XLOC_006505 (adh8a)


Basic Information

Item Value
gene id XLOC_006505
gene name adh8a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 12653975 ~ 12660318 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012610
atctctttctctcttttcattCATCACAGCAATACGACTACACTGGGAAATGGCCACTGCAGGGAAGGTGATCAAATGTCGGGCCGCTGTTGCCTGGGAGCCCAAGGCTCCTCTGATGATGGAGGAAATAGAAGTTGCCCCACCACAGGAAGGAGAAATACGAATTAAGGTTATAGCTACAGGACTTTGTCACACCGACCTTTACCATCTGGTTGATGGGGACAAGCGAGGTTTTCCTGTCGTACTGGGACACGAGAGCGCTGGTGTAGTGGAGAGTGTTGGGCCTGGAGTCACTGATTACAAACCAGGTGATAAGGTCATCCCCCTCTTCCTCTCTCAGTGTGGAAAATGCAAGTTCTGCAAGTGTccaaaaacaaacctgtgtgaAAGCAGCTGGGCAACTAAATATCATGACATTATGGCTGAACCTACAAGCCGCTTCACTTGCCGTGGCCAGACCATCTTGCAGTTCATGGGAACCAGCACCTTCTCCGAGTACACCGTCATCAACCAAAATGCTGTGGCAAAGATTGACGAAAATGCTCCTCTCGACCGCGTGTTTTTGCTCGGCTGCGGCATCACTACTGGTTATGGAGCTGCAGTCAACACAGCTGGGGTTACTCCAGGCTCTGTGTGTGCTGTATTCGGACTCGGTGCTGTCGGTCTGGCTGCAGTCATGGGCTGTAAAAACGCCGGAGCATCTCGCATCTTTGCTGTGGATATCAATGAAAAGAAGTTTGAGAAGGCCAAGGTGTTTGGAGCCACAGATTTCCTGAATCCGAAAGCATACAATAAACCCATCTCTGAAGTGCTGATAGAAATGACCAATGGAGGAGGAGTGGACTTCTCAATCGAGTGCACGGGGAACACTGAAGTAATGAGAAGTGCGCTGGAGTCGTGTGCTAAAGGTTGGGGTGTGAGCGTTGTGGTTGGATGGACTAATGTGCAAGACTTTTCTGCAAAGCCAATTCAGCTCATATATGGGAAAACCTGGAAAGGATCTCTGTTTGGAGGTTTTAAGTGCAAGGATTCAGTTCCGAAACTGGTTCGTGACTACATGTCTGGCAAAATAATGCTTGATGAGTTTATAACCCACAAAATGAATCTGGAGCAGGTCAACGATGCCATCAACCTCATGAAAACTGGACAAGGCATTCGAACCATCATGACTGTATCCAAATGAGAAGCAAACTGTCGTCACAGGACCAGTTTCTACACTACAGTTATTGTGATTAGCTTTCTCTGCAGCTGTTTGCATTCCATGATCCTCTTTAATGGCATATTGCATCTGCTTTATGAAGTGATTCATAAGTGCATGTAAACATTTAACACTAAACACTGTTCTATTCATCTGCAAGGCAAAACGCTTCTGAAATATTTTGCAAGAAAAAGTAATCCTTGGCAAATAAAAAAGAGACAAGCATATATAAATC
>TCONS_00012611
ttactgtGCAAATATATGATATATGCAATATATCAATATCAAATAATTCTACTgtgcagatttattttatttcattattattattttttatgtatttaggccattccaaagtattttttttgtattctagcATTCAAGTTTTCTTTCACAGGTAATTTGATCGGGTTAATATTTATCTGAGATTGTGAAATGTGTAGCTAAAAACAGATGTTTCATATTTCCACTTGATGCTTCCAAACCAAACAGCTGGACAAGCTCCAACTACAGTTGGAGAGCAGATCAGGCAACGCTTAAGCACAGCAGCGGTTATATAAACATCTGTAGTCAatcattaaatatataaaacaagctGAGCCAATTTCTTCTGTATGCCGAAGGTGATCAAATGTCGGGCCGCTGTTGCCTGGGAGCCCAAGGCTCCTCTGATGATGGAGGAAATAGAAGTTGCCCCACCACAGGAAGGAGAAATACGAATTAAGGTTATAGCTACAGGACTTTGTCACACCGACCTTTACCATCTGGTTGATGGGGACAAGCGAGGTTTTCCTGTCGTACTGGGACACGAGAGCGCTGGTGTA

Function

symbol description
adh8a Enables alcohol dehydrogenase (NAD+) activity. Acts upstream of or within cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).

GO:

id name namespace
GO:0006066 alcohol metabolic process biological_process
GO:0006067 ethanol metabolic process biological_process
GO:0046294 formaldehyde catabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0071466 cellular response to xenobiotic stimulus biological_process
GO:0005829 cytosol cellular_component
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0004022 alcohol dehydrogenase (NAD+) activity molecular_function
GO:0004024 alcohol dehydrogenase activity, zinc-dependent molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030529-3 Enables alcohol dehydrogenase (NAD+) activity. Acts upstream of or within cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).

Ensembl:

ensembl_id ENSDARG00000091211

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012610 False 1433 mRNA 0.46 9 12653975 12660318
TCONS_00012611 True 578 lncRNA 0.39 2 12659113 12659765

Neighbor

gene id symbol gene type direction distance location
XLOC_006504 adh8b coding downstream 7223 12633223 ~ 12646752 (-)
XLOC_006503 lrit3b coding downstream 51055 12591508 ~ 12602920 (-)
XLOC_006502 NA coding downstream 66563 12586997 ~ 12587412 (-)
XLOC_006501 enpep coding downstream 72587 12543634 ~ 12581388 (-)
XLOC_006500 si:dkey-20i10.7 coding downstream 159400 12488863 ~ 12494575 (-)
XLOC_006506 fam241a coding upstream 4548 12664866 ~ 12667220 (-)
XLOC_006507 NA coding upstream 88334 12748652 ~ 12756661 (-)
XLOC_006508 nsd2 coding upstream 333533 12993851 ~ 13030851 (-)
XLOC_006509 fgfr3 coding upstream 553249 13213567 ~ 13294872 (-)
XLOC_006510 NA coding upstream 926978 13587296 ~ 13590570 (-)
XLOC_006471 BX537274.2 misc downstream 2389070 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 11827750 825904 ~ 826225 (-)
XLOC_006497 NA non-coding downstream 535725 12117113 ~ 12118250 (-)
XLOC_006496 CR792443.1 non-coding downstream 548081 12105778 ~ 12105894 (-)
XLOC_006492 CR792443.2 non-coding downstream 679407 11974452 ~ 11974568 (-)
XLOC_006482 CR556710.1 non-coding downstream 1088112 11565736 ~ 11565863 (-)
XLOC_006511 CR788322.1 non-coding upstream 984127 13644445 ~ 13644562 (-)
XLOC_006513 CR788322.4 non-coding upstream 1010122 13670440 ~ 13670537 (-)
XLOC_006514 NA non-coding upstream 1077224 13737542 ~ 13740560 (-)

Expression


Co-expression Network