adam17a (adam17,adam17a,LOC107752755,LOC107655315,LOC107707689,LOC107563905)


Basic Information

Item Value
gene id adam17a
gene name adam17,adam17a,LOC107752755,LOC107655315,LOC107707689,LOC107563905
gene type coding
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056715.1
NCBI id CM032084.1
chromosome length 22256391
location 14160519 ~ 14171694 (-)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>XM_043262933.1
CCGGAAGTAGATTCGGCGGAATTCCTCCTCAGATTGTTATCGCAGCAGAATCCGGCGCGACGAGGAGGAACCAGTGCGATAGTGTTCGCGgtgtattgtatttattcacattcaGCATTCAACGggatcatattttatttttatatttaaattcatcCGCTGTCGTCGTGTTCAATAAGCGAACGAAAGGGGAAGGTAAATAACGGACGGTAGATGTTGACAGCCACGGACTTCACATTCAGACATGGTTCTTTGACAGAAGTGATGCTTCATCGCCAGTATGGAGTCTTTGATATTTTATCTAGTGCTGTTAACTCCCCTTTCTATCCGTTGTGCGGTGAAACCAGCATCTGTTGAAGAAGACCCGAGAAATCAGGAAGAGGTGCAAGAGTTTGATGCTCTCAGCTCCATGCTGTCGGACTTTGATGTTGTGCCTGCATCAGATCTGCAGCTTCACTCGGTCAGGAAGAGGGACACGGATGCCCGATCGCATGTGGAGCGCTTGGTCAGCTTCACAGCCCTCCAGAGGCACTTCAAACTGTACTTGACAACCAACACAGACCTTTTCGCTGACAACTTCAAAGCTGTATTCCTAGACGAGAATGGAAAAGAGGACCAATTTGACATTCAGCTACAAAATTACTACAAAGGACACGTAGTAGGAGAGGAGCACTCGCGTGTGCAGGCACACATAGACGGGAAGGAGTTTTCAGCCCACATTCTTACTGAAGATGCTGAATATAATGTAGAGCCCTTGTGGCGGTTTACAGAGTCACCTTCTGATGGCCGTTTGCTGGTGTACCGTTCAGAGGACATTAAAAACATCAGTCGACTGTCCTCACCCAAAGTGTGTGGATATGTGAACACTGACGCTCAGGAGCTCCTGCCAGAAGAGGCGAGAGCAACGGGACAGAAGGCACAGGAGGATGAGCCTCACAACATACAGAGAAGATCTGCGCAGGACAAGAAGAACACCTGCCCGCTGCTGCTAGTGGCAGATCATCGCTTCTACAAGCACATGGGCCGTGGAGAGGAGAGCACCACCCTCAACTACTTGATTGAGCTGATAGACAGAGTGGATGATATATACAGAAACACAACCTGGGATGAGGATTTTAAAGGCTTCGGGGTGCAGATTCAGCAGATAATCATAAACAAGGAGCCCACAAAAGTTGCCCATGGAGACATTCATTACAACATGGATGGCAGCCCATTAGGAAGAAAGGACGGTGTGTGGGATGTGAAGAAGCTTCTAGAACAATTCAGTTATGACATCTCAGACAACGCCTCTACAGTTTGCCTCGCCCACCTCTTCACCTATCAGGACTTTGATGATGGCACTCTGGGTCTGGCTTACGTGGCTCCTTCCAAACAGGGATTGGGAGGACTCTGCCCTAAACCTTACTATCCATCACAAACCGTCAGGAAACCCAGCTACCTAAACACAGGCTTGACAAGCACCATGAATTATGGGAAAACTATTCTAACTAAGGAAGCAGATCTTGTAACAACGCATGAGCTCGGGCACAACTTCGGAGCAGAACACGATCCAGACAACATACCTGCCTGTGCGCCCAGCGATGATCAGGGCGGCAAATATGTCATGTACCCTATTGCGGTCAGCGGAGATCACGTCAACAACAAGCGCTTCTCCAGCTGCAGCAAGTTCTCGGTCAGTAGGACGTTAAGGGTCAAGGCTCATCAGTGCTTTAAGGAGAGGAGCAGCAAGCTGTGCGGGAACTCCCGTGTGGAGGAGGACGAAGACTGTGACCCTGGACTCCTTCATCTCAACGACGACCCCTGCTGCACAGCTAAGTGCAAGTTCAAGAAGCAGGCAGAATGCAGTGACAGGAACAGCCCCTGCTGCAAGAACTGTAGGTTTGAAAGTGCAGATAAGATCTGTCAGGAGACCATCACCGCCACCTGCAAGGGCACGTCAAAGTGCTCAGGCAACAGCAGTGAGTGTCCCACCCCTGGAAACCTGGCTGATAATACAGAGTGTGTGGACAAGGGCCGATGCCAGAAGGGCGAGTGCATGCCTTTCTGTGAGGCCGTGCATCGTCTTGAGTCCTGTGCCTGTAATGAGACTGAGAACTCGTGTAAAGTGTGCTGTAGAAGCAGCAGTGGGCTGTGCGCTCCCTTTGACAGTAATGGGTCGTATCTTTACCTGCGCAAGGGCAAGCCCTGCACCGTTGGCTTCTGTGACGGTTCTGGTAAATGCATGAAGCACGTCCAAGATGTCATCGAACGTTTATGGGACTTTATAGACAAACTGGACATCAACACATTTGGGAAGTTCTTGGCTGATAACATAGTTGGATCAGTGGTggtcttctctctcctcttctgGATTCCCCTAAGCATATTGGTGCACTGTGTGGACAAGAAACTGGATCAACAATATGAGGAAAACTCCAAAACCATGATGTACCCAAGTCAGATGGTGGTGGAGGTGTGTAGTAGAGCTCTCAACTCAGAGCGCAGAGATAATGAGCGGCCTGGAATCGGCGCCCATCCGCATTGTGAAGGCCCCTCATCTGCATTCAGCGGGAGCGCGACCTCAGCCCTCGCTGGGCCCCACGGGCCCCGGCGTCTCACCGGCACAGGAGACGCTCGCCGGCCCAGACCCAGCCAACCTCTCCGCCGCACTCAAAGCGGATCCGCTGCGAATGGCCACAATCGAGGAGGACCCCAGCGGAGACTCCTCTCACCTGGAAGAGGACGGCTTCCGTCAAAGCGGCACAGCTGCCAGGTCCTTCGAGGACCTCACCGGACAGGCAACGCCATCCCGCGGGGACAAGAAGCGGCTGACGAGACAGGCCCGCATTGACAGTAAGGAGACGGAGTGCTGAGGGACTCGGGGGGCAATCGGGCTTCGTTTAAAAGTGTATGTGATGTGTAAACTGCTGACGCATTTCAGTTGGCTCTTAGGAATTTTGTAGCATTCCTTTAATGCACAATTGTAGTTGTTAAAAATAGAATGCTACAGAAACTGGCAAGAGAAATGTCTCAGcatttggtcaaaaaaaaattcagtagaGCTTTGGACAGCATCTTTGGCGGTGAGATATGACTCAGCGGTTATAAGCCGGCAAAAAGACAAATCTAAATGTTGTCAAAATCAAACCTGTAAATAAAATTTTCCTTTGTGGAAGCACAAATATTCTTTTTGACCCCAGTGACTATTGTATGGACACAAAAGGAATATCTTTATGTTCCGCCGGAGAGAGCAAGTAATGCCGGTTgtgtgaatgatgacagaagtttaATTTTAGTGTAAACCATTCCTCTTAATGGTTTTACTCTTTTggcgttgttgttgtttttttgtggtaattGACAATCCCAGGTGCTGTCCTTaaatcttaaagggacagttcaccttcACAATGATGCTATCGTTTCCTCTCcttcatgtcgtttcaaacccaaAAACCACAAgggtatttttaatgaaatcagagATTTCCATccctcattaaaaatgaattctcCCAAAACTttcgctttttaaaatgttcataaagaCTGTATATAAAAGAGTCGAGCATTTCAATCCAGGTCTTCTGCAGAGGtgcaatcattttatatttgcttttcatttacCATAAAGGACGAGCTCTTCATACTGCAGTTTGTGTAGATCAACGTATGGATGATAATAAAATCTAGCATTTAAACCtgttatgggtttggaatgacacgagggtgaggtttggtaaactatccctttaactcgtatttaatattcttttaataCAGTCAGTATGTGCCTTGTAGCATACACTCAGTAGTGcaaattgtttgtatttttatgtatgtataccTCATAAAGAACATGAGCAGCAGGACTACTGCATGACTTTTAATGTTACACTGGTCGACTTGCTGAGAACATTTAAGCTATGCATGTCCTACGCCCTACgtttatgaattaaatgtcATACGTGTTAGGAAACTGTAAGACGAGAGTTTTATTTGACCTGTCCTTAAGGCTTAAAAATTgcacatcattttttttgcattaagttttgtttggtttgattTGTACTACTACATATAGCATCTCGTGTCATTTTAATATAGCAGTATGAATTTGAGAAACACTGAGGGATGTGCGCATTTCgtagtttttctatttttgccaCTAAAATGGTTGTACAGGTGTCCAAAACCGGTCGATATAGTATTCCCCCCACTGTGAAATATCAGACTTTAACCATTAGTCCAATTTTGAGATTGTATTCAATTTTAACGTGCCATAATAAGTCAAACGACTGCGTATAAGTTTTGTATTGTTTCCTACCTTCCTGTATATCAAATCAGAAGTAATTAAAAACGCCTCACTTGGATGTAGAAAGCTGTATCTGATCTAAATCCGCTATCATTCagtgtctgtgtttttgatgCTCGGTTATGTcccatttatttaacatgtattCTTGGGGTTTGAAGCCACACGAATAAAATGTCTCTACACTGa
>XM_043262934.1
GGAAGTAGATTCGGCGGAATTCCTCCTCAGATTGTTATCGCAGCAGAATCCGGCGCGACGAGGAGGAACCAGTGCGATAGTGTTCGCGgtgtattgtatttattcacattcaGCATTCAACGggatcatattttatttttatatttaaattcatcCGCTGTCGTCGTGTTCAATAAGCGAACGAAAGGGGAAGGTAAATAACGGACGGTAGATGTTGACAGCCACGGACTTCACATTCAGACATGGTTCTTTGACAGAAGTGATGCTTCATCGCCAGTATGGAGTCTTTGATATTTTATCTAGTGCTGTTAACTCCCCTTTCTATCCGTTGTGCGGTGAAACCAGCATCTGTTGAAGAAGACCCGAGAAATCAGGAAGAGGTGCAAGAGTTTGATGCTCTCAGCTCCATGCTGTCGGACTTTGATGTTGTGCCTGCATCAGATCTGCAGCTTCACTCGGTCAGGAAGAGGGACACGGATGCCCGATCGCATGTGGAGCGCTTGGTCAGCTTCACAGCCCTCCAGAGGCACTTCAAACTGTACTTGACAACCAACACAGACCTTTTCGCTGACAACTTCAAAGCTGTATTCCTAGACGAGAATGGAAAAGAGGACCAATTTGACATTCAGCTACAAAATTACTACAAAGGACACGTAGTAGGAGAGGAGCACTCGCGTGTGCAGGCACACATAGACGGGAAGGAGTTTTCAGCCCACATTCTTACTGAAGATGCTGAATATAATGTAGAGCCCTTGTGGCGGTTTACAGAGTCACCTTCTGATGGCCGTTTGCTGGTGTACCGTTCAGAGGACATTAAAAACATCAGTCGACTGTCCTCACCCAAAGTGTGTGGATATGTGAACACTGACGCTCAGGAGCTCCTGCCAGAAGAGGCGAGAGCAACGGGACAGAAGGCACAGGAGGATGAGCCTCACAACATACAGAGAAGATCTGCGCAGGACAAGAAGAACACCTGCCCGCTGCTGCTAGTGGCAGATCATCGCTTCTACAAGCACATGGGCCGTGGAGAGGAGAGCACCACCCTCAACTACTTGATTGAGCTGATAGACAGAGTGGATGATATATACAGAAACACAACCTGGGATGAGGATTTTAAAGGCTTCGGGGTGCAGATTCAGCAGATAATCATAAACAAGGAGCCCACAAAAGTTGCCCATGGAGACATTCATTACAACATGGATGGCAGCCCATTAGGAAGAAAGGACGGTGTGTGGGATGTGAAGAAGCTTCTAGAACAATTCAGTTATGACATCTCAGACAACGCCTCTACAGTTTGCCTCGCCCACCTCTTCACCTATCAGGACTTTGATGATGGCACTCTGGGTCTGGCTTACGTGGCTCCTTCCAAACAGGGATTGGGAGGACTCTGCCCTAAACCTTACTATCCATCACAAACCGTCAGGAAACCCAGCTACCTAAACACAGGCTTGACAAGCACCATGAATTATGGGAAAACTATTCTAACTAAGGAAGCAGATCTTGTAACAACGCATGAGCTCGGGCACAACTTCGGAGCAGAACACGATCCAGACAACATACCTGCCTGTGCGCCCAGCGATGATCAGGGCGGCAAATATGTCATGTACCCTATTGCGGTCAGCGGAGATCACGTCAACAACAAGCGCTTCTCCAGCTGCAGCAAGTTCTCGGTCAGTAGGACGTTAAGGGTCAAGGCTCATCAGTGCTTTAAGGAGAGGAGCAGCAAGCTGTGCGGGAACTCCCGTGTGGAGGAGGACGAAGACTGTGACCCTGGACTCCTTCATCTCAACGACGACCCCTGCTGCACAGCTAAGTGCAAGTTCAAGAAGCAGGCAGAATGCAGTGACAGGAACAGCCCCTGCTGCAAGAACTGTAGGTTTGAAAGTGCAGATAAGATCTGTCAGGAGACCATCACCGCCACCTGCAAGGGCACGTCAAAGTGCTCAGGCAACAGCAGTGAGTGTCCCACCCCTGGAAACCTGGCTGATAATACAGAGTGTGTGGACAAGGGCCGATGCCAGAAGGGCGAGTGCATGCCTTTCTGTGAGGCCGTGCATCGTCTTGAGTCCTGTGCCTGTAATGAGACTGAGAACTCGTGTAAAGTGTGCTGTAGAAGCAGCAGTGGGCTGTGCGCTCCCTTTGACAGTAATGGGTCGTATCTTTACCTGCGCAAGGGCAAGCCCTGCACCGTTGGCTTCTGTGACGGTTCTGGTAAATGCATGAAGCACGTCCAAGATGTCATCGAACGTTTATGGGACTTTATAGACAAACTGGACATCAACACATTTGGGAAGTTCTTGGCTGATAACATAGTTGGATCAGTGGTggtcttctctctcctcttctgGATTCCCCTAAGCATATTGGTGCACTGTGTGGACAAGAAACTGGATCAACAATATGAGGAAAACTCCAAAACCATGATGTACCCAAGTAGCGCAGAGATAATGAGCGGCCTGGAATCGGCGCCCATCCGCATTGTGAAGGCCCCTCATCTGCATTCAGCGGGAGCGCGACCTCAGCCCTCGCTGGGCCCCACGGGCCCCGGCGTCTCACCGGCACAGGAGACGCTCGCCGGCCCAGACCCAGCCAACCTCTCCGCCGCACTCAAAGCGGATCCGCTGCGAATGGCCACAATCGAGGAGGACCCCAGCGGAGACTCCTCTCACCTGGAAGAGGACGGCTTCCGTCAAAGCGGCACAGCTGCCAGGTCCTTCGAGGACCTCACCGGACAGGCAACGCCATCCCGCGGGGACAAGAAGCGGCTGACGAGACAGGCCCGCATTGACAGTAAGGAGACGGAGTGCTGAGGGACTCGGGGGGCAATCGGGCTTCGTTTAAAAGTGTATGTGATGTGTAAACTGCTGACGCATTTCAGTTGGCTCTTAGGAATTTTGTAGCATTCCTTTAATGCACAATTGTAGTTGTTAAAAATAGAATGCTACAGAAACTGGCAAGAGAAATGTCTCAGcatttggtcaaaaaaaaattcagtagaGCTTTGGACAGCATCTTTGGCGGTGAGATATGACTCAGCGGTTATAAGCCGGCAAAAAGACAAATCTAAATGTTGTCAAAATCAAACCTGTAAATAAAATTTTCCTTTGTGGAAGCACAAATATTCTTTTTGACCCCAGTGACTATTGTATGGACACAAAAGGAATATCTTTATGTTCCGCCGGAGAGAGCAAGTAATGCCGGTTgtgtgaatgatgacagaagtttaATTTTAGTGTAAACCATTCCTCTTAATGGTTTTACTCTTTTggcgttgttgttgtttttttgtggtaattGACAATCCCAGGTGCTGTCCTTaaatcttaaagggacagttcaccttcACAATGATGCTATCGTTTCCTCTCcttcatgtcgtttcaaacccaaAAACCACAAgggtatttttaatgaaatcagagATTTCCATccctcattaaaaatgaattctcCCAAAACTttcgctttttaaaatgttcataaagaCTGTATATAAAAGAGTCGAGCATTTCAATCCAGGTCTTCTGCAGAGGtgcaatcattttatatttgcttttcatttacCATAAAGGACGAGCTCTTCATACTGCAGTTTGTGTAGATCAACGTATGGATGATAATAAAATCTAGCATTTAAACCtgttatgggtttggaatgacacgagggtgaggtttggtaaactatccctttaactcgtatttaatattcttttaataCAGTCAGTATGTGCCTTGTAGCATACACTCAGTAGTGcaaattgtttgtatttttatgtatgtataccTCATAAAGAACATGAGCAGCAGGACTACTGCATGACTTTTAATGTTACACTGGTCGACTTGCTGAGAACATTTAAGCTATGCATGTCCTACGCCCTACgtttatgaattaaatgtcATACGTGTTAGGAAACTGTAAGACGAGAGTTTTATTTGACCTGTCCTTAAGGCTTAAAAATTgcacatcattttttttgcattaagttttgtttggtttgattTGTACTACTACATATAGCATCTCGTGTCATTTTAATATAGCAGTATGAATTTGAGAAACACTGAGGGATGTGCGCATTTCgtagtttttctatttttgccaCTAAAATGGTTGTACAGGTGTCCAAAACCGGTCGATATAGTATTCCCCCCACTGTGAAATATCAGACTTTAACCATTAGTCCAATTTTGAGATTGTATTCAATTTTAACGTGCCATAATAAGTCAAACGACTGCGTATAAGTTTTGTATTGTTTCCTACCTTCCTGTATATCAAATCAGAAGTAATTAAAAACGCCTCACTTGGATGTAGAAAGCTGTATCTGATCTAAATCCGCTATCATTCagtgtctgtgtttttgatgCTCGGTTATGTcccatttatttaacatgtattCTTGGGGTTTGAAGCCACACGAATAAAATGTCTCTACACTGa

Function

symbol description
adam17a Predicted to enable metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to act upstream of or within integrin-mediated signaling pathway and proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
adam17 Enables PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; regulation of signal transduction; and response to bacterium. Located in several cellular components, including apical plasma membrane; cell surface; and membrane raft. Is integral component of plasma membrane. Colocalizes with cell-cell junction; focal adhesion; and ruffle membrane. Implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Biomarker of renal fibrosis.

NR:

description
disintegrin and metalloproteinase domain-containing protein 17-like

GO:

id name namespace
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0006508 proteolysis biological_process
GO:0004222 metalloendopeptidase activity molecular_function
GO:0008270 zinc ion binding molecular_function

KEGG:

id description
K06059 ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17

RNA

RNA id representative length rna type GC content exon number start site end site
XM_043262933.1 True 4483 mRNA 0.46 20 14160519 14171694
XM_043262934.1 False 4441 mRNA 0.46 19 14160519 14171692

Neighbor

gene id symbol gene type direction distance location
itgb1bp1 itgb1bp1,LOC107655317,LOC107707691,LOC107679818,LOC107752756 coding downstream 13306 14142944 ~ 14147213 (-)
mboat2a mboat2,mboat2a,LOC107553282,LOC107752759,LOC107655319,LOC107707682 coding downstream 76578 14040353 ~ 14083941 (-)
LOC122361864 fut8a,LOC107674109,LOC107752771,LOC107592788,LOC107553275 coding downstream 528521 13626625 ~ 13631998 (-)
dnal1 dnal1 coding downstream 761153 13396400 ~ 13399366 (-)
tedc1 LOC107752774,LOC107697787,LOC107592785,LOC107733103,LOC107594770,LOC107674045 coding downstream 764900 13384540 ~ 13395619 (-)
rnf144aa rnf144aa,rnf144a,LOC107752753,LOC107655314,LOC107553279 coding upstream 1577 14173271 ~ 14204581 (-)
rsad2 rsad2,LOC107752752,LOC107553276,LOC107707684,LOC107655310 coding upstream 35086 14206780 ~ 14209877 (-)
LOC122361997 slc22a15,LOC107750851,LOC107717086,LOC107671142,LOC107553868 coding upstream 220709 14392403 ~ 14397785 (-)
LOC122361878 LOC107594701,LOC107679774 coding upstream 227411 14399105 ~ 14406676 (-)
sox11a sox11a,LOC107752751,LOC107594691,LOC107679744 coding upstream 338078 14509772 ~ 14511663 (-)
G120989 NA non-coding downstream 71644 14088640 ~ 14088875 (-)
G120983 NA non-coding downstream 184293 13975747 ~ 13976226 (-)
G120982 NA non-coding downstream 196649 13963593 ~ 13963870 (-)
G120980 NA non-coding downstream 226834 13933420 ~ 13933685 (-)
G120929 NA non-coding downstream 345505 13777725 ~ 13815014 (-)
G121051 NA non-coding upstream 219690 14391384 ~ 14392042 (-)
G121069 NA non-coding upstream 279929 14451623 ~ 14456789 (-)
LOC122361512 NA non-coding upstream 290431 14462125 ~ 14580868 (-)
G121096 LOC107752749,LOC107594711,LOC107666252 non-coding upstream 605192 14776886 ~ 14777109 (-)
G121123 NA non-coding upstream 619235 14790929 ~ 14792068 (-)
kidins220a id2a,id2,kidins220,LOC107579075,LOC107707685,LOC107553286,LOC107655320,LOC107752760 other downstream 120308 13981547 ~ 14040211 (-)
LOC122361883 LOC107592775,LOC107752809,LOC100537549,LOC108433935,LOC107733136,LOC107674087 other downstream 959827 13193177 ~ 13200692 (-)
G120660 LOC107752798,LOC107592762,LOC107697764,LOC107733171 other downstream 1339851 12817192 ~ 12820668 (-)
LOC122361973 LOC107592804,LOC107697765,LOC107752799,LOC107674033,LOC107733077 other downstream 1368650 12663239 ~ 12791869 (-)
lin52 lin52,LOC107594798 other downstream 1768971 12381281 ~ 12391548 (-)
LOC122361652 LOC107679745,LOC107752800,LOC107594718 other upstream 537797 14709491 ~ 14733577 (-)
myo6b myo6b,LOC107741840,LOC107594692,LOC107679792,LOC107600844,LOC107666253 other upstream 620492 14792186 ~ 14839813 (-)
ptgr2 ptgr2 other upstream 839132 15010826 ~ 15026415 (-)
crip1 crip1,LOC106611282,LOC107679815,LOC107594706,LOC107600860 other upstream 888299 15059993 ~ 15064678 (-)
crip2 crip2,LOC107594708,LOC107752734,LOC107679813,LOC107666262,LOC107741856,LOC107600859 other upstream 912124 15083818 ~ 15099957 (-)

Expression


Co-expression Network