grb2b (grb2b,grb2,LOC108256494,LOC107719324,LOC107672691,LOC108432081,LOC107723603,LOC107672145,LOC105013161)


Basic Information

Item Value
gene id grb2b
gene name grb2b,grb2,LOC108256494,LOC107719324,LOC107672691,LOC108432081,LOC107723603,LOC107672145,LOC105013161
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047607.1
NCBI id CM018553.1
chromosome length 26458119
location 12784297 ~ 12817380 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026916610.2
GGAAGCGGAAATGTTCTCGCTCAATCCAGCAGCATAACAAGCGTCTGGTGAAAAGCTCCATCTCGGTGCTCCTTTAACCCGTTTACTGGAAAAAATAAGCGCAACAAATTGAGTATTGCTCAAAGTTGGATTTAACGAGAAGTAAAAGAAGAGTGAAGGTCCTTCATAAGTGAGCTTCACCGGGTCGTTTATGTGAGAGGATCGTGCCGGAGAGACGCGGGACAGAGACTGGAGGAGAGACCCCGGGAGCCGCACACAGTTGTGTCCTGGACCTGTGCTCGTGTTTATAGAGTCGAGACATCGTCGCCTTCAGCCCATCACAGGGAATAAACTCGGgggcaaaaacaaacaaactcgaTCGAGACGTTTTCCACTTGCTTTGGTGTAGACACACGCAGGTGTTGGAGCTGAATCATGGAGGCCATTGCCAAGTATGATTTCAAAGCGACTGCTGATGACGAGCTGAGTTTTAAACGAGGGGAGATCCTAAAGGTATTAAATGAAGAATGTGACCAGAACTGGTACAAGGCAGAGCTGAATGGCAAAGATGGCTTCATCCCCAAGAATTACATAGAAATGAAAGCACACCCgtggTTCTTTGGGAGGATTCCTCGGGCGAGAGCAGAGGAGCTGCTGAACAAACAGAGGCACGATGGAGCTTTCCTTAttagagagagcgagagtgcGCCTGGAGACTTCTCCCTGTCTGTGAAGTTTGGCAATGACGTGCAGCACTTCAAGGTGTTGCGTGATGGGGCAGGAAAGTACTTTTTGTGGGTTGTAAAGTTCAACTCCCTCAACGAGCTGGTGGATTATCACCGCTCAACCTCAGTCTCTCGAAACCAACAGATTTTTCTACGTGACATTGAGCAGGTGCCTCAGCACCCCACATATGTGCAGGCCCTATTTGACTTTGACCCTCAGGAGGACGGCGAGCTTGGTTTCCGCCGCGGTGATTTCATCCAGGTCCTGGACAACTCGGATCCTAACTGGTGGAAGGGTGCATGCCACGGTCAGACAGGCATGTTCCCACGCAATTACGTCACACCTGTCAATCGGAACATGTAAACAACAGAAGTATAGGTCCCTtctttccaaacacacacacccctcctcaAATAAGCCTAAATGTCCCCCTCTGCCCCTAACACCCTGTGTTTTGcagagtgaaaagagaaaaaatggaaactgaaaaaaagaaaaaaaaaagaggaaaaaaaagggtcaggagagtgtgtgtttctccagTGACATATGggcaaaaagaaaatcaatgctGATTCCTGAGAATTATTGATTGCATCACTATGAACGCTTGCAGCCAGGGTCTAATGAGCCTAAGCTTAGTGCAACACCACACAAATTAACACCACAACAATCCTGTGTGTAGATCTCCCCCAGCTCCGTCTGCCTCCCCATCTTCTCAAATTCAACACCTTTTCATTGTagtgcattttcttttcattacgTTTTGGCTGCATGTTTTAATCACATTGTAACAGGAAATTTTGAGGCCATTTTAAgtttaacaaaagaaaacaagatttaaaaaaatcaaccacATATTAGATAgataccatttttaaaaaaaatgataattgaTGCTAATTACAAGTTGCAGAGTCTGAAATAACAGGCACAAGAACTTTGTACATCAGTTTTTGGCCATGAAAATATACATAGAGAGAATCCATTTTTAAgaagatatatattatatatttgtatgtgtttgtctgttttatctttccacacattttttttgttcagatgTAAATTATGTTCAGTTGTTTTTGGATGAAACGGAGTAGCTCTGGGACATGCTGAATCGTCAGTATAATTTTGATGAATTATAATCTGAGATTTCTCAGATACATCGGCATGCTATTTAACTCGCCACATATTccgtttggagaaaaaaaaaaaagttagttttgGAGCTGCATATTCTTAAACGTAACTGTTTATCAGGACTCTTTCAATGACATGCAGGGAAGAGCCGTTTTATCCTGCAGGAGTTTGTCTAATGTGAAATTGTCGCAAGGCCAGCCACCATTCGAAGCCAAGGTATTTACTgcagccacttttttttttttttttttttcctccctcggGCCGTGAATGTAGCTGACTTTAGACCTTAGAAATGAGCATGAGGGAAGTAAGGTCACTGTCCTGAACCACACACCCGCTCGAGATTTCAGAGGCGCATCTATTTACAGTGTCAAACCCATATATGACCATGTATGCATACACATGAAACAATATGCACAGGAGTGTATACACATTTTAAGCAGATGATTGAAAGTCGTGCAAGTTTGATCTTTCATTATGATGTATTTCGCCAGTTCCCAGACTGGCACCAATAATACCAGTATGCGAAA

Function

symbol description
grb2b Predicted to be located in Golgi apparatus; endosome; and nucleus. Is expressed in central nervous system and trigeminal placode. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
grb2 Enables several functions, including SH3 domain binding activity; insulin receptor substrate binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ionizing radiation; signal transduction in response to DNA damage; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within actin cytoskeleton reorganization. Located in endosome; nucleolus; and nucleoplasm. Part of COP9 signalosome and Grb2-EGFR complex. Implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Biomarker of endometrial carcinoma.

NR:

description
PREDICTED: growth factor receptor-bound protein 2

GO: NA

KEGG:

id description
K04364 GRB2; growth factor receptor-bound protein 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026916610.2 True 2381 mRNA 0.43 6 12784297 12817380

Neighbor

gene id symbol gene type direction distance location
usp43b usp43,LOC108432083,LOC107583297 coding upstream 8482 12695369 ~ 12775815 (+)
ntn1b ntn1,LOC107728387,LOC107583316,LOC107672692,LOC107719327 coding upstream 122681 12616284 ~ 12661616 (+)
tob1a tob1,LOC108432179,LOC107690006,LOC107555665,LOC104949960,LOC107758110 coding upstream 293350 12487277 ~ 12490947 (+)
spag9a LOC108257234,LOC108432181 coding upstream 348648 12396504 ~ 12435649 (+)
kdelr2a erd22,kdelr2a,LOC108432184,LOC107670681,LOC107555655,LOC107728665 coding upstream 394862 12385975 ~ 12389435 (+)
bptf LOC108279852,LOC108432079 coding downstream 12815 12830195 ~ 12862010 (+)
kpna2 kpna2,LOC108261381,LOC108432045 coding downstream 50145 12867525 ~ 12872850 (+)
smurf2 smurf2,LOC108254810,LOC108432078,LOC107748797,LOC107695141,LOC107723598 coding downstream 55885 12873265 ~ 12920930 (+)
ddx5 ddx5,LOC108257112,LOC108432077,LOC107583258,LOC103024726,LOC107723600,LOC107602339,LOC105013158,LOC107748799,LOC107672127 coding downstream 104944 12922324 ~ 12928752 (+)
pglyrp6 pglyrp2 coding downstream 112840 12930220 ~ 12935022 (+)
G210160 NA non-coding upstream 4161 12779249 ~ 12780136 (+)
G210086 NA non-coding upstream 235794 12546433 ~ 12548503 (+)
G209945 NA non-coding upstream 403311 12378946 ~ 12380986 (+)
G209944 NA non-coding upstream 405884 12378159 ~ 12378413 (+)
G209943 NA non-coding upstream 406213 12375907 ~ 12378084 (+)
G210209 NA non-coding downstream 3696 12821076 ~ 12821284 (+)
G210384 NA non-coding downstream 227610 13044990 ~ 13045833 (+)
G210532 NA non-coding downstream 548304 13365684 ~ 13365893 (+)
G210655 NA non-coding downstream 642599 13459979 ~ 13460490 (+)
G210698 NA non-coding downstream 844794 13662174 ~ 13663501 (+)
ndufb10 ndufb10 other upstream 409925 12367566 ~ 12374372 (+)
arhgap17b LOC108279379,LOC108432202 other upstream 594227 12158703 ~ 12190070 (+)
LOC113528416 LOC108275780 other upstream 643926 12135269 ~ 12140371 (+)
tbc1d16 tbc1d16,LOC107559246,LOC107689993,LOC107670685,LOC107562324 other upstream 698239 12049407 ~ 12086058 (+)
luc7l3 luc7l3,LOC107674472,LOC107726809,LOC107654661 other upstream 1206474 11567119 ~ 11577823 (+)
znf653 znf653,LOC104961106,LOC107553636,LOC103393609 other downstream 618001 13435381 ~ 13445686 (+)
zgc:158403 zgc:158403,LOC108258290,LOC108441004,LOC107718630,LOC107553678,LOC107661656,LOC107695678 other downstream 646705 13464085 ~ 13493942 (+)
socs3a socs3 other downstream 1801824 14619204 ~ 14621788 (+)
LOC117598752 NA other downstream 2170706 14988086 ~ 14991450 (+)
G211913 NA other downstream 3100837 15918217 ~ 15968759 (+)

Expression


Co-expression Network