XLOC_006508 (nsd2)


Basic Information

Item Value
gene id XLOC_006508
gene name nsd2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 12993851 ~ 13030851 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012613
GACGTCAGATGGTGAGAATTGCCCTCCTCAATTCCTCGAGCAGTGATCTGTGTCGCTTTGCcattttttgaaataaaaacaaaaacaggtgaTCTGAGAATTGCATGGCTTTGTCTGTACCCACGGGCCCGCGATGGAGTTTGGAGTACGCCGAGGATAAGTGACGATGTTCGTCGGAGAGTCCGCCGCGAACAGAGAGATATTTGAAAAGGCCGGTTGAATTGTGCAGTCGCGTGTCAGCCAATCGGATGCCCCTGGATTACAATGACAGACAGTAAGGGGGGATCGCTGCCTGCAATGCCAGAGCCCAAGAGTCCTACTAGCATGAAACAGCTGTCGGATTCACCCGGTGGACGTAACGGTCTGGTTGATGGGATCACTGATCCTACAATGCTCATGAATAAAGCTGCTACCCAGCTGGCAGCAACACCTCAAGAAAGTGTTCCGCAGATGATTGGCAGTCACGGTCATAACCACACCCACGAGCATCTAAAGGACCTGACGTCCCGCTTGTTAAATGGCGATACAGAAAAAATTCCAAAGCTCTGTGCAGCCCCTGCCGGACAGCCTCTTTTGAAAGGGGTTGAACCTGTTTCTCAACATGCCAGCCCTCCAAGGAAGACCAGCGTTTCTCCTGAACTTACTGTCAAAATAACCAAATGCGTGGTTAATTTAGGTGGGAAGCCAAACCGGTATGAAGTAGATTATACTGAGGAGAAAGCTGAGGAGACGGATGCACCTTTGAGACTACCAGAAGGGGTTCTCACCTCTCCAACTGCCAGGAGAGATAGACAAAAGAAGAAGGGTATGGTGAGGAAGAGGATCCCACCTTATCCAATCTTAACCCATGCTGCAAGTTCTGATCAATCTCCTCTACTGCACCCCACCATAAATTCAAATGACATCACTATTGAACCGTGTGGTCTTCCTGTTGAGTCCATTGAGCACACTCATGGAGACATGCCTACTTGTGTAACTGCCTTTCCAGATGAGCAACCGTTGTCTGACTGTGAAGAGACTGTTGATGCACAGGGTGTGGATGAGACTGATGATGCACAGGGTGAGAATGATGTAAAGGAGAGTTATACCGAAACTCAATCCAATGTGCATTTCTCAGTGGGAGATGTCATCTGGACCAAAGTGTCTGGATATCCATGGTGGCCGTGTATGATCACTACAGACCCGGAGTTTAACATGCACTTTAGGTCAAAAGtGAATAGCCGTACAGGATTATTGTACCATGTACAGTATTTTGGAGATACTCCAGAAAGAGGATATGTTTTTGAGAAGTGCATAGTCACCTTCTCAGGGAAACACCAATACCAGTCACTTAGCCGCAGCAACCAGCTCCCCATTAATATCAGTGGAAGGAAGCGGGCAGTTCCTCGTAAGTTTCGGCAAAAGTGGGAAATAGGTGTGTCACAAGCAAAAGAAGCTTTGGGCCTGCTAACAGAGGAGCGGCTGgccaaatttagctttgtttatGAAGATGGCAAAGCCCAGCTCAACCCTCATATGCTTCAAGTGCTTGAGGAGCAACGCAATCAGGgactgcaggaagagccagttcagAGAGAGCCCCAGGAGCTTGTCAGCCTCACGCCACCTGACTCCACTCATTCCAGCCCCACAAACTCCTCAACAACATCCACAATCCCAAGCCTCTTCTCCAACCCCATAGACAGCAGCACTTCATCAGGGAAAACCGCCCTCCCCAGGAAAGCACGTAAACCGTCAGTGAAGACGAATCGCCGCAAACAGCGCAGCTCGACAATAGAGTGGATAGTGACTGAAGCTTCCTCTGCAAAACAAATGCCCCTGACTGAGTCTACTGTTCAGTGCGAGGTTAATACAGAGCACAAGAAGAAAGGAAAGACAAATGCTGGGAAACGGCCTTACcggaaaaaaGATCTGCTCTGTATTGATCTGGACCTTCAGCCAAAAGCTTCTCAGAAGAAACCAAGACACATCAGGCAGAAGTTTCCTGCAGCACCAAATTCAGTGAAGAAAAGGAAAATTAAAGCAGGAGTCAGTATCTGTGACACGTTAAACACAGTGTCTACTAGTGCAGGACTTTCAGaagtaaAGGCATCTGCACCAAGCACAAAACTCTGGGAGAAGGAAGATGCCTCTtctaaagGAATGAAAAAGGTCTGCAAGCGTTCACGAGAGTCAAAGCAGGATGTGACATTGCAGCCTAAGAAGAAAAGCAAGcttgaaaaagattttaaaaaatggaaaTGCCCAAAGGCAGCATCATCTGCACCGGCTGCTGTTCCTGCACCCAGGGGGAGGAGGCGGAAAACAGACAGAGATGAAAATAGGAAACGATCTAAAAAAGCCTCAAaaGAGGAACCTCCTCCTAAAGCCAAACGTGGTCGCAAGCGGAAAGAGGAGTCGGGCAGGCAATCCTTTCCTGCCTCCAAAAAGTGCCGCCCATCATCTTACGCTGAGCCAGAGAGACCCGATTCTCCCAGTGACAGTACAGACGAATCGCATCCCTCAAAAAAGGCCGAACGCACTCCAGGTGCCAAGAAAGAGAGCGTGTGTCTGGTGTGTGAGCAGACCGGGGAGGATATTGTGACGTGTGCGGGACAGTGCTATGGCACATATCATCTGCATTGTATTGGAGTAGAGCGGTCAGCAGAAAAGATCCTGTGCACTGCCTGCAGTACAGgtgtgcatgtgtgtttcacCTGCAAGAAGTCTGAAGGAGAGGTGCGGCGCTGCTGTGCGCTCCACTGTGGCCGTTTCTATCATGAGGCCTGCGTGCGGTTGAGTGCTCTGACCGTGTTTGAAAACCGAGGCTTCCGCTGCCCGCTGCACACCTGCCTCAGCTGCCACTACAGTGGACGCGCCGCCTGCAAGGCCACCAAAGGAAAGATGATGCGATGTTTGCGGTGTCCTGTGGCCTATCATGTGGGAGACCTGTGTGTGGCTGCAGGCAGTGAGATGATCTCTTCCTCTGCCATTGTGTGCACAAACCACTTCAGGGCTAAGAAAGGCTACAGTCACCACTCGCATGTCAACGTCAGCTGGTGCTTTATCTGCTCAAAAGGTGGCCGTCTGCTGTGTTGCGAGTCTTGTCCGGCTGCGTTTCACCCTGATTGTCTGAACATCGCTATGCCTGATGGCAGCTGGTTTTGCAATGACTGCCGCTCAGGAAAGAAACCTAAATACAGGGATGTCATCTGGGTCAAACTGGGGAACTACAGATGGTGGCCTGCAGAGATCCGTCATCCCAAGAACATCCCAACCAACATCCAGCACCTGCGTCATGAGATTGGAGAGTTCCCCGTCTTCTTCTTTGGCTCTAAAGACTATTTCTGGACGCATCAGGGTCGAGTTTTTCCTTACATGGAGGGAGACAGGGGAAGCAAGTACCAGCAGACTGGCATTGGGAAGGTCTTTAAGAATGCCCTGCTGGATGCTGAAACTCGCTTTAAGGAGATCGAGATGGAGAGAGAGGCAAAAGAGGCTCACGAAAATAACAAGAAGCCTCCTCCATTCAAATACATCAAGGTGAACAAGCCTTGTGGGCGAGTGCAGGTGTACACCGCAGACATCTCTGAGATCCCCAAGTGTAACTGTAAGCCGTCAACTGAGCGGCCCTGCAGCTTTGAGTCTGAGTGCCTGAACCGCATGTTGCTGTACGAGTGCCATCCTCAAGTGTGTCCGGCCGGAGAGCGATGCCAAAACCAGGACTTCACTAAACGCCTCTACCCCGAGACCAAGATCATCCGCACTGCAGGCAAAGGCTGGGGTCTGATTTCGCTGCGGGACATTAAGAAAgGCGAGTTTGTGAATGAATATGTGGGTGAGCTGATAGACGAGGAGGAGTGCAGAAGCAGAATCAGACACGCTCAGGAGAATGACATCACACATTTCTATATGCTCACTATAGACAAGGATCGGATTATAGATGCGGGACCCAAAGGGAACTACTCTCGCTTCATGAACCACAGCTGCCAGCCCAATTGTGAGACTCAAAAATGGACTGTTAATGGAGACACACGCGTGGGCCTGTTTGCAGTGTGTGACATTCCTGCTGGCACTGAGCTGACGTTTAACTATAACCTGGACTGTTTGGGAAATGAGAAAACTGTGTGTCGCTGCGGAGCTCCCAACTGCAGTGGTTTCCTAGGAGACAGACCCAAGAATGGACATACTTCTGAGCCTAAAGCCAAACTTCAGAAGAAAAAGCCCAAACGGAAAAGGGCCCGCAATGAAGGCAAGAAGTCTGAGGATGAGTGTTTCCGCTGTGGAGATGGAGGACAGTTGGTTCTGTGTGATAAGAAGGGCTGCACCAAAGCCTATCACCTCTCCTGTCTGGACCGCACCAAGAGACCTTTCGGCCGCTGGGACTGTCCTTGGCATCACTGTGACGTGTGCGGCAAGAACTCTGCTGCCTTCTGCCAGCTGTGCCCCAACTCATTCTGCAAGGCTCACCAGGAGGGGGCGCTGCGCTCTCACCCACTCACAGGCCAGCTCTGCTGCCAGGAACATGAAGACTCCGACATCCGCCCGCAGACAGAGACCGCACAACTACCACCACCCACCAAACCACGCAAATACAGGCGCAGAGCGGAGGCCAAAACCACCAGCAAAGCACCTCTCAAGAAGAGGCCCAGAAAAAATGCAGaggtgtagtgtttgtgtgtgtgtttgtgtgtagtgcGTTCTTGAACTGTGGAAGCTCCCGCTAATCTCAGCTCCTGTCCCAAATGATTCAGTGATATTGACGTCGCGTTGACTGTTCTGGAAGCACTGTACCTGTCTGATCAGGGAAGCGTTTAACACTGTAGAGCTCCTTAAAGCTGACCATTCAGGTCCCTTCTCCACTTGTTCGGCCTCTTCATGATCTActcgagtgtgtatgtgtgtgtgtttgtttgttagtgtgtttgtGATGAATGGATGACAGGGCTGACAGACTGAAcaccataaataaacagcattacgGGCGCCAAACTTGAAACCGATTGAATCTTggcatagtttttgttttgttttttaaacagtaGATATGTATATGGAAATGTATATGAAAGaccaaaattataataatactggATTTATTGTTAGTTACAGGTGCCAAGAGTCCTTTGTTTTTTAACAAGTGTTATGGTTAAATAAGACACTATGGGTAgccatttcattttttgttttgttttgttttagagtCAGTTTCTTTAACTGTAGagcagcacattttttttaagcTTGGTTCATTTTTTTGTACCATTCTAGAGTTTGAGTTACCAGAATGTTAGGCTGGTGAATCTACCTATTCAGAGTTTTAAAAGTGAATCATGACGGGCTTCTTGTGATACAAGAAATAAAGCTGGTTTTAagca

Function

symbol description
nsd2 Predicted to enable histone methyltransferase activity (H3-K36 specific). Acts upstream of or within cartilage development; embryonic skeletal system development; and histone H3-K36 dimethylation. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including fin; immature eye; nervous system; neural plate; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0051216 cartilage development biological_process
GO:0097676 histone H3-K36 dimethylation biological_process
GO:0010452 histone H3-K36 methylation biological_process
GO:0048706 embryonic skeletal system development biological_process
GO:0000785 chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0046872 metal ion binding molecular_function
GO:0046975 histone methyltransferase activity (H3-K36 specific) molecular_function
GO:0018024 histone-lysine N-methyltransferase activity molecular_function

KEGG:

id description
ko00310 Lysine degradation
ko05202 Transcriptional misregulation in cancer
ko03036 Chromosome and associated proteins

ZFIN:

id description
ZDB-GENE-030131-2581 Predicted to enable histone methyltransferase activity (H3-K36 specific). Acts upstream of or within cartilage development; embryonic skeletal system development; and histone H3-K36 dimethylation. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including fin; immature eye; nervous system; neural plate; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2).

Ensembl:

ensembl_id ENSDARG00000026225

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012613 True 5357 mRNA 0.49 24 12993851 13030851

Neighbor

gene id symbol gene type direction distance location
XLOC_006507 NA coding downstream 237190 12748652 ~ 12756661 (-)
XLOC_006506 fam241a coding downstream 326631 12664866 ~ 12667220 (-)
XLOC_006505 adh8a coding downstream 333533 12653975 ~ 12660318 (-)
XLOC_006504 adh8b coding downstream 347099 12633223 ~ 12646752 (-)
XLOC_006503 lrit3b coding downstream 390931 12591508 ~ 12602920 (-)
XLOC_006509 fgfr3 coding upstream 182716 13213567 ~ 13294872 (-)
XLOC_006510 NA coding upstream 556445 13587296 ~ 13590570 (-)
XLOC_006511 CR788322.1 coding upstream 613594 13644445 ~ 13644562 (-)
XLOC_006512 pimr47 coding upstream 629713 13660564 ~ 13662624 (-)
XLOC_006513 CR788322.4 coding upstream 639589 13670440 ~ 13670537 (-)
XLOC_006471 BX537274.2 misc downstream 2728946 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 12167626 825904 ~ 826225 (-)
XLOC_006502 NA non-coding downstream 406439 12586997 ~ 12587412 (-)
XLOC_006497 NA non-coding downstream 875601 12117113 ~ 12118250 (-)
XLOC_006496 CR792443.1 non-coding downstream 887957 12105778 ~ 12105894 (-)
XLOC_006492 CR792443.2 non-coding downstream 1019283 11974452 ~ 11974568 (-)
XLOC_006514 NA non-coding upstream 706691 13737542 ~ 13740560 (-)
XLOC_006516 NA non-coding upstream 982334 14013185 ~ 14015180 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01180000_03983803_04002213 WHSC1 coding CI01180000 null 3983486 ~ 4002655 (-)
mexican tetra (Astyanax mexicanus) G177282 whsc1l1,LOC107720716,LOC107678004 non-coding NC_035916.1 CM008319.1 18493006 ~ 18494787 (+)