gclc (gclc,LOC107664701,LOC107712340)


Basic Information

Item Value
gene id gclc
gene name gclc,LOC107664701,LOC107712340
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047597.1
NCBI id CM018543.1
chromosome length 33776708
location 26708519 ~ 26719590 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026939535.2
ATCAACGTCGCGTCTCGCGCGGGGGGAAAACTGTCCTCAAACTGCACACGGTTTCTCAGTGTGCGGGAGGGAGGTAGTGTGCTCAGTGCTTTAGCGTGAAACAGTGCGTGAATCACCCTTCGCTGCTTTtatcccagatttttttttttcatcgcTTATATACCGGGAGCTCGCGCGAGGACGCTGGCGCGGAGGACGCGACgtttctaaaaaaatatatatatataataataaataaaacaaccgTTAAGGCCTGTCTCtttttgctagcaagctagtagCTACAACTCGCAGTCGCTTCAGCACCAGAGAAAGTAGCTCGTGTTGTGAGTCTCCTGTCCGTGTCGGAAAGTTTCTTAGCCGTTCGTGCTAATGGGCTTGCTGTCTCAAGGCTCCCCGCTTAACTGGACAGAAACCAAGAAATATGCCGACCATGTCAGAAAACACGGCATCCTGCAGTTTCTCAACATCTACAACAAGGTGAAGGACAGGCAGAAGGATGTGCTAAAATGGGGCGATGAGGTGGAGTACATGTTGGTGGACCTGGATGcgaaaaatgaaaaagcttgTCTGGTTCTGAATGGAAACGAAGTGTTGGATACGCTGCaagaaaagggggaaaaggTCAACCCCAACCATCCAACCCTGTGGAGGCCAGAGTATGGCAGCTACATGATTGAGGGCACTCCAGGACAGCCTTACGGCGGGACAATGTCCGAGTTCAACACCGTAGAAGACAACATGGGCAAACGGAGGAGGGAGGCCTCTTCCGTGCTCAATAAGGACGAGACTCTCTGCACTATCACGTCATTCCCCAGGTTAGGTTGTCCGGGTTTCACAAAGCCAGAGTACAGGCCGACACCTGTTGAAAAAGGAGCGAGCAAGTCCCTCTTCTTCCCCGATGAGGCCATCAACAGACATCCccggttcagCACTTTGACCAGGAACATTCGTCACAGACGAGGGGAGAAGGTGGCGATCAACGTACCGATCTTTAAAGATCAAAACACACCAACTCCATTTGTGGAGAAGTTTCCCGAGGACGACGGGGAGGCGGCAAGCGCAGCTCTCCCTGATCACATCTACATGGACGCCATGGGCTTCGGAATGGGAAACTGCTGTCTGCAGGTCACATTTCAAGCTTGCAGCATCAGTGAGGCTCGATACCTCTATGACCAGCTGGCCACATTCTGCCCCATAGTGATGGCCCTCAGTGCTGCTTCTCCCTTCTATCGTGGCTACATGTCGGATATCGACTGTCGCTGGGGTGTTATCTCAGCCTCTGTGGATGATCGGACTCGGGAAGAACGAGGGCTGGAGCCTTTGAAAAACAACAAGTTCAGGATCCACAAGTCAAGATATGATTCCATTGATAGCTACCTTTCtttttgtggggaaaaatacAATGATATAGAATTGACGAAAGATGACGACATCTACAACCAGCTCTTGGATGCAGGCATTGACAAATTACTGGCCCAGCACATTGCCCACCTCTTTATTCGTGACCCACTGTCGCTCTTTGAGGAGAAGATTAACTTGGATGATGAGAACGAATCAGACCACTTTGAGAATCTTCAGTCAACTAACTGGCAGACCATGAGGTTCAAACCACCTCCTCCCAATTCTGAAATAGGATGGAGAGTTGAGTTTCGGCCCATGGAGgttCAGTTAACCGACTTTGAGAATGCTGCATATGTTGTGTTCATTGTTCTTCTTACACGAGTGATCCTGTCCTACAAGTTAGACTTCCTGATTCCCTTGTCaaagGTTGATGACAACATGAAAGCTGCCCAGAAACGAAATGCAGTGCAAGAAGGCCTTTTTTATTTCAGGAAGGACATCTTTAAAGGCTGCAACCCGTTCTTTGACTCCGCCCAGAATGGCGTTGAGACTAATGAGGATCATGAGGAGTACACTCTGATGAGCATTGACACAATCATTAACGGCAAGGAGGGAGTGTTCCAGGGACTTGTACCAATTCTGAACTGCTACCTGGAGAACATGGAAGTCGATGTAGACACGCGCTGCACCATCTTGAACTACCTGAAACTCATTAAGAAGCGAGCATCGGGAGAACTGATGACCATGGCGAAATGGATGAGGGAATTTGTTGCTACGCATCCACAGTACAAGAAAGACAGCGTGATAACTGACAAAATAAACTACGACCTGCTTTGCAAATGCGACCGAATTGCCAAGGGGGAAGAGCAGTGCCCTGAACTGATTGGTGACCCAGTGAGAAGAGGAAACTGAGTCAGAAGGAGAACACCGTGgcatatgtctctctctctctcttttttttttttt

Function

symbol description
gclc Predicted to enable anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).

NR:

description
glutamate--cysteine ligase catalytic subunit-like

GO:

id name namespace
GO:0045454 cell redox homeostasis biological_process
GO:0006979 response to oxidative stress biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0006750 glutathione biosynthetic process biological_process
GO:0009408 response to heat biological_process
GO:0045892 negative regulation of transcription, DNA-templated biological_process
GO:0009725 response to hormone biological_process
GO:0006534 cysteine metabolic process biological_process
GO:0006536 glutamate metabolic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0050662 obsolete coenzyme binding molecular_function
GO:0004357 glutamate-cysteine ligase activity molecular_function
GO:0016595 glutamate binding molecular_function
GO:0043531 ADP binding molecular_function
GO:0000287 magnesium ion binding molecular_function

KEGG:

id description
K11204 GCLC; glutamate--cysteine ligase catalytic subunit

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026939535.2 True 2310 mRNA 0.48 16 26708519 26719590

Neighbor

gene id symbol gene type direction distance location
elovl5 elovl5 coding downstream 1764 26687125 ~ 26706755 (-)
arfgef3 arfgef3,LOC107751324,LOC107688785 coding downstream 40501 26639549 ~ 26668018 (-)
lhb LOC100304481,LOC108425477 coding downstream 78641 26629250 ~ 26629878 (-)
plpp4 plpp4 coding downstream 87533 26529006 ~ 26620986 (-)
wdr11 wdr11,LOC102787883 coding downstream 241138 26366178 ~ 26467381 (-)
klhl31 klhl31,LOC107664702,LOC107597701,LOC107688788 coding upstream 1229 26720819 ~ 26725438 (-)
bmp5 bmp5,LOC107712332 coding upstream 239514 26959104 ~ 26969207 (-)
col21a1 col21a1,LOC108263596,LOC107681042,LOC107565055 coding upstream 256135 26975725 ~ 27025890 (-)
zmp:0000000760 LOC108262759 coding upstream 314334 27033924 ~ 27055678 (-)
rab23 rab23 coding upstream 493510 27213100 ~ 27223218 (-)
G53204 NA non-coding downstream 122 26707702 ~ 26708397 (-)
G53210 NA non-coding downstream 39698 26668613 ~ 26668821 (-)
G53183 NA non-coding downstream 161010 26547296 ~ 26547509 (-)
G53182 NA non-coding downstream 165297 26542964 ~ 26543222 (-)
G53181 NA non-coding downstream 168723 26539529 ~ 26539796 (-)
G53216 NA non-coding upstream 486 26720076 ~ 26720660 (-)
LOC113542110 NA non-coding upstream 18953 26738543 ~ 26741519 (-)
G53250 NA non-coding upstream 79089 26798679 ~ 26799608 (-)
G53761 NA non-coding upstream 148068 26867658 ~ 26867877 (-)
G53809 NA non-coding upstream 307225 27026815 ~ 27027038 (-)
LOC113542183 NA other downstream 798400 25910018 ~ 25910119 (-)
herc4 herc4,LOC107689351 other downstream 1972631 24661985 ~ 24735888 (-)
lyst lyst,LOC107569426 other downstream 2056672 24451986 ~ 24651847 (-)
LOC113545393 ccdc85a,LOC107716311,LOC107585341 other downstream 2576036 24108351 ~ 24132483 (-)
mlh1 mlh1,LOC104940895,LOC107676366,LOC104940890 other downstream 2668419 24016896 ~ 24040100 (-)
dst dst other upstream 338307 27057897 ~ 27195955 (-)
zgc:163080 tmem14a other upstream 818179 27537769 ~ 27541331 (-)
G54269 NA other upstream 1713630 28433220 ~ 28435411 (-)
cdh23 cdh23,LOC107679169,LOC107676383,LOC106579432,LOC107586104,LOC107549130 other upstream 3159705 29879295 ~ 30111161 (-)
G55209 LOC108263435 other upstream 3392241 30111831 ~ 30122822 (-)

Expression


Co-expression Network