erbb2 (erbb2,LOC108273851)



Basic Information


Item Value
gene id erbb2
gene name erbb2,LOC108273851
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information


Item Value
chromosome id NC_047606.1
NCBI id CM018552.1
chromosome length 26563515
location 2924595 ~ 2952904 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence


>XM_026947856.2
tcgctcttgctCTTCACGCGCGCGCGCTCGCCGCTCGGCAGGAAGTTGTCGAGATTGGAAAGGGTGAAAGAGACAGGACAGAAAACAAAACGAAGCCGACGCGACTTGTTGTTTATGTTTCGGAAAAGTTAGGGAGTCACTGAAGGGTTGAGTAGAGCAGTCCGGGGACCACTGAAGGGATTTACTACCGCAAATAACGACTCGGAGGCGGAATATGGACTGAATGGTGGCCGAAAACCCGATGGAGGCGGCGAGAAGTTTTCGGTTCGTCCTGCTGCTCTGGCTTGTGGGAAAGACGGGAGTCGCGGCGAGAGAAGTATGTCTGGGTACGGATATGAAGCTGGCATTGCCCTCCAGTCTGGAGAACCATTATGAGATGCTACGACTCCTTTACACCGGCTGCCAGGTCGTCCACGGCAACCTGGAGATCACACACCTACAGGGGACGCCAGATCTTTCCTTCCTCAAGGGAATCGTGGAGGTTCAGGGCTATGTGCTGATAGCCCACGTCTCTGTGTCCGTGGTTCCTCTGGAGAATCTGCGCATCATCAGAGGCAGTCAGCTGTACAACTCGAGTTACGCCCTCGCTGTTCTGGGCAACACCGGAGTCTCACAGCTATCGCTCAGGAGTCTCACGGAGATTTTACTGGGTGATGTATACATCTGGGGAAACCCCCAGCTGTGTTTCCCCAACCCCAGGTCTATCACCTGGAAGGACATCATGGCTGACGAGGATCTAAACGGAAAACTGCAGCATCTACAGTCAGCAGCACCTTACTgtCCAGCTTGTCCTAAATCATGTGACTCCAGGGGCTGCTGGGGGCCCACTGTGTCTGACTGCCAAACATtgaCAAACGTGCGCTGTACTTCAGGCTGTAAGCGCTGCAAAGGTCCCGACGCGAGCGACTGTTGTCACGTGCAGTGTGCTGCAGGCTGCACCGGCCCCAAAGACTCCGACTGtctgGCTTGTCGGTACTTTAATGACAGTGGCACGTGCAAAGACAACTGCCCTGCTCCCTCCATCTACGACCCAGTGACGTATCAGTCCAAACCGAACCCCAACAAGAAGTTCAGCTTCGGCGCCACCTGTGTGAAAAAGTGTCCCAATAACTATTTGGCCATGGATGTGGCGTGCACAATGGTTTGCCCTAAAGCCAATCAGGAGGTCATCACCAACCAACCAGATGGCCAGGAGACACAGAAATGTGAAAAGTGTGAAGGAGAGTGTCCAAAAGTGTGTTACGGTCTCGGTATGGGGAACCTCCAGGGGATGACTGCCGTGGAATCCTCCAACATCGCTTCCTTCCAGGGCTGTAAGAAGATCTACGGCAGTCTAGCCTTCCTTACACACTCATTTCAAGGGGACCCGCGCAGTAATTTATCAGGCCTGCAGTCAAGTGACCTTGAAGTGTTCCGAACGTTAGAGGAGATCACAGGTTACCTGTACATCGAAGCGTGGCCAGAGAACCGGAGCGACCTGAGTGTGTTTGAAAACCTGAAGGTCATCAGAGGACGAATGCTTTACAAGGGTGTGTTTTCTCTGGGAGTGCAGTCCCTCCACATCGAGTCTCTTGGCCTGCGTTCTCTGCGCCGCGTTAGCGGCGGCCTCGTGCTCGTCCACAACAACTCCAAGCTGTGTTACACGTCGTCTCTGCCGTGGGCCGCTCTGTTCTACCCGAATCAGGAGCTCAACCTAATCAGCAACAACAACCGAGACCCCAAAACCTGTGtgGCTGAGGGTCATGTGTGTGACTCACTGTGTGCGAATGCAAGCTGCTGGGGTCCCGGGCCGAGTCAGTGTGTGTCGTGTAAGTCATTTCAGCGCGGTATGGAGTGTGTGGAGCAATGCAACATCCAGCATGGtgccTTCAGAGAGTTCATCGACGGATCCTCTTGCGTTTCCTGTCACTCTGAGTGTCGACTAATCAATGGCTCCGCCTCCTGCACCGGCCCTGGAGCAAAcaagtgtgtggagtgtgtgcacTTTCAGGACGGTGACACGTGTGTAGAGCGCTGCCCGAGCGGCGTGAAGGAGGAGCAACACACCATGTGGAAATACGCCAACGAGAGCGGACACTGCGTGCCCTGCGCCACCAACTGCACCGTCTCCTGTACAATGGATGACCGAGGATGTCCAGTTCACCAGAAAACTGGGCCCGGGACGACGATAGCAGCAATCGGTGGTGTGGTTCTCTTCGTCATCCTGCTGGCTCTGCTCATCTTCTATCTGTGCCGGCAAAAGAagctgaagaagaaggagaCTATAAGGAGACGCCTGCAGGAGCACGAGCTGGTGGAGCCGCTGACGCCGAGTGGAGTACAACCCAATCAGGCTCAGATGCGCATCCTGAAGGAAACGGAGCTGAAGAAGTTGCGAGTTCTCGGATCTGGAGCTTTTGGCACTGTCTACAAGGGTATCTGGACTCCTGATGAAGAAACCATGAAGATCCCGGTGGCTATTAAAGTGTTGCGTGAGAACACTTCCCCAAAAGCCAACAAGGAAATTCTGGATgagGCGTATGTGATGGCAGGTGTGGTCAGTCCATACGTGTGCCGCTTGTTGGGAATCTGTTTGACCTCCACGGTGCAACTGGTCACTCAGCTCATGCCGTATGGCTGCCTTCTCGATTACGTCCGAGAGAACAAGGACCGCATCGGATCTCAGTACCTTCTCAACTGGTGTGTGCAGATCGCTAAGGGAATGAGTTACCTGGAGGAGGTCCGACTGGTCCACAGAGATCTGGCAGCCCGAAACGTTCTGGTGAGGAACCCCAACCACGTGAAGATCACAGATTTTGGCCTGGCTCGCCTCCTGGACATAGACGAAACCGAGTACCATGCAGACGGcggaaagGTGCCCATCAAGTGGATGGCTTTGGAGTCAATTCTTCACAGGAAGTTCACTCACCAGAGCGACGTGTGGAGTTACGGAGTGACCGTGTGGGAGTTGATGACCTTTGGCATGAAGCCGTATGATCTCATCCCAGCACGGGATATTCCTGAGCTGCTGGAGCGAGGAGAGCGCCTTCCCCAGCCTCTCATCTGCACCATCGACGTCTACATGATCATGGTCAAATGCTGGATGATTGATCCCGAGTGTCGACCCAGATTCAAGGAGCTGGTGAATAACTTCAGCACCATGGCGCGAGATCCTCCACGCTATGTTGTCATTCCGaatgatGAGCAGATGAGTCTGTCGAGTCTGGTGGACAGTAAGTTTTACCGCACATTGCTGGAAGAAGAAGGAGGGAATGTGAAGGAACTGCTGGATGCAGAGGAGTATTTGGTGCCACAACCCGGATTCTTTGAGAACCAGGCTAACGGACTGACAAGGCATCACTCACACAGGagcacagatCTGGGACTGGAGACGGATGGCATACCAAGTGGGCGGAGCATGCACTCGTCGGTCAGCACTTTGGGGCGGAGTCTATACCCGACACTTCCTGCCGGTGCCACGGTCAATGGAACCTGGGGAGGCTCTCAGTACCGCTCGCTGGCCCGAAGCCAATCCCATTGCTCAGCTGGCGGCCAGTCAGACTCCGTGTTTCTGGACGGGGGCAGGGACGAGCCACCCTCCAGTCCAGGACGCTATAGTAAAGACCCCACTTTCCCCGGGTGCGTGGATGGAGACTTGGAAGTGGATGGGCCGATAAGTTACCCATCACACTCATTGCCACGCAAAACACGCACACAACCAGAGTATGTGAATCAGGACGTCCAGTCAGATCGGGCGAATACGCTGCCGCGTAAATCCACTGAGAGGCGTCTACACAACGGCCTAAGCGCTGGGCGCAGCGTGGAGAACCCTGAGTACCTAGTGCCCACGTCTCCCGCTTTTGACAATCCATATTACTTGGATCTTGTGGCTAAAGTGCCGGGTGGGGCTTCAGCAGTCGGAGCCACATCACCCCCCAGGCAGGTGAACGGATATGTGACACCTACAGCGGAAAACCCGGAGTACCTGGGATTGGCCGAAACCTGGAGCGGCCAGAGAGAGTGCACCTGAGAAGGGGCCGGGGGGgtcagtgaatgagtgaatcagtgaatgagtgagtcatgcactatgtactgtatgttctaGGGCTGTCAGATTGCTTTAAAAATtgcatcattttaattatttaaaatctttagTAGTTGAATATTAAGAAATGCATGATGTTATCGAGCCTTAGCCAGAGTAGCTACACTGTGTTTTCACACAATGTAAACCACAGGTGAAATCtgtgtcacatttttttaatcagaaggAGATGTCATAGCATTTAGAGATTCATAAGCTACATCATAGATTATTTAGAGCAATTTTCCTACAACAGtcaaaaaaaatgtatgcaaCCTGTTGATTAAACTAACACAGGGCATTGTAAGCATGTGACTTTTTACcgttgaaaaatgaaataatcattaaattaGAGTATCTTTGGCAAAGTGAAATTTGTTCTGACAGCCCTAATACATCCGAAACAGTGAATgtcatggatggatggatggagtgagtgagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtggacacttTCTGGTGATGATAGTCTGACCTACAGGAAACTCAAATTCCATCTAAGACATGgaatttccttttaaaatccAATGTAGCATCCGGTGTGTGGACAGCCTGGACAATTTTTGTGGCATCATGTAAACGTCAACTGAAAGACGCAATTCAGACAGTGAATTCAGTGAACTTTGAAAAGTGAATGTCCATGGATAAACCGAACATGGTACGAGCCAGCAGGCATGTAATTATTGGTAAACCATAAATGGTACGAGCCAACAGGGACGTTTTTTTTAAGACGACGCTAATGAAGCACGTGAGAATGTACGAACCAAATGACACTGGATCTGGAAATCACTACTTTGACTATTATTTggatattcattttgttttttttctcaccccATTTCCCTCTCCGTTCCCACCAcgctcttttgtttttggtctTCCAAACATGGCAGCTCAAATCCGGTGTCATTAGTGCTGCTGTTTCCAGGCTAAACTCTGACGTCTGGATCGAGCAGCTTTTATACTATATGTTAATGTGAGACTCTAAAAGCGATGGAGAAGGACAAGAGGTGGCAGGTCATCAGTGTACAACACTCTCCTTGCAGCAGTTTAGTCCTGTTTTTAATGCGCACGTCGACTTTCCCTCGCTGGAATCGCCATCATTATGAGGACTTAAGGCACTGTGGCACACAATCATCAACTAAGATATGATTTGTTCaggattttcacaaaatttaaCAACTTTTCAACTTTCAGTCAGAGTTGTTAATTTATCATCACGCCCGTTATGTAGCAAGCAACAAAACGCAACCCATGTGTTAGACTCCAGTTGTGTTGTTTGAGTGTGTTCTGGTGATCACACTCTCATTGCTGCTCTCAAGTGGCCACTTGTAATGTCATGATGTATGTGATACACACTTAAGGGAAAGTCGATGAAAGTGTGTTATAAACAGTTCTGAAACCCAGGATGTGGCATAGTTCCCACTGTGACAGTTTAATGGTACTATTTGTGTAGAACAAGACCAAGTTGGTccttaatgtgtgtttatatatttttatatatatatatatatatatatatatatatatatatatatatatatatatataaaaaatgtattagtggtattgtttttaaatcacttgCTTAATATCTCTTCAATCATGCCTTTATTTTCTTACATGACCAGAAGTGACATTCAAAATTACAACTAGTTGTTGTAAATACAAGAGAATTACATCTCATCATGTCTTTTCTCAATTCAGTATGTgccatttttttactttttttttttgttcaagtgGAAATGAaggtacaattttttttttttttttttttttttgtccaataaCAGAAATAGAGAAAACTTTGGTGTCCTTCTGAACTtctaaacaaattaaaactggGAAAAAGATTGACTTCTAGACTCAAGCAGATAAATAACTGGTTATAGAGTaaaacaaatacacagtgttagtcaaaagtttttgaacttgtttttttccccattttattacagtttatccGCTATTGgcaattaaatgttcttaaaagtGTTCCTAAATCCCTAAATCTTTGTAAGGACTACACGATTTTTCCAATGAAATAAagccacaaaataaataaataaataaaattaatttctatagggggttcaaaaacttttgactggctGCGTATGTcactattaaacacacacagtatttaattTAGATATGgccttcagttttatttctgctttCATTTCCTAAATTCTAAGCACCTGTGCAGTCTTTCACATCCCGATCCTCCACCTTATAACCTTATATcaatttattcagtttattgcATTGTTTTCCACATAGTTGCAACACAATCTGCTGTAAGATTTGAAAATGCGAAAAAGGTGAAAACCTTTTGGACAAATAAGGGTACAGATTAGGTTCTAACCTATCACAATACtggaaaaaacatttctgtgataAATTTagataaaaagtttaaaacaaataaggTTGGTGATAAGTTTATTTAATAGCTACAAaatcaaacatgaaaaaaaaaaaaaagattcaaaacAGTAGAAAATGTTCACATCGAATCAGCTTCTTCCAGAGTttgtatttcttaaaaaaaaaaaaaaa

Function


symbol description
erbb2 Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within animal organ development; fin regeneration; and nervous system development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including anterior segment eye; cranial ganglion; fin; heart; and primary neurons. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; prostate cancer; and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).

NR:

description
receptor tyrosine-protein kinase erbB-2

GO:

id name namespace
GO:0032285 non-myelinated axon ensheathment biological_process
GO:0060347 heart trabecula formation biological_process
GO:0001755 neural crest cell migration biological_process
GO:0060973 cell migration involved in heart development biological_process
GO:0001837 epithelial to mesenchymal transition biological_process
GO:0006468 protein phosphorylation biological_process
GO:0031101 fin regeneration biological_process
GO:0014044 Schwann cell development biological_process
GO:0048914 myelination of anterior lateral line nerve axons biological_process
GO:0048919 posterior lateral line neuromast development biological_process
GO:0048932 myelination of posterior lateral line nerve axons biological_process
GO:0007413 axonal fasciculation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity molecular_function

KEGG:

id description
K05083 ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2

RNA


RNA id representative length rna type GC content exon number start site end site
XM_026947856.2 True 6656 mRNA 0.47 27 2924595 2952904

Neighbor


gene id symbol gene type direction distance location
pth3r LOC108273556,LOC108443164,LOC103358568,LOC102199980 coding downstream 28247 2874516 ~ 2896348 (-)
rundc3ab rundc3ab,LOC108273494,LOC108443157,LOC107569197,LOC107694077 coding downstream 59606 2856236 ~ 2864989 (-)
LOC113547505 NA coding downstream 179200 2732216 ~ 2745395 (-)
slc4a1b LOC108273570,LOC108410807 coding downstream 286322 2618389 ~ 2638273 (-)
si:dkeyp-118b1.2 si:dkeyp-118b1.2,LOC108273584,LOC103026640,LOC108410802,LOC107684755,LOC107745658,LOC107694074,LOC105909120 coding downstream 308829 2606033 ~ 2615766 (-)
pgap3 pgap3,LOC103358570 coding upstream 4535 2957439 ~ 2967729 (-)
mylpfb mylpfb,LOC108274226,LOC107571443,LOC101482131,LOC107674915,LOC102196412,LOC108443170 coding upstream 18426 2971330 ~ 2975144 (-)
LOC113547471 LOC108274229 coding upstream 26402 2979306 ~ 2982750 (-)
LOC113547497 LOC108274228 coding upstream 32754 2985658 ~ 2989177 (-)
LOC113547499 LOC108274363 coding upstream 44062 2996966 ~ 2998281 (-)
G190048 LOC108273849,LOC108443156,LOC107684759 non-coding downstream 13340 2911012 ~ 2911255 (-)
G189882 NA non-coding downstream 96788 2796507 ~ 2827807 (-)
G189885 NA non-coding downstream 121631 2792827 ~ 2802964 (-)
G189855 NA non-coding downstream 223175 2694780 ~ 2701420 (-)
G189810 NA non-coding downstream 269088 2655303 ~ 2655507 (-)
G190076 NA non-coding upstream 124127 3077031 ~ 3077290 (-)
G190094 NA non-coding upstream 203007 3155911 ~ 3156150 (-)
G190097 NA non-coding upstream 217979 3170883 ~ 3171571 (-)
G190099 NA non-coding upstream 220156 3173060 ~ 3173967 (-)
G190100 NA non-coding upstream 221173 3174077 ~ 3175635 (-)
ndufa4 ndua4,ndufa4,LOC108443163,LOC103023526,LOC107745684,LOC107684782,LOC107569184 other downstream 69102 2852055 ~ 2855493 (-)
LOC117598559 NA other downstream 96843 2793046 ~ 2827752 (-)
LOC113547504 LOC108273577,LOC108273573 other downstream 113204 2786081 ~ 2811391 (-)
smarcd2 smarcd2,LOC107569192,LOC107694073,LOC107684754 other downstream 314822 2591237 ~ 2609773 (-)
LOC113547489 NA other downstream 713616 2194344 ~ 2210979 (-)
trnap-cgg_3 NA other upstream 1958830 4911734 ~ 4918977 (-)
G191056 taok2,LOC108273910 other upstream 1996259 4949163 ~ 4952859 (-)
LOC113527048 LOC108274181 other upstream 2106594 5059498 ~ 5063418 (-)
gdpd3b gdpd3 other upstream 2531787 5484691 ~ 5490925 (-)
G191430 NA other upstream 2658216 5611120 ~ 5613954 (-)

Expression



Co-expression Network