mthfd1b (mthfd1,LOC108269612,LOC108232073)


Basic Information

Item Value
gene id mthfd1b
gene name mthfd1,LOC108269612,LOC108232073
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047604.1
NCBI id CM018550.1
chromosome length 29376037
location 19646283 ~ 19669547 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_034308225.1
GTCGGCGCGCGCGCGGCTGGAGCAGCAGCGGCAGGGTTTCAGTGCGCAACGGAAATTGCGTGGATCATTTCTaagcgtgtgagtgtgtgtgagtgtgtgtgtgagtggtgaaCTTCTGGACAGAGTGGTCAACTTTGTTCTCTGGAGAAGAGAAAGTCAGGAAGCCTACCATGTCGGCCCAAATCATCAGCGGAAAAGAAGTCTCAGCCCAGGTGCGAGAGAGGCTGAAGAAGCAGGTGGAAGAAATGAAGACTCAAGACCCAAACTTCAGACCAGGCTTGGTGGTGTTACAGGTGGGAAACAGAGAGGACTCAAACCTGTACATCAGCATGAAGATGAAAGCTGCTGCTGAGATTGGAATCAATGCGATGCACGTGAGGCTTCCACAGACCGCTACTGAAGAAGAGGTCCTGCAGCGCATCAGAGAGATCAATGAGAACTCCAGTGTGCATGGGCTCATAGTGCAGCTGCCTTTGGACTCCATTCACCGCATTGACACTGAGAAGGTCACCAACGCTGTGGCACCAGAGAAGGATGTAGATGGTTTGACTAGCATTAACGCAGGGAAACTGGCCCGGGGTGACCTTGGAGACTGCTTCATTCCCTGCACTCCCAATGGCTGTATGGAGCTCATTAAACAGACAGGTGTATCCGTGGCAGGAAAACGGGCAGTTGTGATTGGCCGCAGTAAGATTGTGGGTGCACCAATGCACGACCTCCTGCTCTGGAATCACGCCACTGTTACCACCTGTCACTCAAAAACTGCTGACCTGGCAGCTGAGgtGGGAAAGGCAGACATCTTGGTGACCGGGATTGGGAAACCGGAGATGGTGAAGGGCGAGTGGGTGAAGAAAGGTGCTGTAGTCATTGACTGTGGCATCAACCATGTTCCAGACAGCACCAAGCCAAGTGGGAAGCGGGTTGTAGGTGATGTTCACTTTGCCACTGCCAAGGAGCAAGCAGCCTTCATCACGCCTGTCCCAGGTGGAGTCGGCCCCATGACTGTCGCCATGCTCATGCAGaatACCGTACTGAGTGCCAAGCGCTTCCTTCAAGCACATGAACCAGGCAAATGGAACATCTCTTATACCAAGCTCAACTTGCAGAGACCCGTTCCCAGTGATATCGTTATTTCCCGCTCCGGTATACCCAAGCCCATTGACCGTCTGGCCAGAGAGATCGGGCTTCTCTCGGATGAAGTCGAGCTCTATGGCAAGACCAAAGCCAAAGTCCAGTTGGAAACTATTGATCGATTGAAGTCCCAGGCTGATGGCAAATATGTGGTTGTTACTGGGATCACTCCTACACCTCTTGGTGAGGGGAAAAGCACCACTACGATAGGGTTAGTGCAGGCTCTTGGTGCTCACCTCAAGTGCAATGTGTTTGCCTGCGTGCGCCAACCATCTCAAGGCCCCACGTTCGGCATCAAAGGTGGTGCAGCTGGAGGTGGCTATTCTCAGGTTATTCCCATGGAAGAGTTTAATCTTCATCTCACTGGTGATATCCATGCCATCACTGCTGCAAATAACCTGGTGGCTGCTGCCATCGATGCTCGTATGTTTCATGAAGCCACTCAGTCTGATAAGGCACTTTTTAACCGCCTGGTGCCGCTAAGTGGAGGCCAGAGGAAGTTTTCCCCTGTGCAGATCAACCGACTCAAAAAACTGGGCATTGAGAAAACTGATCCGTCCGCACTGACAGAGGAAGAGATCACTCGCTTTGCCAGGCTGGACATTGACCCTGAATCAGTCACCTGGCAAAGAGTGTTGGACACAAATGATCGATTCCTCCGGAAGATTACCATTGGCCAAAGCCCCACTGAAAAGGGCTATACCAGAGCAGCTCAGTTTGATATCACGGTGGCCAGTGAGATCATGGCTGTGTTGGCTCTCACCAGTAGTCTGGAGGACATGAGGCAGAGGCTTGCTAAAATGGTGGTAGCAACCAGTCGCAGTGGAGAGCCCATCACCACAGAAGACCTGggtgtgtgtggagCACTGACAGTGCTAATGAGAGATGCCATCAAACCCAACCTTATGCAGACCCTAGAGGGAAACCCTGTGTTTGTTCACGCCGGCCCTTTCGCCAACATCGCCCATGGAAACTCCTCCATCCTGGCTGATAAAATCGCTCTGAAGCTTGTAGGGCCTGAAGGATTTGTGGTAACTGAGGCAGGCTTTGGTGCAGACATCGGCATGGAGAAGTTTTTCAACATTAAGTGTCGTTACTCCGGGCTGCGTCCTCACGTGGTGGTGCTGGTCGCCACAGTGAGAGCGCTGAAGATGCACGGGGGTGGACCAACGGTCACAGCTGGCATGCCTCTTCCAAAGGAATACATAGAAGAGAACCTGGAGCTGGTGGAGAAAGGCTGCAGCAACCTGAGGAAGCAGATCGAGAATGCCAAGCACTTTGGTGTGCCAGTTGTTGTAGCAGTCAATGCTTTCAAGACAGACACTGATGCTGAACTGCAGCTGATCTGTGAGCTGGCTAAACAGGCAGGAGCGTTTGATGCAGTGCCCTGCACTCACTGGGCAGATGGGGGTGCTGGAGCCACTGAGTTGGGCAAAGCCGTGCAGAAAGCTGCAGAAGCACCCAGCAACTTCAGCTTCCTGTACGACACTGAGTTGCCTGTCGTTGATAAGATCAGAATAATTGCACAGAAGATTTACGGAGCAGATGATGTCGAGCTGCTCCCAGAAGCCCAGCATAAAGTGGAGCTATACACCAAACAGGGTTTTGGCAATTTGCCCATCTGTATGGCAAAGacccatctgtctctttctcatgaTGCTGAAAAGAAGGGTGTGCCCACTGGCTTTGTGCTACCTATTCGTGATATTCGTGCGAGCGTTGGTGCTGGGTTTCTCTACCCACTGGTTGGCACGATGCCCACCATACCAGGCCTCCCAACACGCCCCTGTTTCTACGACATAGATCTGGATCCAGTGACTGGAGAAGTCATCGGTCTCTTCTAACAGATGCTGAATTGAATCCCCCGTAGGCACACTTCTGAACCAGATGTTTGTAATGGTTTAATTAGGAAGCTATATGAGTAGAGTTATAATCATTTCCTGATTGTTTCATAGTTTGTAAGTGGTCTTCATAGTTGTTGGATCAGTATTACAACTATAAGAGTGTTCTGCTATGGAGAGATGTTCTTAGAACTGACAAACTCTCAGAGCCAGCAAAGCCctaaatatttacattcaatTAAATGGGAATGTAATTTGTATGTGATGGGTGGAATTATTCCAACGTACAATCGCTAAAGCCCTTCTAACTGGCCTTGATTCGAgcaattatgcattttatgtaCAGTTAGTTGACACAATGTTGAAAGCATGAGACATTGTGAAAAATTCACAAAGTAGGTCAACAGACTTGGTTAGACACGTAATCATGTGCccattataaaaacaaattaaatcaaaGTGCAGCATGGGAAATTTAAAAATTAGCTACTATCACATCACCTTCCCCATTGAATGTAGTTAAATATggagctgtatttttttctgccaatttggagcatttttaaattcaaagtGCATCACGAATAATGACTACTGGCAATGTGCTTGAGATTGTACGATGGAATTTTTCAGTAGAACTGTGTTAAAACAACAGTTTAATATGAACTATTAGGTATAGGTATTATTACACTTTACGTTAGGGAGGAATACTCTGGAAATTTAGACACAGGAAAACAAAACCAAGTTCATCTGCAAGCAATGTGAAtcagaaaatctgaaatagttaAGAAgggctttttttcttcatacatATAGCATTCCTTTAATGGTACACTACATGATAAATGATCCACTGTATTAATTCTCTGTTACTCTTTGAACTGACAATTTCAGAAATGTACCTGCCATGCAAGTGAAATTTACACAGTCATCATTAAGTAGTACTGAAGATGGTCATGTAATGACTAAACATGGCTTATGTAGGCTGGTTTAAAGACAAAGCTGAGGACTGGAAAAATTGGGGACATGCCCTCAGTTCTATTCCAAACAAACTCTTTAACGTCCAGGTTTGTAACTGAAAGAACTAAGAACTGTAAAGAGTTTATAAACTGTTCACTGTTAAAAGTTTCTCCTATGTCTTAACCttgactttttttcttcatggaattttttttctggaagtCTGACATGGTGTACATGTCCTTTGAATGTCTGAATCACTGTTGTCTTtttacaaaatgaaacatttaaaccTAAAACTGGAACCCCATCTCCATTCCGACAGTCTTGTTAAATAAAGGCATATCCCTTAAAGGCA

Function

symbol description
mthfd1 Enables formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Involved in carboxylic acid biosynthetic process and tetrahydrofolate interconversion. Located in cytosol. Implicated in several diseases, including Down syndrome; cleft lip; developmental cardiac valvular defect; neural tube defect (multiple); and tetralogy of Fallot. Biomarker of Down syndrome.

NR:

description
C-1-tetrahydrofolate synthase, cytoplasmic

GO: NA

KEGG:

id description
K00288 MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_034308225.1 True 4290 mRNA 0.47 27 19646283 19669547

Neighbor

gene id symbol gene type direction distance location
LOC113538896 LOC108269628 coding upstream 16163 19620847 ~ 19630120 (+)
LOC113538831 LOC108269613,LOC108441832 coding upstream 153920 19477213 ~ 19492363 (+)
gcfc2 LOC108270421 coding upstream 171597 19460183 ~ 19474686 (+)
ywhaqb LOC108269934 coding upstream 188724 19449741 ~ 19457559 (+)
dhx32b LOC108269478,LOC108436743,LOC107592761 coding upstream 267509 19369052 ~ 19378774 (+)
plcb2 plcb2 coding downstream 109021 19778568 ~ 19809259 (+)
LOC113538872 ankrd63 coding downstream 167711 19837258 ~ 19839847 (+)
spint1a NA coding downstream 253586 19923133 ~ 19937793 (+)
LOC113538714 plekhg3,LOC108269610,LOC107560184,LOC107726575,LOC107660984,LOC108430640,LOC107678711 coding downstream 272364 19941911 ~ 19984241 (+)
xgb LOC108269631,LOC108430641 coding downstream 318937 19988484 ~ 20014894 (+)
G168207 NA non-coding upstream 49316 19596423 ~ 19596967 (+)
G168175 NA non-coding upstream 121428 19523154 ~ 19524855 (+)
G168011 NA non-coding upstream 667807 18977016 ~ 18978476 (+)
G167913 LOC107572756,LOC107690120,LOC107579140 non-coding upstream 804673 18839609 ~ 18841610 (+)
G167909 NA non-coding upstream 808961 18837091 ~ 18837322 (+)
G168504 inafm2 non-coding downstream 103343 19772890 ~ 19774666 (+)
G168585 NA non-coding downstream 218380 19887927 ~ 19888154 (+)
G168630 NA non-coding downstream 318101 19987648 ~ 19987870 (+)
G168632 NA non-coding downstream 349214 20018761 ~ 20019038 (+)
G168633 NA non-coding downstream 349610 20019157 ~ 20020371 (+)
prlh2r LOC108269650,LOC108425589 other upstream 1067975 18569379 ~ 18578308 (+)
ldah ldah other upstream 1272203 18330467 ~ 18374080 (+)
kidins220a LOC108269813,LOC108425633 other upstream 1723532 17867416 ~ 17922751 (+)
itgb1bp1 itgb1bp1,LOC107707691,LOC107655317 other upstream 1939451 17700467 ~ 17706832 (+)
sox11a sox11b,LOC108269454 other upstream 2215532 17385507 ~ 17430751 (+)
G168191 NA other downstream 5366 19674913 ~ 19687591 (+)
LOC113538915 c9h15orf52 other downstream 53233 19722780 ~ 19766581 (+)
zfyve19 zfyve19 other downstream 210188 19879735 ~ 19886509 (+)
LOC113538658 NA other downstream 243796 19913343 ~ 19922486 (+)
G168650 cep170b other downstream 372930 20042477 ~ 20042935 (+)

Expression


Co-expression Network