XLOC_006028 (fgf8a)


Basic Information

Item Value
gene id XLOC_006028
gene name fgf8a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 28495419 ~ 28501985 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00011895
TCAGCGCGAGCGGGGTTGACATTGGAGACTGACTGGCAATGGGAGAAGAGGAGGGGATAAGAGAGTCCAGCAGCACTGCTTCTTGAAGAAAGCTCATCAGATGCACTGTCCTGCCTCCTCTGACTGACACTCACACAGGACTCACTGGATCAAACGTCAAAGGATCTATTTGTGCTGCGCTCCTCACCTTCATGGACAGCTCGGGATTTCCTCGGGCTGCATGATTACAGGCGCATCAGAGGCGCTTTCGCTTAAACTTGAAAAGTAAATCGTTTACATGCCGCGAGTTTTGCGTAAAGTGCACTTATTTGTTGTTCTCGTTGTAATGAAGGAAATGCAGGTAGTGCATGTACTTGTCAGCGGTGTCAGTCTGAAAAAAACCTTGGACATTTCTTTCTGCTTCTGAGCAGCAACAGATCTTGTAATTTGCCAGTTGACCTGTTCATCATATGTTGCGAGTCACAGTGTGGATACAAACGCAGGACTTTACACATTTGAGCTGGAAAACCTGATATTATTCTATATACACttatttttaatcacttttttacTGAGGCTATAAACATGAGACTCATACCTTCACGGTTGAGTTATCTATTCCTTCACCTCTTTGCGTTTTGCTACTATGCTCAGGTAACCATTCAGTCCCCGCCTAATTTTACACAGCATGTGAGTGAGCAAAGTAAGGTGACGGACCGGGTGAGCCGTAGACTAATCCGGACCTACCAGCTTTACAGCCGAACCAGTGGCAAGCACGTGCAAGTTCTGGCCAACAAGAAAATCAACGCCATGGCCGAAGATGGCGACGTTCATGCCAAGCTTATAGTAGAGACGGACACATTTGGGAGTCGAGTTCGAATTAAAGGAGCTGAAACAGGCTTTTACATCTGTATGAACAGGAGGGGGAAACTGATTGGCAAGAAAAATGGTCTGGGAAAAGACTGCATTTTCACAGAGATAGTCCTGGAGAACAACTACACGGCTCTGCAGAATGTGAAGTACGAAGGCTGGTACATGGCCTTCACGCGTAAAGGTAGACCCCGCAAGGGCTCCAAAACCAGGCAACACCAGCGGGAAGTCCACTTCATGAAGAGGTTGCCCAAGGGACACCAAATCGCAGAGCACAGACCCTTTGATTTCATCAACTACCCTTTCAACAGACGGACTAAACGCACCCGCTACTCAGGAGAGCGTTGAAGAGTGAAGCCAGAGAAAAGGAGAGGACCGAAAGCCAGAGACTTTCTCAAACAATGAACTCCTCTTGTGGACTTCTTAACAAATTTTTGTACTGAGCAACAATATACCTAACCTTTAGTTTTTTATGAATTttcagaaataacaaaaataaggagagaaaaaaagtctcaagaaaaaaaagagatctatttttgtacccctgaCTTTTAGTACTGACCTGTGTAAGATTATAGGTAAGCGAAGCACAGGATGTGTAAGCGCTGACATTTTAGTAGTACGTGGACTTCATCCGTCTATCCTCTCTCGTTCTGCTTTGATTTCGATGGTTTCCGAGTAATTTATAACTCTTCGTATTGCTGCTCAAGGGGACTTGAAGGGCCTGAGAGAGAATGCACTGACAACACAAGGCTGTATTCGGTTACACAGGCAGCAGCCGGGGCACCTCTCGACCACCCAGCGATAAGATACCCAGCTCATCTCTCAGTAACCTCTCTGGTTCTTGATTCTGGAACTCTCTGGAGATAAACACGGTTAAAGCAAACAGagctttaaatacatatttaaatgtggCAGCTACATTTTTGATTATCGCAGGTTTCCTACCGTGGTTTAAACTGTAAATTCCCAGGTGTATAAATGCATTGTATGGACTGTAGGAAAAAGCTTTTGTTctttgttgcattttgtttgtctgtttttttatacaaatataaatatatttttatttgaggatgtgtaaaataattttaatgatgaaaatatttatttaaaaacctgTAATAAATTTACCTTAGGATACTGATGTCTTTTGCTTAATATGTTCCTGATTCAGAATTGCTTTCCAAGCATTCTTTGTTCTGTGGAACAAAatgaaaagtacattttaaaaaaacacaatgaaagtctatggggtcCAAAATTTTGACATTGATTATATGGTCAATCACAGAGAAATGCTTCAagatttcttcatttgttttccaAATATGAAAGAAAGTGTTTCTTTCCATCATTAAGCCTAAATGAAGATCTAAGATTcta
>TCONS_00011896
ATGAGACTCATACCTTCACGGTTGAGTTATCTATTCCTTCACCTCTTTGCGTTTTGCTACTATGCTCAGCATGTGAGTGAGCAAAGTAAGGTGACGGACCGGGTGAGCCGTAGACTAATCCGGACCTACCAGCTTTACAGCCGAACCAGTGGCAAGCACGTGCAAGTTCTGGCCAACAAGAAAATCAACGCCATGGCCGAAGATGGCGACGTTCATGCCAAGCTTATAGTAGAGACGGACACATTTGGGAGTCGAGTTCGAATTAAAGGAGCTGAAACAGGCTTTTACATCTGTATGAACAGGAGGGGGAAACTGATTGGCAAGAAAAATGGTCTGGGAAAAGACTGCATTTTCACAGAGATAGTCCTGGAGAACAACTACACGGCTCTGCAGAATGTGAAGTACGAAGGCTGGTACATGGCCTTCACGCGTAAAGGTAGACCCCGCAAGGGCTCCAAAACCAGGCAACACCAGCGGGAAGTCCACTTCATGAAGAGGTTGCCCAAGGGACACCAAATCGCAGAGCACAGACCCTTTGATTTCATCAACTACCCTTTCAACAGACGGACTAAACGCACCCGCTACTCAGGAGAGCGTTGA

Function

symbol description
fgf8a Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of somitomeric trunk muscle development. Acts upstream of or within several processes, including animal organ development; determination of bilateral symmetry; and nervous system development. Located in extracellular space and lysosome. Is expressed in several structures, including germ ring; head; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8).

GO:

id name namespace
GO:0001708 cell fate specification biological_process
GO:0061386 closure of optic fissure biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0007492 endoderm development biological_process
GO:0051146 striated muscle cell differentiation biological_process
GO:0021549 cerebellum development biological_process
GO:0007498 mesoderm development biological_process
GO:0021555 midbrain-hindbrain boundary morphogenesis biological_process
GO:0046850 regulation of bone remodeling biological_process
GO:0001756 somitogenesis biological_process
GO:0021571 rhombomere 5 development biological_process
GO:0021572 rhombomere 6 development biological_process
GO:0030154 cell differentiation biological_process
GO:0021588 cerebellum formation biological_process
GO:0071599 otic vesicle development biological_process
GO:0055012 ventricular cardiac muscle cell differentiation biological_process
GO:0030177 positive regulation of Wnt signaling pathway biological_process
GO:0061195 taste bud formation biological_process
GO:0009880 embryonic pattern specification biological_process
GO:0030182 neuron differentiation biological_process
GO:0043049 otic placode formation biological_process
GO:0009887 animal organ morphogenesis biological_process
GO:0051216 cartilage development biological_process
GO:0035050 embryonic heart tube development biological_process
GO:0048263 determination of dorsal identity biological_process
GO:0048839 inner ear development biological_process
GO:0003208 cardiac ventricle morphogenesis biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0031076 embryonic camera-type eye development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0008284 positive regulation of cell population proliferation biological_process
GO:0070121 Kupffer's vesicle development biological_process
GO:0007368 determination of left/right symmetry biological_process
GO:0048339 paraxial mesoderm development biological_process
GO:0021703 locus ceruleus development biological_process
GO:0003007 heart morphogenesis biological_process
GO:0061053 somite development biological_process
GO:0048665 neuron fate specification biological_process
GO:0060788 ectodermal placode formation biological_process
GO:0060271 cilium assembly biological_process
GO:0010002 cardioblast differentiation biological_process
GO:0030878 thyroid gland development biological_process
GO:0007420 brain development biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0014709 positive regulation of somitomeric trunk muscle development biological_process
GO:0030901 midbrain development biological_process
GO:0060037 pharyngeal system development biological_process
GO:0030902 hindbrain development biological_process
GO:0030334 regulation of cell migration biological_process
GO:0030903 notochord development biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0060041 retina development in camera-type eye biological_process
GO:0048702 embryonic neurocranium morphogenesis biological_process
GO:0048705 skeletal system morphogenesis biological_process
GO:0042664 negative regulation of endodermal cell fate specification biological_process
GO:0048709 oligodendrocyte differentiation biological_process
GO:0030916 otic vesicle formation biological_process
GO:0030917 midbrain-hindbrain boundary development biological_process
GO:0060059 embryonic retina morphogenesis in camera-type eye biological_process
GO:0005764 lysosome cellular_component
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005104 fibroblast growth factor receptor binding molecular_function
GO:0005105 type 1 fibroblast growth factor receptor binding molecular_function
GO:0005111 type 2 fibroblast growth factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-990415-72 Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of somitomeric trunk muscle development. Acts upstream of or within several processes, including animal organ development; determination of bilateral symmetry; and nervous system development. Located in extracellular space and lysosome. Is expressed in several structures, including germ ring; head; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8).

Ensembl:

ensembl_id ENSDARG00000003399

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00011895 False 2238 mRNA 0.42 5 28495419 28501985
TCONS_00011896 True 600 mRNA 0.50 5 28495983 28500944

Neighbor

gene id symbol gene type direction distance location
XLOC_006027 NA coding upstream 12013 28475601 ~ 28483406 (+)
XLOC_006026 slc2a15a coding upstream 53333 28417297 ~ 28442086 (+)
XLOC_006025 CR762431.1 coding upstream 80860 28406913 ~ 28414559 (+)
XLOC_006024 NA coding upstream 213096 28264236 ~ 28282323 (+)
XLOC_006023 b3gat2 coding upstream 485845 27951688 ~ 28009574 (+)
XLOC_006029 fbxw4 coding downstream 10545 28512530 ~ 28575459 (+)
XLOC_006030 NA coding downstream 63194 28565179 ~ 28567486 (+)
XLOC_006031 wbp1la coding downstream 78372 28580357 ~ 28596765 (+)
XLOC_006032 borcs7 coding downstream 110328 28612313 ~ 28615893 (+)
XLOC_006033 cnnm2a coding downstream 116101 28618086 ~ 28643260 (+)
XLOC_006021 NA non-coding upstream 689539 27785094 ~ 27805880 (+)
XLOC_006022 dre-mir-30e-2 non-coding upstream 700210 27795130 ~ 27795209 (+)
XLOC_006037 CU640488.1 non-coding downstream 238250 28740235 ~ 28740369 (+)
XLOC_006039 NA non-coding downstream 306107 28808092 ~ 28817882 (+)
XLOC_006042 NA non-coding downstream 413553 28915538 ~ 29097526 (+)
XLOC_006043 CU639469.2 non-coding downstream 422861 28924846 ~ 28924965 (+)

Expression


Co-expression Network