XLOC_000058 (spry2)


Basic Information

Item Value
gene id XLOC_000058
gene name spry2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007112.7
NCBI id CM002885.2
chromosome length 59578282
location 5273481 ~ 5277583 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00000114
GTTCACCCCCTTCACTTCCACATGACGCCATTTACAGCATAAACCCGACCTCCTCTccggaaagaagaaaaaaacaagagcTGAAAAACTTGAAAGCAGCACAGTGTGTGCCATGCAGCCAAACATTCAACTTGCGAACCGCAACGCTTCTTCTTGAAAAAGTCTTCAGCGTTTTTATGCTTGTTTTCTTCTATAAAACTCGGCGCATTTTGTTGGATTCTGGAACTTATTACTCTCTTTTTTTGCCATAATTAGCGGTTTAACAGCAAAACACAAACTCCGCTGCGTTCTTGGGAATAAAAAGTCTGACGATATTGGTTCGAGCGAAAAAAATACGCGAATACGGGGACGCGCGACTGTTTGCTATCATCGGGatttttgtgaatgaatctccccATGAACTGAGGACTAACCAATTCCTACTAGTAGGATATactcttcagaacacaaataggGGGTTGAGGTGGTGAGATCACGGACTTCAGATGTGTTCAATGCCAGCCGGAGGGTTCCCACTTCAGAGTAAAGATGGAGACGAGAACTCAAAATGGCGGCAGCGGCTCCTCTGGCTTGCTGCGAGCTTTGCGTGACAGTGGCAGGCCACAGACTGGGGACTCTGAGCCTTGGGATGGTCAGGTGCTCTCCCTGGATCAGATCAGGACCATCCGTGGTAGCAATGAGTACACGGAGGGCCCGACGGTGGCGCCACGGCCCCCGGCCTCTGAGCAAAAAACGGATTCACAAGCTTCCAGCCCAACTTCCACCAGCTCTATTGAGCTGCCCGAGCATAGGAACTCCCTGAGGGCTCAGCAGGCAGGACAGCAGACTCCTCAACAAGCCCCGAGGGGAGGCGTGAGCAGATCCATCAGTGGCACCAGCGATGGTTCACACAGTACCACCAGGGCCAGCACTGGCAGCACCTCATCGGATCAAAGACTTTTGGGAAATGCAGGTGATCGCGTGGTAAGGGTGCAGCCTAAACGTTCTGAGCAGAAGCAGGAGGAACTGAAGCCTTTGTCAGCACCTGTCGGCCCGGCGCCCGATGGCAAGCACTCGGTTCTCTGCGAGGACTGCGGCCGCTGCAAGTGCGAAGGATGCACCTGCCCTCGAACCCTGCCCTCATGTTGGATGTGCGGCCGCAGGTGCGTTTGCTCTGCAACATCCGCGATGGACTATGTGACTTGCGTCTGCTGCGTCAAGTGCCTGTTCTACCACTGCTCTAGCGACGATGAGGATGTGTGCGCGGACAAGCCCTTCTCCTGCACTCAGTCGCATTGCTGCATGCGGTGGTCGGCCATAAGCGTCCTGGCACTTTTCCTGCCCTGCCTGCTTTGCTACCTCCCGGCAAAGGGCTGCGTGGCATTGTGCCAGGCCTGCTACGACTGCACCAGTCGGCCAGGATGCCGCTGCAAGAACAAAGGAGTTGAGAAATAGAGGTTGCTCGGTTCCTGGAGTAGCACTAGGGGAAGATACGTTTATCCGGGACTGTCTCCAGAGCAGTGGAAAATTATTGGCAAACTGTTGTAGTTTTGGCACTGTAAACCAAGAGGTGACAGTGGATTGGCAAAAACTGGTTTGaagtggtttgtttgtttgtttgtttgtgttttgcttttCTCTTATccactttctctctctttctttcactcTTTAAGGGGGGTAATGTTTGTCGCAACAGCCTTCCCTGTTCTTTTCATTTTAAACTGAAGTCCAGAATGTTAGCCCTATTGACATTCAGTAATATGACTGATAAAGGTGACAGACTCTCCTAACTAACTGTTTGTGAATAGTATCTGCGAAAGTATGTAAATTAGCAAATGAGCTCTTTTTCTGagagattttatttttgtacatataATATTTCAACTGTGAAAAGCATTGTGCCAAACCAGAGGCACCTTGACAGATCCATATATATGATGCATATATAAGACGTGTATAGTGCTGTACGTTCGTTCCCGAACGTACACCAATCACTCTTTTGATATTTCGCCTTCTAGAAGAGAAACCTTACATGAATTATCCCTACAACTATACTTGTAAATTGTACAGTGACCCTAAGAAAAACTTTATTTTCTAATTTCAACACATTGTTtagtgtaaaaatatttatttgaagttttattattttataaagtaatatttattttgagaGGCATCTTTATAGGTATCACCCCAACTTTGAGAAACAAAACCTCCTCTGTTGTTGCTGCAAGAAAAGGGTGACAAGGGTGTCAAATCCGATGCATATGTTCactataaaatagaaaatatattaacGTTTTGAAATTAAACAA
>TCONS_00000115
AAAGATGGAGACGAGAACTCAAAATGGCGGCAGCGGCTCCTCTGGCTTGCTGCGAGCTTTGCGTGACAGTGGCAGGCCACAGACTGGGGACTCTGAGCCTTGGGATGGTCAGGTGCTCTCCCTGGATCAGATCAGGACCATCCGTGGTAGCAATGAGTACACGGAGGGCCCGACGGTGGCGCCACGGCCCCCGGCCTCTGAGCAAAAAACGGATTCACAAGCTTCCAGCCCAACTTCCACCAGCTCTATTGAGCTGCCCGAGCATAGGAACTCCCTGAGGGCTCAGCAGGCAGGACAGCAGACTCCTCAACAAGCCCCGAGGGGAGGCGTGAGCAGATCCATCAGTGGCACCAGCGATGGTTCACACAGTACCACCAGGGCCAGCACTGGCAGCACCTCATCGGATCAAAGACTTTTGGGAAATGCAGGTGATCGCGTGGTAAGGGTGCAGCCTAAACGTTCTGAGCAGAAGCAGGAGGAACTGAAGCCTTTGTCAGCACCTGTCGGCCCGGCGCCCGATGGCAAGCACTCGGTTCTCTGCGAGGACTGCGGCCGCTGCAAGTGCGAAGGATGCACCTGCCCTCGAACCCTGCCCTCATGTTGGATGTGCGGCCGCAGGTGCGTTTGCTCTGCAACATCCGCGATGGACTATGTGACTTGCGTCTGCTGCGTCAAGTGCCTGTTCTACCACTGCTCTAGCGACGATGAGGATGTGTGCGCGGACAAGCCCTTCTCCTGCACTCAGTCGCATTGCTGCATGCGGTGGTCGGCCATAAGCGTCCTGGCACTTTTCCTGCCCTGCCTGCTTTGCTACCTCCCGGCAAAGGGCTGCGTGGCATTGTGCCAGGCCTGCTACGACTGCACCAGTCGGCCAGGATGCCGCTGCAAGAACAAAGGAGTTGAGAAATAGAGGTTGCTCGGTTCCTGGAGTAGCACTAGGGGAAGATACGTTTATCCGGGACTGTCTCCAGAGCAGTGGAAAATTATTGGCAAACTGTTGTAGTTTTGGCACTGTAAACCAAGAGGTGACAGTGGATTGGCAAAAACTGGTTTGaagtggtttgtttgtttgtttgtttgtgttttgcttttCTCTTATccactttctctctctttctttcactcTTTAAGGGGGGTAATGTTTGTCGCAACAGCCTTCCCTGTTCTTTTCATTTTAAACTGAAGTCCAGAATGTTAGCCCTATTGACATTCAGTAATATGACTGATAAAGGTGACAGACTCTCCTAACTAACTGTTTGTGAATAGTATCTGCGAAAGTATGTAAATTAGCAAATGAGCTCTTTTTCTGagagattttatttttgtacatataATATTTCAACTGTGAAAAGCATTGTGCCAAACCAGAGGCACCTTGACAGATCCATATATATGATGCATATATAAGACGTGTATAGTGCTGTACGTTCGTTCCCGAACGTACACCAATCACTCTTTTGATATTTCGCCTTCTAGAAGAGAAACCTTACATGAATTATCCCTACAACTATACTTGTAAATTGTACAGTGACCCTAAGAAAAACTTTATTTTCTAATTTCAACACATTGTTtagtgtaaaaatatttatttgaagttttattattttataaagtaatatttattttgagaGGCATCTTTATAGGTATCACCCCAACTTTGAGAAACAAAACCTCCTCTGTTGTTGCTGCAAGAAAAGGGTGACAAGGGTGTCAAATCCGATGCATATGTTCactataaaatagaaaatatattaacGTTTTGAAATT

Function

symbol description
spry2 Acts upstream of or within blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).

GO:

id name namespace
GO:0042127 regulation of cell population proliferation biological_process
GO:0048513 animal organ development biological_process
GO:0046580 negative regulation of Ras protein signal transduction biological_process
GO:0007275 multicellular organism development biological_process
GO:0001525 angiogenesis biological_process
GO:0043407 negative regulation of MAP kinase activity biological_process
GO:0045595 regulation of cell differentiation biological_process
GO:0070373 negative regulation of ERK1 and ERK2 cascade biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0009966 regulation of signal transduction biological_process
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway biological_process
GO:0060841 venous blood vessel development biological_process
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0003674 molecular_function molecular_function

KEGG:

id description
ko04013 MAPK signaling pathway - fly
ko05206 MicroRNAs in cancer

ZFIN:

id description
ZDB-GENE-030131-7038 Acts upstream of or within blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).

Ensembl:

ensembl_id ENSDARG00000078308

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00000114 False 2297 mRNA 0.47 2 5273481 5277583
TCONS_00000115 True 1767 mRNA 0.48 1 5275811 5277577

Neighbor

gene id symbol gene type direction distance location
XLOC_000057 NA coding upstream 243326 4901460 ~ 5030155 (+)
XLOC_000056 FO744838.1 coding upstream 593004 4598060 ~ 4680477 (+)
XLOC_000055 slitrk6 coding upstream 1119149 4101741 ~ 4154332 (+)
XLOC_000054 CABZ01063288.1 coding upstream 1513447 3759924 ~ 3760034 (+)
XLOC_000053 NA coding upstream 1552878 3718666 ~ 3720603 (+)
XLOC_000059 NA coding downstream 33896 5311479 ~ 5313595 (+)
XLOC_000060 tuba8l2 coding downstream 124893 5402476 ~ 5419116 (+)
XLOC_000061 stk16 coding downstream 144856 5422439 ~ 5434261 (+)
XLOC_000062 atic coding downstream 159807 5437390 ~ 5504130 (+)
XLOC_000063 cpo coding downstream 298568 5576151 ~ 5587575 (+)
XLOC_000051 CR352215.2 non-coding upstream 2870257 2403103 ~ 2403224 (+)
XLOC_000064 NA non-coding downstream 429387 5706970 ~ 5728684 (+)
XLOC_000065 NA non-coding downstream 517430 5795013 ~ 5799092 (+)
XLOC_000072 NA non-coding downstream 1102295 6379878 ~ 6554470 (+)
XLOC_000073 NA non-coding downstream 1120627 6398210 ~ 6403223 (+)

Expression


Co-expression Network