mmp14a (mmp14,mmp14a,LOC107691938,LOC107753930)


Basic Information

Item Value
gene id mmp14a
gene name mmp14,mmp14a,LOC107691938,LOC107753930
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047598.1
NCBI id CM018544.1
chromosome length 33267568
location 11159921 ~ 11171340 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026936767.2
GCAGCTCGTCAGACCCCAGCGCGAGCGTCAGTGCCGGAGGACAAAAGAAAAGCGCAGACAAGATGAGACACGAGCGCCTTTAGACTACAGCAACATGCTTTCGCAGATCTGCGCTGCTGATATTGTGCTTTTCCTCAAACTGGTTTTGTACACAAGGTTCTAAGGCGCGATTATTATTGAAGTCTGCATGTTTTATCTCCAGCGTTGAGGCATTTTTTTCCAAAGTTTTCGCTTTTGGACAAACGAGGACGAATTCTAAAACTTTTAATTCCAAGTTTTGGAATTATCTGACTCAGGAAAATCAGGAGTCGGAAGAGGAAAGGGTGATTTAGGCCAGGCGCAGGGTGCTGGTGTAAGTTCTAGTGTTagttattgtgtatttttggaGGATCGGGATGGTCACTTGGTCAGTGCTTTGGCTGGCActcactgctctgggtgtgagCAGTGACAAAGAAGTCCGACCAGAGgtatgGCTACAGCAGTATGGATACCTTCCTCCTGGTGATGTGCATGCTCAGGCTATCCGCTCCCTTAAGGCCATTGCCTCTGCTATCTCCGCCATGCAGAAGTTCTATGGCCTCACCATCACAGGAACCATGGACCCTGAAACACTCAAAGCAATGCAGCGACCACGCTGTGGGGTTCCAGATAAATTTGGcactgagcagaaaagcaacctCAGGAGGAGACGCTACGTCATTCAGGGTCAGAAGTGGAACAAAGCAGAGGTCACCTTCAGCATCCAGAACTACACTCCTAAAGTGGGTGAGTATGCTACTTACGAGGCCATCCGGAAGGCCTTCAAGGTTTGGGAGTCAGTCACGCCACTGAAGTTCCGGGAAATCCCATACTACCAGATCAGAGAAAGGCCTGACAGGTTCGCTGACATCATGCTTTTCTTCGCTGATGGCTACCATGACGATAGCACACCATTTGATGGGGAGGGAGGCTTCCTGGCCCATGCATACTTCCCTGGTCCAGGGATCGGAGGTGACACACACTTTGATGCAGCAGAGCCTTGGACAACTGGCAATGTGGACCAAGGAGGGAATGATGTTTTCCTGGTCGCAGTGCATGAACTGGGTCATGCGCTGGGTTTAGAGCATTCTGGGGATCCTTCTGCCATTATGGCCCCATTCTACCAGTGGATGGAGACCGAGAATTTTGTGCTTCCTGATGATGACAGACGTGGAATACAGCAGATTTAcgGTTCTCGATCAGGAGAGGTGCCGAACCCCCCTGCCCCGCGGCCCACACGCAAATCTGACCGACCCTCAGCCGGGCCTGATATCTGCAAAGGCCACTTTGACACCATCACTATCCTGCGGGGAGAGATGTTTGTCTTTAAGGAAAAGTGGTTCTGGCGAATGCGTGATGGTAAACCTCTGCAGGGTTACCCCATGCCCATCTCACACTTCTGGAAAGGCCTGCCACCCTCTATCAATGCTGCCTACGAGCGTGCGGATGGGAAATTTGTCTTCTTTAAAGGCGATAAGTATTGGGTGTTTAGTGAGGCCACTTTGGATCATGGCTATCCTAAAACCTTTAAGGAGCTGGGCACAGGCCTTCCTACAGACAGAATAGACGCTGCTCTCTTCTACACCCCAAATGGAAACAcctactttttcagaggaagCAAATATTACCGCTTCAATGAGAACACACGCTCTGTGGACTCAGATTACCCCAAACCCATCAGTACATGGAGTGGAGTGCCCGATGATATCAAAGGAGCCATTATAAATGAGGATAGAGCCTACACCTACTTCTACAAAGCCAACAAATATTGGAAGTTCAACAACAAGCAGATGAAGGTGGAGTCTGGCTACCCCAAGTCTGTCCTGACTGACTGGATGGGCTGTGAGCGTGAGGAGTCTACAAAGCCAGACGGAACTGATGAGGAAGTCATCATCATTGAGGTGAACAAGTCAGACGGATTTGCTGGAGGGGCAGCAGTCATAGTGATCCCTCTCTTCCTGTTGGCCTGTGTGCTCATAGTTCTGGGAGCATTGCTGTTCTTCCGGCGCTACGGTACCCCACGACGCCTCCTCTACTGCCACCGCTCTCTACTGGACAAGGTTTAAAGATCAAGGGATGGAAACCGAGAAGAGATAGGGATGTAGGGGCAATAGCAGGGGTGAAGAGAAAGGGTATGGGGAGGGGGATAATGGTAGAATGGAGAGGCTTTGCTCAGATGGAGATGAAAAGGACTTTGAGATTGTTTACAGAACAgcaaggaagaaaagaaggagaaggagggaaggaaggatgaAGAAGTGAAGCGACAGAAAAGGGAACAATGCGTATTGTTTTGGTAGTTACTTGTACATCTCTGCCATAATGAATAGACccatgaaggagagagagagaaatacagagaaaaagagggagctcatttaaaaaaacatttttattgaataCGTTGAAAGAAAGTAAAGCACTTTTTATTGTATCAgccctccctcttcctctcttgTAGTCTGTCTCTCCCAAATCCAACGACTCCAGCCACAGTGCTGTATGATTAATGTCTTTGTTTCTGCTTTCATAAATTTCCATCTCACCTCTGGTTTTAGCTCTTAAATTTAGCCACAATCTTTTGATTTCTCCCAAAACCCTTCTATCGTTATATTCCCTTCAGTGCCTTCAACCTCTCAGGTAACGTTCCTTACCTGCATTCGTGAAGATAACCAAATTAATCTGTATTTTCACAGACATGCTTgtttttagattaaaaatattaacccCTAGTGAAAGATGTCttcaaaacatacagtatatctcaACAGTAGAGACTGCTGAGTTTGAAAGGGTAAAGGTGAAAGGTCAAAGTTCAGGGAGGAAGTGTGGCTCAGGCTCCTGAAAGGAGGCCAGTTTTTATTTACACCTAGAGAGAAGAGCTGTCTTGCAGGTACATCTCCagatattaattttataaagtGTTTGTTACCATgtattgttattaatgttattaatgattgcgcttgttattattataactatggttattgttattattgttctcCGTATTTagtccttttttattttgtagtcATTTCAAGTCCTGCTGGACAGAGGCAGAATGTGACTGATATTAAAATGACTCccagtttattttaatgttaaaaacatcAGGTTATTCCATGGGAAATAAACATACTTGTATGAAAGATTCAAAATAATGTTGAGGAATTATAGACGTTGTTAGGAAGAAGATCGGAAAAATACTTACGAACACCAGCCCTGTTGACAGGCCAAAGttgctgtgtgttatttttgcaataatgtttatgtgcctttatatgaaaaaaaaaatctcactggaTTTATTGTATTTGGATGGTTCTTTGGAGAAAACGTGTTCTTTTGGGTGGAGCAAAAGTTTTCGGAGAGGAATAAACCtgattatgcaaaaaaaa

Function

symbol description
mmp14a Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of or within several processes, including gastrulation; retinal ganglion cell axon guidance; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; head; head mesenchyme; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
mmp14 Enables endopeptidase activity and metalloaminopeptidase activity. Involved in several processes, including endodermal cell differentiation; regulation of protein localization to plasma membrane; and zymogen activation. Located in several cellular components, including extracellular space; intermediate filament cytoskeleton; and macropinosome. Colocalizes with cytoplasm. Implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Biomarker of artery disease (multiple); breast carcinoma; diabetic angiopathy; dilated cardiomyopathy; and transitional cell carcinoma.

NR:

description
matrix metalloproteinase-14-like

GO:

id name namespace
GO:0042074 cell migration involved in gastrulation biological_process
GO:0051216 cartilage development biological_process
GO:0009948 anterior/posterior axis specification biological_process
GO:0006508 proteolysis biological_process
GO:0030010 establishment of cell polarity biological_process
GO:0060027 convergent extension involved in gastrulation biological_process
GO:0001666 response to hypoxia biological_process
GO:0048701 embryonic cranial skeleton morphogenesis biological_process
GO:0031012 extracellular matrix cellular_component
GO:0005509 calcium ion binding molecular_function
GO:0004222 metalloendopeptidase activity molecular_function
GO:0008270 zinc ion binding molecular_function

KEGG:

id description
K07763 MMP14; matrix metalloproteinase-14 (membrane-inserted)

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026936767.2 True 3422 mRNA 0.45 10 11159921 11171340

Neighbor

gene id symbol gene type direction distance location
LOC113540324 NA coding upstream 22495 11130175 ~ 11137426 (+)
LOC113539896 LOC108261535 coding upstream 48827 11090981 ~ 11111094 (+)
LOC113540335 LOC108267929,LOC108261535 coding upstream 96393 10989215 ~ 11063528 (+)
LOC117596976 LOC108267929 coding upstream 171355 10964062 ~ 10988566 (+)
LOC117596975 LOC108267982 coding upstream 197362 10944179 ~ 10962559 (+)
ajuba ajuba coding downstream 12395 11183735 ~ 11191994 (+)
dhrs4 dhrs4,dhrs1,LOC103023174,LOC107753983,LOC108440044,LOC107742330,LOC107563424 coding downstream 69334 11240674 ~ 11244577 (+)
cideb cideb,LOC108440045 coding downstream 84598 11255938 ~ 11258662 (+)
si:dkey-183c6.8 LOC108267925,LOC108434846 coding downstream 212094 11383434 ~ 11400606 (+)
LOC113539902 LOC108267738,LOC108267739,LOC108267932,LOC108267740,LOC108267931,LOC108261673,LOC108267937,LOC108267938 coding downstream 268748 11440088 ~ 11445185 (+)
LOC113540371 NA non-coding upstream 137125 11020133 ~ 11022796 (+)
G62416 NA non-coding upstream 249779 10907025 ~ 10910142 (+)
G62373 NA non-coding upstream 295060 10864655 ~ 10864861 (+)
LOC117596985 NA non-coding upstream 343369 10815750 ~ 10816552 (+)
trnak-cuu_20 NA non-coding upstream 628393 10531456 ~ 10531528 (+)
G62549 NA non-coding downstream 5689 11177029 ~ 11193851 (+)
LOC117596983 NA non-coding downstream 11430 11182770 ~ 11183734 (+)
G62554 NA non-coding downstream 43815 11215155 ~ 11215743 (+)
G62572 LOC108261673,LOC108267931,LOC108267740,LOC108267738,LOC108267932,LOC108267935,LOC108267938 non-coding downstream 104099 11275439 ~ 11366783 (+)
G62585 LOC108267738,LOC108267739,LOC108267932,LOC108267937,LOC108267938,LOC108267241,LOC108267941 non-coding downstream 148757 11320097 ~ 11360515 (+)
c4h4orf48 c7h4orf48 other upstream 496510 10657357 ~ 10663411 (+)
trnak-cuu_19 NA other upstream 664451 10495398 ~ 10495470 (+)
trnak-cuu_18 NA other upstream 668052 10491797 ~ 10491869 (+)
trnak-cuu_17 NA other upstream 669271 10490578 ~ 10490650 (+)
trnak-cuu_16 NA other upstream 670485 10489365 ~ 10489436 (+)
LOC117596972 LOC108267738,LOC108267932,LOC108267931,LOC108267739,LOC108267937,LOC108261673,LOC108267938,LOC108267933,LOC108267935,LOC108267740 other downstream 419375 11590715 ~ 11605230 (+)
si:ch211-200p22.4 LOC108267499,LOC108434851 other downstream 473561 11644901 ~ 11705336 (+)
si:dkey-112a7.4 LOC108268066 other downstream 1121151 12292491 ~ 12295133 (+)
tmem88b tmem88,bcl6b,LOC108267673 other downstream 2035317 13206657 ~ 13219859 (+)
slc16a13 slc16a13 other downstream 2104122 13275462 ~ 13285834 (+)

Expression


Co-expression Network