psen2 (psen2,LOC107675694,LOC107684264,LOC107757025)


Basic Information

Item Value
gene id psen2
gene name psen2,LOC107675694,LOC107684264,LOC107757025
gene type coding
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056699.1
NCBI id CM032068.1
chromosome length 31761587
location 24895841 ~ 24902227 (-)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>XM_043239967.1
CGGGCGTCACGTGGCGCGGCGAGGATCAGCTGATCGGGATCGCTTCCTTGTTGGGATTCGCGATGTTTTGACGGAGTCCTGCTGCAATCGTCGCCGCTGGCTCGTCCTTCATGTAAACACGGTCACGTCTGAAGCTCTAGGCATTTGGCTTCTGTCACCTTCTCTTAATGAATACCTCAGACAGCGAAGAGGACTCTTACAACGAGAGGTCCGCTCTGGTCCAGTCCGAAAGCCCAACCATCCCCTCGTACAACCATGATCACGATTTGTCTCTGCCCCAGAAAACGGACACCAAACGGCGGCAGCCAGCCAGTTCAGTTTTGGATGAGCCAGGGCCGGCGGAGCGAGAGCGAGCGTCCACTCCTGacggagaggaagaggagctgACCCTCAAATACGGCGCTAAGCACGTCATCATGCTCTTCATCCCTGTCACGCTCTgcatggtggtggtggtggcaACAATCAAGTCTGTCAGTTTCTACACGGAGAAGACCTCACAGCGGCTcatCTACACTCCGTTCGAAGAGGATCCGAACTCTGTCGGTCAGAGGCTCTTGAATTCGCTCCTCAACACCATCGTCATGATCAGCGTGATTGTGGTCATGACCATAATACTGGTGGTGCTTTATAAGTATCGCTGCTATAAAttcaTTCACGGCTGGCTGATTCTGTCGTCACTGATGTTGCTCTTTTGGTTCAGCTTCATGTATCTGGGTGAGGTGTTCAAGACGTATAACGTGGCTATGGACTACCCAACGTTAGTGATGATCATCTGGAACTTCGGCGTGGTGGGAATGATCTGCATCCACTGGAAAGGGCCTCTGCGGCTGCAGCAGGCTTACCTCATTGTTATCAGCGCCCTCATGGCCCTCATCTTCATCAAATACCTGCCCGAATGGTCGGCATGGGTCATACTAGGAGCCATCTCCATATACGATCTGATAGCGGTGCTTTGTCCGAAAGGGCCTTTGAGGATGCTGGTGGAGACGGCGCAAGAAAGAAACGAACCAATTTTCCCTGCACTCATATATTCatCTGCTATGGTTTGGATGGTCGGCATGGCTGACTCTAGTCATCCAGATTCAGCGGATGAAAGGCAGCGGAATGAGGGCGGAGCCCGGGCGCAGGAAGGGGTGGAGTCAGAAGACGATGCGGCCCAGGGAGGGAGGCGGCGGGATTCAGCAGAAGAGGACCTCGAGGAAGACCGAGGGGTGAAGCTGGGTCTCGGTGATTTCATCTTCTACAGTGTCCTGGTGGGGAAGGCGGCCGCTACCGGAGGAGACTGGAACACCACACTGGCCTGTTTCGTGGCCATCCTCATTGGACTGTGCCTGACGCTTCTCCTTCTGGCCATTTTCAAGAAGGCTCTGCCGGCTCTGCCCATCTCCATCACCTTCGGCCTGGTCTTCTACTTCTCCACAGACAATCTGGTACGGCCCTTCATGGACAGCCTGGCAGCCCACCAGTACTACATCTGACAGAAACCCACAGACACGTGAAGGACTTTATCAAAACAGCCGTTTCGTTTCAAGAGATTCAAACGTTTTTAGTTCTTATCTGAGCAGGGTTCTGATCTTGCTGGGACTCTCCAGGTGAGTGAACGAAGGTGTGAAATGTATCGAAACAAGCAAACCGATTTCAGTTCTGAGCTggcattttgatttttttttattaagaggCCGCGCATCAGCTCTTTAGGATATACAGtagttttactattttttgtACTTACTGAGAAGGCGTCTCGAGTGTTAAAGAAGGGTCTTCTTGACATAATGACTGATAAAGTGAAGAACAGAGACTCGGTCCTCAGACAGAAGCCTGTATATGTGGCCTACGTGCAGCAGTGTGAGTGCTGTAGGCTTGCCAGTGGTTACAGCATAATAAACTAATCACACAAATAGA
>XM_043239977.1
GCTTTCACTCTAGACGCGGGGGAGGAAGTGGCTTTCCGGACACATCAGGAGACGTCGGACAGTCAGGGATCACGATGAACGCTTTGATCTGGGTTTGAGGAGCTTTATGAGAATATGACAGCATGATGAGTAGAAACAGGGACGTATCACACTAATTACAGCTGCGGGGAAACGCGTGTGTTGTCACAGATATTATGCTTCGTTTATAAAGCTCTAGGCATTTGGCTTCTGTCACCTTCTCTTAATGAATACCTCAGACAGCGAAGAGGACTCTTACAACGAGAGGTCCGCTCTGGTCCAGTCCGAAAGCCCAACCATCCCCTCGTACAACCATGATCACGATTTGTCTCTGCCCCAGAAAACGGACACCAAACGGCGGCAGCCAGCCAGTTCAGTTTTGGATGAGCCAGGGCCGGCGGAGCGAGAGCGAGCGTCCACTCCTGacggagaggaagaggagctgACCCTCAAATACGGCGCTAAGCACGTCATCATGCTCTTCATCCCTGTCACGCTCTgcatggtggtggtggtggcaACAATCAAGTCTGTCAGTTTCTACACGGAGAAGACCTCACAGCGGCTcatCTACACTCCGTTCGAAGAGGATCCGAACTCTGTCGGTCAGAGGCTCTTGAATTCGCTCCTCAACACCATCGTCATGATCAGCGTGATTGTGGTCATGACCATAATACTGGTGGTGCTTTATAAGTATCGCTGCTATAAAttcaTTCACGGCTGGCTGATTCTGTCGTCACTGATGTTGCTCTTTTGGTTCAGCTTCATGTATCTGGGTGAGGTGTTCAAGACGTATAACGTGGCTATGGACTACCCAACGTTAGTGATGATCATCTGGAACTTCGGCGTGGTGGGAATGATCTGCATCCACTGGAAAGGGCCTCTGCGGCTGCAGCAGGCTTACCTCATTGTTATCAGCGCCCTCATGGCCCTCATCTTCATCAAATACCTGCCCGAATGGTCGGCATGGGTCATACTAGGAGCCATCTCCATATACGATCTGATAGCGGTGCTTTGTCCGAAAGGGCCTTTGAGGATGCTGGTGGAGACGGCGCAAGAAAGAAACGAACCAATTTTCCCTGCACTCATATATTCatCTGCTATGGTTTGGATGGTCGGCATGGCTGACTCTAGTCATCCAGATTCAGCGGATGAAAGGCAGCGGAATGAGGGCGGAGCCCGGGCGCAGGAAGGGGTGGAGTCAGAAGACGATGCGGCCCAGGGAGGGAGGCGGCGGGATTCAGCAGAAGAGGACCTCGAGGAAGACCGAGGGGTGAAGCTGGGTCTCGGTGATTTCATCTTCTACAGTGTCCTGGTGGGGAAGGCGGCCGCTACCGGAGGAGACTGGAACACCACACTGGCCTGTTTCGTGGCCATCCTCATTGGACTGTGCCTGACGCTTCTCCTTCTGGCCATTTTCAAGAAGGCTCTGCCGGCTCTGCCCATCTCCATCACCTTCGGCCTGGTCTTCTACTTCTCCACAGACAATCTGGTACGGCCCTTCATGGACAGCCTGGCAGCCCACCAGTACTACATCTGACAGAAACCCACAGACACGTGAAGGACTTTATCAAAACAGCCGTTTCGTTTCAAGAGATTCAAACGTTTTTAGTTCTTATCTGAGCAGGGTTCTGATCTTGCTGGGACTCTCCAGGTGAGTGAACGAAGGTGTGAAATGTATCGAAACAAGCAAACCGATTTCAGTTCTGAGCTggcattttgatttttttttattaagaggCCGCGCATCAGCTCTTTAGGATATACAGtagttttactattttttgtACTTACTGAGAAGGCGTCTCGAGTGTTAAAGAAGGGTCTTCTTGACATAATGACTGATAAAGTGAAGAACAGAGACTCGGTCCTCAGACAGAAGCCTGTATATGTGGCCTACGTGCAGCAGTGTGAGTGCTGTAGGCTTGCCAGTGGTTACAGCATAATAAACTAATCACACAAATAGA

Function

symbol description
psen2 Predicted to enable endopeptidase activity. Acts upstream of or within several processes, including amyloid-beta formation; melanocyte differentiation; and nervous system development. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including Z disc; ciliary rootlet; and dendritic shaft. Predicted to be integral component of plasma membrane. Is expressed in female organism; heart; male organism; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2).

NR:

description
presenilin-2

GO:

id name namespace
GO:0042987 amyloid precursor protein catabolic process biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007220 Notch receptor processing biological_process
GO:0050435 amyloid-beta metabolic process biological_process
GO:0006509 membrane protein ectodomain proteolysis biological_process
GO:0061053 somite development biological_process
GO:0006816 calcium ion transport biological_process
GO:0030318 melanocyte differentiation biological_process
GO:0007420 brain development biological_process
GO:0022008 neurogenesis biological_process
GO:0005743 mitochondrial inner membrane cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0035253 ciliary rootlet cellular_component
GO:0045121 membrane raft cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0030424 axon cellular_component
GO:0030426 growth cone cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0000139 Golgi membrane cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0005634 nucleus cellular_component
GO:0005938 cell cortex cellular_component
GO:0009986 cell surface cellular_component
GO:0030018 Z disc cellular_component
GO:0043198 dendritic shaft cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0004190 aspartic-type endopeptidase activity molecular_function

KEGG:

id description
K04522 PSEN2, PS2; presenilin 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_043239967.1 False 1908 mRNA 0.52 11 24895841 24902227
XM_043239977.1 True 1985 mRNA 0.51 11 24895841 24902067

Neighbor

gene id symbol gene type direction distance location
spast LOC107749266,LOC107675648,LOC107757022 coding downstream 4374 24883400 ~ 24891467 (-)
gprin3b LOC107729386,LOC107594421,LOC107675731,LOC107583186,LOC107757021,LOC107684268 coding downstream 83671 24806784 ~ 24812170 (-)
zgc:154142 zgc:154142,LOC107676135,LOC107594422 coding downstream 93416 24785279 ~ 24802425 (-)
fam13a fam13a,LOC107757018,LOC107684269,LOC107594423,LOC107675741 coding downstream 111389 24743634 ~ 24784452 (-)
col17a1a LOC107684270,LOC107594448,LOC107583183,LOC107729338 coding downstream 188664 24690982 ~ 24707177 (-)
jag1a jag1a,LOC107675628,LOC107594417,LOC107747432 coding upstream 20969 24923196 ~ 24951265 (-)
esf1 esf1,LOC107757029,LOC107747407,LOC107684260,LOC107675607 coding upstream 74813 24977040 ~ 24984030 (-)
LOC122329700 sgms2,LOC107729360,LOC107675923,LOC107594470,LOC107684311,LOC107757011 coding upstream 232669 25134896 ~ 25138647 (-)
LOC122329893 kif16b,LOC107594414,LOC107747412 coding upstream 306550 25208777 ~ 25225402 (-)
spred2a spred2a,LOC107747416,LOC107675542,LOC107757033,LOC107583232 coding upstream 550977 25453204 ~ 25466466 (-)
G6058 NA non-coding downstream 22300 24872629 ~ 24873541 (-)
LOC122345669 LOC107684322,LOC107676340,LOC107594467,LOC107756997,LOC107583244 non-coding downstream 32467 24840914 ~ 24863374 (-)
G6049 NA non-coding downstream 82318 24813313 ~ 24813523 (-)
G6019 NA non-coding downstream 206145 24689178 ~ 24689696 (-)
G5780 NA non-coding downstream 334388 24560839 ~ 24561453 (-)
G6061 NA non-coding upstream 8914 24911141 ~ 24913468 (-)
G6077 NA non-coding upstream 84757 24986984 ~ 25204897 (-)
G6081 NA non-coding upstream 95425 24997652 ~ 24998787 (-)
G6082 NA non-coding upstream 105681 25007908 ~ 25009573 (-)
G6091 NA non-coding upstream 177769 25079996 ~ 25081855 (-)
G6056 NA other downstream 25376 24868441 ~ 24870465 (-)
LOC122341607 LOC107729348,LOC107676039,LOC107578077,LOC107729356,LOC107594453,LOC107676194,LOC107729349,LOC107706808 other downstream 598250 24291431 ~ 24297591 (-)
atp5md taf5,LOC107676012,LOC107583167,LOC107574147,LOC107684290 other downstream 644602 24193721 ~ 24251239 (-)
si:dkeyp-80c12.8 NA other downstream 674395 24218594 ~ 24221446 (-)
LOC122351900 tcf7l2,lef1,LOC107750316,LOC107757012,LOC107684275,LOC107676173,LOC107594427 other downstream 812965 24061440 ~ 24082876 (-)
G6073 NA other upstream 70264 24972491 ~ 24973371 (-)
G6074 LOC107583193,LOC107757030,LOC107747412 other upstream 86549 24988776 ~ 24993345 (-)
G6078 kif16b,LOC107747412,LOC107583193 other upstream 92256 24994483 ~ 24995820 (-)
LOC122349000 gstcd,LOC107757010,LOC107676029,LOC107729368,LOC107594450,LOC106610363,LOC107684312 other upstream 122495 25024722 ~ 25063882 (-)
G6085 hadh,LOC107594428,LOC107729339 other upstream 223824 25126051 ~ 25127824 (-)

Expression


Co-expression Network