hmgcra (hmgcr,hmgcra,LOC107699716,LOC107587518,LOC107720287)


Basic Information

Item Value
gene id hmgcra
gene name hmgcr,hmgcra,LOC107699716,LOC107587518,LOC107720287
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047618.1
NCBI id CM018564.1
chromosome length 20251756
location 7509917 ~ 7518413 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026931070.2
AGGTGATTGGCCTCAGCGCCGGAGAGCTCACTTAAACGGCTGGGTGTGGATTAATACTGGCCGCTTTTCCTAACAGCACCGGCTGAGTGTCACTCCTACCACCCTGTCATTTACCCCTGGGGTAATACAGTTAATGCATTAAGGCCCATATGCGAGGAGTTCAGTAACCAGCTCCACATTACTGCTGTAATtatctgtcctttttttctggCATCGTTGCAATACGTCTGAGAGACCGAAATGCTGAGCAGACTTTTCCGACTCCACGGCCTGTTTGTGGCCTCCCACCCCTGGGAGGTGATTGTGGCTACTGTGACTCTCACCATCTGCATGATGTCCATGAACATGTTCACTGGCAATAACCGCATTTGTGGTTGGAACTTTGACTGCCCCAAGTATGAGGAGCAAGTCCtcagcagtgacatcatcattCTGACAATCACACGATGCATTGCAATTGTCTACATTTACTTCCAATTTCAAAATCTTCGGCAGCTTGGATCAAAGTATATACTGGgtATTGCTGGCCTTTTCACCATCTTCTCCAGTTTTGTGTTTAGCACTGTTGTGATTCATTTCTTGGATAAGGAGCTGACCGGTTTAAATGAGGCATTGCCATTCTTCCTGCTACTGATTGACCTCTCCAAAGCATGTGCTCTGGCAAAATTTGCACTCAGTTCAAACTCACAGGATGAGGTTAGAGAAAACATAGCCAGAGGAATGGCAGTACTGGGTCCAACGTTCACTCTGGATGCGCTGGTGGAGTGTCTAGTAATTGGTGTAGGGACCATGTCAGGTGTTCGCCAGCTTGAGATCATGTGCGGCTTTGGATGCATGTCTATCCTTGCCAACTACTTTGTCTTCATGACTTTCTTCCCAGCCTGTGTCTCATTAGTGCTTGAGTTATCCAGGGAAAGCAGAGAGGGACATCCTATCTGGCAGCTGAGCCACTTTGCCCGTGTcctggaggaagaggaggacaaCAAACCCAATCCGGTCACACAGAGAGTCAAGATGATCATGTCTCTTGGCCTGGTGATGGTTCACGCTCACAGTCGATGGATTGCAGATCCTGCATCTCCAAACGGAACTCTGGATGTTCCTCAAGTGGGAATGAGTTTAAATTCACCCAAGAGGATTGAGCCGGATATGCCCTTGTGGCAGTTCTACCTGTCCAGAATGATCAGCATGGACATTGAGCAGGTCATCACGTTAGGTCTTGCCCTCTTCCTGGCTGTGAAGTACATCTTCTTTGAGCAGGTGGAAATGGAGTCTACGCTGTCTCTTAAAGTCTCTACTCCCACCACCGTGCTCACACAGAGAAGGTGTCCTGACCAGTGCTGCAGGAAGGAAGTGACCCCCTGCTCTAACAAGACTGAGAAGCCCactgctcctcctcctgtcaTCACTAAAGAGGAAAGAGATTTAGTGATAAAGCCATTGCCTATCAAGACTGACCCAACTCCAAAAAGCATGTTTGTGGTGGGAGAGGAGGAAACCTTGGACAGTAGTGTTTTGGTGGAGCCTCAGCCCAGCATCCCCTCAGAGCCCAGGCCAGTGGAAAAGTGTTTGACCATTCTGAAAGACCCACAGATGGGTGCTCGATACCTGAGTGATGCTGAGGTTATTATGTTAGTAAATGCAAAGCACATTCCTGCCTATAAGCTGGAGGCGGTGATGGAGAGCCCAGAGAGAGGGGTGATGATCCGCAGGAAGATGCTCCGCCCCAAACTCCCCAAGACTTCTGCACTCACATGCCTTCCCTACAAAGACTACAACTACTCTCAGGTCATGGGAACTTGCTGTGAGAACATCATTGGTTACATGCCGGTTCCAGTGGGTGTTGCAGGCCCTCTGTTGTTGGATGGAAAGCAGTTCCAGGTCCCACTGGCTACAACCGAGGGCTGTCTTGTGGCTAGCACGAATCGAGGCTGCAGAGCGATAGCTCTGGCTGGTGGAGTCAGCAGCAGGCTTTTGGCTGATGGTATGACCCGTGGCCCTGTGGTTCGCTTACCTTCTGCCTGCAAGGCTGCTGAGGTCAAGGCATGGCTAGAGACCCCAGAGGGCTACAAGTGCATTAAAGAGGCATTTGACAACACTAGCAGGTTTGCTCGTTTAGAGAAGCTCCTGATTGGCCTTGCTTCACGTAATCTGTATATACGATTCCAGTCCCAAACTGGAGATGCCATGGGGATGAACATGATCTCAAAGGGAACAGAGCAGGCTCTGGCTAGGCTTAAAGAAGAATTCCCTGAGCTGCAGGTCTTGGCAGTTAGTGGGAACTACTGCACTGATAAAAAACCAGCTGCTATTAACTGGATTGAGGGCAGGGGCAAGTCTGTGGTGTGTGAAGCTACCATACCTGCTCAAGTTGTCAGAGAGGTTTTAAAGACTAGTACGGAAGCACTGGTGGATCTAAATATCAATAAAAACCTTGTGGGTTCTGCCATGGCAGGAAGTATTGGGGGCTACAATGCTCATGCCGCCAACATCGTTGCTGCTATTTACATCGCATGTGGACAGGACCCGGCTCAGACAGTGGGCAGCTCTAACTGTATCACTCTAATGGAGGCAGCAGGACCCACAGGAGAGGATCTTTACATCAGCTGCACCATGCCTTCCATTGAGCTGGGCACTGTAGGAGGAGGCACCAATCTGGCACCTCAACAAGCCTGTCTGCAGatgTTAGGCGTGCAAGGTGCCAGTGAGACGTGTCCTGGTGAGAATGCCCGGCAGCTTGCCAGGGTGGTGTGTGCCACCGTGCTGGCAGGGGAGATATCACTCATGGCTGCTCTTGCTGCCGGACAGCTAGTCAAAAGTCACATGACACATAATAGgtCAAAAGTAAATTTACAAGGCACACCAGGAAGCTGCACAAAACAAGCATCTTAGGACTTAACTGGATGCCTAAAATGGGGATAATATAAGCAACACTAAAGGAAAAagactcaaaaggaaaaaaCCCCACACTTCAGGCACATTTGAGTACTTTTACTATTAAGTAAAAGTCAAATGAATGgctgaaacaaaaatatttccaacatcCAGTCCAGGGGAGAAACGCTTTCATTCTCATTTACGGAGTGCCACAATCATCTCAAAGACTGTTGAAATCACAACATTAATGATCACTGTGTAATGTTCgaacattttacttttacacatCTTAGAACTGATGGTGTTTCTGATGCCATCAGTGTTATTGGATGCACATAacgtaatttatttttttcatatttcactaTTTATAGAAAAAACCATGAGGCATATTTTTTGTTATACAGAATGTCAACTGGCCAACATGGAGAGCAATCACCAATTCctacagatttttctttttagaattATCTTAAATTGACAAATTGAGCCTTCTGCAGTTATTCCCAGTTACTTTTATCTGAATGCATGTGGGTTTTACAGATATAGAAACtgatattatttaattactgatatattgattattattaatatatgcaAGGGTTTGGTTGAAGGGAAGATTGCGAACACACAACTATTTCCCAAAGGTGCTATAATGGCCTTACTGACGTCAGTCAGCTATTGCTTGTGCGTGGAAATACAGCAAGAACTGTGAATGTGCACTGTACATGTACAATAATACACACCACCTTATGTACTGCCCATGCACATGGAGCTTTTATTGCTTACTGGCTTTGCTTATGTGGTCAAACTAATTGTGAAAGAAGCACGTACTACTGTTCATGCAGTCTTTTTCAAATGCtgcacccccacccccccaaatatatgattcatttttctaGAAAAACACAAGATAATGAAcagttatatgtttttataattaaaacatgaaagggaaatttttaataaactctgggaaaaaaaattcaa

Function

symbol description
hmgcra Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Acts upstream of or within skeletal muscle tissue development. Predicted to be located in endoplasmic reticulum; membrane; and peroxisome. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).
hmgcr Enables NADPH binding activity; coenzyme A binding activity; and hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum and peroxisomal membrane. Implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple).

NR:

description
3-hydroxy-3-methylglutaryl-coenzyme A reductase

GO:

id name namespace
GO:0007517 muscle organ development biological_process
GO:0015936 coenzyme A metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0008299 isoprenoid biosynthetic process biological_process
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0050661 NADP binding molecular_function
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function

KEGG:

id description
K00021 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026931070.2 True 3867 mRNA 0.46 20 7509917 7518413

Neighbor

gene id symbol gene type direction distance location
ttc37 ttc37,LOC107735852 coding downstream 55419 7429317 ~ 7454498 (-)
zgc:194908 mctp1 coding downstream 97540 7410907 ~ 7412377 (-)
mctp1a mctp1,LOC107756292,LOC107703246,LOC107720291 coding downstream 135512 7268166 ~ 7374405 (-)
kiaa0825 kiaa0825 coding downstream 283233 7106152 ~ 7226684 (-)
fam172a fam172a,LOC107756291 coding downstream 405058 6937285 ~ 7104859 (-)
snapc4 NA coding upstream 89371 7607784 ~ 7620562 (-)
entr1 sdccag3 coding upstream 102936 7621349 ~ 7627854 (-)
otpb otpb,otp,LOC108255424,LOC108423578,LOC107587559,LOC107720233,LOC107555478 coding upstream 280796 7799209 ~ 7802780 (-)
lhfpl2b lhfpl2,LOC108423653 coding upstream 333548 7851961 ~ 7863470 (-)
homer1b homer1b,LOC108255354,LOC108423652,LOC107720277,LOC107703256,LOC107555494,LOC107699726 coding upstream 353779 7872192 ~ 7896685 (-)
G351266 NA non-coding downstream 42964 7466596 ~ 7466953 (-)
G351033 NA non-coding downstream 308365 7200746 ~ 7201552 (-)
G350906 NA non-coding downstream 421881 7087714 ~ 7088036 (-)
LOC113537000 NA non-coding downstream 595574 6902293 ~ 6914343 (-)
G350714 NA non-coding downstream 767315 6742393 ~ 6742602 (-)
G351308 NA non-coding upstream 19625 7538038 ~ 7538341 (-)
G351362 NA non-coding upstream 30173 7548586 ~ 7642268 (-)
G351384 NA non-coding upstream 116689 7635102 ~ 7636193 (-)
G351517 NA non-coding upstream 262367 7780780 ~ 7781553 (-)
G351529 ckmt2,ckmt2b,LOC107602239,LOC107665780 non-coding upstream 270661 7789074 ~ 7848880 (-)
G350867 NA other downstream 734768 6764914 ~ 6775149 (-)
LOC113542569 NA other downstream 1157545 6346663 ~ 6352372 (-)
pappab LOC108255326,LOC108423596 other downstream 1388958 6056981 ~ 6120959 (-)
LOC117595919 NA other downstream 1930936 5575788 ~ 5578981 (-)
LOC113542328 hectd4 other downstream 1986636 5362282 ~ 5523281 (-)
ccdc180 ccdc180 other upstream 67059 7585472 ~ 7597962 (-)
card9 card9 other upstream 84494 7602907 ~ 7607466 (-)
hint2 hint2,LOC102299676,LOC102195764,LOC102781852,LOC104963271 other upstream 1035234 8553647 ~ 8556676 (-)
malt1 malt1 other upstream 1052104 8570517 ~ 8586011 (-)
sh2d3cb sh2d3c other upstream 1122529 8640942 ~ 8654612 (-)

Expression


Co-expression Network