alox5a (alox5,alox5a,LOC107747471,LOC107582511,LOC107690200,LOC107678516,LOC107708393)


Basic Information

Item Value
gene id alox5a
gene name alox5,alox5a,LOC107747471,LOC107582511,LOC107690200,LOC107678516,LOC107708393
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047597.1
NCBI id CM018543.1
chromosome length 33776708
location 18831551 ~ 18837797 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026945920.2
AGAAGTAGAAAAGAGGAAATGCTTTCAGCGAGAGACTACAGTGGGTTCACTGTGGAGACACAGAAGCTTGTCCGCTTGTGTGACCAGGATGCCTTCATACACTGTGACTGTTGCCACGGGCTCTCAGTGGTTTGCTGGCACTGATGACTACATCTACCTGACCCTGGTGGGGACGGAGTGCAGCAGTGAGAGAACACTTCTGGATAAACCACTATATAATGACTTTGAACGAGGCGCGGTGGACTCATATGATGTCAAAGTGGCAGAGGACCTTGGTGACTTAGAGCTTCTGAAGATCGAGAAGAAAAAGTACTGGATGCAAGATGACTGGTATTGTAAATACATTACAGTGAAGACACCCATTGGAGATTACATTGAGTTCCCCTGTTTTCGCTGGGTAGTGGACGATAAAGAGGTGATACTTCGAGATGGCAGAGCTCGCCTGCCTCAGCATGACAAAACCAGAGTGGCAAAACAACACAGACGCAAGGAGCTGGAAAACAGACAGAAGACTTTTAGATGGAAGGAATGGCATCCTGGCTTTCCCATGAGCATTGATGCAAAAACCCATAAAGAGCTACCACGTGACATCCAGTTTGACAGTGAGAAAGGCATAGATTTCGCCCTCAACTACAGTAAAGCgATAGAGAACCTCTGTGTTAACCAGTTTATGCACATGTTCCAGTCCTCTTGGGGAGATTTTGCAGATTTTGAGCGGATATTTGTGAGGATCAAGAACACAATATCAGAGTATGTGATGCAGCACTGGAAAGAAGACTTCATGTTCGGATATCAGTTCCTAAATGGCTGTAATCCTGTCATGATCGAGAAGTGTACAAAAATACCAGATAATTTTCCAGTCACACATGAAATGGTGAAAGACTGCTTGGAAAGAGACCTCACTCTAGAAGATGAACTTAAGGCAGGAAACCTGTTCATTGCAGATTATAAGATTATGGATGACATCACGCCTAATGCTACAGATCCTTGTACCCTGCAGTATTTAGCTGCACCCATTTGCTTGCTGTACAAGAACAGTCAGAACAAAATTCTGCCAATCGCCATACAGCTGAGTCAAACCCCAGGGGAAGACAGCCCAATCTTTCTGCCTAGTGATAATGAGTATGACTGGCTGCTGGCCAAGATCTGGGTGAAATCTTCAGACTTTCATGTGCACCAGACAGTCACACACCTCCTGAGGACTCATTTGATATCAGAGGTTTTTGGCATTGCTATGTACCGACAGTTGCCTGCTGTTCATCCAGTGTATAAGTTGCTGGTGCCACATGTTCGTTTCACAATTGCCATCAATACAAAAGCACGCGAGCAACTTATCTGCGAATGTGGAATCTTTGACAAGGCTAATGGTACAGGTGGAGGTGGCCATGCAGAGCTAGTGCAGAAAGCCATGAAGACGTTCACCTATAAGTCCTTGTGCTTTCCGGAGTCCATAAAGGCTCGAGGCATGGACAGCAAGGAGGAGCTtccctactactactacagagATGATGGCAACAAAGTGTGGGAGGTAATCAAAAGTTTTGTCACAGATGTGGTGCACATATACTATGATAGTGACAAAACGGTACTGGAGGATGAGGAGATACAGGCATTCGTCAAAGATGTCTGCAGCTTTGGAATGCAGGATTTTGACTATTGTGagtttccGAAATCATTGCAGAACCGAGAGCAGCTGGTGGAGTACCTGACTGTTATAATCTTCACAGCTTCTGCACAACATGCTGCCATCAACTTTGGACAGTATGACTGGTGTTCATGGATCCCCAACGCTCCCCCCACTATGCGAAAACCCCCGCCTACAAAGAAGGGCCAGGTGGATATAGAATTCATCGTGACTAGTTTGCCTGACCGTGGTCGCTCCTGCTGGCATCTCGGAGCAGTGTGGGCTCTTAGTCAGTTCCAGGACAATGAGTTGTTCTTAGGCATGTATGCTGATGAACACTTCATTGACAAACCGGTGAAGAAAGCCATGGAGACTTTCCGGGAAAAGCTGGATGAGCTGTCCAAAGCCATCAAAAATCGCAACGAGGGGAAGAAACTCCCCTACTACTACCTGTCTCCAGACAGAATCCCAAACAGTGTTGCTGTCTGAG

Function

symbol description
alox5a Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
alox5 Enables arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; leukotriene A4 biosynthetic process; and lipoxin biosynthetic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Biomarker of several diseases, including cholangiocarcinoma; common cold; pancreatic cancer; pulmonary fibrosis; and pulmonary hypertension.

NR:

description
PREDICTED: arachidonate 5-lipoxygenase isoform X1

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function
GO:0005506 iron ion binding molecular_function

KEGG:

id description
K00461 ALOX5; arachidonate 5-lipoxygenase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026945920.2 True 2114 mRNA 0.46 14 18831551 18837797

Neighbor

gene id symbol gene type direction distance location
washc2c fam21c coding downstream 3229 18810075 ~ 18828322 (-)
zfand4 zfand4 coding downstream 23954 18788701 ~ 18807597 (-)
march8 march8,LOC107095557 coding downstream 45088 18716883 ~ 18786463 (-)
vdac2 vdac2,LOC108444242,LOC107582506,LOC107747461,LOC107690181 coding downstream 120276 18700916 ~ 18711275 (-)
zgc:110045 zgc:110045,LOC108262845,LOC108444131,LOC107582498,LOC107708438,LOC107721227,LOC107678543 coding downstream 673367 18128349 ~ 18158184 (-)
slc25a16 slc25a16,LOC107678603,LOC107708451,LOC107747470 coding upstream 7355 18845152 ~ 18852107 (-)
si:dkey-228d14.5 LOC108262905 coding upstream 60366 18898163 ~ 18903520 (-)
mat1a mat1a,LOC108263526,LOC107678534,LOC107582520,LOC107708460,LOC107733750,LOC105911600 coding upstream 174184 19011981 ~ 19018909 (-)
sfxn3 LOC108263463,LOC108441766,LOC107678536,LOC107708462,LOC107582521,LOC107570532,LOC107733760 coding upstream 199195 19036992 ~ 19044321 (-)
lzts2a lzts2 coding upstream 227236 19065033 ~ 19114569 (-)
G48476 NA non-coding downstream 658369 18167020 ~ 18173182 (-)
LOC117596862 NA non-coding downstream 739938 18087504 ~ 18091613 (-)
G48419 NA non-coding downstream 746746 18083657 ~ 18084805 (-)
G48411 NA non-coding downstream 784665 18037687 ~ 18046886 (-)
G48368 NA non-coding downstream 843920 17987422 ~ 17987631 (-)
G48938 NA non-coding upstream 5956 18843753 ~ 18844635 (-)
G48940 NA non-coding upstream 15716 18853513 ~ 18853713 (-)
G48947 NA non-coding upstream 52766 18890563 ~ 18890812 (-)
G48954 NA non-coding upstream 90385 18928182 ~ 18929502 (-)
G48970 NA non-coding upstream 119360 18957157 ~ 18957459 (-)
lrmda c3h10orf11,cunh10orf11,c13h10orf11,LOC103041229,LOC107747465,LOC107678567,LOC107708444 other downstream 218030 18330368 ~ 18613521 (-)
col13a1 col13a1 other downstream 1170132 17578178 ~ 17661419 (-)
LOC113538666 LOC108263686,LOC108442385,LOC107699307,LOC107586507,LOC107708387 other downstream 1257129 17561404 ~ 17574422 (-)
cisd1 cisd1,LOC108263303,LOC108443718,LOC105902329,LOC107549159,LOC107747252,LOC107665600 other downstream 1355459 17471187 ~ 17476092 (-)
morn4 morn4,LOC107747296,LOC107719210,LOC107702749 other downstream 1848822 16979131 ~ 16982729 (-)
G49195 rab11fip5,LOC108263817,LOC107582533,LOC107733767 other upstream 478690 19316487 ~ 19319733 (-)
atrn atrn,LOC107568639,LOC107693325,LOC107695011 other upstream 776920 19614717 ~ 19667661 (-)
slc4a11 slc4a11,LOC107695019 other upstream 878803 19716600 ~ 19768134 (-)
metap1 metap1,LOC107556924 other upstream 1344256 20182053 ~ 20205593 (-)
atp10d atp10d,LOC107556926 other upstream 1387112 20224909 ~ 20256520 (-)

Expression


Co-expression Network