itgb3b (itgb3,itgb3b,LOC107698806,LOC107700113,LOC107706862)


Basic Information

Item Value
gene id itgb3b
gene name itgb3,itgb3b,LOC107698806,LOC107700113,LOC107706862
gene type coding
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056710.1
NCBI id CM032079.1
chromosome length 20499150
location 11553111 ~ 11568617 (+)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>XM_043254270.1
TGGTGCGATGTCTGTTCTGTAGCGTAAAGAAAGGAGGAGGGCACAGACCGCACAAACCGCTGATGCACTCGGGCGATAAAGAGCGATAAACGGCCGTATGAGCTGACTGACAAGTTAACCGAGATGGAGAAAACTTCACCCAAACTCTTCAGTTTATGGATTTATTGTGTAATTGTATTCCTTACTGATGCTGGACTAGGCTCCAACATCTGTACTTCTCGAGGAGCCAGCACATGTCAGCAATGCCTGGCAGTGCATCCTACCTGTGCATGGTGCTTTCAAGAGGATTTTGGACAAAATGTACCTGGTTCCTCCCGATGTGACCTGAAGAAGAACCTCATAGAAGCAGGATGCAGAAAAGGAGCTTTGGAGTATCCCATCAGCAAAATGCATGTGACAGAGAACAAAGATCTCAGTGACAAAGCTTCGGGATCCACCACCGACGTCACCCAGATCCAACCTCAGAGCATGCACATCTCTCTGAGGCCTGATGATTCCCAGGTCTTCACACTGAAAGTCCGCCAGGTTGAGGACTACCCTGTGGACTTGTATTATCTGATGGATTTGTCCTACTCCATGAATGACGATCTGTCTCAGCTGCGACGGCTGGGGAAAGGCCTGGCTGAAGAGATGAGTAAAACCACCAGCAATCTACGCATGGGCTTTGGGGCTTTTGTGGATAAACCCGTGTCACCGTACATGTACATCTCACCTCAAGAAGCTGTGTTAAATCCCTGTTACTCCATCCCATACAAATGCCAGCCTCAgtttggctacagacatgttcTGTCTTTGACGGAGGAGGTCAGCCGCTTTACAGAGGAAGTGAAGAAACAGAAGGTGTCTCGGAACAGGGACGCGCCAGAGGGAGGCTTTGATGCCATTATACAGGCCGCCGTGTGCAAGGAGAAAATTGGTTGGAGACCAGGTGCTTCTCACTTACTGGTTTTCACTACAGATGCCAAGACACACGTGGCACTCGATGGGCGCCTGGCAGGGATTGTACGACCCAATGATGGCCAATGTTACGTGGGCACAGATAACGTCTACAATATGTCTACAACTATGGACTATCCATCCCTGGCATTAATCACAGAGAAAATGTCAGAGAACAATATAAATCTCATCTTTGCTGTGACTAGCCATGTGGAATCACTCTATAAGAACTACAGTGAGCTGATCCCTGGCACTGCGGTGGGCACGTTGTCCGAGGACTCTCATAATGTCATCCAGTTGATTCAGGATGCATACGCTAAACTGCGTTCTAAGGTTGAGCTGGAGCTCTTGAATGTCCCTGAAGAGCTCAGTCTGACATTTAATGCCACATGTCTCAATGGAGAGGTCATCCCTGGGCTAAGATCCTGCTCTGGCCTCAAAAGAGGAGATACAGTGTCCTTCAGTGTAGAAGCTCGGGCCAGAGGCTGTCCTAAAGAGAAGCGTAAGACCTTCACCATCAAACCGGTGGGCTTCAAAGACACCTTGCAGATCACAGTCAACTTCGAGTGCGAGTGTAAATGCCAAGCTAAAGCAGAGCCTGACAGTCCCATCTGTCACCACGGCAATGGCACCTACGAGTGTGGGATCTGCCTGTGCAATCCGGGACGATTGGGTCCCAGGTGTGAGTGTGCAGAGGGGGACTACAGCCCCACCGAGCAGGACGCCTGCACCGGGCCAGACAAAGTGGTCTGCAGCGGTCGTGGAGACTGTGTGTGCGGCCAGTGTGTGTGCCACAATAATGATTTCGGCAAGGTGTGGGGGAAGAGGTGTGAGTGTGACGATTTCAGCTGTCTGCGGTACAAAGGAGAGCTCTGCTCAGGTCATGGCACTTGTTCCTGTGGTTTTTGTCAGTGTGATCCTGACTGGAAGGGGGAGAACTGCAACTGTTCTACTCGTACAGACACCTGTATGTCCAGTTTGGGGCTGTTGTGCAGTGGTcgtggtcagtgtgtgtgtgggagctGTGAATGCACTCAGCCTGGGGCCTACGGCTCTACCTGCGACAAATGCCCCACCTGCCCTGACGCTTGTACACTGAAGAAGGACTGTGTGGAATGTAAGCATTTTAAGAGAGGAAAACTCTTCGATGATGACACTTGCACTCGAATTTGCAGAGATGAAATCAGACTGGTGGATGATTTGGTGTTCCATGATAAGAATGCAGTAAACTGCACCTATAAAGATGAGGACGACTGCGTGCAAAGGTTTCAGTACTATGAGGACAACAGCGGCAAATCCATCCTGTTTCTGGTGAAAGAACCAGACTGCCCTAAAGGCCCTGATATCTTGGTGGTGCTCCTGTCAGTAGCTGGGGCCATTCTGATCTTGGGTCTGGCTGCCCTGCTTATCTGGAAACTGCTTATCACCATCCATGATCGGCGTGAATTTGCAAAGTTTGAGGAGGAGCGAGCACGTGCCAAGTGGGAAACGGGCCACAACCCCCTCTACAAAGGTGCCACATCAACATTCACTAACATCACATACCGAGGCAAGGACTGACCACAGGGAGCAAAGGAAGAATCGGAAGGCACTAACAGACagtgttcatattttaaaagtattaatgtttttgtaaaatgcaatatgCAAATTGAACACGATCAGGAAAGttgtacatatttttgttgtaCATATGTAAAGTCAAAAATGCCATAGTCCCTCTGTGGAAGTCTTTCTGTTTGTCACTGGATGAATGTTAATCTTAACATTTTCTACATGACTGTATTTGACGACAGCACCGTGCCTGGAAAGATAGTTTCACACTGTAGTGACACACGCGTCAAGCcatttcctccctctctctgcttCCTCACAGATATGAATGATAAAAAGCCTGAGCAATCTTTCCAACTACTGATGGCCTGTGGTAACACTGAATCCCTCATCACGAGCAAGAAACGTTCTTAATATAAGCTGTTCTCTTCGCTGTGGTTATAGCTTTGTTAATAATATGTAACTATAGAGGTAGctttttaatcacacacaccTTCAGTGCACAATTTTGGTGGGGTTCGCTTATCAAGTGGTGTATAAAAATGGGCAAGAGTTGTTTGTCGGCATAACTTTTACAAAACGCACGCCAAAAATagagacatttttattatttgtctgGCAGAATGACCTTAAAAGCCAAAAGTCCTCATCCGctcaaatgcaaaaaagtaaCAGTGCCCTCCAATGGAAAAATAAGGAATGGGTTGTGTATATTGATGCTGTAAGACTGGGACCAAATGTAGTACGTGTAAATTCAAGTTAGACAGaaacaacgaaaaaaaaaaaaaaaaaaaattttatgtgatatatttaagtatcattatatttcttatatctAACGATGGAACACAATtcaattttaataacaataaaacatgatataGTGTGTGTA

Function

symbol description
itgb3b Predicted to enable fibronectin binding activity and integrin binding activity. Predicted to contribute to fibrinogen binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within platelet aggregation. Part of integrin complex. Is expressed in brain; cardiovascular system; dental epithelium; digestive system; and pectoral fin fold. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3).
itgb3 Enables several functions, including fibronectin binding activity; protein disulfide isomerase activity; and signaling receptor binding activity. Contributes to C-X3-C chemokine binding activity and growth factor binding activity. Involved in several processes, including apolipoprotein A-I-mediated signaling pathway; negative regulation of lipid localization; and positive regulation of protein phosphorylation. Acts upstream of or within negative regulation of low-density lipoprotein receptor activity. Located in several cellular components, including cell projection membrane; focal adhesion; and melanosome. Part of several cellular components, including alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and alphav-beta3 integrin-PKCalpha complex. Is active in glutamatergic synapse. Implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Biomarker of several diseases, including Graves' disease; carcinoma (multiple); diabetic retinopathy; myelodysplastic syndrome; and platelet-type bleeding disorder 16.

NR:

description
PREDICTED: integrin beta-3

GO:

id name namespace
GO:0070527 platelet aggregation biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007044 cell-substrate junction assembly biological_process
GO:0030334 regulation of cell migration biological_process
GO:0007160 cell-matrix adhesion biological_process
GO:0060055 angiogenesis involved in wound healing biological_process
GO:0008305 integrin complex cellular_component
GO:0005515 protein binding molecular_function

KEGG:

id description
K06493 ITGB3, CD61; integrin beta 3

RNA

RNA id representative length rna type GC content exon number start site end site
XM_043254270.1 True 3382 mRNA 0.47 15 11553111 11568617

Neighbor

gene id symbol gene type direction distance location
mmrn2b LOC107749343,LOC107698811,LOC107550061,LOC107700129,LOC107582854 coding upstream 208514 11335781 ~ 11344597 (+)
glud1b glud1b,LOC107739271,LOC107700126,LOC107698813,LOC107550058,LOC107749346,LOC108430434 coding upstream 232406 11306072 ~ 11320705 (+)
epas1a LOC107698815,LOC107550055,LOC107739260,LOC107700124,LOC107582769 coding upstream 254606 11278272 ~ 11298505 (+)
prkcea prkcea,LOC107550054,LOC107698816,LOC107739250,LOC108274197,LOC108430457 coding upstream 275620 11230187 ~ 11277491 (+)
six3b six3b,LOC107550037,LOC107698799,LOC107582771,LOC107739239,LOC107749382,LOC107700110 coding upstream 340346 11210251 ~ 11212765 (+)
ndel1a ndel1a,LOC107706877,LOC107698805,LOC107700135,LOC107552751,LOC107727307,LOC107582761 coding downstream 883 11569500 ~ 11578830 (+)
armc7 armc7,LOC107706878,LOC107706863 coding downstream 11959 11580576 ~ 11581865 (+)
chad LOC107552753,LOC107727306,LOC107706882,LOC107698804,LOC107675646,LOC107582760 coding downstream 17433 11586050 ~ 11594542 (+)
faap100 LOC107706879,LOC107669495,LOC107552754,LOC107727314,LOC107666926 coding downstream 34357 11602974 ~ 11607362 (+)
arhgap12b arhgap12b,LOC107669490,LOC107552758,LOC107727310 coding downstream 66264 11634881 ~ 11677480 (+)
G87282 LOC107552728,LOC107706876,LOC107700134,LOC107698791,LOC107582764,LOC107727319 non-coding upstream 12007 11473846 ~ 11541104 (+)
G87272 NA non-coding upstream 37115 11438405 ~ 11515996 (+)
G87285 NA non-coding upstream 56119 11484193 ~ 11496992 (+)
G87240 NA non-coding upstream 133899 11260106 ~ 11419212 (+)
G87241 ldb3,LOC107743565,LOC107696891 non-coding upstream 160739 11377113 ~ 11392372 (+)
G87331 NA non-coding downstream 173364 11741981 ~ 11744405 (+)
G87341 NA non-coding downstream 231739 11800356 ~ 11800627 (+)
G87343 NA non-coding downstream 234670 11803287 ~ 11803627 (+)
G87337 chmp2a,LOC106589279 non-coding downstream 253446 11822063 ~ 11823322 (+)
G87617 NA non-coding downstream 428673 11997290 ~ 11997512 (+)
svila LOC107686370,LOC107657481,LOC107584371,LOC107749370,LOC107549408 other upstream 970566 10523143 ~ 10582545 (+)
LOC122355633 rhoq other upstream 1053413 10497425 ~ 10499698 (+)
LOC122355192 opn4b,LOC107552747,LOC107739286,LOC107568552,LOC107582762,LOC107700131 other upstream 1056834 10481492 ~ 10496277 (+)
LOC122355255 NA other upstream 1654110 9883033 ~ 9899001 (+)
LOC122355252 fam20cl,LOC107741571,LOC107664989,LOC107570372,LOC108436593,LOC102782963,LOC108259419 other upstream 1678596 9864814 ~ 9874515 (+)
G87315 zeb1b,LOC107666916,LOC107706887,LOC107727309,LOC107582755,LOC107552760,LOC107669492 other downstream 126227 11694844 ~ 11701655 (+)
hoxb6b hoxb6b,LOC107669478,LOC107706870,LOC107582852,LOC107552740,LOC107666911,LOC107727299 other downstream 313534 11882151 ~ 11884097 (+)
nbr1a nbr1,LOC107669491,LOC107706899,LOC107582742,LOC107727312,LOC107666919 other downstream 368224 11936841 ~ 11945635 (+)
G87817 NA other downstream 1164147 12732764 ~ 12737649 (+)
gall si:rp71-1c10.8,LOC107677873,LOC107743798,LOC107675007,LOC107566084,LOC107754084,LOC107563807 other downstream 1191757 12760374 ~ 12762731 (+)

Expression


Co-expression Network