Item | Value |
---|---|
gene id | XLOC_006636 |
gene name | ret |
gene type | coding |
species | zebrafish (Danio rerio) |
category of species | model fish |
Item | Value |
---|---|
chromosome id | NC_007124.7 |
NCBI id | CM002897.2 |
chromosome length | 52186027 |
location | 25584556 ~ 25632756 (-) |
genome version | GRCz11_2017_zebrafish_Genome |
symbol | description |
---|---|
ret | Enables protein homodimerization activity. Acts upstream of or within several processes, including autonomic nervous system development; axon extension; and branchiomeric skeletal muscle development. Predicted to be located in membrane raft and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in nervous system; pharyngeal arch; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene). |
id | name | namespace |
---|---|---|
GO:0048484 | enteric nervous system development | biological_process |
GO:0065003 | protein-containing complex assembly | biological_process |
GO:0033674 | positive regulation of kinase activity | biological_process |
GO:0072114 | pronephros morphogenesis | biological_process |
GO:0007275 | multicellular organism development | biological_process |
GO:0006468 | protein phosphorylation | biological_process |
GO:1901166 | neural crest cell migration involved in autonomic nervous system development | biological_process |
GO:0016310 | phosphorylation | biological_process |
GO:0014707 | branchiomeric skeletal muscle development | biological_process |
GO:0007155 | cell adhesion | biological_process |
GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | biological_process |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological_process |
GO:0045121 | membrane raft | cellular_component |
GO:0030424 | axon | cellular_component |
GO:0005886 | plasma membrane | cellular_component |
GO:0005887 | integral component of plasma membrane | cellular_component |
GO:0016020 | membrane | cellular_component |
GO:0043235 | receptor complex | cellular_component |
GO:0016740 | transferase activity | molecular_function |
GO:0005509 | calcium ion binding | molecular_function |
GO:0005515 | protein binding | molecular_function |
GO:0005524 | ATP binding | molecular_function |
GO:0042803 | protein homodimerization activity | molecular_function |
GO:0000166 | nucleotide binding | molecular_function |
GO:0004672 | protein kinase activity | molecular_function |
GO:0016301 | kinase activity | molecular_function |
GO:0004713 | protein tyrosine kinase activity | molecular_function |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | molecular_function |
id | description |
---|---|
ko04020 | Calcium signaling pathway |
ko05200 | Pathways in cancer |
ko05230 | Central carbon metabolism in cancer |
ko05216 | Thyroid cancer |
ko05223 | Non-small cell lung cancer |
ko01001 | Protein kinases |
id | description |
---|---|
ZDB-GENE-980526-307 | Enables protein homodimerization activity. Acts upstream of or within several processes, including autonomic nervous system development; axon extension; and branchiomeric skeletal muscle development. Predicted to be located in membrane raft and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in nervous system; pharyngeal arch; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene). |
ensembl_id | ENSDARG00000055305 |
RNA id | representative | length | rna type | GC content | exon number | start site | end site |
---|---|---|---|---|---|---|---|
TCONS_00012814 | False | 5094 | mRNA | 0.44 | 19 | 25584556 | 25632756 |
TCONS_00012813 | True | 4230 | mRNA | 0.46 | 20 | 25584556 | 25632756 |
gene id | symbol | gene type | direction | distance | location |
---|---|---|---|---|---|
XLOC_006635 | csgalnact2 | coding | downstream | 3253 | 25569831 ~ 25581303 (-) |
XLOC_006634 | mcmbp | coding | downstream | 35674 | 25531004 ~ 25548882 (-) |
XLOC_006633 | BX005252.1 | coding | downstream | 53908 | 25530534 ~ 25530648 (-) |
XLOC_006632 | tial1 | coding | downstream | 99804 | 25472005 ~ 25484752 (-) |
XLOC_006631 | itprip | coding | downstream | 176169 | 25403413 ~ 25408387 (-) |
XLOC_006637 | si:dkey-192p21.6 | coding | upstream | 9294 | 25642050 ~ 25720907 (-) |
XLOC_006638 | sgpl1 | coding | upstream | 92791 | 25725547 ~ 25750910 (-) |
XLOC_006639 | pdlim1 | coding | upstream | 130152 | 25762908 ~ 25774183 (-) |
XLOC_006640 | NA | coding | upstream | 143633 | 25776389 ~ 25778815 (-) |
XLOC_006641 | rel | coding | upstream | 162755 | 25795511 ~ 25819825 (-) |
XLOC_006471 | BX537274.2 | misc | downstream | 15319651 | 10264741 ~ 10264905 (-) |
XLOC_006338 | rn7sk | misc | downstream | 24758331 | 825904 ~ 826225 (-) |
XLOC_006629 | NA | non-coding | downstream | 299840 | 25210158 ~ 25284716 (-) |
XLOC_006619 | NA | non-coding | downstream | 961331 | 24590420 ~ 24623225 (-) |
XLOC_006620 | AL831745.2 | non-coding | downstream | 977929 | 24602410 ~ 24606627 (-) |
XLOC_006618 | AL831745.1 | non-coding | downstream | 996336 | 24585224 ~ 24588220 (-) |
XLOC_006643 | NA | non-coding | upstream | 213776 | 25846532 ~ 25853311 (-) |
XLOC_006644 | NA | non-coding | upstream | 376741 | 26009497 ~ 26703804 (-) |
XLOC_006645 | NA | non-coding | upstream | 900598 | 26533354 ~ 26544816 (-) |
XLOC_006646 | AL627132.1 | non-coding | upstream | 934310 | 26567066 ~ 26567184 (-) |
species | gene id | symbol | gene type | chromosome | NCBI id | location |
---|---|---|---|---|---|---|
grasscarp (Ctenopharyngodon idella) | CI01000012_11981083_11993407 | RET | coding | CI01000012 | null | 11981083 ~ 11994093 (+) |
bowfin (Amia calva) | AMCG00003217 | NA | coding | CM030139.1 | CM030139.1 | 14788125 ~ 14800222 (+) |