apex1 (apex1,LOC107658891)


Basic Information

Item Value
gene id apex1
gene name apex1,LOC107658891
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047612.1
NCBI id CM018558.1
chromosome length 23372418
location 12430448 ~ 12435191 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026923617.2
atattttttttagtcagGCAAACATTTGGGCAGCACCATGCTGGGGAACATGTGCAGCACTTTGAGCACAAAGCTTTAGAGCTGAGCGGAACAGAGAACTCCTGACCTGTAGTAGTTTTTATTAAGTGTGGCTGTGTTTGGTGTGCGTGTGCGTCTGTGTGCGCGTGCTGTGTGGAGTCTCAGAAACATGCCGAAGAGAGCCAAGAAAAACGAGGAGGCTTCTGCAGAAGCAGGCAACGACAACGGAACAGAAACAAAGAAATCGAAGAAGGCAAAGGAACCCGAAGCCCCAGTTTTATATGAAGATCCCCCAGATAAGCTGACCAGCAAGGATGGCCAGCCAGCCAACTTGAAGATAACCTCTTGGAATGTAGATGGCATTCGTGCCTGGGTTAAGAAGAATGGGCTTGATTGGGTGCGTCAAGAGGCTCCAGATGTGCTTTGTCTTCAGGAGACAAAGTGTGCTGAGAGAGCTTTACCAGCAGATATCACCTCTATGCCTGAGTATCCATATAAGTATTGGGCAGGCTCAGAAGATAAAGAGGGTTACAGTGGAGTGGCCATGCTGTGCAAGACTGAGCCTCTTAAAGTCACTTATGGCATTGGAAAAGAGGAGCATGACAAAGAGGGCCGTGTGATCACTGCCGAGTTCCCTTCCTTCTTCCTGGTTACTGCATACGTGCCCAATGCTGGGCGTGGCCTGGTTCGCCTCGACTACCGCAAAACGTGGGACGTAGACTTCCGTGCGTACCTGAGCAACCTGGACAGTCGTAAGCCCCTGGTGCTGTGTGGTGACCTCAACGTGGCCCACCAGGAGATTGACCTGAAGAACCCCAAAGGCAACCGTAAGAATGCAGGCTTCACTCCTGAAGAGCGCGAGGGTTTCAGCCAGCTTCTGGCAGCCGGCTTTACCGATAGCTTCCGTGAGCTGTATCCGGAGCAGACCAACGCCTACACCTTCTGGACGTACATGATGAACGCACGGGCCAAGAACGTGGGCTGGCGCCTGGACTACTTCGTGCTCTCAGCTGCTTTGCTCCCAAGCTTGTGTGACAGCAAGATTCGTAATACAGCCATGGGGAGTGATCACTGCCCCATCACTCTCCATCTGGCTGTATAGACATATGACCACTTCTGTCAGTATGGGTTCGCATTCACTACTTCCTAAGAGCAGTGGggcttttgctttttttctaaCTTGTGTAGATTGAGGCAAACTCTTTCAATATCTATATCTCtttcctgaaatattttacaagTTAAAAAGCCCAGACCTATAATTAGGTCATTAGAGCTAAGAGGGAACCGAAGGTTGTTTTGATTCACTGTTTGTAGTTTTGTTGCAGATATTATTcccaagatgttttttttcttgttctgtgTTAGTTCTAATATTCTCTCAAAGAAGCCTGACCGCAAAGTATGGCGTATGATGGAGACTTTGATCTTGTGTATTTTTCTGACATATCTTTCTTCTGTCATTCCATGAAGCAGATGTAATGACAACATTCTAGTCATGTGAAATGGAAACAAAAGCAGATCCCTTGTACCCCAGCTGAACAACAAAGCAGACTTCATGTTGCAACTGGATCAATTTTCACAAAAGTAATGAGACATTACCACCAAATTTTGaatttcaaaaaacaaacaaaaaaaaaaaaaacactagtgaTTCTAGCACTTTATAGCTCTTATAGCGCTTCActttatagaaataattaaGAAAGACCCTAGGGTTAGGgtctaactctaaccctaaccctagtgtctaaccctaaccctagcaaGACAAGCTTTCAGACAAATGACTTTGTATCGCTGCATTGTAATACTGTCAGAAACAACAGAAGGTGATTGATAAGAGAGAAAGCTCACTTGGGGTTCAGTTTCAGGTATGAACTAGTTAAGATTTGTTAGGTTCATTTACCATCAATTGACAGTTGCTTAGTAATCATCTTCACTGTGCTTCCTACCTTTATTGCAAAACAGTtaggttatttttttattcatgtctaTTGAAACAATAAATTGCTGAACAAAGGCA

Function

symbol description
apex1 Predicted to enable DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; and phosphodiesterase I activity. Acts upstream of or within several processes, including heart contraction; heart looping; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum; mitochondrion; and nuclear lumen. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

NR:

description
PREDICTED: DNA-(apurinic or apyrimidinic site) lyase

GO:

id name namespace
GO:0010628 positive regulation of gene expression biological_process
GO:0080111 DNA demethylation biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0001947 heart looping biological_process
GO:0060047 heart contraction biological_process
GO:0006281 DNA repair biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0016607 nuclear speck cellular_component
GO:0005730 nucleolus cellular_component
GO:0005739 mitochondrion cellular_component
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0003723 RNA binding molecular_function

KEGG:

id description
K10771 APEX1; AP endonuclease 1

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026923617.2 True 2044 mRNA 0.44 5 12430448 12435191

Neighbor

gene id symbol gene type direction distance location
LOC113532240 NA coding downstream 15374 12411859 ~ 12415074 (-)
LOC113531803 NA coding downstream 20918 12402179 ~ 12409530 (-)
mapk11 mapk11,LOC108279456,LOC103035641,LOC108442323,LOC107725929,LOC107656380,LOC107583972,LOC107579565,LOC105020226,LOC107658913 coding downstream 35927 12375791 ~ 12394521 (-)
mapk12b mapk12b,LOC108279513,LOC108442322,LOC103035956,LOC107579544,LOC107656379,LOC103459704,LOC107710136,LOC103151778 coding downstream 56064 12369609 ~ 12374384 (-)
LOC113532409 NA coding downstream 62902 12363808 ~ 12367546 (-)
si:ch211-214j24.10 LOC108279797 coding upstream 10707 12445898 ~ 12451585 (-)
shisal1a LOC108279994,LOC108442307,LOC107725687,LOC107676911,LOC107583751 coding upstream 53204 12488395 ~ 12517683 (-)
cmasa NA coding upstream 134877 12570068 ~ 12579954 (-)
LOC113532438 NA coding upstream 145732 12580923 ~ 12581063 (-)
kcnj8 kcnj8,LOC108279966,LOC107725582,LOC107655555,LOC107729834,LOC107690420,LOC107587158 coding upstream 149646 12584837 ~ 12588680 (-)
G281486 NA non-coding downstream 61183 12368959 ~ 12369265 (-)
G281455 NA non-coding downstream 176293 12251314 ~ 12254155 (-)
G281373 NA non-coding downstream 336389 12093857 ~ 12094059 (-)
G281362 NA non-coding downstream 394086 12033096 ~ 12036362 (-)
G281102 lrp6,LOC102306404,LOC101476287 non-coding downstream 719464 11707690 ~ 11710984 (-)
G281510 LOC108279795,LOC108442313 non-coding upstream 22372 12457563 ~ 12459092 (-)
G281527 NA non-coding upstream 41073 12476264 ~ 12477629 (-)
LOC113532391 NA non-coding upstream 711091 13146282 ~ 13147358 (-)
G281964 NA non-coding upstream 733484 13168675 ~ 13210493 (-)
G281981 NA non-coding upstream 823961 13259152 ~ 13285718 (-)
dusp16 dusp16 other downstream 677535 11721063 ~ 11752913 (-)
G281092 mansc1 other downstream 770121 11657890 ~ 11660327 (-)
G281074 rad51ap1 other downstream 842424 11586304 ~ 11588024 (-)
vegfab vegfa,LOC108435123 other downstream 1171036 11238935 ~ 11259412 (-)
sobpb LOC108279441 other downstream 1336272 11079168 ~ 11094176 (-)
LOC113531972 muc19,LOC108280038 other upstream 2704734 15139925 ~ 15184075 (-)
alg12 alg12 other upstream 3965730 16400921 ~ 16406863 (-)
LOC113532230 LOC108280029,LOC107562148,LOC107687569,LOC107741714,LOC105912408 other upstream 4403344 16838535 ~ 16853395 (-)
phf21b phf21b other upstream 4523321 16958512 ~ 17027865 (-)
LOC113532261 smkr1 other upstream 5543572 17978763 ~ 17988280 (-)

Expression


Co-expression Network