XLOC_006660 (tlx1)


Basic Information

Item Value
gene id XLOC_006660
gene name tlx1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 28267997 ~ 28272299 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012860
CATGCAGTCAATGCAGTTAGATAACGACAAGTCTGGACTAAACTGCGTTTTAGTTGCTGTATGATAACTCGGGTGACGTGGGGGATCGCAGGAGCGCGCGCCTCTCCACACCATGGATCATATGGGAGCGCATCTCCACCAGACGCACGCAGACACCATCAGTTTTGGGATCGATCAGATTCTCAACAATGCAGACCAGGGGAGCTGCATGATCACCAACCCCAGAATGCAGGACCTGGACTACGGTTTGGGCTGCATAGTCAGCACAGCATACAATACCATGACTGGTAACTACAACGTCAATAACTCCTCTGGATACAATGGAAACTCTTGCAGCGTCGGGTCCTACAACATGAACTTGGGCGCGAATGTTAACGGAAATTGCCTTAATTCGTCGGGAGTGATCCGGGTTCCTGCACACCGGCCGCTGGGCAGCGTTCACTCGTCCATTCCCACAAGCGCTGCCACGGTGCCAAGTATGGGAAGCATGGGCACTATTAACAATCTCACGGGATTAACGTTTCCGTGGATGGAGAGTAACAGGAGATATACCAAAGACAGGTTTACAGTGGCCCTCTCACCGTTCACTGTAACACGCCGTATAGGTCACCCGTACCAGAACCGAACACCTCCGAAGAAGAAGAAGCCCCGGACGTCGTTCACGCGCCTTCAGATATGTGAGCTGGAGAAACGCTTTCACCGTCAGAAGTATCTGGCGTCAGCCGAGAGAGCAGCCTTAGCGAAAGCACTTAAAATGACTGATGCGCAGGTCAAAACATGGTTCCAGAACAGAAGAACGAAATGGAGGCGGCAGACAGCGGAGGAGAGAGAAGCCGAGCGACAACAAGCCAACCGAATTCTAATGCAGCTTCAGCAAGAAGCTTTTCAAAAGACTATAAACCAGCCTGTTACTCCAGACCCAATCTGTCTACACAACAGCTCTCTATTCGCACTTCAGAACCTGCAGCCCTGGACTGAGAACACGGCAAAAATCAGCAGCGTTCCCAACACTGACTGATGGAGACTTGTGGACGCGCGGTGTACAGAGGAATATCCCAACAGCACATTACTTCTTTTAActaaattactattttatttgtaACATGAAACTTGTTTAAAGTAACTTTAATAATTGCCTTTCTCGTGCAGAATAATCAGTTTTGAAATTGATTTTTATAGGTTTGATCAtttccattttaaaatgcaaCGAACAAATTGTTATTGCGCATTTGGTTTGTCTCTTGCGCATTCATTTTATTTGGTATATACCATACCTACTTCTAAGATCTGACGCGTgtgataacactttataatacctTAAATTAAACATCACAACATTTTACAAATGAAATATAGATAACAAACGTACGAGCCTTAGTTAAATTAGGGGCTTTTCTAAAagcataataatttaatttaattgatattAGGTCAGAAATCGCCACAGAACTAATTGTGCATGGGCTATGTTAAATTAGAACAcctaaatggataaataaaattGCCATAGCACACATCTTCCTCCGTCACTAGAAAAAGGCTCTCTGTTCTAATACTTTTTTGTGGAGAAAAAGGAGCATTACTGCTTGTTTGGTGAAGCTAAAACGAATAGTGAACGCCACCTTTCTGATGTAGCCTATGAAATATACGGTAAGCGTCGTTATTAAAATCCTTTTTATTGAAAGAATAGGCACACGCAGGGTGAAAGGTTGCACTTCTTAACCCACAATCGAGCGAAAACTAAAGTTTCTCTTTTACTGTCTTACGACGGTCTCTTTCACTTCTGACAGTTTACAGTCGCGATACCCTCTGTCAGTAGAATGTGAATTGAAAAATTAAGCTATTAAAATCGTTTAATTGGGTGTACTTTGAATATAAAggaattaaaaagtaaatgtatCCAAGTTCAAAGTACTAAATAGTCGATTTGTTCAATATTTAATAGCCTATATGCACATTTTTAACTTGTTCCTACACTGAAAGAAAATGGATAATATTACAGTTATTATAAACTGTTATcacaaaattaatattattattattattaggcttaCCAATTTGGCTtttgttactatttttttttataatcacagaGGGACCGAATTTTTGCACGTTTGTTAACCTAAGTGggctaacatttttaaaaatcgacACGATTTAAAAGTAGTCTACAAGGGTCTACATAATGGAATTTCATTTGTTATGCAACTATGGTGAAGACGG

Function

symbol description
tlx1 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in spleen. Human ortholog(s) of this gene implicated in adult T-cell leukemia. Orthologous to human TLX1 (T cell leukemia homeobox 1).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0048513 animal organ development biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function

KEGG:

id description
ko05202 Transcriptional misregulation in cancer
ko03000 Transcription factors

ZFIN:

id description
ZDB-GENE-021021-2 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in spleen. Human ortholog(s) of this gene implicated in adult T-cell leukemia. Orthologous to human TLX1 (T cell leukemia homeobox 1).

Ensembl:

ensembl_id ENSDARG00000003965

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012860 True 2223 mRNA 0.41 3 28267997 28272299

Neighbor

gene id symbol gene type direction distance location
XLOC_006659 sdhaf4 coding downstream 2078 28264834 ~ 28265919 (-)
XLOC_006657 smap1 coding downstream 4129 28009727 ~ 28263868 (-)
XLOC_006658 CR392046.1 coding downstream 88447 28179434 ~ 28179550 (-)
XLOC_006656 ogfrl1 coding downstream 351432 27900446 ~ 27916565 (-)
XLOC_006655 NA coding downstream 451356 27801415 ~ 27816641 (-)
XLOC_006661 BX950184.1 coding upstream 4599 28276898 ~ 28417158 (-)
XLOC_006662 lbx1a coding upstream 33499 28305798 ~ 28308138 (-)
XLOC_006663 NA coding upstream 155178 28427477 ~ 28444818 (-)
XLOC_006664 NA coding upstream 225503 28497802 ~ 28513347 (-)
XLOC_006665 NA coding upstream 274113 28546412 ~ 28572464 (-)
XLOC_006471 BX537274.2 misc downstream 18003092 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 27441772 825904 ~ 826225 (-)
XLOC_006654 CR356236.2 non-coding downstream 577721 27690160 ~ 27690276 (-)
XLOC_006650 NA non-coding downstream 990288 27271338 ~ 27277709 (-)
XLOC_006649 NA non-coding downstream 1040247 27227361 ~ 27227750 (-)
XLOC_006668 NA non-coding upstream 404822 28677121 ~ 28719230 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000012_10489814_10496226 TLX1, TLX1.L coding CI01000012 null 10489727 ~ 10496584 (+)
bowfin (Amia calva) AMCG00003344 tlx1,LOC107585374,LOC107588667,LOC107694453 coding CM030139.1 CM030139.1 20159328 ~ 20165583 (-)