spast (spast)


Basic Information

Item Value
gene id spast
gene name spast
gene type coding
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047620.1
NCBI id CM018566.1
chromosome length 19313417
location 15060921 ~ 15072345 (-)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>XM_026932137.2
GGAGtaccgcgcatgcgcagtacaAGAGTGTATCTTTGACAGCCACTCTGGCATGACCAGACTGTAAACAACACACGCACTGAAGCCGGAACTGcgaatattaatgaattaaatggCCCGGATGGAATTTTGAAGCGGATTAGTTTTGTTATGGAAGCGTTATGCCCAGTAAATGTGAATGAATTCAGCTCCTGGAAGCAGAGTGAAGTGGAAGAAGAGAACCGCAGCCCGGATTGGGCCTGCACCCGGGGACACCTGTGACCAGGAGGcgcttcatcatcatcatcatcatcatcatcatcatcttcctcctcaAACTCCTCTTCATTCTCATCCTCCTCCGCGTTTCTACCACCTTCTAGTCCTTTTCTCTCCGTTCCTGGTCCTCTATTCAGTGCTCGGGGTGGTGATTTGGCGTCTGTGTGCACTTCTAGCCTGGTTTTTCAAGCCCATCTCTCGCACCATGGCTACCAGAGCGAGGGAAGCGGATGGCAGAGACAGCGATGCCACCGGAGATCTGATCAAAAAGCACCACAAACAGGCGTTTGAGTTCATCTCAGTGGCGCTGCGCATCGACGAGGATGAGAAAGGACACAAGGATCAGGCAGTGCAGTGGTACCGTAAGGGCATCgctgagctggagaaaggcaTCTGCATTGAGGTCACAGGCACTGGGGAGAAAGCAGAACGAGCCAGGCGGCTACAAGCTAAAATGAACAACAACCTAATTATGGCCAAAGAACGTTTGCAACTACTGGCCGAGCTCAGCTCAGATTCCTCGCACGCTGTAAACACTGACAGCATTAACTCTCCTCTCTCCAACGGCAGCCTCCGCCCAGCCAGCAGTGTTGAACCTAAGAAGACAGACACCTCTTCATCTCTGGTGAAGGTGAAGCCTGCTAGACCTCCCTCCAGCGCCCCCCAGCGCACAAGTGGGTTCACTGCACCAGCTGCAGGCCGAACTGGACCCCAGTCCAACCACAAGgctccAGCAGGTCGGGGAGCTGCCAGAGGGAGCACTAAAGCCAGCGCTGCTCCTTCCACtccacagaggaagagagacatgAAGAACTTTAAGAACGTGGACAGCAAACTGGCCAACCTCATCCTCAATGAGATAGtggacagtggcTCGGCGGTGAGGTTCGAGGATGTAGCAGGTCAGGAGTTGGCCAAACAGGCACTGCAGGAGATCGTGATCCTGCCGGCACTGCGGCCTGAGttgtttacAGGGCTGAGAGCTCCAGCGAGAGGACTGCTGCTGTTTGGGCCTCCTGGTAACGGGAAGACCATGCTGGCAAAAGCTGTTGCCATGGAATCCAACGCTACCTTCTTCAACATCAGTGCTGCCAGTCTGACCTCCAAATACGTTGGTGAAGGTGAGAAATTGGTACGCGCTCTGTTTGCCGTTGCCCGAGAACTGCAGCCGTCAATCATCTTCATTGatGAAATAGACAGTCTCCTGTGtgaaaggagagaaggagagcatGATGCCAGCAGGAGACTGAAGACTGAGTTCCTCATTGAGTTTGATGGGgTACAGTCAGGAGGAGACGACCGGGTGCTGGTGATGGGAGCCACAAATCGTCCTCAGGAGTTGGATGAGGCCGTGCTCAGGCGCTTTGCGAAGAGGATTTACGTGACCTTACCCTCAGAAGAGactCGGCTGAAGCTGCTGAAGAATCTCCTGAGTAAACATGGCAACCCACTGACGCAGAAAGAACTGAATCAGCTAGCCAAgatgactGATGGTTACTCAGGCAGTGATCTGACCTCCTTGGCTAAAGACGCTGCACTGGGACCCATACGAGAGCTTCTTCCAGAGCAAGTGAGGAACATGGCAGCAAATGAGATGAGGAACATCCGTTTCTCGGATTTCGCCGAGTCTCTGAAGAAGATCAAGAAGAGTGTCAGTCCTCAGACTCTGGAGCAGTATGCACGCTGGAACCGGGAGTATGGAGACACCACTGctgtatgacacacacacaaacactccttCTTGTTTTACCTCTGGACTGTGACGTGAGACATTATTGGTCTTTTCCAAATAGATGAAGCAAACTGTTCTTACTGTTTTTACGCTGTTTACCCTTTTGGAGAGCAGACACTTTTGAATGAGAGTTTGTTCTTACTGTGATTAAACATGCTTGTGATTTGGGAGACGTCACACATGAGGACACTTTTGATTCACACAAATCCCTGGGGAAGAAAAAAGGATGATTGCTTTGTTTAAGTGTTAAATTACCAGAAGAAATGAGGCTTCCACGTTATAAATCGCACATCttcaggttttgtttttctcttacTGCATGCTCAAAACAAGAACCGGCCCAAATGGGAACCAGCAGAAGTTGAGGTATGTGTTACTTTTCCACCAACTGGAAAGACGACTGGAGCGGTCATAGtgacagtgacatcatcagttgTGTGCATCAACACATGCTGTTAAGTTGAACATGGAAAAGGTACTTGGATTAACACTTTGGTTTTCTGGCAGTTTGGCCGTTGTAAACAACATATACGAAATGACAGAATGGTTCATTGATGACAGGTTATTAAATTGCATTAATGTTAAGACAAAACATTGCAGAATTAGTCATTTTAATACTGCTGTGTTTATTCTGACATAAAACTACCATACTACAAACTACATTATTCTGaaataaaactacacaaaactACACATTTTAACAAACCCAGCGCCAACATCTGTAACtgttatgtatttaatttttttttcttcaatattcagtgtgtatcaacacacagtgttattagccccgcccccaaggATGCGTCTGGTGGTTCTTCGCACCTGTGCCTTAGTTTTTCTGCAGCTTCCTGATACGAATATCAGGCTGTTAGAATGAGGTACAGTCTGAGATGTGTGCTGTAGCAGAGACAGGCAGTGATCTCAGCTTTTGTGTGCTTTGTACAGAGTGTATAATGACTGTATTTcagaataatgtaaataaactcAGTAATATGGCCAAGAAATCTCACTGACGTGTATGGAAGTGCCAAAAGCCCTGTATTTAAAGCAATAACTTGTGAACTCATGATGTTAGACGAGACTTACCCTGTGTACTGTGTTTAGTACTTCTGGTAAGAGCCAGAGAACTTACCTATGTTGTAAATTTGTAGTTGTTGAAGGAATTTTGTGATCGTTTTCACTCGTTTGTATGTTTCTGCAGTGTCAGGTATTGACCAGTAGGGGGCAGCAGATGCACAGCAAATCTACGGGTCACTGCAAAATAAAGCATGAAATGGAGAGcaaattatattacaatattacagaaGCTTaaa
>XM_026932138.2
GAGtaccgcgcatgcgcagtacaAGAGTGTATCTTTGACAGCCACTCTGGCATGACCAGACTGTAAACAACACACGCACTGAAGCCGGAACTGcgaatattaatgaattaaatggCCCGGATGGAATTTTGAAGCGGATTAGTTTTGTTATGGAAGCGTTATGCCCAGTAAATGTGAATGAATTCAGCTCCTGGAAGCAGAGTGAAGTGGAAGAAGAGAACCGCAGCCCGGATTGGGCCTGCACCCGGGGACACCTGTGACCAGGAGGcgcttcatcatcatcatcatcatcatcatcatcatcttcctcctcaAACTCCTCTTCATTCTCATCCTCCTCCGCGTTTCTACCACCTTCTAGTCCTTTTCTCTCCGTTCCTGGTCCTCTATTCAGTGCTCGGGGTGGTGATTTGGCGTCTGTGTGCACTTCTAGCCTGGTTTTTCAAGCCCATCTCTCGCACCATGGCTACCAGAGCGAGGGAAGCGGATGGCAGAGACAGCGATGCCACCGGAGATCTGATCAAAAAGCACCACAAACAGGCGTTTGAGTTCATCTCAGTGGCGCTGCGCATCGACGAGGATGAGAAAGGACACAAGGATCAGGCAGTGCAGTGGTACCGTAAGGGCATCgctgagctggagaaaggcaTCTGCATTGAGGTCACAGGCACTGGGGAGAAAGCAGAACGAGCCAGGCGGCTACAAGCTAAAATGAACAACAACCTAATTATGGCCAAAGAACGTTTGCAACTACTGGCCAGCAGTGTTGAACCTAAGAAGACAGACACCTCTTCATCTCTGGTGAAGGTGAAGCCTGCTAGACCTCCCTCCAGCGCCCCCCAGCGCACAAGTGGGTTCACTGCACCAGCTGCAGGCCGAACTGGACCCCAGTCCAACCACAAGgctccAGCAGGTCGGGGAGCTGCCAGAGGGAGCACTAAAGCCAGCGCTGCTCCTTCCACtccacagaggaagagagacatgAAGAACTTTAAGAACGTGGACAGCAAACTGGCCAACCTCATCCTCAATGAGATAGtggacagtggcTCGGCGGTGAGGTTCGAGGATGTAGCAGGTCAGGAGTTGGCCAAACAGGCACTGCAGGAGATCGTGATCCTGCCGGCACTGCGGCCTGAGttgtttacAGGGCTGAGAGCTCCAGCGAGAGGACTGCTGCTGTTTGGGCCTCCTGGTAACGGGAAGACCATGCTGGCAAAAGCTGTTGCCATGGAATCCAACGCTACCTTCTTCAACATCAGTGCTGCCAGTCTGACCTCCAAATACGTTGGTGAAGGTGAGAAATTGGTACGCGCTCTGTTTGCCGTTGCCCGAGAACTGCAGCCGTCAATCATCTTCATTGatGAAATAGACAGTCTCCTGTGtgaaaggagagaaggagagcatGATGCCAGCAGGAGACTGAAGACTGAGTTCCTCATTGAGTTTGATGGGgTACAGTCAGGAGGAGACGACCGGGTGCTGGTGATGGGAGCCACAAATCGTCCTCAGGAGTTGGATGAGGCCGTGCTCAGGCGCTTTGCGAAGAGGATTTACGTGACCTTACCCTCAGAAGAGactCGGCTGAAGCTGCTGAAGAATCTCCTGAGTAAACATGGCAACCCACTGACGCAGAAAGAACTGAATCAGCTAGCCAAgatgactGATGGTTACTCAGGCAGTGATCTGACCTCCTTGGCTAAAGACGCTGCACTGGGACCCATACGAGAGCTTCTTCCAGAGCAAGTGAGGAACATGGCAGCAAATGAGATGAGGAACATCCGTTTCTCGGATTTCGCCGAGTCTCTGAAGAAGATCAAGAAGAGTGTCAGTCCTCAGACTCTGGAGCAGTATGCACGCTGGAACCGGGAGTATGGAGACACCACTGctgtatgacacacacacaaacactccttCTTGTTTTACCTCTGGACTGTGACGTGAGACATTATTGGTCTTTTCCAAATAGATGAAGCAAACTGTTCTTACTGTTTTTACGCTGTTTACCCTTTTGGAGAGCAGACACTTTTGAATGAGAGTTTGTTCTTACTGTGATTAAACATGCTTGTGATTTGGGAGACGTCACACATGAGGACACTTTTGATTCACACAAATCCCTGGGGAAGAAAAAAGGATGATTGCTTTGTTTAAGTGTTAAATTACCAGAAGAAATGAGGCTTCCACGTTATAAATCGCACATCttcaggttttgtttttctcttacTGCATGCTCAAAACAAGAACCGGCCCAAATGGGAACCAGCAGAAGTTGAGGTATGTGTTACTTTTCCACCAACTGGAAAGACGACTGGAGCGGTCATAGtgacagtgacatcatcagttgTGTGCATCAACACATGCTGTTAAGTTGAACATGGAAAAGGTACTTGGATTAACACTTTGGTTTTCTGGCAGTTTGGCCGTTGTAAACAACATATACGAAATGACAGAATGGTTCATTGATGACAGGTTATTAAATTGCATTAATGTTAAGACAAAACATTGCAGAATTAGTCATTTTAATACTGCTGTGTTTATTCTGACATAAAACTACCATACTACAAACTACATTATTCTGaaataaaactacacaaaactACACATTTTAACAAACCCAGCGCCAACATCTGTAACtgttatgtatttaatttttttttcttcaatattcagtgtgtatcaacacacagtgttattagccccgcccccaaggATGCGTCTGGTGGTTCTTCGCACCTGTGCCTTAGTTTTTCTGCAGCTTCCTGATACGAATATCAGGCTGTTAGAATGAGGTACAGTCTGAGATGTGTGCTGTAGCAGAGACAGGCAGTGATCTCAGCTTTTGTGTGCTTTGTACAGAGTGTATAATGACTGTATTTcagaataatgtaaataaactcAGTAATATGGCCAAGAAATCTCACTGACGTGTATGGAAGTGCCAAAAGCCCTGTATTTAAAGCAATAACTTGTGAACTCATGATGTTAGACGAGACTTACCCTGTGTACTGTGTTTAGTACTTCTGGTAAGAGCCAGAGAACTTACCTATGTTGTAAATTTGTAGTTGTTGAAGGAATTTTGTGATCGTTTTCACTCGTTTGTATGTTTCTGCAGTGTCAGGTATTGACCAGTAGGGGGCAGCAGATGCACAGCAAATCTACGGGTCACTGCAAAATAAAGCATGAAATGGAGAGcaaattatattacaatattacagaaGCTTaaa

Function

symbol description
spast Predicted to enable ATP hydrolysis activity; microtubule-severing ATPase activity; and tubulin binding activity. Acts upstream of or within several processes, including cytoplasmic microtubule organization; generation of neurons; and positive regulation of microtubule depolymerization. Predicted to be located in midbody and nuclear membrane. Predicted to be active in microtubule cytoskeleton and nucleus. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).

NR:

description
spastin-like isoform X3

GO:

id name namespace
GO:0034214 protein hexamerization biological_process
GO:0045773 positive regulation of axon extension biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0007032 endosome organization biological_process
GO:0051260 protein homooligomerization biological_process
GO:0007049 cell cycle biological_process
GO:0051013 microtubule severing biological_process
GO:0001578 microtubule bundle formation biological_process
GO:0006200 obsolete ATP catabolic process biological_process
GO:0051301 cell division biological_process
GO:0021955 central nervous system neuron axonogenesis biological_process
GO:0031117 positive regulation of microtubule depolymerization biological_process
GO:0031122 cytoplasmic microtubule organization biological_process
GO:0007416 synapse assembly biological_process
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005874 microtubule cellular_component
GO:0005634 nucleus cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0048487 beta-tubulin binding molecular_function
GO:0043014 alpha-tubulin binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008568 microtubule-severing ATPase activity molecular_function
GO:0008017 microtubule binding molecular_function

KEGG:

id description
K13254 SPAST; spastin

RNA

RNA id representative length rna type GC content exon number start site end site
XM_026932137.2 True 3306 mRNA 0.47 17 15060921 15072345
XM_026932138.2 False 3224 mRNA 0.47 16 15060921 15072344

Neighbor

gene id symbol gene type direction distance location
LOC113537617 NA coding downstream 102720 14953561 ~ 14958201 (-)
cct4 cct4,LOC107700877,LOC107594293 coding downstream 162779 14890222 ~ 14898142 (-)
fam161a fam161a coding downstream 172012 14880246 ~ 14888909 (-)
xpo1a xpo1,LOC108258411,LOC107746076,LOC107729732,LOC107703835,LOC100380723,LOC106585804 coding downstream 182337 14854881 ~ 14878584 (-)
usp34 usp34,LOC107746122,LOC107729952 coding downstream 208968 14787119 ~ 14851953 (-)
rln3b rln3 coding upstream 2326 15074671 ~ 15077616 (-)
dcaf15 dcaf15,LOC106592097,LOC106594349 coding upstream 31832 15104177 ~ 15113293 (-)
dla LOC108258338,LOC103023774,LOC108438608,LOC107746130,LOC107703728,LOC107598533,LOC107700799,LOC107594356 coding upstream 63888 15136233 ~ 15142801 (-)
ccsapa LOC108258518 coding upstream 100393 15172738 ~ 15180828 (-)
acta1a acta1,LOC102689871,LOC108414322,LOC108430668,LOC103383882 coding upstream 109288 15181633 ~ 15186072 (-)
G376574 NA non-coding downstream 15562 15044712 ~ 15045359 (-)
G376364 NA non-coding downstream 25455 15035165 ~ 15035466 (-)
G376171 NA non-coding downstream 321114 14739369 ~ 14739807 (-)
G376127 taf5l non-coding downstream 399610 14657946 ~ 14661311 (-)
G376093 NA non-coding downstream 528237 14532367 ~ 14532684 (-)
G376602 NA non-coding upstream 26671 15099016 ~ 15101012 (-)
G376608 LOC108259073 non-coding upstream 59672 15132017 ~ 15132290 (-)
G376613 NA non-coding upstream 75440 15147785 ~ 15147985 (-)
G376615 NA non-coding upstream 80547 15152892 ~ 15153120 (-)
LOC117596121 NA non-coding upstream 85801 15158146 ~ 15158646 (-)
akt3b akt3b,LOC108259077,LOC108438606,LOC107594289,LOC107703832,LOC107729704,LOC101071975 other downstream 99869 14910662 ~ 14961052 (-)
b3gnt2a LOC108259010 other downstream 311187 14740132 ~ 14749734 (-)
ifngr1 NA other downstream 348275 14697239 ~ 14712646 (-)
G376143 NA other downstream 376593 14682387 ~ 14684328 (-)
meis1a meis1 other downstream 536405 14460283 ~ 14524516 (-)
triobpa LOC108259073 other upstream 45167 15117512 ~ 15129256 (-)
dpy30 dpy30,LOC107684266 other upstream 340079 15412424 ~ 15458205 (-)
G376956 NA other upstream 845283 15917628 ~ 15920553 (-)
khsrp khsrp other upstream 857408 15929753 ~ 15942730 (-)
vps54 vps54,LOC107709616 other upstream 891531 15963876 ~ 15984959 (-)

Expression


Co-expression Network