTTTTATTTTCTAAGGATGTGTAGACGGGCTAGCGCGTTAGCCGTTGAGGCTAGACGGAGCGCGAGCTGAGTGCGAGCGGGGCTCTGACGACCGATCTTCAAGTGGAAGCACCGGAGAGGATTTTCTCTCCGCCTTTCCGCTCAATCACGGCGGCTTCGGTGCGACCAGAGACTTGTCGTGCACTAGAGATTCTGCAGTTCCAGACGTGGGAAGTTGCTTATCTTTTCACCCAGGGCTCGTCTGAGCCGAGGAGGGCATTTTGGAAGCCGGGCCTGTGGTGGTTTGGAGCGAGGCCCTTGATGAGTGAGCCACAGCAGACTCCATTCTAGCTAGCTGGGGGACTGCGAAACGAGCAGAGCATAAAGACGACCGACCGTCCGAAAGCAACAATACTCTCTCTCACACTAAAAACCCTAAAGACTCCTGTCACAGCCATGGCTGCGATCATAAAGGAATTTGTCAGTAGAAATAAAAGGAGATACCAAGAAGACGGGTTCGACTTGGACTTGACATACATTTATCCTAACATAATAGCTATGGGTTTCCCTGCTGAAAGACTGGAGGGTGTATATAGAAACAACATAGATGATGTAGTGAGGTTTCTTGATTCAAAGCATAAAGATCATTACAAGATATATAACCTATGTGCAGAAAGACATTACGATACTGCCAAATTTAACTGCAGAGTTGCACAGTATCCATTTGAGGATCACAATCCTCCTCAGCTAGAGCTCATTAAACCTTTCTGTGAAGATTTGGATAAATGGCTCAGTGAAAATGACAATCATGTGGCTGCCATTCACTGCAAAGCTGGAAAGGGAAGAACGGGTGTCATGATTTGTGCGTACTTGTTACACCGAGGCAAATTCAAAAAAGCACAAGAGGCTCTGGACTTCTACGATGAAGTTAGGACCAGAGACAAGAAGGGAGTGACTATTCCCAGTCAGAGGCGATATGTATACTACTATAGCTACCTTCTGAGGAATAAGCTGGAGTACAAACCTGTGGCCTTGCTCTTTCACAAGATGGTGTTTGAGACAGTGCCTATGTTCAGTGGAGGGACCTGCAATCCTCAGTTTGTGGTGTACCAGCTGAAGGTGAAAATTCACACCTCAAACCCAGCGCACACAAGAAGAGAGGAGAAGTACATGTTCTTCGAATTTCCTCAACCACTGCCTGTGTGTGGGGACATCAAGGTGGAGTTCTTCCACAAACAAAACAAGATGATGAAGAAGgagAAAATGTTCCACTTCTGGGTGAACACCTTTTTCATCCCTGGGTCAGAGGAGAGCACAGAGAAAGTGGAAAATGGAGGTTTAGTGAAGGACCTGGATGGAATACAAACAGCAGAGAGAGGAGAGAATGACAAAGACTATTTAATTCTTACTTTAAGTAAGACGGATTTGGATAAAGCGAACAAGGATAAAGCCAACAGATACTTCTCTCCCAATTTTAAAgttaaaatgttttttacgaAAACAGTGGAGGAACCATCCAACTCAGAGGCCAGCACTTCTACTTCTGTAACCCCGGATGTTAGCGATAATGAACCGGACCATTATCGTTATTCGGACACAACAGACTCAGACCCTGAAAATGAACAGTACGATGAAGAACAGATTACtaaagtttgaaatatttttatggGAAGAAAAAAGTAAACATGCGTAACAGAGTTGTATAAAGGAGAAAACTTGAATATGAACTCAAagcaagtacttttttttttttttttttcacccctgttatttctttctttatttttttccaaccTCCCCTCAATGCAGAACTAGAACACATCACAAATGCCACCAGTTTACGGACAAAAATGCTGACTTGTTTTGGTTCATTCCCCCCCTCCCTCTCCATGAAGTATCGACACTGATGTTCCTTGAGAAAACAGCGTCAGTAgctattatgtaaatacatgttcACGGCGTAACACAAAAAAGGAAGCCTAGTGAGGATGGGAGATTGTTTATGGGAGAAATCGAGTGAAGATCGAAATTTGCTGCTCCATCAACCTGTTTGAACCGAGGCCAGTGCTTTAATCAGCGTTCATTCCCCATGTCTGTTCTTCTCTAGTCTCTACCTACTGTGAAACTCTCCTCATGCTGCTGGAAGGCCACCATGTGTCAGTCGGGCACTGGAAACTGCACCTTTcaccttttgtttttaattctgcTTTCATCATTATTACCACTGCTAGTGTGGAGGTGATAATGCTTCCTCTAAATCCATGACTTCATGGCAGAAATCGCTCCACCGTGTATTCTTACTTTTTTATGCAAATATACACTCAACAGGGAAACCCGTGTTGCAATAATGTTGATCGTGTGCATGTTATTGGAATCCGTTTCCATGTTGTccaataaatagtatacattgtTTTTCTTAAAAGAGGTTTCTAAAGTCTTTTACAATTCGGGTTTGGGAAGAAAACAAATTGGTGTCACTTTTTCTTCTGCAGATGGGATTTTAATCTCTAAACATACCCCTGAGTGgctcttcattttttaaaattcctgTTTCCCCTATAAAAATATTCATGGTTTGAGCTCTCAGTAGTGTCATAAAATCATAAAAGGATTATTTTATGGGACACTGATCAATGCGAGGGCTCCACATGGCCACGGTTCACAGGTCAGATCAGGTGTACAGCATTTTACTGCATGTAAACATGGAGAAAAGCCCTTTTCTGAATGTATCAACCTTGGATGCAAGTTTCAGTTTGATTTGAGCGACATTCACATGGTTTTTCCCTTCTTCCCGGCTGCGTTAGACATCAGATCTTTGGCTTCCCTATAACATCTTTGTAGCCTTATTGTGCATGATCGAATCAAATCTGGATCATTTGTCCAGCAATGGTGCTTGCACACTCACGGTGTAGAGAACAGTCAAACAACCTTATGGTGCAAGCGTTCAATCGTGCTGCAGTGCGCGTCCTTACTGTTGGAAGCAGTTAAACCAACAATCCGGTGTCTATCACTCGCTGGAGTTCATTTTTAGATGCTTTTTTTTCCTTGTTCTTGAACAGTCTTCATTCCCTTTGGAATGAGCATAGTGCAGCTACGGATTTTACACAAAGTCTTGTGCTTGCTTCAGAAATATTAAAGCCCTATATATgagaatatttaaatgtataattttcttTTAAGCATGCCAAATCTTTTTTAACACCTGGCTTACGTGGTcagagcaaaaaacaaaaaataca
>TCONS_00010144
TGATGGAAGTTTGAGAGTGTAACAGGCAGTGGAGCAGTGGAGGATAAGGACAGAACCGGAGGTGTCTCTTACGCCACATTTAAATATCGAGTTTTTCATTTCTTGGTGGAGGCTGTCACATTTTGTTTCATGTGTTGGAACCTGGTCATCGCGGATTGTCGTAGAGTTTAATGGCTTTTATTTTCTAAGGATGTGTAGACGGGCTAGCGCGTTAGCCGTTGAGGCTAGACGGAGCGCGAGCTGAGTGCGAGCGGGGCTCTGACGACCGATCTTCAAGTGGAAGCACCGGAGAGGATTTTCTCTCCGCCTTTCCGCTCAATCACGGCGGCTTCGGTGCGACCAGAGACTTGTCGTGCACTAGAGATTCTGCAGTTCCAGACGTGGGAAGTTGCTTATCTTTTCACCCAGGGCTCGTCTGAGCCGAGGAGGGCATTTTGGAAGCCGGGCCTGTGGTGGTTTGGAGCGAGGCCCTTGATGAGTGAGCCACAGCAGACTCCATTCTAGCTAGCTGGGGGACTGCGAAACGAGCAGAGCATAAAGACGACCGACCGTCCGAAAGCAACAATACTCTCTCTCACACTAAAAACCCTAAAGACTCCTGTCACAGCCATGGCTGCGATCATAAAGGAATTTGTCAGTAGAAATAAAAGGAGATACCAAGAAGACGGGTTCGACTTGGACTTGACATACATTTATCCTAACATAATAGCTATGGGTTTCCCTGCTGAAAGACTGGAGGGTGTATATAGAAACAACATAGATGATGTAGTGAGGTTTCTTGATTCAAAGCATAAAGATCATTACAAGATATATAACCTATGTGCAGAAAGACATTACGATACTGCCAAATTTAACTGCAGAGTTGCACAGTATCCATTTGAGGATCACAATCCTCCTCAGCTAGAGCTCATTAAACCTTTCTGTGAAGATTTGGATAAATGGCTCAGTGAAAATGACAATCATGTGGCTGCCATTCACTGCAAAGCTGGAAAGGGAAGAACGGGTGTCATGATTTGTGCGTACTTGTTACACCGAGGCAAATTCAAAAAAGCACAAGAGGCTCTGGACTTCTACGATGAAGTTAGGACCAGAGACAAGAAGGGAGTGACTATTCCCAGTCAGAGGCGATATGTATACTACTATAGCTACCTTCTGAGGAATAAGCTGGAGTACAAACCTGTGGCCTTGCTCTTTCACAAGATGGTGTTTGAGACAGTGCCTATGTTCAGTGGAGGGACCTGCAGGGATTCTGCTGTAAAAAGCAAGAGTGAGCAGATTCCACATGGGTTCAGAAAAACCAATTGGCATTGGGATCCTCAGTTTGTGGTGTACCAGCTGAAGGTGAAAATTCACACCTCAAACCCAGCGCACACAAGAAGAGAGGAGAAGTACATGTTCTTCGAATTTCCTCAACCACTGCCTGTGTGTGGGGACATCAAGGTGGAGTTCTTCCACAAACAAAACAAGATGATGAAGAAGgagAAAATGTTCCACTTCTGGGTGAACACCTTTTTCATCCCTGGGTCAGAGGAGAGCACAGAGAAAGTGGAAAATGGAGGTTTAGTGAAGGACCTGGATGGAATACAAACAGCAGAGAGAGGAGAGAATGACAAAGACTATTTAATTCTTACTTTAAGTAAGACGGATTTGGATAAAGCGAACAAGGATAAAGCCAACAGATACTTCTCTCCCAATTTTAAAgttaaaatgttttttacgaAAACAGTGGAGGAACCATCCAACTCAGAGGCCAGCACTTCTACTTCTGTAACCCCGGATGTTAGCGATAATGAACCGGACCATTATCGTTATTCGGACACAACAGACTCAGACCCTGAAAATGAACAGTACGATGAAGAACAGATTACtaaagtttgaaatatttttatggGAAGAAAAAAGTAAACATGCGTAACAGAGTTGTATAAAGGAGAAAACTTGAATATG

Function

symbol description
ptenb Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).

GO:

id name namespace
GO:0030097 hemopoiesis biological_process
GO:0006629 lipid metabolic process biological_process
GO:0002275 myeloid cell activation involved in immune response biological_process
GO:0046855 inositol phosphate dephosphorylation biological_process
GO:0046856 phosphatidylinositol dephosphorylation biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:0061515 myeloid cell development biological_process
GO:0006470 protein dephosphorylation biological_process
GO:0048870 cell motility biological_process
GO:0001568 blood vessel development biological_process
GO:0008285 negative regulation of cell population proliferation biological_process
GO:0051896 regulation of protein kinase B signaling biological_process
GO:0007399 nervous system development biological_process
GO:0014065 phosphatidylinositol 3-kinase signaling biological_process
GO:0060027 convergent extension involved in gastrulation biological_process
GO:0016311 dephosphorylation biological_process
GO:0031174 lifelong otolith mineralization biological_process
GO:0042995 cell projection cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005634 nucleus cellular_component
GO:0016605 PML body cellular_component
GO:0005737 cytoplasm cellular_component
GO:0008138 protein tyrosine/serine/threonine phosphatase activity molecular_function
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity molecular_function
GO:0042577 lipid phosphatase activity molecular_function
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity molecular_function
GO:0004721 phosphoprotein phosphatase activity molecular_function
GO:0004725 protein tyrosine phosphatase activity molecular_function
GO:0004438 phosphatidylinositol-3-phosphatase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030616-47 Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).

Ensembl:

ensembl_id ENSDARG00000056623

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00010143 False 3380 mRNA 0.43 9 17399852 17424162
TCONS_00010144 True 1947 mRNA 0.45 10 17401366 17424174

Neighbor

gene id symbol gene type direction distance location
XLOC_005280 lipf coding downstream 198824 17158642 ~ 17201028 (-)
XLOC_005279 stambpl1 coding downstream 247713 17117405 ~ 17152139 (-)
XLOC_005278 ifit9 coding downstream 364513 17033494 ~ 17035339 (-)
XLOC_005277 ifit10 coding downstream 371597 17025726 ~ 17028255 (-)
XLOC_005276 ifit11 coding downstream 375773 17019905 ~ 17024079 (-)
XLOC_005282 papss2b coding upstream 34775 17458949 ~ 17479078 (-)
XLOC_005283 minpp1b coding upstream 58433 17482607 ~ 17492885 (-)
XLOC_005284 usp42 coding upstream 146501 17570675 ~ 17602958 (-)
XLOC_005285 dlgap5 coding upstream 209180 17633354 ~ 17655683 (-)
XLOC_005286 ccz1 coding upstream 233050 17657224 ~ 17686404 (-)
XLOC_005275 BX000534.1 non-coding downstream 401410 16997206 ~ 16998442 (-)
XLOC_005273 NA non-coding downstream 433044 16964656 ~ 16966808 (-)
XLOC_005272 NA non-coding downstream 456604 16942204 ~ 16943248 (-)
XLOC_005269 BX000534.2 non-coding downstream 498093 16901645 ~ 16901759 (-)
XLOC_005265 BX322603.1 non-coding downstream 653305 16743052 ~ 16746547 (-)
XLOC_005289 dre-mir-2192 non-coding upstream 282618 17706792 ~ 17706901 (-)
XLOC_005291 NA non-coding upstream 297627 17721801 ~ 17727540 (-)
XLOC_005295 NA non-coding upstream 800360 18224534 ~ 18227730 (-)
XLOC_005298 NA non-coding upstream 1029033 18453207 ~ 18454407 (-)
XLOC_005303 AL772266.1 non-coding upstream 1314239 18738413 ~ 18738529 (-)

Expression


Co-expression Network