bcl2a (bcl2)


Basic Information

Item Value
gene id bcl2a
gene name bcl2
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047616.1
NCBI id CM018562.1
chromosome length 21037487
location 12181785 ~ 12234183 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026938147.2
aaaaaaaacgcgcTTCTCATCAGCTGCAGCTTTGCGCCACACAACTTCAGGATCTCTGGTTCGCTTTCGTGTCATATCAGCCTAAATGCTCCAGGCAGTTGGCGCCAGTCCCCGTCGGGATCGCAAGAAAATCGACGCGCGAGACAGATGTGACCGGCGTGGAAATGGATCTCGTGTTGGTTTTGAGGTTTTGCTCCGCGACAGACTGTTTTCAGGTTGTTTCTGAGATGCGTTCCGAGTGACCCCCGAAATTACGCATTGCGCGTCAGCTCAATTCACGGTGTCTAAAAAAATGGCAAACCAAAGTCCCTATGACAATCGGGATATCGTAGAGAAGTATCTGTATCACAAACTTTTGAAGCGAGGCTACGTGTGGGAGTTCCGCGCCGGAGCAGAGGAAGACGACGGATCGAGGGAGCCGCCGGCGGAAGTTGTGGATCGCAGGCCGCGCGCCGTCTTGCCGCTGCACCGCGTTCTGCGCGAGGCCGGCGATGAGATCGAGCGGACGTACCAGCGCGACTTCGCGGCCATGTCGGACCAGCTGCACTTCACCCCGAGCACTGCGCAGCGCCGCTTCACCGCCGTCATCGAGGAGCTGTTCCGGGACGGCGTCAACTGGGGACGCATCGTGGTCTTCTTCGAGTTCGGGAGCACCCTTTGCGTGGAGAGCGTGAACCAGGAGATGGCGTCCCAGGTGGACAACATAGCAAGTTGGATGACGGATTACCTGAACGGGCCATTGCAGAACTGGATTCGGGACAATGGAGGCTGGGATGCCTTTGTGGAGCTCTACAGTCATCAGAGAGCATCCTTGTTCCACCCCTGGCCCTATTTAAAGACAGTCTTTGGCCTGGCAGCACTGGGAGCAGCAGGAGTCACTATTGGCGCGCTTTTTTCTCAGAAGTGATCATCTGGATCATCAACACCTGtccttctttttctgtctgtcctctGGCTTATGAAGGCACTTGGTTTAACAGCGTAGCACTGCCCTGGTGTTCCGTCCATGTTATGGAGCTGTCCTTGAAACTGGAGTGGGAGAAATGCaatgataaaaaaacaaaacaaaacaaaaaaaaaacgagaagCTCCTACACATGTACTATAACTATCACTGCCATGTATAGATCTagatacaaatatatatttacacatatacacacacacagcaaacacagaaTGTACAACTCCCAAATTCATGgaccacatcagcacacacaaaTGACATTTAGTTCTTTTACTGtaaactttatttacatttgaacTTCTATGAACCTGCAATGCCAGAGGTCCCCATATGATCTTTATTATGGTTTTATTACTTTGTGTGTAGCATGGAATGATATGTGTATAACGTAggagttggaaaaaaaaaaaaaaaaaaaaaaagaaatgaaccaAGAGACTGCTATGAATGCTCCACTGTCTGCATGCATAGTGGCAAGCTACTTTTTTGCATGATGGCCTTTTCAGCATGGAAAAGCACCACCTGTGTAGGACATTGTTGggtgttattttttcttttttatctgtctttctccttctcaAATGTTTCTCAGCGTTCCTCCCAAAAGTAGCAAGTGCTGCTCGTTCCTCATTAGGCATGCTCGTCTGTTTGAATGGCGGGCGAATCTCTGGATTTGTCCTTGCTGGATAACCGCTAAGCACTCGCTTCACTTGCTTTCAACAGCTTAAAAGTTGTGTTCTGAGGTATACCACACCTGAATGTATaatatgtgtctctgtgtatggTGTGACTCTAGAGACATTTAACCTTTCTCATCTCGTCTGGTGTcactttgcttttatttcatgtcccttttattaaaaaaaaggaaagaaaaaatttGAGGGCTAAAAGCCATCAAATAAGATTATTTAAGGGGTAGAACCTGAAAAGCAGGATGCAGGTAGAGAgatgtaagagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgattgtaagTAGAATGTGTTGAGAGAGAGCTTAGCCAGAAAAGGTGGGTATCTCTTAGCCCATTACAGCAACCAGAGATAAAGCAGGGCAGCTGGGGTCAGCCAGGTGTGGTAGGGAGGGGGTTGGGGGTACGGGGAGGGGGCAGGTAGCAACAGAGGCTTCATTCAGCATGGCACAGTGAGCATCCAGGGAGCAGAAGCTCCAGAAAGACATAGTAgaaagtgaataataataataatgatgataataataatacttattattattattattattattattattattgttattattattattattgatttattttattttattttcttatttttatacattattttcacatcattaaaAAGTCAAACATTATGTGACCCCCCTGGACAATTGAGGCAGCGCAGTGGGGGTCTAATGACCCAATGGAGACAGACCTAGAATTCGAACCAACCTTCTGGACCATTCAACAAGTACGGAACCATGACTGCTGAGTTACCATTGCTCAGTGTGCTCTTGTGTCGAAGGAATTAGCTTGAAACTAGACAACTGAACCTGTgtgcttctgctgctgctttcaTCCTGAGCAGAACCCAAGCGGTATCAGATATCCCAGTGCTCTCTATGCGGAGGATTTAAAGACATTGAGACATCTGTCTGACACGTTCAGCTAGGGACCTATAGTTTCCCCTGGCAGGTAGAATCTTTGACAATCATGGCGTAgtaaaatattatgtttactTGTTAATGTTTTACTGTCATTTAATCTCATCTAAGTGATGTAACCAGTCATTTTAATATGTAAAGGCCTAAGTGATGGAGCTTTGTCTCCAGAATGCAAGTTATCTAGTAGTCCATCAAATTTAATGGCAGAactcatgtttcatgttctaaaggtacaaaaacctGGACGTAATGCAATGTTAAGCTTCTGCTTTGAATGCAGAagtatgtttattatgtatCTTATGAGTATCTTACGGGAGAGAGTTGAAGACTCGCACTGTAACATCATGTATTTTAATGGCTGCTAATGAGATGTGTAGCTCTCAGCAATGTAACATCCTCGTCATTGAGACATCATATGATGCTGCTTTATGATACAGCAAAAACTGCCACTGGTGGGGAGCTGTACTGAAATCTCCCCACTCTGTAAGCTTCATTCATCAGGAAGGGTCTAAAGACTCAGACGGCCTTAGTGTGATTGTATAAACACTCCGGATCAAGAGAAATTGTTGTTTGCCGAGTTTGACAAATGAGGTCAGGGCCAGAGTTTCCCAAAAGAAACATTCTGTAGAACAGTTAAAGTAGTGTGAAAGATGCATTGAGTAGTTTATTAAAACCAGCTTTTTCAACTGaaatcattattcattttaagatgaataattaatttgtaagaCGTTTTTGGGAAATTTTTGGCTCAGATGGTGATTCCCCAACTCTATCTTATGTAAAAATTTACAGAAATGCTAGCAATCTCAGATGTAACCTTTACCCAAGTTGGCTTGTGGTAACTGTTACAAATTGGCATTTAGGTAAGGTGTTGGGTACACTTGATATTTCCATGATTAACGCTTTCTAAAACAGAATCCGAGATAGGATTGTGTCTCCTCTGTCTCCAGGAGCAATTATAATGCAACAAattgaggtttaaaaaaaaaaaaaattgatcatCCTGCTGCAAGCCTTGAGGAGACACTGAGAAACGGAGAGTAGAAAAGTAAAATACCTGCAGAGGATTCCAGTGCAATCTTGGAGCCGctaaacatgtgaaacttcCATGCTTTGGagtatgttaatgttaattggTGCGATTTATTATGAGATCGTTCTCATAGTTGAGGGGAGGGCTTTTGAAAGAGCTACCTGGAATCGGTCCTGGGTTAGTacctttttgttatttaatatatgtatattttattatatatcatCGGTTCTCATATTACAAAGAAATTTCAAAGCCAAAATAGGAAGTTTTCCGGCTTCTTAATTGGGACAATGGCACAACAAAGCTTCATTACGATGAATTTGAATGTCAtatctatactgtatatgtgtctcCTTCTACCACTATGCATTGTTAATGTTTATGTCCATTGATAAAGCATGAAAGCATCTCTCTGGGTTCTTCATCAGTTTAATTATCAAGGAGGGAGTGTTTAACTGAGTAAAGGTGGGAGGCTTTTCCTCTGTGTGAATTGATCTGTTGTAATTTCTGTGTTTATGACAGCGCCAGTTGGTATTTAACCCTGTTATTTACATTATGTATGAGtgtgattgtgattttttttttattattattattttggctgCAGCATTTTGGAGTTACTTTCAGCTATGTGatttttatatgcatttctgCAATGTCTTGTTTTCTGAAAAATATGCCCCAATCAGctctacattatatataattgtgaaaaaaaggttaatgcactttttttgtctgtttaggCAGCTAATATCATAGAACCATTTCCAAAACATGCCACAATGAAAGAGCCAAGCCAGACacaacattcatttttttctgttttgtaattttattgcttttcttATTTTGTACCTTTCATTTCACAGGGTAGCACTAAATTTAATTATGGAACCTTTAAACCTGAACAAAATATCCACggtattttgtatattaaaagATGATAGCTAGAGGATCATGGTTTATACTTTATCAGATCCTCTTATTGCAGTCATTATTTGTTCTGCTTTCGAAATGTAGCCTGCATAAACCACTGTTCAAgctgtttttgttgtattttgttttaatttatccTCATAACCCTTAGGTGTTCTGATATGCCCATACTATTTTGTTCTCTTCTTCCTATCATAAGCTAACAATGATGTGTcctaattaaaagaaaaaccttgCCTTAC

Function

symbol description
bcl2 Enables several functions, including BH3 domain binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including B cell receptor signaling pathway; negative regulation of apoptotic process; and positive regulation of B cell proliferation. Acts upstream of or within several processes, including B cell proliferation; apoptotic signaling pathway; and negative regulation of apoptotic process. Located in endoplasmic reticulum; mitochondrial outer membrane; and nucleus. Part of pore complex. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Biomarker of several diseases, including cervix uteri carcinoma in situ; ductal carcinoma in situ; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and urinary system cancer (multiple).

NR:

description
apoptosis regulator Bcl-2-like

GO:

id name namespace
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand biological_process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage biological_process
GO:0005741 mitochondrial outer membrane cellular_component
GO:0042803 protein homodimerization activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function

KEGG:

id description
K02161 BCL2; apoptosis regulator Bcl-2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026938147.2 True 4852 mRNA 0.41 2 12181785 12234183

Neighbor

gene id symbol gene type direction distance location
LOC113541340 LOC108256745,LOC108434245 coding upstream 2164 12162455 ~ 12179621 (+)
vps41 vps41,LOC107722032,LOC107558337,LOC107748298 coding upstream 238277 11900755 ~ 11943508 (+)
fam49bb fam49bb,LOC108256504,LOC108434236,LOC103032810,LOC107724568,LOC107748306,LOC107691432,LOC103456840 coding upstream 628568 11488916 ~ 11553217 (+)
asap1b LOC108256502,LOC108256646,LOC108434233 coding upstream 695480 11391309 ~ 11486305 (+)
LOC113541334 LOC108256505 coding upstream 798979 11378301 ~ 11382806 (+)
hs6st1b hs6st1b,LOC108256600,LOC108434959,LOC107558548,LOC107697682,LOC107677314,LOC107729660,LOC107590258,LOC106579591 coding downstream 194274 12428457 ~ 12499046 (+)
LOC113541349 LOC108256200 coding downstream 472756 12706939 ~ 12708003 (+)
ccl34b.4 LOC100304628 coding downstream 476443 12710626 ~ 12712651 (+)
LOC113541231 cntnap2,cntnap2a,LOC108256453,LOC108256478,LOC108256479 coding downstream 532377 12766560 ~ 13015109 (+)
cul1b cul1,LOC107686696,LOC107595130,LOC107727219,LOC107741709,LOC107695409 coding downstream 786984 13021167 ~ 13042516 (+)
G330976 NA non-coding upstream 38920 12141943 ~ 12142865 (+)
G330962 NA non-coding upstream 147726 12024576 ~ 12034059 (+)
G330911 cdv3 non-coding upstream 235547 11944030 ~ 11946238 (+)
G330908 NA non-coding upstream 285894 11895666 ~ 11895891 (+)
G330869 NA non-coding upstream 307593 11873992 ~ 11874192 (+)
G331161 NA non-coding downstream 214579 12448762 ~ 12450347 (+)
G331277 NA non-coding downstream 498626 12732809 ~ 12733703 (+)
G331280 NA non-coding downstream 506934 12741117 ~ 12741678 (+)
LOC113541232 NA non-coding downstream 563178 12797361 ~ 12802125 (+)
G331342 NA non-coding downstream 810132 13044315 ~ 13049452 (+)
prkag2a prkag2,prkag2a,LOC108256599,LOC108434244,LOC106590432,LOC106579597,LOC107729655,LOC107590261,LOC107757712 other upstream 24998 12062332 ~ 12156787 (+)
ankha ankh,ankha,LOC108256444,LOC108434238,LOC107724566 other upstream 433226 11717415 ~ 11748559 (+)
acad11 acad11,LOC107715568,LOC104947469 other upstream 1197576 10874209 ~ 10984209 (+)
G330257 NA other upstream 1206870 10973264 ~ 10974915 (+)
gli3 gli3,LOC108444237 other upstream 1413425 10595130 ~ 10768360 (+)
G331263 LOC108256200,LOC100304628 other downstream 472756 12706939 ~ 12712678 (+)
G331476 NA other downstream 1023711 13257894 ~ 13258416 (+)
stau2 stau2,LOC107691439 other downstream 2900170 15134353 ~ 15314968 (+)
si:ch73-173p19.2 LOC108256301 other downstream 3017452 15251635 ~ 15265895 (+)
G332636 NA other downstream 3331992 15566175 ~ 15566663 (+)

Expression


Co-expression Network