LOC122351900 (tcf7l2,lef1,LOC107750316,LOC107757012,LOC107684275,LOC107676173,LOC107594427)


Basic Information

Item Value
gene id LOC122351900
gene name tcf7l2,lef1,LOC107750316,LOC107757012,LOC107684275,LOC107676173,LOC107594427
gene type misc
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056699.1
NCBI id CM032068.1
chromosome length 31761587
location 24061440 ~ 24082876 (-)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>TU8172
TATGTCAAATTTATTAGGGACCTGCTAATTCAGATCTGTTTTCCAGCATTCCTTAAAATGTCCCCAGATCACTTCAGAAGTGTCCTGTAAATCCTATATTTTACGCAGACAATGCACTGatttcactcctgaatctcatTTCTAATTGGTTCGACTGACGGCGTTACGACACCGTTTTCGTTTCCAACAATCCCAAAATGAATCGGAGAACGGCACCAGCGTCTCCTACCTCCACATTCTGCGCTCTCCGTCCATTTGTTGGAAGCGACGTATAAAATCCCCCTTTACTTTCCTCAGGAGCGTCAGTCAacgcgtgcgcgcgcgcgcgctcgagCGAGGTGTCAATCAAAGCGGCGGCTTCCCTTTCATCTCTACAGTCAGTCAGAGATCAGGGGGAGGAGTACAGCACTACACTCTCTCCAAGCCCAACATTACTCTCAGTCTCTGCTGAGCGCATTTCTGAAGAGGGACACCTTTTTACCCAAGAAACCAAACGGGAATGACACACAGCATCTGAACTccggcacttttttttttttttttttgagtcggGCTTTTTAAACAGCCAAAGCGGTCCTGCGTTCAACTCACGCGTCTAACTTTTTCGTCTGAGAACGCCACGGGAGTCGTGctttaacttttaaaacacGTCGCGTTTGGATCCTCGCGCGCGGCCGTAGACCAAACACTCGCGCGCGTGTTTGGAGTGCGCCCGGGCTGAAATTATACGGGGTTTTCTCGTCCAGCGCCTTCGCTTTCCGGGCGTTTGTAGGGTGAGGAGGACTTTCAATCACCCGAGAAATGCCGCAGTTGTCAGGTGGAGGAGGCGGCGGGGACCCGGAGCTCTGCGCCACCGATGAAATGATCCCGTTCAAAGACGAGGGAGACCCGCAGAAGGAGCAGATCTTCGCGGAGATCAGCCACTCCGAGGAGGAGGGAGACTTAGCGGAGATCAAGTCATCTCTGGTCAACGAGACAGAGATCAGTCCCAACAGTAACAGTCACGACGCAGCTAGACAGTCCCAAATAACACCAGACTCTTATCATGAGAAGCACAGGGACCATCCGGACGATGGCAAGCATCAAGACATGTACAGCAAAGGCCACCCGTACCCCAGTTACCCAGGATACATCATGATGACCAATATGAACAATGAACCCTACATGAACAACGGCTCTCTCTCGCCTCCCATTCCCAGAGCG
>TU8175
aaagcaaTGATATCGCACGTTAGATATTAAGTTGTTAATATCTCTCTCCTACATTTTTGAACAGGCAGCTAGACAGTCCCAAATAACACCAGACTCTTATCATGAGAAGCACAGGGACCATCCGGACGATGGCAAGCATCAAGACATGTACAGCAAAGGCCACCCGTACCCCAGTTACCCAGGATACATCATGATGACCAATATGAACAATGAACCCTACATGAACAACGGCTCTCTCTCGCCTCCCATTCCCAGAGCG
>XM_043249306.1
aaaaaaaaaaaaaaaacgtatcacTTTGAGCTGGACCGACTGACCGCTGAAGGAAAAACCTGACGGAGAAATGAGTGATTATCCGCCGGCGGAGGACAGGCCTTGCCGGACGTCCTGAGACGCAGCTCTCGCTGTGATCCGCAAAAGAACCactccaaaagaaaaaaagaaaagagaaaaaaaaaaaaaaaaacgaacaatgCCGTGCGCGTGAACTTCTGTGTGTGCGACCCTTTGGTGCGGGACACACACATGCGCCCGCTCAAACACAATAGCAGTTTTGGGAAAGAAGCTAAGGTTGAAAAAGAACAAGAAGAGAGGGAAGAAAGGAGAAATACTCTTATTCGTTGGCGGGAGTGAGAGGTGGAGGACAGGGGAGGGCCGCGGCGCTGCTCATGTACCCGAGAGAAGGCCTTTCACTGGGGCTGGAGGAGAGGGGAGGAAAGACTGGCTCTCTGGCCTCTGGGCTGTCTCTCCTGCAGCAGGTTGGCTGCTGGCAATTCAGTCTTAATGCCTGGTCTAATAAGGTCCCCGTGGTACAGCACCCTCACCATGTGCACCCGCTCACACCTCTGATCACCTACAGCAATGAGCACTTCACGCCTGGGAACCCCCCTCCACATCTACAGGCAGACGTGGACCCCAAAACAGGAATCCCAAGGCCTCCACATCCTCCAGATATATCTCCCTACTACCCCCTGTCACCTGGCACTGTAGGCCAGATTCCCCATCCGCTAGGATGGTTAGTACCACAGCAAGGTCAACCAGTTTACCCAATCACGACGGGAGGTTTCAGACACCCCTACCCAACTGCCCTCACTGTCAATGCGTCCATGTCAAGGTTCCCTCCTCACATGGTGCCCCCCCACCACAGTTTGCACACCACAGGGATCCCCCACCCAGCCATCGTCACGCCCAACGTCAAGCAGGAGTCCTCTCACAGTGACATCGGCTCCCTCAACAGCTCGAAACATCAGGATGCgaaaaaagaggaggaaaagaagAAGCAGCCGCACATAAAGAAACCTCTGAACGCATTCATGCTTTACATGAAGGAAATGAGAGCCAAAGTGGTGGCAGAATGCACACTGAAAGAGAGCGCAGCTATCAACCAGATCCTAGGCCGAAGGTGGCATGCTCTGTCTCGAGAGGAGCAGGCCAAATACTACGAGTTAGCCAGGAAAGAACGACAGCTTCACATGCAGCTGTACCCCGGCTGGTCGGCACGAGACAACTATgggaaaaagaagaagagaaaaagggAAAAGCAGGCAGGAGAGGGCAATGGTAAGTGAGCTGCAATTATCTCTCATATTAAAGCAGACCCATCATCTGTCACAAGTGTGACATCTCAAAGATGAAAGtccagcctttttttttttcttatctctTTTTTGTGCCTGCCTCATTTTGTATATAGCTATGCTACCCAATGCAATATTTACACGATAGACTGCTTGTTATCCCCCTCTTCTCCCCTTGCCCCATGTCGAGCGTTAATAACATTGAATATGCATGACCCCCACCACCTCCTC
>XM_043249314.1
TCCCTTTCATCTCTACAGTCAGTCAGAGATCAGGGGGAGGAGTACAGCACTACACTCTCTCCAAGCCCAACATTACTCTCAGTCTCTGCTGAGCGCATTTCTGAAGAGGGACACCTTTTTACCCAAGAAACCAAACGGGAATGACACACAGCATCTGAACTccggcacttttttttttttttttttgagtcggGCTTTTTAAACAGCCAAAGCGGTCCTGCGTTCAACTCACGCGTCTAACTTTTTCGTCTGAGAACGCCACGGGAGTCGTGctttaacttttaaaacacGTCGCGTTTGGATCCTCGCGCGCGGCCGTAGACCAAACACTCGCGCGCGTGTTTGGAGTGCGCCCGGGCTGAAATTATACGGGGTTTTCTCGTCCAGCGCCTTCGCTTTCCGGGCGTTTGTAGGGTGAGGAGGACTTTCAATCACCCGAGAAATGCCGCAGTTGTCAGGTGGAGGAGGCGGCGGGGACCCGGAGCTCTGCGCCACCGATGAAATGATCCCGTTCAAAGACGAGGGAGACCCGCAGAAGGAGCAGATCTTCGCGGAGATCAGCCACTCCGAGGAGGAGGGAGACTTAGCGGAGATCAAGTCATCTCTGGTCAACGAGACAGAGATCAGTCCCAACAGTAACAGTCACGACGCAGCTAGACAGTCCCAAATAACACCAGACTCTTATCATGAGAAGCACAGGGACCATCCGGACGATGGCAAGCATCAAGACATGTACAGCAAAGGCCACCCGTACCCCAGTTACCCAGGATACATCATGATGACCAATATGAACAATGAACCCTACATGAACAACGGCTCTCTCTCGCCTCCCATTCCCAGAGCGTCTAATAAGGTCCCCGTGGTACAGCACCCTCACCATGTGCACCCGCTCACACCTCTGATCACCTACAGCAATGAGCACTTCACGCCTGGGAACCCCCCTCCACATCTACAGGCAGACGTGGACCCCAAAACAGGAATCCCAAGGCCTCCACATCCTCCAGATATATCTCCCTACTACCCCCTGTCACCTGGCACTGTAGGCCAGATTCCCCATCCGCTAGGATGGTTAGTACCACAGCAAGGTCAACCAGTTTACCCAATCACGACGGGAGGTTTCAGACACCCCTACCCAACTGCCCTCACTGTCAATGCGTCCATGTCAAGGTTCCCTCCTCACATGGTGCCCCCCCACCACAGTTTGCACACCACAGGGATCCCCCACCCAGCCATCGTCACGCCCAACGTCAAGCAGGAGTCCTCTCACAGTGACATCGGCTCCCTCAACAGCTCGAAACATCAGGATGCgaaaaaagaggaggaaaagaagAAGCAGCCGCACATAAAGAAACCTCTGAACGCATTCATGCTTTACATGAAGGAAATGAGAGCCAAAGTGGTGGCAGAATGCACACTGAAAGAGAGCGCAGCTATCAACCAGATCCTAGGCCGAAGGTGGCATGCTCTGTCTCGAGAGGAGCAGGCCAAATACTACGAGTTAGCCAGGAAAGAACGACAGCTTCACATGCAGCTGTACCCCGGCTGGTCGGCACGAGACAACTATgggaaaaagaagaagagaaaaagggAAAAGCAGGCAGGAGAGGGCAATGGTAAGTGAGCTGCAATTATCTCTCATATTAAAGCAGACCCATCATCTGTCACAAGTGTGACATCTCAAAGATGAAAGtccagcctttttttttttcttatctctTTTTTGTGCCTGCCTCATTTTGTATATAGCTATGCTACCCAATGCAATATTTACACGATAGACTGCTTGTTATCCCCCTCTTCTCCCCTTGCCCCATGTCGAGCGTTAATAACATTGAATATGCATGACCCCCACCACCTCCTC

Function

symbol description
lef1 Enables sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; fin development; and fin regeneration. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Is expressed in several structures, including midbrain hindbrain boundary neural rod; nervous system; neural crest; pleuroperitoneal region; and trunk. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).
tcf7l2 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in digestive system development. Acts upstream of or within several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Located in nucleus. Is expressed in several structures, including anterior neural plate; brain; digestive system; gonad; and sensory system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).

NR:

description
transcription factor Tcf4 variant M9

GO:

id name namespace
GO:0060070 canonical Wnt signaling pathway biological_process
GO:0022407 regulation of cell-cell adhesion biological_process
GO:0048747 muscle fiber development biological_process
GO:0021542 dentate gyrus development biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0042100 B cell proliferation biological_process
GO:0061153 trachea gland development biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0001755 neural crest cell migration biological_process
GO:0001756 somitogenesis biological_process
GO:0071864 positive regulation of cell proliferation in bone marrow biological_process
GO:0071866 negative regulation of apoptotic process in bone marrow cell biological_process
GO:0002040 sprouting angiogenesis biological_process
GO:0021861 forebrain radial glial cell differentiation biological_process
GO:0021873 forebrain neuroblast division biological_process
GO:0071895 odontoblast differentiation biological_process
GO:0021879 forebrain neuron differentiation biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0046632 alpha-beta T cell differentiation biological_process
GO:0030223 neutrophil differentiation biological_process
GO:0001837 epithelial to mesenchymal transition biological_process
GO:0016202 regulation of striated muscle tissue development biological_process
GO:0032696 negative regulation of interleukin-13 production biological_process
GO:1900052 regulation of retinoic acid biosynthetic process biological_process
GO:0060729 intestinal epithelial structure maintenance biological_process
GO:0032713 negative regulation of interleukin-4 production biological_process
GO:0032714 negative regulation of interleukin-5 production biological_process
GO:0001569 branching involved in blood vessel morphogenesis biological_process
GO:0031101 fin regeneration biological_process
GO:0021943 formation of radial glial scaffolds biological_process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0050769 positive regulation of neurogenesis biological_process
GO:0048341 paraxial mesoderm formation biological_process
GO:0048922 posterior lateral line neuromast deposition biological_process
GO:0060784 regulation of cell proliferation involved in tissue homeostasis biological_process
GO:0021979 hypothalamus cell differentiation biological_process
GO:0030879 mammary gland development biological_process
GO:0001649 osteoblast differentiation biological_process
GO:0048069 eye pigmentation biological_process
GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis biological_process
GO:0007420 brain development biological_process
GO:0033334 fin morphogenesis biological_process
GO:0030326 embryonic limb morphogenesis biological_process
GO:0033336 caudal fin development biological_process
GO:0033339 pectoral fin development biological_process
GO:0060561 apoptotic process involved in morphogenesis biological_process
GO:0048699 generation of neurons biological_process
GO:0060325 face morphogenesis biological_process
GO:0005667 transcription regulator complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0070016 armadillo repeat domain binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0008013 beta-catenin binding molecular_function
GO:0008301 DNA binding, bending molecular_function
GO:0045295 gamma-catenin binding molecular_function
GO:0030331 estrogen receptor binding molecular_function

KEGG:

id description
K04491 TCF7L2; transcription factor 7-like 2

RNA

RNA id representative length rna type GC content exon number start site end site
TU8172 False 1203 TUCP 0.51 3 24079049 24082876
TU8175 False 259 lncRNA 0.46 2 24079049 24080110
XM_043249306.1 False 1535 mRNA 0.51 8 24061440 24076141
XM_043249314.1 True 1861 mRNA 0.52 10 24061440 24082517

Neighbor

gene id symbol gene type direction distance location
LOC122348966 LOC107675992,LOC107569046,LOC107729366 coding downstream 22784 24032892 ~ 24038656 (-)
neurl1aa neurl1,neurl1aa,LOC107676877,LOC107746052,LOC107746293,LOC107692176 coding downstream 858304 23152502 ~ 23203136 (-)
setd4 setd4,LOC107676883,LOC107560975,LOC107603051,LOC107746057,LOC107692116,LOC107746281,LOC107603006 coding downstream 1147832 22909995 ~ 22913608 (-)
si:dkey-22n8.3 NA coding downstream 1196749 22860868 ~ 22864691 (-)
pknox1.2 pknox1.2,LOC107560978,LOC107676856,LOC107603046,LOC107692119,LOC107718250,LOC107746279,LOC103022264 coding downstream 1200728 22851708 ~ 22860712 (-)
LOC122330280 zgc:154142,LOC107676135,LOC107594422 coding upstream 8532 24091408 ~ 24101289 (-)
LOC122351487 LOC107675992,LOC107729366,LOC107569046 coding upstream 81669 24164545 ~ 24168636 (-)
gsk3bb si:dkeyp-80c12.7,gsk3b,LOC107729358,LOC107569048,LOC107675878,LOC107684292 coding upstream 139247 24222123 ~ 24242004 (-)
zgc:175214 zgc:175214,rn122,LOC107675969,LOC107684287,LOC108434705,LOC105891037 coding upstream 185202 24268078 ~ 24274231 (-)
LOC122351310 LOC107675897,LOC107574145,LOC107684327,LOC107706793,LOC107729342,LOC107684326 coding upstream 192853 24275729 ~ 24278863 (-)
LOC122351911 NA non-coding downstream 228 24058013 ~ 24061212 (-)
G5568 NA non-coding downstream 324547 23735976 ~ 23736893 (-)
G5583 NA non-coding downstream 325837 23733174 ~ 23735603 (-)
LOC122346633 NA non-coding downstream 347983 23708413 ~ 23713457 (-)
G5577 NA non-coding downstream 438559 23619700 ~ 23622881 (-)
LOC122350488 NA non-coding upstream 93015 24175891 ~ 24177649 (-)
G5763 NA non-coding upstream 417517 24500393 ~ 24501238 (-)
LOC122362739 gstcd,LOC107757010,LOC107684312,LOC107729368,LOC107676029 non-coding upstream 420097 24502973 ~ 24508467 (-)
G5769 NA non-coding upstream 468707 24551583 ~ 24551880 (-)
G5780 NA non-coding upstream 477963 24560839 ~ 24561453 (-)
LOC122350023 LOC107675992,LOC107729366,LOC107569046 other downstream 19482 24037063 ~ 24041958 (-)
LOC122351696 LOC107729347,LOC107583214,LOC107566139,LOC107746059,LOC108434669,LOC106951888,LOC108258286,LOC106586852,LOC105012299 other downstream 144992 23771024 ~ 23916448 (-)
gja5b cx41.8,LOC107746285,LOC107676875,LOC107566537,LOC107692115,LOC107746055,LOC107676898,LOC107746286,LOC107566538,LOC107692192,LOC107603053,LOC107746072 other downstream 1031130 23018238 ~ 23030310 (-)
G5468 cbr1,LOC107746284,LOC107560976,LOC107692178 other downstream 1145035 22913900 ~ 22916405 (-)
itsn1 itsn1,LOC107746280,LOC107718832 other downstream 1158026 22864831 ~ 22903414 (-)
atp5md taf5,LOC107676012,LOC107583167,LOC107574147,LOC107684290 other upstream 110845 24193721 ~ 24251239 (-)
si:dkeyp-80c12.8 NA other upstream 135718 24218594 ~ 24221446 (-)
LOC122341607 LOC107729348,LOC107676039,LOC107578077,LOC107729356,LOC107594453,LOC107676194,LOC107729349,LOC107706808 other upstream 208555 24291431 ~ 24297591 (-)
G6056 NA other upstream 785565 24868441 ~ 24870465 (-)
G6073 NA other upstream 889615 24972491 ~ 24973371 (-)

Expression


Co-expression Network