AMCG00007857 (igf1ra,igf1r,LOC101079603,LOC105904485,LOC106949861)


Basic Information

Item Value
gene id AMCG00007857
gene name igf1ra,igf1r,LOC101079603,LOC105904485,LOC106949861
gene type coding
species bowfin (Amia calva)
category of species ecological fish

Chromosome Information

Item Value
chromosome id CM030123.1
NCBI id CM030123.1
chromosome length 53548854
location 33866963 ~ 33870738 (+)
genome version AmiCal1_2021_bowfin_Genome

Sequence

>AMCG00007857
atggatttaattttaaagcagaGGATGGGTCAGCCTCTGTACTGTATCGACATTCGAAATGAAATCAGTGAACTGAAACGGCTGGAGAACTGCACTGTAGTGGAGGGCTACCTGCAGATCCTGCTGATAGGCGAGAAGTTCAGCAACCAAAACCAGGACATCTTCCGCACCCTTCGCTTCCCCAAGCTCACCATCATCACCGACTACCTGCTGCTGTTTCGCGTCACTGGCCTGGAGAGCCTGAGGGACCTCTTCCCCAACCTCACGGTCATCCGGGGCCGCAACCTCTTCTACAACTATGCCCTGGTGATCTTTGAGATGACCAGCCTGAAGGACATCGGCCTCTTCAACCTGCGCAACATCACCCGTGGCGCCATCCGCATAGAGAAGAACCCCGACCTCTGCTACCTGGACTCGGTGGACTGGTCCCTCATCATGGATGCCGAGTACAACAACTTCATCGCCGGCAACAAGCAGTCCAAGGAGTGCGGCGATGTCTGCCCTGGCATCATGGAGGACGACCCTCAGTGCATCAAGACCAACTTCAATGACAATTACAACTACCGCTGCTGGACCTCCAACCACTGCCAGAAAGGTAAGAACTGTGAAGTTTTAATGAAGTCTTAA

Function

symbol description
igf1ra Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; eye; gill; musculature system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
igf1r Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade. Acts upstream of or within peptidyl-tyrosine autophosphorylation. Located in intracellular membrane-bounded organelle and membrane. Part of alphav-beta3 integrin-IGF-1-IGF1R complex; protein kinase complex; and receptor complex. Implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Biomarker of several diseases, including Kuhnt-Junius degeneration; autoimmune disease (multiple); endocrine gland cancer (multiple); neurodegenerative disease (multiple); and prostate disease (multiple).

NR:

description
insulin-like growth factor 1 receptor isoform X1

GO:

id name namespace
GO:0021522 spinal cord motor neuron differentiation biological_process
GO:0018108 peptidyl-tyrosine phosphorylation biological_process
GO:0048752 semicircular canal morphogenesis biological_process
GO:0031076 embryonic camera-type eye development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0048009 insulin-like growth factor receptor signaling pathway biological_process
GO:0031101 fin regeneration biological_process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0003007 heart morphogenesis biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0016021 integral component of membrane cellular_component
GO:0043548 phosphatidylinositol 3-kinase binding molecular_function
GO:0043560 insulin receptor substrate binding molecular_function
GO:0005520 insulin-like growth factor binding molecular_function
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular_function
GO:0005524 ATP binding molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function

KEGG: NA

RNA

RNA id representative length rna type GC content exon number start site end site
AMCG00007857 True 627 mRNA 0.53 2 33866963 33870738

Neighbor

gene id symbol gene type direction distance location
AMCG00007853 si:dkey-12e7.1,LOC105904526,LOC108427511,LOC103035474,LOC106573761,LOC107583743,LOC107738678 coding upstream 107121 33758703 ~ 33759842 (+)
AMCG00007847 LOC108243329,LOC107714027,LOC107654092,LOC100696938 coding upstream 219455 33646519 ~ 33647508 (+)
AMCG00007846 NA coding upstream 226627 33619303 ~ 33640336 (+)
AMCG00007845 klhl25,LOC106560960,LOC107714043 coding upstream 509278 33350094 ~ 33357685 (+)
AMCG00007841 NA coding upstream 1016758 32528802 ~ 32850205 (+)
AMCG00007858 LOC107583745 coding downstream 69664 33940402 ~ 33984780 (+)
AMCG00007860 NA coding downstream 130299 34001037 ~ 34010551 (+)
AMCG00007863 lrrc28,LOC107706938,LOC107563201,LOC107662304,LOC107690794 coding downstream 173874 34044612 ~ 34052190 (+)
AMCG00007864 NA coding downstream 194393 34065131 ~ 34083321 (+)
AMCG00007865 LOC107715609 coding downstream 352161 34222899 ~ 34225641 (+)
G26704 NA non-coding upstream 978923 32887790 ~ 32888040 (+)
G26698 NA non-coding upstream 1244433 32622260 ~ 32622530 (+)
G26645 NA non-coding upstream 2043990 31822740 ~ 31822973 (+)
G26625 NA non-coding upstream 2085072 31781638 ~ 31781891 (+)
G26483 NA non-coding upstream 2648641 31218110 ~ 31218322 (+)
G26826 NA non-coding downstream 118308 33989046 ~ 33990588 (+)
G26825 NA non-coding downstream 121440 33992178 ~ 33993982 (+)
G26875 NA non-coding downstream 378458 34249196 ~ 34253554 (+)
G26895 NA non-coding downstream 395383 34266121 ~ 34266418 (+)
G26923 NA non-coding downstream 755224 34625962 ~ 34626229 (+)
AMCG00007854 NA other upstream 72022 33763513 ~ 33794941 (+)
AMCG00007827 ell3,LOC103370942,LOC102298519,LOC102798071,LOC108431223,LOC107714787 other upstream 2426585 31414154 ~ 31440378 (+)
G26258 tpm1,tpma,LOC108237348 other upstream 4047411 29755040 ~ 29819552 (+)
AMCG00007788 NA other upstream 4142229 29622311 ~ 29724734 (+)
AMCG00007769 acsbg1 other upstream 4860584 29003095 ~ 29006379 (+)
AMCG00007873 fam174b,LOC103466638,LOC101474125,LOC102798031,LOC103147863 other downstream 1740244 35610982 ~ 35620801 (+)
AMCG00007889 NA other downstream 2425480 36296218 ~ 36302841 (+)
AMCG00007923 LOC105031092,LOC105901836,LOC102299656,LOC101482251 other downstream 3333132 37203870 ~ 37216558 (+)
G27518 NA other downstream 4274246 38144984 ~ 38146850 (+)
AMCG00007952 romo1,LOC102788570 other downstream 4297832 38168570 ~ 38170146 (+)

Expression


Co-expression Network