shha (shh)



Basic Information


Item Value
gene id shha
gene name shh
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information


Item Value
chromosome id NC_047598.1
NCBI id CM018544.1
chromosome length 33267568
location 28476431 ~ 28491847 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence


>XM_026936156.2
aatgcgcGCGCTGTCGGTGGGTCTGTGCCTCGCGCTGCTGGTGCTGCTGCCGGTGCGCGCGTGCGGTCCGGGCCGCGGTTACGGCCGGCGGAAGCACCCGAAGAAGCTGACTCCGCTCGCGTACAAGCAGTTCATCCCCAACGTGGCGGAGAAGACGCTGGGCGCGAGCGGGCGCTACGAGGGCAAGATCACGCGCAACTCGGAGCGCTTCAAGGAGCTCACGCCCAACTACAACCCGGACATCATCTTCAAGGACGAGGAGAACACCGGGGCCGACCGGCTCATGACCCAGagaTGCAAAGACAAGCTGAACTCGCTGGCGATCTCGGTGATGAACCAGTGGCCGGGGGTTAAGCTGCGCGTGACCGAAGGATGGGACGAAGACGGCCACCATTTTGAGGAGTCGCTTCACTACGAGGGCCGAGCCGTGGACATCACCACGTCCGACCGAGACAAAAGCAAATACGGCACGCTGTCTCGCTTAGCCGTGGAGGCCGGCTTCGACTGGGTGTACTACGAGTCCAAAGCGCACATCCACTGCTCCGTTAAAGCAGAGAACTCTGTGGCAGCGAAGTCGGGTGGCTGTTTTCCCGGCTCGGCTCGCGTCCGCCTGAAGGATGGAGCGATGAAGGAGGTGAAGGACCTGAACGTGGGAGACGAGGTCCTGGCAGCGGACGAGTTCGGGAACCTCGTCTACAGCGAGTTTATCATGTTCGCCGACCGCGACGGCGCCAGGAGACGAGCGTTCCGCATCATCGAGACCCGGAACCCGCCGACGAGGATCGCCCTCACCGCCGCGCACCTGCTCTTCATCGTCCAGAACTCCACGCTGACTGAGACGTTCGCCAGCGACGTCACACCGGGACAGGAAGTGATGATACTGGACGAGGGAGGACGCCATCTTCGTGCGGTCACGGTGGACCGGATTTACGAAGAAGAACGTGAGGGATCCTTTGCGCCGCTGACTGGTCACGGCACCATCGTGGTGGACGACGTCCTCGCTTCCTGTTACGCCGCCGTACAGAACCAGAAGCTGGCGCACTTAGCGTTCACGCCCGTCCGCTTCGTCCACAAGGTGGCGCCGTTTTTGTTCGCCGGATCAGTCCAGAATGACGGCGTGCACTGGTACTCTGACTTCCTGTATCGAATCGGGACACGGATTTTAGGCGAAGCTGCTTTTCATCCGCTCAGCATGGAGGACAAGAGCTGAAAGACAAAATGtccatatatatacatatataaatatatcaaagACTAATGTAGGATACAAGACAATattagaatataaataaaaagagacaaacGGGCCCCCCTTTctggaagaggaaaaagaggagggatatttattattttacagacaccatctcaaaaaaaaaaaaagaaaaaaggaaaaaaagaaagaaatggagccTTAAAAGTGTCCTGAATAATTTATTCACACGTGAACTTGGGctgctgatctctctctctctctctctatctctcactctctatctctctctatctatctctctgtctctatcacacacatacatatatacaggattgtgtttcagcatgtgtgtgtgcagaatcTATTTTTGTAtacttcaagaaagaaagaaaaatgaacgAAAAATGTTCTGTGCTACTAAGGCATGTGCCGATTGCGATTTCTTAACTTTTTCTTCTTACAGGCATCAACAAGGGGGGCGGAGCTTAACTTAAACATTGTGTAACTGAAGCTAGCCGCCATGTCCGCTTACGATCAGCTAGCTATCATCGGACTAACTTTAATCGCGTCTATTAAAGCTAGTATTTTGCGTCCAAGCAGTACGACGAGCTGAAAAAGCGAAAAAGAAAAACGAACGATGTCACATGACATCTCAAATTTAACTTAAGCCCCGCCCTTTTTGGACAAGTTACTTCAGTCAAAATCGGTGTTCGCATTCAAATTTCTCGAAAATAAAAGACTAAAATGCTGCCTCTttaacaggacaaaaaaaaacggCCTCGTCCCAAATAGTGACGTTATTTTTAAACGTTATTttatcggcacatgcctacGTGcgtctgactgactgactgttatatatatttttcggGATTGGGGGGGtccataaattatatttttctacACAGAATTGTAAATTAGATTTTGACTGTTCGATCGTTGCCGAATCACTTGAAATAGTGTAAATTAtgagaatatattttaatttaaatagtcACAGAGTTTCTTCTTGCTATTAtccttcttattatttttattattattattattatttttactattatcatcattattttttcatcatttttgtctcatgtccagtttgactttttttttctcatgtcgTTGCTCTTTTTCGGAAAACAGAACTGCacattttgaacatttcacTCTCCTAACCGCAGAGTTACAGACTAATTAATACGTAACTCCTGTAAATTtactaaaatgtattttttttttcctccattttttttgtaataggTGAATAGTTTTATAGGAATAAAAATGTAGCAGATATGCACAGGCTCAATGTGTCAGGAAATGTATAGAGatgattatttatatgtttatattataaaaaaa

Function


symbol description
shh Enables calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including hemopoiesis; positive regulation of sclerotome development; and positive regulation of smoothened signaling pathway. Acts upstream of or within epithelial-mesenchymal signaling involved in prostate gland development. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Biomarker of autism spectrum disorder; biliary atresia; glomerulonephritis (multiple); multiple sclerosis (multiple); and temporal lobe epilepsy.

NR:

description
sonic hedgehog protein A-like

GO:

id name namespace
GO:0042694 muscle cell fate specification biological_process
GO:0032835 glomerulus development biological_process
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway biological_process
GO:0048741 skeletal muscle fiber development biological_process
GO:0007224 smoothened signaling pathway biological_process
GO:0001756 somitogenesis biological_process
GO:0045494 photoreceptor cell maintenance biological_process
GO:0048795 swim bladder morphogenesis biological_process
GO:0042462 eye photoreceptor cell development biological_process
GO:0031018 endocrine pancreas development biological_process
GO:2000223 regulation of BMP signaling pathway involved in heart jogging biological_process
GO:0007267 cell-cell signaling biological_process
GO:0042476 odontogenesis biological_process
GO:0048557 embryonic digestive tract morphogenesis biological_process
GO:0060956 endocardial cell differentiation biological_process
GO:0048839 inner ear development biological_process
GO:0016539 intein-mediated protein splicing biological_process
GO:0001839 neural plate morphogenesis biological_process
GO:0031076 embryonic camera-type eye development biological_process
GO:0048618 post-embryonic foregut morphogenesis biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0008285 negative regulation of cell population proliferation biological_process
GO:0006508 proteolysis biological_process
GO:0061035 regulation of cartilage development biological_process
GO:0008015 blood circulation biological_process
GO:0035143 caudal fin morphogenesis biological_process
GO:0048663 neuron fate commitment biological_process
GO:0010001 glial cell differentiation biological_process
GO:0010002 cardioblast differentiation biological_process
GO:0021984 adenohypophysis development biological_process
GO:0007411 axon guidance biological_process
GO:0033339 pectoral fin development biological_process
GO:0030902 hindbrain development biological_process
GO:0048702 embryonic neurocranium morphogenesis biological_process
GO:0048703 embryonic viscerocranium morphogenesis biological_process
GO:0001947 heart looping biological_process
GO:0021508 floor plate formation biological_process
GO:0005886 plasma membrane cellular_component
GO:0005615 extracellular space cellular_component
GO:0046872 metal ion binding molecular_function
GO:0008233 peptidase activity molecular_function

KEGG:

id description
K11988 SHH; sonic hedgehog

RNA


RNA id representative length rna type GC content exon number start site end site
XM_026936156.2 True 2578 mRNA 0.47 3 28476431 28491847

Neighbor


gene id symbol gene type direction distance location
ro60 trove2 coding downstream 189773 28276696 ~ 28286658 (-)
cdc73 cdc73 coding downstream 201116 28238896 ~ 28275315 (-)
LOC113540124 NA coding downstream 280374 28173321 ~ 28196057 (-)
LOC113540126 NA coding downstream 305450 28157829 ~ 28170981 (-)
LOC113540134 LOC108267236 coding downstream 335524 28124082 ~ 28140907 (-)
lmbr1 lmbr1 coding upstream 83061 28574908 ~ 28605243 (-)
LOC113540234 csrp1a,LOC100304834,LOC107697020,LOC107559179,LOC108425502,LOC107673143,LOC107707378 coding upstream 119344 28611191 ~ 28619112 (-)
LOC113540232 LOC108267757,LOC108430781,LOC107591375,LOC107668940 coding upstream 127969 28619816 ~ 28628143 (-)
dcaf8 dcaf8 coding upstream 140907 28632754 ~ 28642395 (-)
scp2a scp2,scp2a coding upstream 177132 28668979 ~ 28680704 (-)
G72726 NA non-coding downstream 4660 28397661 ~ 28471771 (-)
G72709 NA non-coding downstream 92971 28343134 ~ 28383460 (-)
G72720 NA non-coding downstream 97299 28365657 ~ 28379132 (-)
G72658 pfn2,pfn2l non-coding downstream 331565 28081544 ~ 28144866 (-)
G72665 NA non-coding downstream 335993 28138866 ~ 28140438 (-)
G72796 NA non-coding upstream 175476 28667323 ~ 28668643 (-)
LOC117597077 NA non-coding upstream 221187 28713034 ~ 28717955 (-)
G72824 otol1a,LOC108267659,LOC103045957,LOC108430690,LOC107701323,LOC107560771,LOC107593893,LOC107722646,LOC105899147 non-coding upstream 291076 28782923 ~ 28784140 (-)
G72893 NA non-coding upstream 340537 28832384 ~ 28833720 (-)
LOC117597038 NA non-coding upstream 400169 28892016 ~ 28896799 (-)
trnas-uga_2 NA other downstream 239626 28236724 ~ 28236805 (-)
trnas-uga_1 NA other downstream 240164 28236186 ~ 28236267 (-)
LOC117597043 NA other downstream 250828 28197991 ~ 28225603 (-)
prkag2b LOC108267467,LOC108430764,LOC108434244 other downstream 434646 28016064 ~ 28041785 (-)
pcyt1aa pcyt1a,LOC108267677,LOC108430756,LOC103040438,LOC107709348,LOC107671662,LOC107559373 other downstream 920444 27547752 ~ 27555987 (-)
LOC113540437 fam159a other upstream 156477 28648324 ~ 28652425 (-)
LOC117597168 NA other upstream 295767 28787614 ~ 28791829 (-)
LOC117597037 dnajb4,LOC107566472,LOC107681825,LOC107599850,LOC107690981,LOC107751861,LOC108430719 other upstream 381731 28873578 ~ 28884965 (-)
usp33 usp33,LOC106569751,LOC107708728,LOC107751869 other upstream 656791 29148638 ~ 29171921 (-)
LOC113540665 LOC108267691,LOC108437516,LOC107715522,LOC107681815,LOC105889505 other upstream 1072374 29564221 ~ 29575727 (-)

Expression



Co-expression Network