XLOC_006504 (adh8b)


Basic Information

Item Value
gene id XLOC_006504
gene name adh8b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 12633223 ~ 12646752 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012606
GGCGTAGTCTTTTGTATGTCCAGTTCTGCATGTTTGTTAGTCTCAAAGTGTGTGTGCAGTCCTAGTTGTTTGCATACCGCGCACTAAATCCAAAACAGCAGATTTTTTGCTGTGATTTTTGACCTTCCTGCGTCCACATCTTGTGAAACAATACGACTACACTGGGAAATGGCCACTGCAGGGAAGGTGATCAAATGTCGGGCCGCTGTTGCCTGGGAGCCCAAGGCTCCCCTGGTAATGGAGGAAATAGAAGTTGCCCCACCACAGGAAGGAGAAGTTCGAATTAAGATTTTATATACAAGTCTGTGTCACACAGACCTTTTTCATCTCTTGGAGTCGACAGACAATAAAGGTTTTCCCACTATACTGGGGCATGAAGCAGCTGGAGTGGTAGAGAGCGTTGGACCTGGAGTCACTGAATTCAAACCAGGTGATAAGGTCATTCCAAATTCTGGCTGTCAGTGCAGAGAATGCAAGTTCTGCAAAAGTCCCAGAACAAATCTGTGTGAGCGCAGCTGggTAAATGATCATATTGAATATATGTCATATCCCAAAACAAGTTTCACCTGCCGGGGTAAGCCCATCCTGCAGTTCACCAACACAGGAACTCTGGCCGAGTACATCGTTATTAGACAGATTTATGTGGTAAAGATTGATGATGATGCTCCTCTGGACCGCGTGTGTCTGCTGGGCTGTGGAGTCACTACTGGATACGGAGCTGCCGTCAACTCGGCTGGGGTTACTCCAGGCTCTGTGTGTGCCGTGTTTGGACTTGGTGCGGTTGGTCTAGCTGCAGTCATGGGCTGTAAAAACGCCGGAGCATCTCGCATCTTTGCTGTGGATATCAATGAAAAGAAGTTTGAGAAGGCCAAGGTGTTCGGAGCCACAGATTTCCTGAATCCGAAAGCATACAATAAACCCATCTCTGAAGTGCTGATAGAAATGACCAATGGAGGAGTGGACTTCTCTCTGGAGTGTGTGGGCAACACTGAAGTATCGAGGCTTGCACTGGAGTCGTGTGCTAAAGGTTGGGGTTTGAGTGTTTTGGTTGGATACACTAATACGGACTTCTCTTCAAAGCCAATTCAACTCATATATGGAAAAACCTGGAAGGGAACTCTTTTAGGAGGTTTTAAGATCAAAGACGGTGTTCCAAAACTGGTTCTGGACTACATGTCTGGCAAAATAATGCTGGATGAGTTTATAACTCAAAGAATGAAACTGGAGCAAGTCAATGATGTCGTCAAACTCATGAAGAATGGAGAATGCATTCGATGCATCCTGGATATGTCCAAATAAGAGGGAAATTATCTTCACCATACTGACCTCTACAGTACAAGACAAACAGATGGAAATGGAGACATTCCATACAAGTTTAATGTACTGTAGATGTAACTTAAGTGTGTCAATCTTGTACTCCAATTATGATTATAAGCTCCTGAACGATCTTGTCACGTGTTGAAAAATGTGATTCTTTGttgcgcataaaaaaaaaacaaataaagaagaaaatataCTTTA
>TCONS_00012607
CAGCAATACGACTACACTGGGAAATGGCCACTGCAGGGAAGGTGATCAAATGTCGGGCCGCTGTTGCCTGGGAGCCCAAGGCTCCCCTGGTAATGGAGGAAATAGAAGTTGCCCCACCACAGGAAGGAGAAGTTCGAATTAAGATTTTATATACAAGTCTGTGTCACACAGACCTTTTTCATCTCTTGGAGTCGACAGACAATAAAGGTTTTCCCACTATACTGGGGCATGAAGCAGCTGGAGTGGTAGAGAGCGTTGGACCTGGAGTCACTGAATTCAAACCAGGTGATAAGGTCATTCCAAATTCTGGCTGTCAGTGCAGAGAATGCAAGTTCTGCAAAAGTCCCAGAACAAATCTGTGTGAGCGCAGCTGggTAAATGATCATATTGAATATATGTCATATCCCAAAACAAGTTTCACCTGCCGGGGTAAGCCCATCCTGCAGTTCACCAACACAGGAACTCTGGCCGAGTACATCGTTATTAGACAGATTTATGTGGTAAAGATTGATGATGATGCTCCTCTGGACCGCGTGTGTCTGCTGGGCTGTGGAGTCACTACTGGATACGGAGCTGCCGTCAACTCGGCTGGGGTTACTCCAGGCTCTGTGTGTGCCGTGTTTGGACTTGGTGCGGTTGGTCTAGCTGCAGTCATGGGCTGTAAAAACGCCGGAGCATCTCGCATCTTTGCTGTGGATATCAATGAAAAGAAGTTTGAGAAGGCCAAGGTGTTCGGAGCCACAGATTTCCTGAATCCGAAAGCATACAATAAACCCATCTCTGAAGTGCTGATAGAAATGACCAATGGAGGAGTGGACTTCTCTCTGGAGTGTGTGGGCAACACTGAAGTATCGAGGCTTGCACTGGAGTCGTGTGCTAAAGGTTGGGGTTTGAGTGTTTTGGTTGGATACACTAATACGGACTTCTCTTCAAAGCCAATTCAACTCATATATGGAAAAACCTGGAAGGGAACTCTTTTAGGAGGTTTTAAGATCAAAGACGGTGTTCCAAAACTGGTTCTGGACTACATGTCTGGCAAAATAATGCTGGATGAGTTTATAACTCAAAGAATGAAACTGGAGCAAGTCAATGATGTCGTCAAACTCATGAAGAATGGAGAATGCATTCGATGCATCCTGGATATGTCCAAATAAGAGGGAAATTATCTTCACCATACTGACCTCTACAGTACAAGACAAACAGATGGAAATGGAGACATTCCATACAAGTTTAATGTACTGTAGATGTAACTTAAGTGTGTCAATCTTGTACTCCAATTATGATTATAAGCTCCTGAACGATCTTGTCACGTGTTGAAAAATGTGATTCTTTGttgcgcataaaaaaaaaacaaataaagaagaaaatataCTTT
>TCONS_00012608
GTTAGTCTCAAAGTGTGTGTGCAGTCCTAGTTGTTTGCATACCGCGCACTAAATCCAAAACAGCAGATTTTTTGCTGTGATTTTTGACCTTCCTGCGTCCACATCTTGTGAAATTCAGGAGGCTACAGAGACGAAGAGAGGGAGTGTGCAAGAGCACATGATTGCTTCATCCGTTTAAAACTAGGGTATAAAAACTACTGCCAGAGGATCTCATTGTCTCTTTGCATTCACAGCAATACGACTACACTGGGAAATGGCCACTGCAGGGAAGGTGATCAAATGTCGGGCCGCTGTTGCCTGGGAGCCCAAGGCTCCCCTGGTAATGGAGGAAATAGAAGTTGCCCCACCACAGGAAGGAGAAGTTCGAATTAAGATTTTATATACAAGTCTGTGTCACACAGACCTTTTTCATCTCTTGGAGTCGACAGACAATAAAGGTTTTCCCACTATACTGGGGCATGAAGCAGCTGGAGTGGTAGAGAGCGTTGGACCTGGAGTCACTGAATTCAAACCAGGTGATAAGGTCATTCCAAATTCTGGCTGTC
>TCONS_00012609
TCTGCATGTTTGTTAGTCTCAAAGTGTGTGTGCAGTCCTAGTTGTTTGCATACCGCGCACTAAATCCAAAACAGCAGATTTTTTGCTGTGATTTTTGACCTTCCTGCGTCCACATCTTGTGAAACAATACGACTACACTGGGAAATGGCCACTGCAGGGAAGGTTCGTAAACTTGTCTTTTGGTCTGTTTTCATTTGTGCTGCAGAGCAGTTCATGCATTTTTAATACAACTATATGTTTAACCTCATGTCCTTTTACCTATTGATCACGTTTACAAATTTGCAATGCAAAAAGTCCTACTGTGAAGTCTAATGTTATACACAGAAGACTGCTGTGGACATTTGGAGAtattcttttataatttttttgatgaGTATTAGTATAATACATGACTATAATATGGCTTAATAGTATTGCTTTGCTAACCATATTGACTTACTGAAAAGATTAAATTGTGTAAAAAGACTACATGAAAAGGTTTAGACATCAAAcgctaaagtgacatttgtgcATTCATATTTTACTTTAAGTCTTTTAAAGAAATTTGTAATGTTTTAGTCTCCCACTTCATCAACTCAAATAGACACTAGCACTAAATGAGCTCTTACAGTTTCACTGAGTTAATATTTAGCTTTAGAGATAGAGAAATCAGATAGTTGTGGCTCTAAAATGTGTTAATGTTTTCATTGGCTGGACAAACTCCAACTGAAGTCAGTGAGTACAGATC

Function

symbol description
adh8b Enables alcohol dehydrogenase (NAD+) activity and formaldehyde dehydrogenase activity. Acts upstream of or within formaldehyde metabolic process and octanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).

GO:

id name namespace
GO:0006066 alcohol metabolic process biological_process
GO:0006070 octanol metabolic process biological_process
GO:0046292 formaldehyde metabolic process biological_process
GO:0046294 formaldehyde catabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005829 cytosol cellular_component
GO:0046872 metal ion binding molecular_function
GO:0018467 formaldehyde dehydrogenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0004022 alcohol dehydrogenase (NAD+) activity molecular_function
GO:0004024 alcohol dehydrogenase activity, zinc-dependent molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030529-2 Enables alcohol dehydrogenase (NAD+) activity and formaldehyde dehydrogenase activity. Acts upstream of or within formaldehyde metabolic process and octanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).

Ensembl:

ensembl_id ENSDARG00000024278

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012606 False 1521 mRNA 0.44 10 12633223 12646752
TCONS_00012607 False 1375 mRNA 0.44 9 12633224 12645584
TCONS_00012608 False 545 lncRNA 0.46 5 12642268 12646717
TCONS_00012609 True 727 lncRNA 0.35 2 12644979 12646728

Neighbor

gene id symbol gene type direction distance location
XLOC_006503 lrit3b coding downstream 30303 12591508 ~ 12602920 (-)
XLOC_006502 NA coding downstream 45811 12586997 ~ 12587412 (-)
XLOC_006501 enpep coding downstream 51835 12543634 ~ 12581388 (-)
XLOC_006500 si:dkey-20i10.7 coding downstream 138648 12488863 ~ 12494575 (-)
XLOC_006499 lamtor3 coding downstream 147147 12479264 ~ 12486076 (-)
XLOC_006505 adh8a coding upstream 7223 12653975 ~ 12660318 (-)
XLOC_006506 fam241a coding upstream 18114 12664866 ~ 12667220 (-)
XLOC_006507 NA coding upstream 101900 12748652 ~ 12756661 (-)
XLOC_006508 nsd2 coding upstream 347099 12993851 ~ 13030851 (-)
XLOC_006509 fgfr3 coding upstream 566815 13213567 ~ 13294872 (-)
XLOC_006471 BX537274.2 misc downstream 2368318 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 11806998 825904 ~ 826225 (-)
XLOC_006497 NA non-coding downstream 514973 12117113 ~ 12118250 (-)
XLOC_006496 CR792443.1 non-coding downstream 527329 12105778 ~ 12105894 (-)
XLOC_006492 CR792443.2 non-coding downstream 658655 11974452 ~ 11974568 (-)
XLOC_006482 CR556710.1 non-coding downstream 1067360 11565736 ~ 11565863 (-)
XLOC_006510 NA non-coding upstream 940544 13587296 ~ 13590570 (-)
XLOC_006511 CR788322.1 non-coding upstream 997693 13644445 ~ 13644562 (-)
XLOC_006513 CR788322.4 non-coding upstream 1023688 13670440 ~ 13670537 (-)
XLOC_006514 NA non-coding upstream 1090790 13737542 ~ 13740560 (-)

Expression


Co-expression Network