XLOC_006509 (fgfr3)


Basic Information

Item Value
gene id XLOC_006509
gene name fgfr3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 13213567 ~ 13294872 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012614
AAACTGTTAGTGGGAGTCTGTGAGCCAAGCTTTCACACAGCACCAAACGCCCCGCACTTCACAACCGACCCAGCGGCGCAGCGGAGCAGTTGTGCCCGGACAGCGCAGCGTAGTAGAGCGGACACTCAAAACTACCCGTGCGCTCCTTTACACGAGACAGTCGAGTGTGATTTTGATACACTTTTCACCGGTTTAAGGACTGGACAGAGTCGGACAGCTTAAGAGGCTGTGGTGAATACGACTTCTGTCCCAAACACTCCACTGACTTCGCGTCTTTCCTTTTCGCCTGGATTTGGAAACTTCAGTGGATTTGGATGATTTGCCCCCTGCATGTGATTCACGAAACATCTGGAGGGACCAGTCTTTCTTAAAAACCCAATCAACGTATTTTGTGGTGACCTTGGAAAGGATTACTGTCACGAAATAATTTGGTGGGGGACAGGCAGAcagcagtgtgtttgtgtgagtgtgtggcaGCGCTCCATTGACAGCATGTGTGGAACGGTTGAGGATGTCTGAGTCTGCTCTCCGTGGTGAGGAAAGTCGTCCCCGCGTCGCTCCGACCGGGATGGTCCCACTCTGTCTCCTCCTGTACCTCGCAACCCTCGTCTTCCCACCAGTGTACAGTGCACACCTGCTGTCCCCAGAGCCCACAGACTGGGTATCGAGTGAGGTGGAGGTGTTTCTGGAGGACTATGTGGCGGGAGTCGGGGATACAGTAGTTCTGTCCTGCACGCCGCAAGACTTCCTCCTTCCCATTGTATGGCAAAAAGACGGAGACGCCGTTTCTTCAAGCAACCGTACACGAGTGGGCCAGAAAGCCCTCCGCATCATCAATGTCTCCTATGAAGACTCGGGTGTTTACTCCTGCAGACATGCCCACAAGAGCATGCTTCTGAGCAACTACACCGTCAAAGTCATCGATTCGCTGTCCTCTGGTGATGATGAGGACTATGATGAAGATGAGGACGAGGCAGGTAATGGAAATGCAGAAGCTCCATACTGGACCCGTTCGGACCGGATGGAGAAGAAACTATTGGCTGTTCCTGCTGCCAATACAGTCAAGTTCCGCTGTCCTGCTGCTGGCAACCCAACGCCCAGTATCCATTGGCTGAAAAATGGCAAGGAATTCAAGGGAGAGCAGAGAATGGGCGGCATTAAGCTGAGGGATCAGCAGTGGAGCTTGGTCATGGAGAGTGCCGTTCCATCCGACCGGGGAAATTACACATGTGTGGTGCAGAACAAATACGGGACAATCAAGCACACTTATCAACTCGATGTGCTGGAGCGCTCCCCTCACCGGCCCATCTTACAGGCAGGACTGCCAGCCAATCAGACGGTAGTGGTGGGCAGTGATGTGGAGTTCCACTGTAAGGTGTACAGTGATGCTCAGCCACACATCCAGTGGCTGAAACACATTGAAGTCAATGGAAGCCAATATGGGCCCAATGGCGCCCCCTACGTCAATGTTCTTAAGACTGCTGGGATAAATACTACGGATAAAGAGCTGGAGATTCTCTACCTGACCAATGTGTCTTTCGAGGATGCGGGGCAATACACTTGTCTGGCAGGGAACTCGATTGGCTATAACCATCACTCTGCTTGGCTTACAGTCTTACCAGCGGTGGAGATGGAGAGAGAGGATGATTATGCAGACATCCTCATCTATGTGACAAGCTGCGTGCTCTTCATTCTCACCATGGTCATCATTATTCTCTGCCGAATGTGGATAAACACGCAGAAGACTCTCCCGGCACCACCTGTTCAAAAACTGTCCAAATTCCCCCTCAAGAGACAGGTGTCCTTGGAATCCAACTCTTCCATGAATTCAAACACCCCGCTGGTCAGGATCGCCCGCCTGTCATCCAGCGATGGGCCGATGTTGCCTAACGTGTCTGAACTTGAACTGCCCTCTGACCCCAAGTGGGAGTTTACTCGAACAAAGTTAACGTTGGGGAAACCGTTGGGAGAGGGCTGCTTTGGGCAGGTGGTGATGGCTGAAGCCATTGGGATTGACAAAGAAAAACCCAACAAACCTCTAACTGTTGCTGTCAAGATGCTCAAAGATGACGGCACAGATAAAGACCTGTCAGACCTTGTGTCTGAAAtggagatgatgaagatgattggGAAACATAAGAACATCATTAACTTGCTGGGAGCATGTACTCAAGACgGTCCTCTGTACGTGCTGGTAGAATACGCCTCTAAAGGGAATCTTAGGGAATACTTACGAGCCAGAAGGCCACCTGGGATGGACTACTCATTCGACACCTGTAAGATCCCAAACGAAACGCTAACATTTAAAGACCTGGTGTCCTGCGCCTATCAGGTCGCCAGGGGTATGGAGTACCTGGCCTCAAAGAAGTGTATCCATAGGGACCTCGCAGCCCGGAATGTTCTGGTTACCGAGGACAACGTGATGAAGATTGCAGACTTCGGCCTTGCCAGAGATGTGCACAACATTGACTACTACAAGAAGACCACCAACGGTCGTCTGCCCGTCAAATGGATGGCACCAGAAGCACTGTTCGATCGCGTCTACACGCACCAGAGCGATGTGTGGTCTTATGGTGTGTTGTTGTGGGAGATTTTCACTCTTGGTGGATCCCCGTATCCAGGTATCCCAGTGGAGGAGCTCTTTAAACTGCTGAAGGAAGGCCATCGGATGGACAAACCGGCCAACTGCACTCATGAACTGTACATGATCATGCGAGAATGTTGGCATGCTGTTCCTTCACAAAGACCCACGTTCagacagctggtggaggaccacGACAGGGTTCTTTCCATGACCTCCACTGACGAGTACCTGGACCTCTCTGTACCGTTCGAGCAGTATTCACCGACCTGTCCGGACTCCAACAGCACCTGTTCCTCTGGCGATGACTCTGTGTTTGCCCACGACCCCTTACCTGAGGAGCCATGCCTCCCTAAACACCACCACAGCAACGGGGTCATACgaacataaagaaaaaaaaaacagggagcTTTAGGGTTTGGCTGCACTGGACCAGCATGTGGCAGAGAAGCGCAGTGTGGGGATCTCATGAAAGCTTCAGACTTTCAGCTGTTCGCAGGTTTGAAGGACGGATTTAGCTTTTCTCCTTCAGCACCTGCTTTTCTTCCAAATCATTATTCAGCTTTTTGTCTTTGAAAAGAGAATTCCTATTTTTGTATTCGGCCAGTTTCGTTTTTCCACAGTGAGAAGGGTCAAACCATTCCGtgcctaccaaaaaaaaaaaacagaaaaaaacagacaatTGCTGAACTAACTAAGAATGGATCAACACTGTGTGATGGCACAGTTCGGATAAGAGTCGTCCTGTCGAACGTGGACAAGACGTGATTTTACAGCAATATCTGACTGGAGTGAGAATCAAACCCATGGCCAGTCTCTTTTCTCCACTCCTCACAAAGATCCTTTTTTTaagaaggaaagagagagaggtcTCCTAGATGTGAGATTTAATTggaagataaatatatataactgtGTGCTTTGTATGTATCTTaaagtttttattgtaaatatatagatataaatatgtATCATATTGCAGTCGGTAGCAGTGTACTAAAAAAGAGAAGAAAGGCAACATTTTTAAAGCAAGTGATTATACACTGTTGAGATCATGTAAACATTTAAtcttaaaaaagcaaaacaaaagttttatttgAATTAACGTGTATATTTGTAAAGCTATTTATAGACTTAAGGTTTTTAAGGGGGTCTAAAATTATAGTGGGGTTTTGGTACTGTAAACAAGGGTCGTTTTcttttctttgaatttttgtaAGTTATTTACCACAGAAGTGCAAGATCACAACCAGtgggttgtattttattttatttttgctttcttttctttcttttttgttccaTTAGTTTACAGTGACGAGAATGTATGAGTAACTAATTGGCGATAGTAGCAGAGTTTAATGAAATTTTCTAATCTGAAAGCATGAAACAGGTACTATTTGCTGTATCTCAGTATTGAATCCTATGGTAAAAGGACCACGAGTGCTTCTGCTCTTTACGAGAAAACTGCAGACTTACACTTAAAGcacttttatataataaaaatattttccatatttggGCTTCCATGCATGACAGTTCACCAtagtatttctttaaaaaaacagtgtTGGTTTTCTCCAAAGGCGAGTGCTGTGGTCcttttatttaacattatatgAAGGAGTGCTATGAGGGTGAAACCTAACATAGCGTTTATAGATTATATGGTGAAACCATATTTCAAATTTATCGCTCTTATTTGCTCTTTTTGCTAATGAATATGTATAATAACACTTTGAGGTAATCCTCCGGGTCGGTATGTTTGCAAAGTGCCAAAATCTTTCTCTCTGCTCTGAGTTTTATGTTAATGAGTACAGAACCGTTATTGCTATTCAACTCTAGCGTGCATGGTTGTCAGATGAGTGTCTCTGGCCCTGCGAATCGAAGCGAAGCATTATGGGATAGCTTGGTTGTGTCTCAGGGTGTCCTCAGACAATTGCATTCAAGCAGAAAGCTGGCAATAATATATAatagggggagaaaaaaagaggaTGATTCGCTTGCTGCTAAACTCGAAAACTGTAGATTTGATGGGAGGTGACTGTACAGGTGGCTCCCTCCTCCTGCAAACCATTGAATTTTTTTGTACTTGTTAAGTGCCTGGGAGGGAGTTGAGCGGCTTGCAAAATGTGTACGGTTTGAATGTACAGCCACTTCAGTAAAGGTTTAAGCAGGGTGTTTCTTAAAAGCGAGAACGTTAATATTTGTAAGGCACTTTGATGCATTGAGAGTGGTAGCACACTGGATGAGAAGCTCAGCACTGTGTCATGTTTAAAATCAGTTCATCTGATGCTTATAATCTGATCACTAAACTTGATTGAAGGTGGTTCAAAGTGTTCGAAGAAACATATAGCTTTTTTGTAAATAACACCAACTTAATTAAAGCAACAAAAGAAATCTGAAATTGCATACTAATACATATATAGTAGGTGAAAAACACTCTGTTACACATGTAAACTATTATTCCCTGAAAAACAGAGATGTTGTGTTGATACTATTTGGGGATCCACTTAGAATGGGAGCCATGTGTGACAAAAGTATGATGTCTGAATTTAAAAACTGGGCAAACATGTACTATAATGTACTATACTACACACATTCATAATATGTAGCCTATACTTTTTAAGTACTTGTGTAGTTATTTATTCAGAACAAGTACAGTACCTACTCAATTATGCAATTTGAGGATGCTGCCCAGATGTTGCATGTGTCAAGATTTTTTAACAGCCCATCTGGAAACAAAAGCTGTGCCTGAAAGCTTTACATTTAAATTCCAAGGCAGGATGGCATCAGGCACGTCTGAATCTGAACTGTGATCGAATTTTGAAGGCAGTCTAGATGTGCCCTTCACTGCTCTCCATATCCCACAAACTTGAGCGTCCCATTACTGACAGTTGAGCTGAAAAATAAACATGATGTTGTCTACATCATGTCATGACCGTTTTCCACATTTGAGGGCATTTCTAGCAAGTATTTAATACTGTAGTAAGCAAAAAAATCCCCTGGTTATCACCAACGTTCTCTTTATCTTACTGTACATGTTTTGCTGTCTCAGAACCCTGTCGAAATCCAGTTTTACAATGTGCCTTCATGCACAAATGCTGACCCTAATTTCACTGCCTGATAGGCCAGCGAGGCAACAAGTCATGTCACTTTTtgcccccattgacttccatttatatttgtgcaaatgcaTAAGACTGAAAATGCAACGAGTTTCGCATGTTGCTGCGTTCAAAAGTTCAAGCTTTGTGAATTATTCACTGAGCTAAATAAAAGccaagcaagcattttttttctttgattttaaaagatgtctaatagatgacTAATAGATGTCAAACATAGCCGTctaggctaaaacaaggctaaattggagctgtcagtgaaaatagaatagaataggccaaaactagactagtcatcaaataaacagaaatgattgACTACACATAAAGTCTGTCCAGTcggtctatttgacgactagtctagttttgggctgttcTTAGATGTTTATAAGATAGTTTTGTTGTTTTAGCCAAACTGTCAACATTAAGATGTCTATTaaacgtctattaaacacaaaattgttagCTGGtagattaaaaatgttaaatatagagCAATCAACCGTTTTATCAAAGTCACATCAATGTGTTTTGTCCTGTACCTTTTTGCAGCTCCTCCAGAACAAATTTCTCATTCTCAAACTCTATTGAGAGCACAACTTAAGCTCTCAGACACAACTTTAATATTGAAATAGACAGCCAATGTTTTACAACTATGAAATGTAGTTATCATGATCAACTAAATGCAAGGTCTTCAAAAGTATGTGTAGTTATGGACTTTTCAAAGCTCCCCAAATTGTTTATCGACATCACTGTTACATTTTTAAACTCCTAAATAATGTACTTAAATAAACAAACTGTGACTGGTAGATTTACATACCAGTCAATCAATCACTGGTTGGTTTTTGGCCAATAAAAGTATGAAATTGTCCAGACGTTCTGTTGTCATTTTGGCTAATATTGTTAAACTCTATTCTTATTGTTCCTGCTGTATTGTTTGTAAAATATAAGTTGGATCTGCTGTACTGCTCTTTTAATTCAATATACTGTAGCAGTCAAATGTTTGAATTTGGATGCAGCTCAACTGTTTAAAATTTAAAGACATTGTGCTGTGCTTTTCATCCAGTTGTGCAACCactttaatgggatagttcacccaaaaaataccGCCATTTACTTACCCTCTGCTTGTTTCATTCCTCTTTTGAATACAGTGGATGAAATTCTGAATTCTGAATGTTTAAAAACAGGTAGTCATTGACTACCCttagttaatttgtttgtattttcccCTACACTGGGTGTCAGTAGTTACCAGTTTTTAAAATTCGTTTGAAAAAGAACTTGAGGGATTgagtaaattaattttatttttgtggaaCTATTTCTTTCATTCTCAGATTATGTACTTTTCAGATTTGAATGACATTGTTCTGTATTTCCTTCTCCCAGCTGAGGGACTTCATGTTTATCCAGTGTTTGTCCATAATGAGTTATTGATTTACTGTTTGGTGTGGGATGGCAGGGCAGGGCAAGCGATCGCTCTCAgcttactcttttttttaatttttaaattgtttgtacAACCTGTAACCTCTGGCTCCCCTCCTTATCCTCCGCTCTACTACTGACAGCCATCTTGCATTGTTTTAGACATATCAAACAATGTTGCTGGTCCTCCCCCCCCCCATCACTAACCTACATTATTTATTCCCTATATTATTtatgtttgatttattgtttgtttgtttttttcatcctTTGACTTTCATGCCCTTGTCTTATTCAAAAGGACAGCATTCCCTtcacattttgttgttgttgttgctgtttatgATGGAGGTAGAGCCAGGATGCGTTTTTCAGAGTTGAAGAAAGTTTTCTTTAATGTTTACAAGGAACATCCAGACAGTTTTCTAAAGGACGGTGTGTTTCCCAGCACTTTTTAAGCAGCTGGATGATGATGAGCAATACTGGTCTGATGTCAACACTCTTTGATTTGACTCATTTGTTCTTTTCTTCAATGTGATACAGTAGCTCTATGTGATAGTGCCATTCAGCTCTTATTAGAATTAAGCTATTAAATTAAGTTATAGATTTAAATTTGCGAATGATTGTTATGTGTCAAGTAGATTTTATCtaggtctttttttttcttgttcacagGGATGAAATATTCTTTTCGGTAATATTTCTTACATTGCATTCCAGGTAGATTTGGGTTTTACATGCGATGAGGTAACATCAGCATCTGCATCGCTCTTCATTTAACAAAAGAGTGGAATAGTCGACTAAcagtgttttatgttttattttcccATGTCTCTGTGTCTGTGGAACATTCCGTTTTGTTTCAGTTGTGCCCCTTACGAGCTGTTAAACCTCTTTACACTCTATCAGTCTGTGCCTGACAGAATTACGCTGTCAATCAAAACCttttcaataaacaaaacaaaatga

Function

symbol description
fgfr3 Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cranium; gut; nervous system; neural rod; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).

GO:

id name namespace
GO:1902036 regulation of hematopoietic stem cell differentiation biological_process
GO:0006915 apoptotic process biological_process
GO:0033674 positive regulation of kinase activity biological_process
GO:0007275 multicellular organism development biological_process
GO:0043410 positive regulation of MAPK cascade biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0006468 protein phosphorylation biological_process
GO:0008284 positive regulation of cell population proliferation biological_process
GO:0016310 phosphorylation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0017134 fibroblast growth factor binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0005007 fibroblast growth factor-activated receptor activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04014 Ras signaling pathway
ko04015 Rap1 signaling pathway
ko04020 Calcium signaling pathway
ko04151 PI3K-Akt signaling pathway
ko04144 Endocytosis
ko04550 Signaling pathways regulating pluripotency of stem cells
ko04810 Regulation of actin cytoskeleton
ko05200 Pathways in cancer
ko05206 MicroRNAs in cancer
ko05230 Central carbon metabolism in cancer
ko05219 Bladder cancer
ko01521 EGFR tyrosine kinase inhibitor resistance
ko01001 Protein kinases
ko04090 CD molecules

ZFIN:

id description
ZDB-GENE-000816-1 Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cranium; gut; nervous system; neural rod; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).

Ensembl:

ensembl_id ENSDARG00000004782

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012614 True 8112 mRNA 0.42 18 13213567 13294872

Neighbor

gene id symbol gene type direction distance location
XLOC_006508 nsd2 coding downstream 182716 12993851 ~ 13030851 (-)
XLOC_006507 NA coding downstream 456906 12748652 ~ 12756661 (-)
XLOC_006506 fam241a coding downstream 546347 12664866 ~ 12667220 (-)
XLOC_006505 adh8a coding downstream 553249 12653975 ~ 12660318 (-)
XLOC_006504 adh8b coding downstream 566815 12633223 ~ 12646752 (-)
XLOC_006510 NA coding upstream 292424 13587296 ~ 13590570 (-)
XLOC_006511 CR788322.1 coding upstream 349573 13644445 ~ 13644562 (-)
XLOC_006512 pimr47 coding upstream 365692 13660564 ~ 13662624 (-)
XLOC_006513 CR788322.4 coding upstream 375568 13670440 ~ 13670537 (-)
XLOC_006514 NA coding upstream 442670 13737542 ~ 13740560 (-)
XLOC_006471 BX537274.2 misc downstream 2948662 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 12387342 825904 ~ 826225 (-)
XLOC_006502 NA non-coding downstream 626155 12586997 ~ 12587412 (-)
XLOC_006497 NA non-coding downstream 1095317 12117113 ~ 12118250 (-)
XLOC_006496 CR792443.1 non-coding downstream 1107673 12105778 ~ 12105894 (-)
XLOC_006492 CR792443.2 non-coding downstream 1238999 11974452 ~ 11974568 (-)
XLOC_006516 NA non-coding upstream 718313 14013185 ~ 14015180 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01180000_04082957_04114030 FGFR3 coding CI01180000 null 4082648 ~ 4114030 (-)