mlh1 (mlh1,LOC104940895,LOC107676366,LOC104940890)


Basic Information

Item Value
gene id mlh1
gene name mlh1,LOC104940895,LOC107676366,LOC104940890
gene type misc
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047597.1
NCBI id CM018543.1
chromosome length 33776708
location 24016896 ~ 24040100 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_034302677.1
CCCACTTAGGTAGAAAGTTGTTTCTCCCGATTATAAAGAAAGTAAACTATACAGCCGTAACTTATATACCACAGTTGAcgtatgaaaataaattttgtcGCCTATTTAAGTATTTAGGTCGCTCTCTAATAGCCTTTTAGGTAGTACGACTTGTTCACGATGGACTAAATATACACAATTTTagtaaagttttaataaaatccCGAGACAGTGGCTGTAAGGCATTATGGCAGGCGTGATCCGGAGGCTGGATGAGACCGTTGTGAACCGCATTGCTGCTGGAGAAGTCATTCAACGACCTGCTAATGCGATTAAAGAAATGATTGAGAACTGTCTGGATGCAAAGTCCACCAACATTCAGGTGATTGTCAAAGAGGGAGGACTGAAGCTGATCCAGATTCAGGATAATGGCTCTGGAATTAGGAAAGAAGACCTGGAAATTGTTTGTGAGAGGTTTACAACAAGCAAGCTTCAGACTTTTGAGGATCTTGCATCTATTTCAACTTACGGTTTCAGAGGAGAAGCACTTGCCAGCATAAGCCATGTAGCCCATGTTACAATTACCACAAAAACAGCAGATGGAAAATGTGCCTACCGAGCAAGCTACTGTGATGGGAAACTGAAAGCCCCAGCGAAACCTTGTGCTGGAAACCAAGGGACACTGATCTCAGTAGAAGACCTGTTCTATAATGTACAAACCCGAAGGAAAGCCCTTAAAAGCCCCAGTGAAGAATACTCCAGGATTGTGGAAGTAGTAAGTAGATATGCTGTTCACAATTCTGGGAAAAGCTTTACTGTCAAAAAGCAAGGAGAGATGGTGGCTGATGTGAAGACTTTCACCACTGCCTCAGTTTTGGACAACATTCGGGTGGTTTTTGGAGTAGCACTAAGCAGGGAGTTGATGGAAGTGGGGTGTGAGGATCAGAAGCTTGCTTTCAGACTGAAGGGTTATATCTCAAATGCCAACTACTCTGTCAAGAAGTGTATCCTCATCCTGTTCATCAACCATCGTTTAGTGGAATCCAGTGCCTTGAAGAAAGCAATTGAGACCGTTTATACAGCATAtcttcccaaaaacacacatccTTTTCTTTATCTCAGtttggaaattgcacctcATAATGTTGATGTGAATGTGCATCCCACGAAGCATGAAGTGCACTTCCTCCATGAAGACTGTATCATTGGAAGCATTCAGAAACACATTGAGAGTAAACTACTTGGCTCCAATTCTTCCCGCACTTATTTTACACagACTTTACTTCCTGGGGTGTCAGTATCTGTCAGTGATGTAAAAAGCTCAAGCAGTTCAACAGCTGACCCCAGTGATCGTAACTGTCCCAATCAAATGGTGAGAACTGACAGCAAGGCCCAAAAACTAGATGCTTTTCTACAGCCAGCAAataacatttcttcagttccctgcCTCATTGCAAGTCTTCCAAAACCTATCCCAGCTACTGCTAATTTTGAAGCAGAAATGAGTGATGGTCCTGAGAAGTTCCTGGCCAGTGCTGCAAACAGCATGCAGACTGATAGTGCACATGTCCAGTCAGAGGCTCCCCTGAGGAAACGGCCTCATGTTGATGTTGACGAGGAAAAGGAGAATGTGACATTGGCCTGCAGTCCCCGTAGACGGGTCATCAGGTTAACCAGCGTGAAGGAGTTGCGAAATGAAATCACAGAACAAGCTCATAAAGGTTTGCAGGAGATACTACATAATCATTCATTTGTTGGATGCGTCAATCCCCAGTGGTCTCTAGTCCAACACCACACCAAACTGTACCTGTTAAACAACACCAAACTCAGtCAGGAGCTGTTTTACCAGATTTTGATGTATGATTTTGGTAACTTCGGTGTCCTCTGGTTGTCGAATCCAGCCCCTCTGTATGACTTGGCCATCTTGGCACTGGACTCGGAGGAAAGTGGCTGGACAGAGGAGGATGGGCCTAAAGAAGGACTGGCCCAGTATATAGTAGATTTCTTGAAGAAAAAAGCTGAAATGTTGGAAGATTATTTCTCCATGAAGATAGATGAGgaAGGGAATCTGACTGCTCTACCACTTCTGCTAGATAACTATAGTCCTGCAATGGAGGGTCTGCCATTGTTCATCCTGCGCTTAGCCACAGAGGTGAACTGGGACAGCGAGAAGGATTGTTTCCATGACTTCAGTAAAGAGTGCAGTTACTTGTATTCCATAAGAAAAGAGTACACCCTGGAGCCAGAGGCAGGAACAGACCTTGCAGAGGCAGAGGCGAGCTGGCAGTGGAAAGTTGAACACATTCTCTTCAAAGCATTGCGCTCTCTCATCCCACCAAAACACTGTAGTGAAGATGGCAGTGTCCTCCATATAGCCAACCTGCCTGACCTCTACAAAGTGTTTGAGAGATGCTAAAAACCTGCtgttgaaatgaataaatttataatcTCACGTGTGCTTTGATGTTAGAAAGCAGTCAGGAAGCCTGTCTTTGTTTACCTATATTACCCATATACATATTCTGTTGTCATATTTTATGGGCTTTGTTACATGGATTTTGGCTATTGAAGATGAATATTTGTATACAATGTTCATACTTTAAGATGTGTTCACtttataatgtgtttaaaaccaataaatattttattattca
>XR_004577819.1
ACCCACTTAGGTAGAAAGTTGTTTCTCCCGATTATAAAGAAAGTAAACTATACAGCCGTAACTTATATACCACAGTTGAcgtatgaaaataaattttgtcGCCTATTTAAGTATTTAGGTCGCTCTCTAATAGCCTTTTAGGTAGTACGACTTGTTCACGATGGACTAAATATACACAATTTTagtaaagttttaataaaatccCGAGACAGTGGCTGTAAGGCATTATGGCAGGCGTGATCCGGAGGCTGGATGAGACCGTTGTGAACCGCATTGCTGCTGGAGAAGTCATTCAACGACCTGCTAATGCGATTAAAGAAATGATTGAGAACTGTCTGGATGCAAAGTCCACCAACATTCAGGTGATTGTCAAAGAGGGAGGACTGAAGCTGATCCAGATTCAGGATAATGGCTCTGGAATTAGGAAAGAAGACCTGGAAATTGTTTGTGAGAGGTTTACAACAAGCAAGCTTCAGACTTTTGAGGATCTTGCATCTATTTCAACTTACGGTTTCAGAGGAGAAGCACTTGCCAGCATAAGCCATGTAGCCCATGTTACAATTACCACAAAAACAGCAGATGGAAAATGTGCCTACCGAGCAAGCTACTGTGATGGGAAACTGAAAGCCCCAGCGAAACCTTGTGCTGGAAACCAAGGGACACTGATCTCAGTAGAAGACCTGTTCTATAATGTACAAACCCGAAGGAAAGCCCTTAAAAGCCCCAGTGAAGAATACTCCAGGATTGTGGAAGTAGTAAGTAGATATGCTGTTCACAATTCTGGGAAAAGCTTTACTGTCAAAAAGCAAGGAGAGATGGTGGCTGATGTGAAGACTTTCACCACTGCCTCAGTTTTGGACAACATTCGGGTGGTTTTTGGAGTAGCACTAAGCAGGGAGTTGATGGAAGTGGGGTGTGAGGATCAGAAGCTTGCTTTCAGACTGAAGGGTTATATCTCAAATGCCAACTACTCTGTCAAGAAGTGTATCCTCATCCTGTTCATCAACCATCGTTTAGTGGAATCCAGTGCCTTGAAGAAAGCAATTGAGACCGTTTATACAGCATAtcttcccaaaaacacacatccTTTTCTTTATCTCAGtttggaaattgcacctcATAATGTTGATGTGAATGTGCATCCCACGAAGCATGAAGTGCACTTCCTCCATGAAGACTGTATCATTGGAAGCATTCAGAAACACATTGAGAGTAAACTACTTGGCTCCAATTCTTCCCGCACTTATTTTACACagACTTTACTTCCTGGGGTGTCAGTATCTGTCAGTGATGTAAAAAGCTCAAGCAGTTCAACAGCTGACCCCAGTGATCGTAACTGTCCCAATCAAATGGTGAGAACTGACAGCAAGGCCCAAAAACTAGATGCTTTTCTACAGCCAGCAAataacatttcttcagttccctgcCTCATTGCAAGTCTTCCAAAACCTATCCCAGCTACTGCTAATTTTGAAGCAGAAATGAGTGATGGTCCTGAGAAGTTCCTGGCCAGTGCTGCAAACAGCATGCAGACTGATAGTGCACATGTCCAGTCAGAGGCTCCCCTGAGGAAACGGCCTCATGTTGATGTTGACGAGGAAAAGGAGAATGTGACATTGGCCTGCAGTCCCCGTAGACGGGTCATCAGGTTAACCAGCGTGAAGGAGTTGCGAAATGAAATCACAGAACAAGCTCATAAAGGTTTGCAGGAGATACTACATAATCATTCATTTGTTGGATGCGTCAATCCCCAGTGGTCTCTAGTCCAACACCACACCAAACTGTACCTGTTAAACAACACCAAACTCAGtCAGGAGCTGTTTTACCAGATTTTGATGTATGATTTTGGTAACTTCGGTGTCCTCTGGTTGTCGAATCCAGCCCCTCTGTATGACTTGGCCATCTTGGCACTGGACTCGGAGGAAAGTGGCTGGACAGAGGAGGATGGGCCTAAAGAAGGACTGGCCCAGTATATAGTAGATTTCTTGAAGAAAAAAGCTGAAATGTTGGAAGATTATTTCTCCATGAAGATAGATGAGGTGGgaAGGGAATCTGACTGCTCTACCACTTCTGCTAGATAACTATAGTCCTGCAATGGAGGGTCTGCCATTGTTCATCCTGCGCTTAGCCACAGAGGTGAACTGGGACAGCGAGAAGGATTGTTTCCATGACTTCAGTAAAGAGTGCAGTTACTTGTATTCCATAAGAAAAGAGTACACCCTGGAGCCAGAGGCAGGAACAGACCTTGCAGAGGCAGAGGCGAGCTGGCA

Function

symbol description
mlh1 Predicted to enable ATP hydrolysis activity. Acts upstream of or within meiosis I and spermatogenesis. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Is expressed in testis. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1).

NR:

description
DNA mismatch repair protein Mlh1 isoform X1

GO:

id name namespace
GO:0006298 mismatch repair biological_process
GO:0016446 somatic hypermutation of immunoglobulin genes biological_process
GO:0043060 meiotic metaphase I plate congression biological_process
GO:0007283 spermatogenesis biological_process
GO:0006200 obsolete ATP catabolic process biological_process
GO:0051026 chiasma assembly biological_process
GO:0007131 reciprocal meiotic recombination biological_process
GO:0007141 male meiosis I biological_process
GO:0000795 synaptonemal complex cellular_component
GO:0032389 MutLalpha complex cellular_component
GO:0032390 MutLbeta complex cellular_component
GO:0005712 chiasma cellular_component
GO:0030983 mismatched DNA binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0032407 MutSalpha complex binding molecular_function
GO:0003697 single-stranded DNA binding molecular_function
GO:0016887 ATPase activity molecular_function

KEGG:

id description
K08734 MLH1; DNA mismatch repair protein MLH1

RNA

RNA id representative length rna type GC content exon number start site end site
XM_034302677.1 True 2633 mRNA 0.43 19 24016896 24040099
XR_004577819.1 False 2270 misc_RNA 0.44 19 24017264 24040100

Neighbor

gene id symbol gene type direction distance location
mrpl14 mrpl14,LOC102799944 coding downstream 149366 23862719 ~ 23867530 (-)
mgme1 mgme1 coding downstream 176036 23837939 ~ 23840860 (-)
kifc1 kifc1,LOC108261151,LOC108261048,LOC108261613 coding downstream 266135 23727152 ~ 23750761 (-)
c1d c1d coding downstream 336915 23672419 ~ 23679981 (-)
phf10 phf10,LOC106589650 coding downstream 967772 23032198 ~ 23049124 (-)
arid4b arid4b,LOC107690809,LOC102789854 coding upstream 150318 24190418 ~ 24316428 (-)
LOC113542016 sipa1l2 coding upstream 772874 24812974 ~ 25090822 (-)
dnajc12 dnajc12 coding upstream 1268206 25308306 ~ 25330202 (-)
msh6 msh6 coding upstream 1454576 25494676 ~ 25504756 (-)
LOC113541965 zc3h6,LOC102799538,LOC100704674 coding upstream 1645584 25685684 ~ 25697851 (-)
G51903 NA non-coding downstream 11211 24005388 ~ 24005685 (-)
G51887 NA non-coding downstream 70551 23944851 ~ 23946345 (-)
G51876 NA non-coding downstream 134561 23882027 ~ 23882335 (-)
G51781 NA non-coding downstream 291808 23724878 ~ 23725088 (-)
LOC113544646 NA non-coding downstream 300956 23687614 ~ 23715940 (-)
G51943 NA non-coding upstream 96406 24136506 ~ 24136795 (-)
LOC117596863 NA non-coding upstream 220252 24260352 ~ 24269139 (-)
G52097 NA non-coding upstream 347281 24387381 ~ 24392746 (-)
G52076 NA non-coding upstream 375219 24415319 ~ 24416426 (-)
G52147 NA non-coding upstream 508571 24548671 ~ 24605747 (-)
G51576 NA other downstream 562679 23447908 ~ 23454217 (-)
znf318 znf318 other downstream 1228092 22774355 ~ 22788804 (-)
LOC113541574 LOC108263228 other downstream 1445028 22565771 ~ 22571868 (-)
LOC113540944 eml4,LOC107586470,LOC107698167 other downstream 1893247 22035285 ~ 22123649 (-)
G50837 NA other downstream 2066707 21949855 ~ 21950189 (-)
LOC113545393 ccdc85a,LOC107716311,LOC107585341 other upstream 68251 24108351 ~ 24132483 (-)
lyst lyst,LOC107569426 other upstream 411886 24451986 ~ 24651847 (-)
herc4 herc4,LOC107689351 other upstream 621885 24661985 ~ 24735888 (-)
LOC113542183 NA other upstream 1869918 25910018 ~ 25910119 (-)
dst dst other upstream 3017797 27057897 ~ 27195955 (-)

Expression


Co-expression Network