XLOC_006546 (alox5a)


Basic Information

Item Value
gene id XLOC_006546
gene name alox5a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 18128275 ~ 18174864 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012675
TCTCCAGCTTGAAAATGCCCAGCTACACGGTGACTGTTGCCACTGGCACTCAGTGGTTTGCTGGCACCGATGATTATATTTATCTGACTCTGGTGGGCTCTGAGGGCTGCAGTGACAGGACCCTGCTGGATAAACCCCTCTACAACGACTTCGAGAGAGGAGCGGTGGACTCATATGACATCAGCGTAGGAGAGGATCTTGGTGAAATTCAGCTGGTTAAAATTGAAAAGAAGAAATACTGGATGCACGACGACTGGTACTGTAAATACATCACGGTGAAGACACCCTATGGAGATTATGTGGAGTTCCCCTGCTTCCGCTGGTTGGTTGATGACAAAGAGGTGATCCTCAGAGATGGCAGGGCTCGATTGCCACAGCACGACAAGACCGGAGTGGCGAAACAGCACAGGCGCAAAGAACTGGAACAGAGACAGAAGACATACAGATGGAAAGAATGGCATCCTGGCTTCCCGATGAGTATCGACTGCAAAGCCCATAAAGAGCTTCCACGGGACATTCAGTTTGACAGCGAGAAAGGAGTGGACTTTGTGCTTAACTACAGCAAAGCGATCGAGAATCTGTATGTGAACCAGTTCATGCACATGTTCCAGTCCTCATGGGGAGATTTCGCAGACTTTGAGCGGATATTTGTGAGAATTAAGAACACAATATCAGAATATGTGATGGAGCACTGGAAAGAAGACTTCATGTTTGGATATCAATACTTAAACGGCTGTAATCCAGTGGTCATCAAAAAATGCACTGAAATTCCTGACAAGTTTCCAGTCACACATAACATTGTGGAAGACAGTCTGGAGAGGGGTCTCACACTGGAAGAGGAGCTCAAGGAAGGAAACATCTTTATTGCTGACTATGAGATAATGGATGGTGTCACCGCCAATTCTACAGACCCTTGCACCCTTCAGTACTTGGCGGCACCCATGTGTCTGCTATATAAGAACAGTCAGAACAAAATAATGCCGATTGCCATCCAGCTGCATCAGAAACCAGGAGAGGACAATCCCATCTTCCTTCCCAGTGACGATGAGTATGACTGGTTGCTGGCCAAAATCTGGGTGAGATCTTCAGACTTTCACGTCCATCAGACAGTCACTCATCTCCTCAGGACGCATCTGATTTCTGAGGTCTTTGGCATAGCCATGTTCAGACAGCTGCCTGCAGTTCATCCTGTTTTTAAGCTGCTGTTACCACACATCCGTTTCACCATTGCCATTAACACCAAGGCTCGTGAGCAGCTCATCTGTGAGTGTGGACTCTTTGACAAGGCTAATGGGACAGGTGGAGGTGGACACATAGAACTTGTCCAGAGGTCCATGAAGGTCTTCACGTACAAGTCCTTGTGTTTCCCAGAGAATATAAAAGCACGAGGCATGGACAGCCAGGAGGAACTGCCATACTACTTCTACAGAGATGATGGCTGCGCGGTCTGGGAGACTGTGAAAAGTTTTGTGTCCGATGTTGTTGACATCTACTATGACAAAGATGAAACGGTGCAGGAGGATGAAGAGATCCAGGCGTTTGTCAAAGATGTTTGCAGCTTTGGAATGCAGGATTTGGACCATTGTGaatttcCCAAGAGTTTGCAAACCAAAGAGGAACTGGTGGAGTATCTAACTGTCGTCATCTTTACTGCCTCTGCACAACACGCTGCAGTAAACTTTGGCCAGTATGACTGGTGTTCATGGATCCCAAACTCCCCACCAACCATGCGGAAACCTCCTCCTATGAAGAAAGGCGAGGTGGACTTACAGTATATAGTGGAGAGTCTGCCTGACCGAGGACGCTCCTGTTGGCATCTGGGAGCTGTTTGGGCCCTCAGTCAGTTTCAAGAAAATGAGttgttcCTAGGCATGTATCCAGATGAACACTTTATTGAGAAACCGGTGAAAGAGGTCATGGTGAAATTTGGCAAGAAACTTGCAGAAGTGAGCAAAACCATCAAGAATCGAAATGAGGGAAAGAAGCTGCCTTACTACTATCTGTCTCCAGACAGAATCCCAAACAGTGTGGCTGTGTAA
>TCONS_00012676
GCCACTGGCACTCAGTGGTTTGCTGGCACCGATGATTATATTTATCTGACTCTGGTGGGCTCTGAGGGCTGCAGTGACAGGACCCTGCTGGATAAACCCCTCTACAACGACTTCGAGAGAGGAGCGGTGGACTCATATGACATCAGCGTAGGAGAGGATCTTGGTGAAATTCAGCTGGTTAAAATTGAAAAGAAGAAATACTGGATGCACGACGACTGGTACTGTAAATACATCACGGTGAAGACACCCTATGGAGATTATGTGGAGTTCCCCTGCTTCCGCTGGTTGGTTGATGACAAAGAGGTGATCCTCAGAGATGGCAGGGCTCGATTGCCACAGCACGACAAGACCGGAGTGGCGAAACAGCACAGGCGCAAAGAACTGGAACAGAGACAGAAGACATACAGGTTTGATGCAACTTTTAAAATAAGGTCAACCACTGCAGCAGTTGCGGACATCAAGAAAAGGGATTTCCTCATACGTGCACTT

Function

symbol description
alox5a Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).

GO:

id name namespace
GO:0051122 hepoxilin biosynthetic process biological_process
GO:0034440 lipid oxidation biological_process
GO:0043651 linoleic acid metabolic process biological_process
GO:0019369 arachidonic acid metabolic process biological_process
GO:0019372 lipoxygenase pathway biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005635 nuclear envelope cellular_component
GO:0004464 leukotriene-C4 synthase activity molecular_function
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function
GO:0005506 iron ion binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0051213 dioxygenase activity molecular_function
GO:0004051 arachidonate 5-lipoxygenase activity molecular_function
GO:0008391 arachidonic acid monooxygenase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-090311-47 Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).

Ensembl:

ensembl_id ENSDARG00000057273

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012675 False 2039 mRNA 0.47 14 18128275 18174864
TCONS_00012676 True 489 lncRNA 0.49 3 18167461 18174826

Neighbor

gene id symbol gene type direction distance location
XLOC_006545 washc2c coding downstream 5942 18073211 ~ 18122333 (-)
XLOC_006544 zfand4 coding downstream 58854 18019709 ~ 18069421 (-)
XLOC_006543 march8 coding downstream 117067 17751866 ~ 18011208 (-)
XLOC_006542 vdac2 coding downstream 398801 17714296 ~ 17729474 (-)
XLOC_006541 NA coding downstream 434456 17686484 ~ 17693819 (-)
XLOC_006547 slc25a16 coding upstream 4232 18179096 ~ 18195942 (-)
XLOC_006548 si:dkey-228d14.5 coding upstream 157821 18332685 ~ 18345854 (-)
XLOC_006549 BX908770.1 coding upstream 346629 18521493 ~ 18548729 (-)
XLOC_006550 mat1a coding upstream 454056 18628920 ~ 18637244 (-)
XLOC_006551 CR932438.1 coding upstream 470026 18644890 ~ 18645005 (-)
XLOC_006471 BX537274.2 misc downstream 7863370 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 17302050 825904 ~ 826225 (-)
XLOC_006540 NA non-coding downstream 597739 17494297 ~ 17530536 (-)
XLOC_006538 NA non-coding downstream 1249205 16868380 ~ 16879070 (-)
XLOC_006537 BX323467.1 non-coding downstream 1820392 16307767 ~ 16307883 (-)
XLOC_006536 NA non-coding downstream 1866702 16260651 ~ 16261573 (-)
XLOC_006552 CR932438.2 non-coding upstream 474628 18649492 ~ 18649682 (-)
XLOC_006554 CR932361.2 non-coding upstream 540446 18715310 ~ 18715426 (-)
XLOC_006556 NA non-coding upstream 835308 19010172 ~ 19016833 (-)
XLOC_006557 NA non-coding upstream 1101309 19276173 ~ 19277332 (-)

Expression


Co-expression Network