cftr (cftr,LOC107738689,LOC107596947,LOC107583749)


Basic Information

Item Value
gene id cftr
gene name cftr,LOC107738689,LOC107596947,LOC107583749
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047600.1
NCBI id CM018546.1
chromosome length 31307711
location 14426532 ~ 14453076 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_034305411.1
GAGAGCTGGAGAGTGTGAACCTCTCACTAGCTCCTGGGACTCAAGCGCGCGCGCTCACTCGACGACGCTGCTCAGTGTGGTGACGGACGCGATCctcgcgcgcgcgcgctcgctTTCGCCTCATTCACGCAAGTGATTGCTCGGCGAAGAGCTCTCTAATAACACACTCAATCTGAAAGTGGACAGTTTGTGAAGGCATTCCTCATGCATAAGCGGCACGGCTTCCATGGTTAGCAGACGCGCTCCCGGGCTTGTTTTAGGATGCAGAGATCACCTGTGGATGATGCCGGCTTCCTTTCGAGATACTTTTTCTGGTGGACAAGCCGTATTATGCGAAAGGGTTTTAGGGAAAAGCTGAAGCCATCAGATGTGTATCAGGCTCCATCGCAGGATGCTGCGGACGTGCTTGCAGAACGTCTGGAAAAAGAATGGGACAGAGAAGTTGTATCTGCAAAGAAAAAACCCAGTCTCCTACGAGCACTTTCCCGATGCTTCATTCGACCCTTTATCTTATTTGGAGTCCTCCTCTATTTTGGGGAAGCCACAAAAACTGTGCAGCCACAGCTCCTGGGCCGAATCATCGCCTCATTCGACCCCTACCATGAGCCAGAGCGAGAACAGGGCTACTTCCTGGCCTTAGGCCTAGGCCTGCTGTTTATCACCCGCTTCCTCTTGCTGCAGCCCGCCGTGTTTGGGCTGCACCACCTGGGCATGCAGATCCGCATTGCCCTTTTCAGCTTAATTTATAAAAAGACACTAAAGCTATCCAGCAGAGTGTTGGACAAGATCAGTACAGGGCAGCTGGTCAGCCTGATGTCAGCCAACTTGGGCAAGTTTGATCAGAGCCTGGGCATGGCCCACTTTGTATGGATTTCACCTTTGCAGTGTATCCTGTGTGTGGGACTAATTTGGGAGCTCATTCAATTCAACAGCTTCTGTGCCCTTGCTGCAATCTCCCTGCTAGGAGTCATCCAGGCCTGTCTTTCTCATAAAATGGGACCTTACAAagcacAAAGGATACTGCTTACTAATAAGCGTCTTGCCCTGACCTCGGAGATTATGGAGAATCTGCACTCAGTGAAAGCCTATGGCTGGGAGGAGATCATGGAGACCATCATCAGGAATATCAGACAAGATGAGGTCAAGCTGACCAGGAAGATCGGCTCCCTGCGCTACTTCTACAGCTCTGCCTACTTCTTTTCTGCTATATGGGTGATCACGGCAGCAGTGGTGCCCCAAGCCCTCACAACGGGCATCACCTTGCGACGCATCTTTACCACTCTCTCATACTGCATGGTGCTGCGCATGACCGTCACACGCCAGCTACCTGCTTCCATCCAGATGTGGTACGACACCATCAGGCTTATATGGAAAATTGAGGATTTTCTTAGCAAAGAAGAATACAAACTGATGGAGTATGACCTCAGCATTACAGACATGGAACTTGAAAACATTACAGCTTCCTGGGATGAGGGAATTGGCGAGCTCTTTGAGAAGATTAAGCAAGAGAACAAAGCGAATGGCTATCCAAACGGAGATGGACTCTTCTTCACCAACCTCTACATAACACCTGTGCTTAGGAATATCAGCTTGCACTTGGAGAAGGGTGAAATGCTGGCAGTGGCTGGATCCACAGGATCCGGAAAGAGCTCTCTGTTAATGACCATCCTGGGCGAGCTGGTCCCTTCCTCAGGAAAAATCCGACACAGTGGCCGTGTCTCCTACTCCTCCCAGACTGCCTGGATCATGCCTGGTACCATCCGAGACAACATCCTGTTTGGGCTGACCTATGAAGAATACCGCTATAGCAGAGTGGTTAAAGCATGCCAACTAGAGGAGGACCTGGCTGCGCTTCCTGAGAAGGATAGGACGCCTTTGGCAGAGGGGGGACTGAACCTGAGTGGGGGACAGAAAGCACGGGTCGCCCTAGCTAGGGCTGTGTACAGAGATGCTGATACCTACCTGCTGGATGCACCTTTCACACATTTGGATATTgctacagagaaagagatattTGACAAGTGTCTGTGCAGGCTCATGGCCTCCAAGACCCGCGTTGTGGTCACCAACAAGATTGAACACCTAAAGCGGGCCGACAAGATCCTGCTGCTGCACAAcggtgagtgttttttttatggcaCGTTCTCAGAGCTGCAGTCACGACGGCCTGACTTCAGCTCTTTGTTGCTGGGTCTGGAGGCCTATGACAACGTTACTGCCGAACGCCGCTGCTCCATCCTCACTGAGACACTACGCAGAGTATCTGTGGATGAAACCTCAGGGATACGTCCCGATCGTCCGTCCTACCGGCAGGTGGCTCCTCCCACCTACAAAGACGAGAGGAAGGCGTCAGTGATCGTCAACCCACTGGCGGCCGACCGTAAGGCTTCCTTCATCCAAGTGATCGAAGAGGAGACCAAGCGGCCACTGCCTGACCGCAAGTTCTCCCTGGTGCCTGAGAATGAGCTGGTGGACGAGTCGTTCATGGGGAATGATATGTATCACAACCACGGCGTGCACATGGCAGGCCAGAGAAGGCAGTCTGTGCTGGCCTTTATGACCAACACACAGGGTCTAGGTAGACGTGACCAGCTCCAGACCTCCTTCCACAGACGCCTGTCCATTGTGCCCCAGAGTGAGCTGGCCTCCGAGCTGGACATCTATACCCGAAGACTGTCCAAAGACAGTATCTACATCACCGGAGAAATGGAGGACGAGAATATTGAGGCATGCTTTGCAGATGAACAAATAGAGGATACTTTTGAAACCACAAAATGGAACACGTATGTCAGATATGTGTCGACCAACAAAAGTCTCACATATGTTCTgatcttcatcctcatcatttATGCTATTGAGGTGGCTGGATCTGTTGTTGGGATTTTTCTGATAACTGATGAGATCTGGAAAGAGGAGCATCCTAGCCCAAATGCCACCAAGCAAACCAACTTATCACTATCTGGTACACAGTATGCTATCACTGCCCAACCCAACAGCAGCTATTACATCATTTACATCTATGTAGCAACGTCGGAGAGCATCTTAGCTCTGGGCTTTTTTCGGGGTCTACCTCTGGTCCACACCATGATCACCATATCCAAGAAACTGCATCAGAAAATGCTGAGCTCTGTGTTAAGGGCACCAATGTCTGTCCTCAACACCATGAAGACAGgTTGCATCATGAACAGATTCACTAAGGACATGGCTACTATAGATGACATGTTGCCTCTGCTGATGTTTGACCTTGTCCAGCTGAccctggtggtgctgggatgcATTCTGGTGGTGTCCATCATGCGGCCATACATATTCCTTGCAGCTACACCCTTGGCCTTAGTCTTTATTGTGATGAGGAAGTACTTCCTGCGCACAGGTCAACAGCTGAAACAAATGGAGACAGAAGCTCGAAGTCCCATCTTCTCCCATCTCATCATCTCACTAAAAGGACTGTGGACGATCCGGGCCTTTGACCGGCAGGCATACTTTGAAACTCTGTTCCATAAAgtcctcaacacacacacagccatctgGTTCCTCTACCTTTCCACCCTGCGCTGGTTCCTCTTCCGCGCTGACATCatctatttcttcttcttcacgcTCGCTGCCTGGATTGCAGTAGGAACCAACCAGGACAAACCGGGTGAGGTTGGTATCATTATAGCTCTGGCGATGCTCATTCTAGGCACCTTCCAGTGGTGTGTTGTCACCAGCATTGCAGTGGATGGAATGATGCGTTCTGTGGAGCGCGTCTTTAAGTTCATCGACCTGCCGTCTGAGGAGCCCAAACCTAGGCTGGGCAAGAGAAAAGCCTCGACCCTGGTCATTGAGAACCCGGAGGCCTGCACTGACACTTGCTGGCCCATCCATGGGCAGATGGACATACGCAACTTAACAGTCAAATACACTGAGGCGGGACATGCCGTGCTCAAGAACCTCTCTTTCAGCGTGGAGGGTGGACAGAAGgTGGGCATACTGGGCAGGACAGGTTCTGGGAAAAGCACACTATTCAATGCGCTCCTGCGTCTGGCCTACACAGATGGAGACATGTCTATTGATGGCGTCTCTTGCTATAACATGTCCCTGCAAAAATGGAGGAAGGCTTTTGGTGTGGTGCCTCAGAAAGTTTTCATCTTTACTGGGACATTTCGGATGAACCTGGACCCATGTGGACGCCACAGTGACAAGGAGCTGTGGAGGGTTGCTGAGGAGgtgggGCTTAAGTCAGTGATTGAGCAATTTCCAGATAAACTGGATTTCCAGCTGGAATACGGGGGTCATGTGCTCAGCTACGGCCACAAGCAGCTGATGTGTCTGGCTCGATCCATCCTCAGTAGGGCCCGAATCTTGCTGCTGGATGAACCCAGTGCCCACCTTGACCCCATAACTGTGAAGGTACTGAAGAAGACGCTCAGGCAGTCCTTCTCCTCCTGCACTATCTTACTGTGTGAACACAAAGTGGAACCGCTGCTTGAGTGCCAGTGCTTCCTGATGATGGAGCAGGGCAAGGTAAAGACTTATGAGTCAATCCAGCGCCTGCTGAACGAGACCAGCCAGCTGAAACAGGCCATGAGTCCAGCCGAGCGCCTCAAACTGTTCCCACGCCGCAACTCTAGCATGCGTGTGCCGCAGCCCAAACTGAGTTCCGTCACACTTACACTACAGGAGGAGACTGAGGACGACATCCAAGACACTCGTCTCTAAGCCCCAGGCAATCAGACACTAACAGAGACTCTGCCTTCATGAGCTCCTGCTAACTTAGGACTACTCATGTCCTATACAATATGATACGATTGTGGTACAATAAATGAACATCCTTTTTATACAtgcaataaatataatttaaggtACTTTATAGACTTTCATAACAGGAGACAGTGGGACCAGGAAATGATCATCCCACTGTAAAAAGTCAAAAAGACACTTTTATCATGTTCTTCTTCTTGGTGGCCTTCACAGATCATTTTTCAGAACAGTTGTAAATCTTCTCAACTTATTTATTGAATTGTCAGTCCACAAGCCTCAAACTTGTTCCTGTAAAAGTACTGCAAAATGTGCTTTTGTAAAATGCATGCacaacttttacttttattttttttatttaggaattTTATTTAACTACTAACAAATTAGGCCCGAAATGAAATGCAAAGTGTTAGTactatggattttttttttttttacactaccGGTCAGAGGTTTGAAAACAAAGCTAactttgtgaaaa

Function

symbol description
cftr Enables ATP binding activity; ATP hydrolysis activity; and chloride channel activity. Acts upstream of or within several processes, including Kupffer's vesicle development; germ cell migration; and regulation of neutrophil chemotaxis. Located in apical plasma membrane. Is integral component of membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; forerunner cell group; head; and pleuroperitoneal region. Used to study cystic fibrosis and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator).

NR:

description
cystic fibrosis transmembrane conductance regulator

GO:

id name namespace
GO:0042742 defense response to bacterium biological_process
GO:0090022 regulation of neutrophil chemotaxis biological_process
GO:0055085 transmembrane transport biological_process
GO:0070121 Kupffer's vesicle development biological_process
GO:0002679 respiratory burst involved in defense response biological_process
GO:0006811 ion transport biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0005254 chloride channel activity molecular_function
GO:0042626 ATPase-coupled transmembrane transporter activity molecular_function

KEGG:

id description
K05031 CFTR, ABCC7; cystic fibrosis transmembrane conductance regulator

RNA

RNA id representative length rna type GC content exon number start site end site
XM_034305411.1 True 5227 mRNA 0.50 27 14426532 14453076

Neighbor

gene id symbol gene type direction distance location
bida NA coding upstream 61727 14355893 ~ 14364805 (+)
wee2 wee2 coding upstream 71612 14349167 ~ 14354920 (+)
agk agk coding upstream 91209 14325076 ~ 14335323 (+)
rapsn rapsn coding upstream 111715 14304663 ~ 14314817 (+)
kbtbd4 kbtbd4,LOC107596956,LOC107738697,LOC107686314,LOC107708223,LOC107672308 coding upstream 125868 14295711 ~ 14300664 (+)
pgpep1l pgpep1l coding downstream 75800 14528876 ~ 14533258 (+)
fam169b fam169b coding downstream 187884 14640960 ~ 14648967 (+)
arpin arpin coding downstream 200839 14653915 ~ 14657137 (+)
kmt5b kmt5b,LOC108264420 coding downstream 223468 14676544 ~ 14686478 (+)
chka chka,LOC108424340,LOC107738676,LOC107726368 coding downstream 242701 14695777 ~ 14709427 (+)
G99276 ighmbp2 non-coding upstream 107878 14317597 ~ 14318654 (+)
G99261 NA non-coding upstream 164015 14261441 ~ 14262517 (+)
G99260 kif23 non-coding upstream 165790 14257912 ~ 14260742 (+)
G99006 NA non-coding upstream 436379 13989942 ~ 13990153 (+)
G98996 NA non-coding upstream 502219 13891424 ~ 13924313 (+)
G99362 NA non-coding downstream 177259 14630335 ~ 14631361 (+)
G99516 LOC108263939 non-coding downstream 272542 14725618 ~ 14725938 (+)
G99518 NA non-coding downstream 276908 14729984 ~ 14730183 (+)
G99704 NA non-coding downstream 573411 15026487 ~ 15027086 (+)
G99705 NA non-coding downstream 602191 15055267 ~ 15058771 (+)
skor1b skor1 other upstream 384080 14035228 ~ 14042452 (+)
smad3b smad3,LOC108264458,LOC108424035,LOC107740443,LOC107755098 other upstream 470181 13932539 ~ 13956351 (+)
G98972 NA other upstream 637142 13785095 ~ 13789390 (+)
G98946 megf11 other upstream 710766 13691607 ~ 13715766 (+)
nlrc5 nlrc5 other upstream 1567998 12837299 ~ 12858534 (+)
G99341 synm other downstream 67725 14520801 ~ 14524480 (+)
carmil2 carmil2,rltpr other downstream 847406 15300482 ~ 15346146 (+)
G100306 NA other downstream 1896381 16349457 ~ 16349787 (+)
G100345 NA other downstream 2147181 16600257 ~ 16601067 (+)
rgma NA other downstream 2204525 16657601 ~ 16680793 (+)

Expression


Co-expression Network