egfra (egfr,LOC107747514,LOC107691124)


Basic Information

Item Value
gene id egfra
gene name egfr,LOC107747514,LOC107691124
gene type misc
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047615.1
NCBI id CM018561.1
chromosome length 21248730
location 17570649 ~ 17636609 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026946216.2
GGAGTAGAGCCTCCTCTCTCGCTCTTTAGCGCAGAAGACGAAGGAGGAGCTGTCAAAAGTTTTAAGTCGGGACAGATTCCGTGAATTGGGACAAAACTTCATACACACGcgctcacacagacacacacacatacacacgcacacacacacgtccgcCAACGGAGGCGCGTTCCAGTTATGGAGTAACACGATTACAAATCGAGAGATACTTATAAAGCGTTAAAAGAGACGAAATGGAGACTTTGGTCAAGACCGGATTCCTCTTTTCTTTGCTGATTTCCTTGGGCTCGTGCGCGACGCCGGAAAAGAAAGTGTGTCAGGGGGGGAACAACAGACTGACACTGCTGAGCACTGTAGATGATCACTACCAGAACATGGTGAAGATGTACAGCAACTGCACCGTGATCCTGGAGAACCtggaaatcacacacacctcgcACAAGCATGATCTGTCCTTTCTCAAGacCATTGAAGAAGTTGGAGGCCACGTTCTCATAGCTCTGAACAAAGCGCCAGTAATCCCACTGGACAACCTGCGCATCATCCGAGGTCACTCGCTGTACGATAATGAATTTGCCTTGGCAGTCCTGTCAAATTATAACCAAACCACAGCCAAAGGAGTGAACCAGCTGTCCCTCAACAGCCTCACCGAAATACTCCGCGGTGGTGTGAAGTTCGCCAACAACCTTTACTTATGTAACGCAGAGACCATCCAATGGGCCGACATTGTGAACCTGAAGAGCAATCCTAAAATAATCGAACATCGGAATGTTACCAAAGAGCTCTGTAAGAAGTGTGACCAAAGCTGTTACAATGGCTCGTGTTGGGCTCCTGGCCCTCAAAACTGCCAGACTTtcaCAAAGCTGGTGTGTGCTGAGCAGTGCTCCGGGAGATGTAAAGGCCCCAAACCCAGCGACTGCTGCAACGAGCACTGTGCGTCTGGCTGCACCGGCCCGAAACCTACAGACTGCCTGGCCTGCAGGGACTTCCAAGATGACGATACATGCAAAGATGCATGCCCTCCTCTCATGCGCTacaaccccaacacacaccagcTGGCCCCCAACCTGGACGGGAAGTACAACTTCGGGGCCACGTGTGTGAAGAAGTGTCCGCatAACTATGTGGTCACAGACCATGGCGCATGTGTGCGAGCGTGCAGTTCTGGAACTTACGAAGTGGACGAGGACGGGCTCAGGAAGTGCAAGAAGTGTGACGGTCTGTGTCCAAAAGTGTGCTCTGGACTAGGAGTGGGTCATCTAACTCACGTCATGTCAGTCAACGCTACCAACATCGATTCCTTCGAGAACTGCACGACTATCAATGGAGACATCTCCATCCTGAGGACAACGTTCCTGGGGGATAAATTTACTGGCACTAAACCACTGGATCCTGCCAGACtcaacattttcaaaacagtCAAAGAAATTACTGGCACTCTACTGATTCAGTACTGGGCACAGGACATGCCTTCTCTCAGTCCCTTCGAAAACCTGGAGGTGATCCGCGGAAGAACTAAACACCaAGGTACAGTGAGTCTGGGTGTCAGCGGGACTCCCATCACGCACCTGGGTCTGCGCGCTCTGCGGGAAATCAGCGACGGCGATGTAGCCGTCACGCACAACGCCAAACTGTGCTACAACAGTCCAGATCACTGGAAACGCCTGTTTAAATCCAACACGCAGAGTGTCCGACCCATGCAGAACGCAGACGCCGCTACCTGTGCGGCGCAGAACCGTACCTGTGATGAGATGTGTACGTCTGACGGATGCTGGGGTCCGGGGCCCACCATGTGCTTCAGCTGCGTGAGCTACAGCCGCAAGAAAAGCTGCGTGGCCTCCTGTAACCTCCTGGAGGGTGAGCCACGTGAGTGTGAGGTCAATAAGACGTGTCTGGAGTGTGACCCCGAGTGCAAGCCTCTTAACGGAACTCATACCTGCACCGGGCCTGGTCCTGACATGTGTAAGGAGTGTATTAACTACAAAGACGGCCCACACTGCGTGTCGCGCTGCCCGCAGGGGGTACCCGGGGAGAAGGACACGCTCGTGTGGAAATACCCAGACAGCAAGCGGGTGTGCCAGCTCTGCCACCCCAACTGCACCCAGGGATGCACTGGACCAAAACTTCAAGACTGCAAAGGCACAAGTGACACGAGCACGTCAATCATCGCCGCCAGCGTGGTCGGAGGGCTCCTGGCTTTCGTCATTCTCTGCCTGGCCGTGGCCGTTTTAATCAGGAGACGGAAGATCAAGCGGAAGAGAACGTTGCGCAGATTACTGCAGGAAAGAGAGttAGTGCAGCCGCTCACTCCCAGCGGAGAAGCTCCGAACCAGGCGCTGCTGCGCGTCCTCAAAGAGACCGAGTTCAAGAAGATCAAAGTGCTCGGCTCCGGAGCTTTCGGCACCGTGTATAAGGGTTTATGGGTCCCCGAAGGAGAAGACGTGAAGATTCCCGTCGCCATTAAGGTTTTACGAGAGGCCACATTGCAGAAAGCTAACAAGGAGATCCTGGATGAGGCCTACGTGATGGCGAGCGTGGAACACCCGCACGTGTGCCGTCTGCTGGGCATCTGCCTGACCTCCAACGTGCAGCTGGTGACCCAGCTCATGCCCTATGGCTGCCTGCTCGACTACGTCAAGGCGAACAAGGACAACATCGGCTCGCAGCACCTGCTCAACTGGTGTGTGCAGATCGCTAAGGGTATGAACTACTTGGAAGAGCGCCACCTGGTGCACAGGGATTTGGCCGCGCGCAATGTGCTGGTGAAAACCCCTCAGCATGTGAAGATCACTGACTTCGGCTTGGCCAAACTCCTCAGCGCTGATGAGAAAGCGTACCACGCAGATGGAGGGAAGGTGCCGATAAAATGGATGGCCCTTGAATCCATCCTTCACCGGACCTACACGCATCAAAGTGACGTATGGAGTTATGGTGTGACCGTTTGGGAGCTGATGACATTCGGGACGAGGCCTTATGATGGAATTCCTGCCAGTGAAATCGCCGGGGTCctggagaaaggagagagactCCCTCAGCCGCCCATCTGCACCATCGACGTCTACATGATCATGGTCAAATGCTGGATGATTGACGCAGACAGCAGACCAAGATTCAGGGAGCTCATTGCAGAGTTTTCCAAGATGGCACGAGATCCAACACGTTACCTGGTCATTCAgGGCGATGAGCGGATGCACCTGCCCAGTCCCACAGACTCCAGATTCTACCGCAGTCTGATGAGCGGAGTGGATCTGGACGAGGCCGTGGATGCCGATGAGTATTTATTGCCCAACCATGGCTTCTTCAGCAGCCCCAGCACGTCTCGTACACACCTACTGCACTCTGTGAGCCTGAACAGCAGCATCGGGTCGTGCCAGAACAGGAACGGGGCTCTCGTGCCGGTGCGTGAGAACAGCCTCATGCTGCGCTACATCCCCGACCCCACTGAGCGCATCCTGGATGGAGATTTCCAGCCTGCTCCAGAATACATGAACCAGAATGGCAGCACCGTTTTCTCGGACATGTCCAACCCCATCTATCAGCACCCTGCGCGTGCGGCCCTGGACGAGACCGAGGAGGACTACCTGAACTGCTTCAGAAACCCAGCGACCATCACTTCTCCTAACTCCGCCCCCGAGTACCTAAACACCTCCCACTCTCAGCTCTTTTCCCCCCTCACTTCCAGCCAGAAGCAGCCGAACGGGCACGGCTACATCGCGCAGAACAGCATCGACAACCCCGACTACCAGCAGGACTTCTTTCCGGTGGGGACCAAGCCGAACGGGCACCTCCCAGCCGCAGAGAACTCTGAGTACATGGGTGTGGAGGTGCACTAGCATGCTTCAGAAGGGTGTGGACTCTGTAAAAGCGATGTGACTGGACTTATGCAGGCAGGCTGTACTGCAGTGCTTTGGTGGAGGCTCTGAACTGCCATGAACTTGTTGGTTCATTTGAgagtttttaagtttttatgtttctttggAGCTGGACGGTGTGTAAGCCACAAACCTGTATGCCACAACAGACTGCAAATCAATCTCCGAATTTTAATCCGATTCACAGTCTAACTATGTACAGGATTTGAGCACATCCTGTATCATTAGATTTCAAGATCGAACTTGAAGCTTGCAGAAATTTGGCAATTTTAGGGCAGGTTTTCTcacttacacttttttttctgcacctGTGACTGGTTGAGTGTGAAAGCACTTCGAAAATGCAATCCAGGGAACACGTCTCTGGTCTGAAGGTGTGTATTGGACTGGGATCTCGTGCAGGCAGTCAGAAATTAAGATCACAAGCCATGCATAAATAATACACAGCTATTGTTACTATTACTTAATGACCAATTTCtccattttagcattttttttctatacaacTTCATAATTTGGCCCcatgccaattcccacccaccagctatTATACGACAGTTACCAAGCAAGAGGGTGAGGGCTAACACGTGCTCTTCCGCagacatgagctcacagacacgcacgattggctagtgtcgctgtgattgacagagaagagcgagtatgcccctcccacacaGAGAGCACGGCCAGGTTTACTCCCTTGGCTCCCGGACACAGATGGCCGTGGCATCGTCTGGTTTTGAACTCGCGATCTTACAACGATAGGGCGAAATCTTTTAGCCTccatttgagcttttttttctgtcagaagaaacagaagagtAAAGAGTTAAAGATGAGCTTAGCACAAAGCAAAATTTACTACTGGAAGTGAACATCCTTTTCACATCCCTGCATTCTTTCCTGTTcaagtgaatatttttttatcacttAAATTTTATCCACATCAGTCCTGAAACCTCATCATATTCTTTCCTGTTTCAGGGAAAGACATGTTGTGGCTCTGCAGAGAAGACAATGACCTTATAGTATATATGGAGCTAAAAACatcaaacatgaaaaatatttttgtatggaATTGAGCAGGTTTGAATAAAAGgctaaattaataatacatCAATTAATAATGTGCATATTGTTTcccatttcacacacaaaaaaaaacttcactcaCAGCATAACTAAAGTATCAACCTGGTCAGAAAAAACGTCTTCTGTATGAGAACCATGTCATGATTGCACCTTCCTTCAAACAGTCCCAGAATCAGATTTTTCTGCCTCGAATGTGAAAACGATTTTAAAAGAAACCCATCAAGAGAAGCTCACGAGCATCACGCGTTGTACAAACCAGATTGTGCTCTGTAGCACGTAGCTTTCAGTCTCTCATCAGCAGAA
>XR_003404718.2
AGGAGTAGAGCCTCCTCTCTCGCTCTTTAGCGCAGAAGACGAAGGAGGAGCTGTCAAAAGTTTTAAGTCGGGACAGATTCCGTGAATTGGGACAAAACTTCATACACACGcgctcacacagacacacacacatacacacgcacacacacacgtccgcCAACGGAGGCGCGTTCCAGTTATGGAGTAACACGATTACAAATCGAGAGATACTTATAAAGCGTTAAAAGAGACGAAATGGAGACTTTGGTCAAGACCGGATTCCTCTTTTCTTTGCTGATTTCCTTGGGCTCGTGCGCGACGCCGGAAAAGAAAGTGTGTCAGGGGGGGAACAACAGACTGACACTGCTGAGCACTGTAGATGATCACTACCAGAACATGGTGAAGATGTACAGCAACTGCACCGTGATCCTGGAGAACCtggaaatcacacacacctcgcACAAGCATGATCTGTCCTTTCTCAAGacCATTGAAGAAGTTGGAGGCCACGTTCTCATAGCTCTGAACAAAGCGCCAGTAATCCCACTGGACAACCTGCGCATCATCCGAGGTCACTCGCTGTACGATAATGAATTTGCCTTGGCAGTCCTGTCAAATTATAACCAAACCACAGCCAAAGGAGTGAACCAGCTGTCCCTCAACAGCCTCACCGAAATACTCCGCGGTGGTGTGAAGTTCGCCAACAACCTTTACTTATGTAACGCAGAGACCATCCAATGGGCCGACATTGTGAACCTGAAGAGCAATCCTAAAATAATCGAACATCGGAATGTTACCAAAGAGCTCTGTAAGAAGTGTGACCAAAGCTGTTACAATGGCTCGTGTTGGGCTCCTGGCCCTCAAAACTGCCAGACTTtcaCAAAGCTGGTGTGTGCTGAGCAGTGCTCCGGGAGATGTAAAGGCCCCAAACCCAGCGACTGCTGCAACGAGCACTGTGCGTCTGGCTGCACCGGCCCGAAACCTACAGACTGCCTGGCCTGCAGGGACTTCCAAGATGACGATACATGCAAAGATGCATGCCCTCCTCTCATGCGCTacaaccccaacacacaccagcTGGCCCCCAACCTGGACGGGAAGTACAACTTCGGGGCCACGTGTGTGAAGAAGTGTCCGCatAACTATGTGGTCACAGACCATGGCGCATGTGTGCGAGCGTGCAGTTCTGGAACTTACGAAGTGGACGAGGACGGGCTCAGGAAGTGCAAGAAGTGTGACGGTCTGTGTCCAAAAGTGTGCTCTGGACTAGGAGTGGGTCATCTAACTCACGTCATGTCAGTCAACGCTACCAACATCGATTCCTTCGAGAACTGCACGACTATCAATGGAGACATCTCCATCCTGAGGACAACGTTCCTGGGGGATAAATTTACTGGCACTAAACCACTGGATCCTGCCAGACtcaacattttcaaaacagtCAAAGAAATTACTGGCACTCTACTGATTCAGTACTGGGCACAGGACATGCCTTCTCTCAGTCCCTTCGAAAACCTGGAGGTGATCCGCGGAAGAACTAAACACCaAGGTACAGTGAGTCTGGGTGTCAGCGGGACTCCCATCACGCACCTGGGTCTGCGCGCTCTGCGGGAAATCAGCGACGGCGATGTAGCCGTCACGCACAACGCCAAACTGTGCTACAACAGTCCAGATCACTGGAAACGCCTGTTTAAATCCAACACGCAGAGTGTCCGACCCATGCAGAACGCAGACGCCGCTACCTGTGCGGCGCAGAACCGTACCTGTGATGAGATGTGTACGTCTGACGGATGCTGGGGTCCGGGGCCCACCATGTGCTTCAGCTGCGTGAGCTACAGCCGCAAGAAAAGCTGCGTGGCCTCCTGTAACCTCCTGGAGGGTGAGCCACGTGAGTGTGAGGTCAATAAGACGTGTCTGGAGTGTGACCCCGAGTGCAAGCCTCTTAACGGAACTCATACCTGCACCGGGCCTGGTCCTGACATGTGTAAGGAGTGTATTAACTACAAAGACGGCCCACACTGCGTGTCGCGCTGCCCGCAGGGGGTACCCGGGGAGAAGGACACGCTCGTGTGGAAATACCCAGACAGCAAGCGGGTGTGCCAGCTCTGCCACCCCAACTGCACCCAGGGATGCACTGGACCAAAACTTCAAGACTGCAAAGGCACAAGTGACACGAGCACGTCAATCATCGCCGCCAGCGTGGTCGGAGGGCTCCTGGCTTTCGTCATTCTCTGCCTGGCCGTGGCCGTTTTAATCAGGAGACGGAAGATCAAGCGGAAGAGAACGTTGCGCAGATTACTGCAGGAAAGAGAGttAGTGCAGCCGCTCACTCCCAGCGGAGAAGCTCCGAACCAGGCGCTGCTGCGCGTCCTCAAAGAGACCGAGTTCAAGAAGATCAAAGTGCTCGGCTCCGGAGCTTTCGGCACCGTGTATAAGGGTTTATGGGTCCCCGAAGGAGAAGACGTGAAGATTCCCGTCGCCATTAAGGTTTTACGAGAGGCCACATTGCAGAAAGCTAACAAGGAGATCCTGGATGAGGCCTACGTGATGGCGAGCGTGGAACACCCGCACGTGTGCCGTCTGCTGGGCATCTGCCTGACCTCCAACGTGCAGCTGGTGACCCAGCTCATGCCCTATGGCTGCCTGCTCGACTACGTCAAGGCGAACAAGGACAACATCGGCTCGCAGCACCTGCTCAACTGGTGTGTGCAGATCGCTAAGGGTATGAACTACTTGGAAGAGCGCCACCTGGTGCACAGGGATTTGGCCGCGCGCAATGTGCTGGTGAAAACCCCTCAGCATGTGAAGATCACTGACTTCGGCTTGGCCAAACTCCTCAGCGCTGATGAGAAAGCGTACCACGCAGATGGAGGGAAGGTGCCGATAAAATGGATGGCCCTTGAATCCATCCTTCACCGGACCTACACGCATCAAAGTGACGTATGGAGTTATGGTGTGACCGTTTGGGAGCTGATGACATTCGGGACGAGGCCTTATGATGGAATTCCTGCCAGTGAAATCGCCGGGGTCctggagaaaggagagagactCCCTCAGCCGCCCATCTGCACCATCGACGTCTACATGATCATGGTCAAATGCTGGATGATTGACGCAGACAGCAGACCAAGATTCAGGGAGCTCATTGCAGAGTTTTCCAAGATGGCACGAGATCCAACACGTTACCTGGTCATTCAgGCGATGAGCGGATGCACCTGCCCAGTCCCACAGACTCCAGATTCTACCGCAGTCTGATGAGCGGAGTGGATCTGGACGAGGCCGTGGATGCCGATGAGTATTTATTGCCCAACCATGGCTTCTTCAGCAGCCCCAGCACGTCTCGTACACACCTACTGCACTCTGTGAGCCTGAACAGCAGCATCGGGTCGTGCCAGAACAGGAACGGG

Function

symbol description
egfr Enables several functions, including actin filament binding activity; enzyme binding activity; and epidermal growth factor-activated receptor activity. Contributes to nitric-oxide synthase regulator activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of intracellular signal transduction; and regulation of protein metabolic process. Acts upstream of or within epidermal growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; endosome; and membrane raft. Part of receptor complex. Is active in ruffle membrane. Colocalizes with endosome. Implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Biomarker of several diseases, including Human papillomavirus infectious disease; breast cancer (multiple); carcinoma (multiple); chronic obstructive pulmonary disease; and pulmonary hypertension.

NR:

description
PREDICTED: epidermal growth factor receptor-like isoform X2

GO:

id name namespace
GO:0006468 protein phosphorylation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity molecular_function

KEGG:

id description
K04361 EGFR, ERBB1; epidermal growth factor receptor

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026946216.2 True 5270 mRNA 0.51 28 17570650 17636609
XR_003404718.2 False 3386 misc_RNA 0.54 26 17570649 17631608

Neighbor

gene id symbol gene type direction distance location
c1ql3b c1ql3b,LOC108280659,LOC107747511,LOC107566459,LOC107599856,LOC107691085,LOC107691073,LOC107681760,LOC107708591 coding upstream 53282 17514697 ~ 17517367 (+)
gpt2l LOC108280657,LOC108430180,LOC107599855,LOC107708598 coding upstream 63262 17487387 ~ 17507387 (+)
hecw1b hecw1b,LOC108280656,LOC108433086,LOC107600217,LOC107662981 coding upstream 92828 17433918 ~ 17477821 (+)
ccr12a LOC108280814 coding upstream 140924 17427910 ~ 17429725 (+)
si:ch211-106n13.3 LOC108280813,LOC108433067 coding upstream 143385 17400391 ~ 17427264 (+)
yme1l1b yme1l1,yme1l1b,LOC108430171,LOC107708459,LOC107566723,LOC107747521 coding downstream 205840 17842449 ~ 17853870 (+)
rab18b rab18,rab18b,LOC108430170,LOC107566717,LOC107708473,LOC107681801,LOC107691240,LOC107550439 coding downstream 223702 17860311 ~ 17872029 (+)
wacb LOC108280665 coding downstream 329284 17965893 ~ 17979122 (+)
bambib LOC108280666,LOC108430169 coding downstream 354116 17990725 ~ 17994678 (+)
gnb4a gnb4,LOC108280743,LOC108440866,LOC103030165,LOC107705311,LOC107653516,LOC107564248,LOC105899196,LOC107724752 coding downstream 798740 18435349 ~ 18449078 (+)
LOC117599934 NA non-coding upstream 33489 17525571 ~ 17537160 (+)
G321704 LOC108410862 non-coding upstream 609915 16958745 ~ 16960734 (+)
G321602 NA non-coding upstream 677625 16892813 ~ 16893024 (+)
G321591 NA non-coding upstream 711071 16792714 ~ 16859578 (+)
G321585 NA non-coding upstream 781042 16789186 ~ 16789607 (+)
G322146 NA non-coding downstream 85329 17721938 ~ 17786701 (+)
G322233 LOC108280496 non-coding downstream 217939 17854548 ~ 17855258 (+)
G322324 NA non-coding downstream 437720 18074329 ~ 18074748 (+)
G322365 NA non-coding downstream 562231 18198840 ~ 18199709 (+)
G322398 NA non-coding downstream 592786 18229395 ~ 18231463 (+)
fuz fuz other upstream 86972 17478834 ~ 17483677 (+)
LOC117599970 LOC108280611,LOC108261562,LOC108261692,LOC108261605 other upstream 710967 16838768 ~ 16859682 (+)
LOC117595733 LOC108280611,LOC108261562,LOC108280614,LOC108280616,LOC108261605,LOC108261692 other upstream 776951 16791402 ~ 16793698 (+)
LOC117599973 LOC108280611,LOC108261605,LOC108261562,LOC108261692,LOC108280616 other upstream 781681 16756631 ~ 16788968 (+)
LOC117599972 LOC108280611,LOC108280616,LOC108261562,LOC108261605,LOC108280614,LOC108280615,LOC108261692 other upstream 822309 16742805 ~ 16748340 (+)
si:ch211-162e15.3 LOC108280563 other downstream 589312 18225921 ~ 18227233 (+)
pex5lb pex5lb,LOC108280742,LOC108440867,LOC107653517,LOC107564246,LOC107660316 other downstream 757414 18394023 ~ 18430022 (+)
slc44a5a slc44a5,slc44a5a,LOC108280730 other downstream 1179400 18816009 ~ 18871360 (+)
ssbp3a ssbp3,ssbp3a other downstream 1308089 18944698 ~ 18985082 (+)
gng12a gbg12,gng12a,gng12,LOC107705318,LOC107700509,LOC105895117 other downstream 1568049 19204658 ~ 19220229 (+)

Expression


Co-expression Network