XLOC_006449 (HTRA2)


Basic Information

Item Value
gene id XLOC_006449
gene name HTRA2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 9288383 ~ 9300299 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012514
GACCATTTACCACTTCCGGTATAGTGACAAACCTTCCAGTCAGAGCAAGGACTGGACAGGCACACATCGACGAGCGTATGTCAAGAGCATTCAGCCATATATTCCTTATTAAATAGGTTTACTATCATTATCTTCACTTAGACTTTAGGTAATGTATTCGACGCAGTGATGTGAAGTCCTGTTTCTATCGGGATTGAGTGTTTTCAACATCTGATGCAACATGGCAACCTCGCATGTTAATCGCTGTCTCCTAAGGACAATTACGAGATGTCATCGGGACAGCAGCCGGCAGCTGAACTTGACGACAGTAAGGGCATTAGGACACTTTTCTAACTTTTCTTCAGGTAAAGAGGAACACGTTGAAACTGTGGATCCACCGCGGGGTTCAGGAGGCGGCAGTGGCACATCTCGACTGGCGGTCGCGCTCGGACTGGGACTCGGCGGAGCAGCGGCTGTATTTTCATTAAGAGGAGAAGACAATAAAGATGCCCTACAGAGGACAGTCGCGGTTAAGAATTTGCTGATTGATAGCATATTACCTACTGTCCAGTGTGCTTCTCCATTTAAACCTGACAGCCCGCGGTACAAGTATAATTTCATCGCGGATGTGGTGGAGAAGTCCACCCCTGCTGTGGTCTACATCGAAATCGTTGGCCGACACCCCTTTTCTGGTCGTGAGGTACCCATCTCGAATGGCTCTGGCTTTATAGTAAGTAGTGATGGCCTGATAGTGACAAATGCCCATGTGGTCGCCAACAAGCGTGGTGTTCGTGTCAAACTGACCAATGGTGAGACTTACAACGCCACAGTTCAGGATGTGGACCAGGCTGCAGACATCGCCACCATCAAAATCAATGTTAAGaatcctctaCCAACGTTGCGTCTTGGCAAGTCATCTGATGTGCGTCAAGGTGAATTTGTGGTTGCCATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTCTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATTTTGGAAATTCAGGAGGGCCTCTCATAAACCTGGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCTATTCCCTCAGACAGAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCGGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCGAAGAACTAAGGATGCGAGACCCGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAAGGTGAACACGTCGGAGGAGATATATAATGCTGTGAGGACCAGCGAAAGCTTAAATGTGGTGGTCCGCCGGGGGGCCGACCTGCTCATGCTGCACATGACCCCAGAGTCCACAGAGTGACATCAAGTCAAGTATTTAGTAAGATTAAGAAATGGTGAGTAATGAGAAGCTGTCATAGTTGGAGCTGTTGTAAGAAAGGAATCATCTAAAGAGTTGAACAGTTTTAGCAAACGCTGGACATTCGTGTAGTAAACGTGTTTCTGGAAGCGTATGAAATAATGTGGATGATTCAGACTTCTGTACACTGGATAAACCTCAATGTGTCTGCGCAAACTACACTATCAGTATTGATTTGAAGGAATATCACTGAATATTTTGTTTAGGATTGTCATGATGGCAACAAACACTCAAAGACCTTAATAAAACTGGGTGCTCTTATTGTGAAAAtgctgatgttttgtattgagtcTTACATTCTCATGTTACGAcgtttgtattttaatacatttttctgaacAGCTCTGATTTCACAATAAACCATTGGAATATTTATGGATGA
>TCONS_00012515
ATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTCTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATTTTGGAAATTCAGGAGGGCCTCTCATAAACCTGGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCGGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCGAAGAACTAAGGATGCGAGACCCGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAAGGTGAACACGTCGGAGGAGATATATAATGCTGTGAGGACCAGCGAAAGCTTAAATGTGGTGGTCCGCCGGGGGGCCGACCTGCTCATGCTGCACATGACCCCAGAGTCCACAGAGTGA
>TCONS_00012518
cagaatcctctaCCAACGTTGCGTCTTGGCAAGTCATCTGATGTGCGTCAAGGTGAATTTGTGGTTGCCATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTCTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATTTTGGAAATTCAGGAGGGCCTCTCATAAACCTGTGAGAAAGGACCCACATTTGTGGACTACAGTGGTCTTCTAACACGCAACAAAATTATGtttgtaagaaacatttttacccgagagctttttgtattataaatggtgaaatccagatttgccactcgtcttcttttaaaaaaagacgcaAATCCAGTTcgcgttgattgtcctgtctctacggatTTGGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCTATTCCCTCAGACAGAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCGGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCGAAGAACTAAGGATGCGAGACCCGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAAGGTGAACACGTCGGAGGAGATATATAATGCTGTGAGGACCAGCGAAAGCTTAAATGTGGTGGTCCGCCGGGGGGCCGACCTGCTCATGCTGCACATGACC
>TCONS_00012516
GGCTTTTATGTTTGGAAGGCCATTTTTGCAAttgattttttacagtttactttTACCACAGTTCTAGTACATGGCCATATAGTCTGACATAATGTCATTGTGTTCTctgtcttgtcccagaatcctctaCCAACGTTGCGTCTTGGCAAGTCATCTGATGTGCGTCAAGGTGAATTTGTGGTTGCCATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTCTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATTTTGGAAATTCAGGAGGGCCTCTCATAAACCTGGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCTATTCCCTCAGACAGAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCGGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCGAAGAACTAAGGATGCGAGACCCGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAAGGTGAACACGTCGGAGGAGATATATAATGCTGTGAGGACCAGCGAAAGCTTAAATGTGGTGGTCCGCCGGGGGGCCGACCTGCTCATGCTGCACATGACC
>TCONS_00012517
GACACCCCTTTTCTGGTCGTGAGGTACCCATCTCGAATGGCTCTGGCTTTATAaatcctctaCCAACGTTGCGTCTTGGCAAGTCATCTGATGTGCGTCAAGGTGAATTTGTGGTTGCCATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTCTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATTTTGGAAATTCAGGAGGGCCTCTCATAAACCTGGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCTATTCCCTCAGACAGAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCGGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCGAAGAACTAAGGATGCGAGACCCGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAA
>TCONS_00012519
GGCACACATCGACGAGCGTATGTCAAGAGCATTCAGCCATATATTCCTTATTAAATAGGTTTACTATCATTATCTTCACTTAGACTTTAGGTAATGTATTCGACGCAGTGATGTGAAGTCCTGTTTCTATCGGGATTGAGTGTTTTCAACATCTGATGCAACATGGCAACCTCGCATGTTAATCGCTGTCTCCTAAGGACAATTACGAGATGTCATCGGGACAGCAGCCGGCAGCTGAACTTGACGACAGTAAGGGCATTAGGACACTTTTCTAACTTTTCTTCAGGTAAAGAGGAACACGTTGAAACTGTGGATCCACCGCGGGACTTTCTTTTCAGACACCCCTTTTCTGGTCGTGAGGTACCCATCTCGAATGGCTCTGGCTTTATAGTAAGTAGTGATGGCCTGATAGTGACAAATGCCCATGTGGTCGCCAACAAGCGTGGTGTTCGTGTCAAACTGACCAATGGTGAGACTTACAACGCCACAGTTCAGGATGTGGACCAGGCTGCAGACATCGCCACCATCAAAATCAATGTTAAG

Function

symbol description
htra2 Enables identical protein binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; cellular response to retinoic acid; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including chromatin; cytosol; and mitochondrial intermembrane space. Part of serine-type endopeptidase complex. Implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Biomarker of Alzheimer's disease; endometrial cancer; ovarian cancer; prostate cancer; and stomach cancer.

GO: NA

KEGG:

id description
ko04210 Apoptosis
ko04214 Apoptosis - fly
ko04215 Apoptosis - multiple species
ko05012 Parkinson disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko01002 Peptidases and inhibitors
ko03110 Chaperones and folding catalysts

Ensembl:

ensembl_id ENSDARG00000069909

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012514 False 1970 mRNA 0.45 8 9288383 9300299
TCONS_00012515 False 588 mRNA 0.49 7 9288822 9291499
TCONS_00012518 False 841 lncRNA 0.46 7 9288840 9291568
TCONS_00012516 False 771 lncRNA 0.47 6 9288840 9291685
TCONS_00012517 False 604 mRNA 0.48 7 9288940 9295890
TCONS_00012519 True 543 processed_transcript 0.46 2 9295685 9300241

Neighbor

gene id symbol gene type direction distance location
XLOC_006448 HTRA2 coding downstream 3973 9261815 ~ 9284410 (-)
XLOC_006447 HTRA2 coding downstream 30652 9240925 ~ 9257731 (-)
XLOC_006446 si:dkey-33c12.11 coding downstream 75168 9188209 ~ 9213215 (-)
XLOC_006445 HTRA2 coding downstream 104205 9165861 ~ 9184178 (-)
XLOC_006444 HTRA2 coding downstream 197029 9074797 ~ 9091354 (-)
XLOC_006450 mrps26 coding upstream 3255 9303554 ~ 9311253 (-)
XLOC_006451 si:dkey-33c12.3 coding upstream 13478 9313777 ~ 9318891 (-)
XLOC_006452 BX901922.1 coding upstream 33018 9333317 ~ 9335891 (-)
XLOC_006453 si:dkey-33c12.4 coding upstream 39620 9339919 ~ 9368535 (-)
XLOC_006454 grxcr1b coding upstream 140027 9440326 ~ 9442942 (-)
XLOC_006338 rn7sk misc downstream 8462158 825904 ~ 826225 (-)
XLOC_006471 BX537274.2 misc upstream 964442 10264741 ~ 10264905 (-)
XLOC_006437 NA non-coding downstream 511906 8760694 ~ 8776477 (-)
XLOC_006435 BX004962.2 non-coding downstream 632936 8655119 ~ 8655447 (-)
XLOC_006434 BX004962.1 non-coding downstream 638332 8649711 ~ 8650051 (-)
XLOC_006428 NA non-coding downstream 1058218 8168713 ~ 8230165 (-)
XLOC_006426 NA non-coding downstream 1539182 7747111 ~ 7749201 (-)
XLOC_006458 NA non-coding upstream 201468 9501767 ~ 9558425 (-)
XLOC_006467 NA non-coding upstream 776916 10077215 ~ 10118935 (-)
XLOC_006468 NA non-coding upstream 850620 10150919 ~ 10232078 (-)
XLOC_006469 NA non-coding upstream 949875 10250174 ~ 10253034 (-)
XLOC_006472 NA non-coding upstream 974987 10275286 ~ 10346890 (-)

Expression


Co-expression Network