psen1 (psen1,LOC107684238,LOC107753355,LOC107687832,LOC107723284)


Basic Information

Item Value
gene id psen1
gene name psen1,LOC107684238,LOC107753355,LOC107687832,LOC107723284
gene type coding
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056715.1
NCBI id CM032084.1
chromosome length 22256391
location 18347425 ~ 18355107 (-)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>XM_043263612.1
CTCAGCGCTTCCGTGTCAGTCTCACCGCGTCCCGCTTCACAGTATTGAGGGCTTTTATCAGCCAGAATCCAGATTCCAGATCCTGTTGTGTCTATGATCCCTGGGTCACTTCACAGCACCGATGGCTGATAATGTGGAAAATGCTGTCAACAATGTGtcaAGCGACGGGCCGGAGGTCAGCCGGCACACGGAGACGACTCCCGGCCGCACCGAGGTGGAGCTGAACGGCCAGCCGCCCACCGCCCGGCCCCCGCAGGTGGTCACGGACAGCGAGGAGGACGAGGACGAGGAGCTCACCCTCAAGTACGGAGCCAAGCACGTGATCATGCTGTTCATCCCCGTCACGCTGTGCATGGTGGTGGTCGTGGCCACCATCAAGTCGGTCAGTTTCTACACGCAAAAGGACGGCCAGCAGCTGATCTACACTCCGTTCCGTGAGGACACCGAGACGGTGGGGCAGCGTGCGCTCAACTCCATGCTCAACGCCACCATCATGATCAGTGTGATAGTGGTCATGACCCTGGTGCTGGTGGTGCTCTACAAGTACCGATGCTACAAGgtgatTCAAGCCTGGCTGTTCTTCTCCAACCTTCTCCTgctcttctttttctccttcatttATTTAGGGGAAGTGTTCAAGACGTACAACGTGGCCATGGACTACTTCACGTTGGCGGTGATCATCTGGAACTTCGGCGTGGTGGGAATGATCTGTATCCACTGGAAGGGTCCGCTGCGGCTCCAGCAGGCCTATCTGATCATGATCAGCGCTCTCATGGCCCTGGTCTTCATCAAGTACCTGCCGGAGTGGACTGCCTGGCTCATCCTCGCTGCTATATCCGTCTACGATCTGCTGGCCGTGTTGTGCCCGAAAGGACCTCTGCGTATCCTTGTGGAAACTGCTCAGGAGAGAAACGAACCCATCTTTCCCGCTCTCATTTACTCCTCAACCATGGTGTGGCTGTTTAATATGGCGGACAGCGCTGAGACCAGGAATAATTCCAGCCATCCAGTTCCTCAACAGGAGAACCAGGTTGCCATGGCACCCACGGCTCAGCCGGAGGATGATGGAGGCTTCACCCCAGCTTGGGTCAATCAGCAGCAGCATCAGCTCGGCCCCATGCAGTCCACTGAGGACAGCAGACGAGAGATCCAGGACATGCCCTCCGCTCGCCCGGCGCCCGTAGAAGACGACGAAGAGCgcgGTGTGAAGCTGGGTTTGGGAGACTTCATCTTTTACAGTATGCTGGTGGGTAAAGCATCAGCCACAGCCAGCGGGGACTGGAACACGACGCTAGCCTGCTTTGTGGCCATTCTCATCGGTTTATGTCTAACTTTGCTCCTCCTGGCCATCTTCAAAAAGGCCCTTCCAGCTCTCCCCATCTCCATAACCTTCGGCCTGGTCTTTTACTTTGCCACCGATAACCTTGTGCGGCCGTTCATGGATCAGCTGGCCGTTCATCAGTTCTACATTTAGCACGGAGAAGAGGTCACTCCTCACGCACTCCACTTTACAGCTAATTCCCAGAATCCTCTTGCAGGGAACGTGAACCCTGTAGACTAGCACacctctcctcttcctctggaCACACGACTGGATTCGCTGTTTTTGGCATTGAATGACTCTATTAATTACAGTGCCTCTCCGGCGGTTCGTCTGATCCTGATATTGGCTTTGGTAACATCTCCGGGCGATATGCTGAACATTTGTTTGTACGCTGACTACCTTTCATGTAAGAATGGATCAAAGTGATTGACTTTATCACTTCATTCAAAGTTTGATGAACTCTGGTGTATGGAATGGGACCAGAGCTTGCTTTGTCCACCCTTGGATTCACTTTCTAGGCATTACATTAATTCCAGCTCTGATATAATGAGCATTAACCCAAAGCTCTGTGTATGATATGGCTGCAGACACAGAGGTAGGTACTGATCACTTTTGTTGGTCTTCTGAGAGTGCCTGTGATgctttaagtttttgtttttaacaccAACCATTTGACCATGTTTGAGACGATGTTCTGGGCTACTCTAGCGTGAAATCAAGTGCTGATCCAAGCTACTGTTCGCTCTCCTGAAAAGCGTGAGAGCGCCTTTTGGAATGTATAAACTTTCTCTATAATTTCCTGTGTGTTCGCAAAAGATGTCAGGAGactcgtttaatttttttgttgttgatgttttgtttctcttctttttttttttttttttatttaccagcAAAATGGTTGATCGAATGACTTTTACTTTCATAGTATCCACACCTTttgtcatttaaagaaaatgcaaatgttttgtaacTAAATTGAAAGGTTCACAAATAAAGGGGTTGCTCATTTGAGCAAATTTCAA
>XM_043263613.1
TACTTGAACAGTTTCGCGTGCAAAAGTAGGGACGACTCCTTTGCGTTTTGAAGTGTTCACTTATAGCGGATTCGCGTAATTTATCTAGAGCTGCGGTTGATAACCAGGCGGCTATCAGAAGCGCTGACTAGCCTCGAGCTACGCTGATGTCAAATGAATCGATGCTTTATTTAGTCACAAACGGTTGTTTTGCCTGAAACGGAAATAATTCGATTCGGAGTCGTTTTGGAGAGGAAAAGGAAACAGTATTTCCTCAGCTGTCTGTTAAGACAAATACCACAATAATACCATCCTGTTGTGTCTATGATCCCTGGGTCACTTCACAGCACCGATGGCTGATAATGTGGAAAATGCTGTCAACAATGTGtcaAGCGACGGGCCGGAGGTCAGCCGGCACACGGAGACGACTCCCGGCCGCACCGAGGTGGAGCTGAACGGCCAGCCGCCCACCGCCCGGCCCCCGCAGGTGGTCACGGACAGCGAGGAGGACGAGGACGAGGAGCTCACCCTCAAGTACGGAGCCAAGCACGTGATCATGCTGTTCATCCCCGTCACGCTGTGCATGGTGGTGGTCGTGGCCACCATCAAGTCGGTCAGTTTCTACACGCAAAAGGACGGCCAGCAGCTGATCTACACTCCGTTCCGTGAGGACACCGAGACGGTGGGGCAGCGTGCGCTCAACTCCATGCTCAACGCCACCATCATGATCAGTGTGATAGTGGTCATGACCCTGGTGCTGGTGGTGCTCTACAAGTACCGATGCTACAAGgtgatTCAAGCCTGGCTGTTCTTCTCCAACCTTCTCCTgctcttctttttctccttcatttATTTAGGGGAAGTGTTCAAGACGTACAACGTGGCCATGGACTACTTCACGTTGGCGGTGATCATCTGGAACTTCGGCGTGGTGGGAATGATCTGTATCCACTGGAAGGGTCCGCTGCGGCTCCAGCAGGCCTATCTGATCATGATCAGCGCTCTCATGGCCCTGGTCTTCATCAAGTACCTGCCGGAGTGGACTGCCTGGCTCATCCTCGCTGCTATATCCGTCTACGATCTGCTGGCCGTGTTGTGCCCGAAAGGACCTCTGCGTATCCTTGTGGAAACTGCTCAGGAGAGAAACGAACCCATCTTTCCCGCTCTCATTTACTCCTCAACCATGGTGTGGCTGTTTAATATGGCGGACAGCGCTGAGACCAGGAATAATTCCAGCCATCCAGTTCCTCAACAGGAGAACCAGGTTGCCATGGCACCCACGGCTCAGCCGGAGGATGATGGAGGCTTCACCCCAGCTTGGGTCAATCAGCAGCAGCATCAGCTCGGCCCCATGCAGTCCACTGAGGACAGCAGACGAGAGATCCAGGACATGCCCTCCGCTCGCCCGGCGCCCGTAGAAGACGACGAAGAGCgcgGTGTGAAGCTGGGTTTGGGAGACTTCATCTTTTACAGTATGCTGGTGGGTAAAGCATCAGCCACAGCCAGCGGGGACTGGAACACGACGCTAGCCTGCTTTGTGGCCATTCTCATCGGTTTATGTCTAACTTTGCTCCTCCTGGCCATCTTCAAAAAGGCCCTTCCAGCTCTCCCCATCTCCATAACCTTCGGCCTGGTCTTTTACTTTGCCACCGATAACCTTGTGCGGCCGTTCATGGATCAGCTGGCCGTTCATCAGTTCTACATTTAGCACGGAGAAGAGGTCACTCCTCACGCACTCCACTTTACAGCTAATTCCCAGAATCCTCTTGCAGGGAACGTGAACCCTGTAGACTAGCACacctctcctcttcctctggaCACACGACTGGATTCGCTGTTTTTGGCATTGAATGACTCTATTAATTACAGTGCCTCTCCGGCGGTTCGTCTGATCCTGATATTGGCTTTGGTAACATCTCCGGGCGATATGCTGAACATTTGTTTGTACGCTGACTACCTTTCATGTAAGAATGGATCAAAGTGATTGACTTTATCACTTCATTCAAAGTTTGATGAACTCTGGTGTATGGAATGGGACCAGAGCTTGCTTTGTCCACCCTTGGATTCACTTTCTAGGCATTACATTAATTCCAGCTCTGATATAATGAGCATTAACCCAAAGCTCTGTGTATGATATGGCTGCAGACACAGAGGTAGGTACTGATCACTTTTGTTGGTCTTCTGAGAGTGCCTGTGATgctttaagtttttgtttttaacaccAACCATTTGACCATGTTTGAGACGATGTTCTGGGCTACTCTAGCGTGAAATCAAGTGCTGATCCAAGCTACTGTTCGCTCTCCTGAAAAGCGTGAGAGCGCCTTTTGGAATGTATAAACTTTCTCTATAATTTCCTGTGTGTTCGCAAAAGATGTCAGGAGactcgtttaatttttttgttgttgatgttttgtttctcttctttttttttttttttttatttaccagcAAAATGGTTGATCGAATGACTTTTACTTTCATAGTATCCACACCTTttgtcatttaaagaaaatgcaaatgttttgtaacTAAATTGAAAGGTTCACAAATAAAGGGGTTGCTCATTTGAGCAAATTTCAA

Function

symbol description
psen1 Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; beta-catenin binding activity; and cadherin binding activity. Acts upstream of or within several processes, including amyloid-beta formation; cell surface receptor signaling pathway; and optomotor response. Is intrinsic component of membrane. Is expressed in blastomere; brain; female organism; heart; and male organism. Used to study Alzheimer's disease and Alzheimer's disease 3. Human ortholog(s) of this gene implicated in Alzheimer's disease (multiple); Pick's disease; dilated cardiomyopathy 1U; frontotemporal dementia; and hidradenitis suppurativa. Orthologous to human PSEN1 (presenilin 1).

NR:

description
presenilin-1-like

GO:

id name namespace
GO:0060070 canonical Wnt signaling pathway biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007220 Notch receptor processing biological_process
GO:0034205 amyloid-beta formation biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0016485 protein processing biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis biological_process
GO:0006509 membrane protein ectodomain proteolysis biological_process
GO:0061053 somite development biological_process
GO:0006816 calcium ion transport biological_process
GO:0030318 melanocyte differentiation biological_process
GO:0007420 brain development biological_process
GO:0001946 lymphangiogenesis biological_process
GO:0036269 swimming behavior biological_process
GO:0005743 mitochondrial inner membrane cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0035253 ciliary rootlet cellular_component
GO:0045121 membrane raft cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0030424 axon cellular_component
GO:0030426 growth cone cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0031594 neuromuscular junction cellular_component
GO:0000139 Golgi membrane cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0005634 nucleus cellular_component
GO:0005938 cell cortex cellular_component
GO:0009986 cell surface cellular_component
GO:0030018 Z disc cellular_component
GO:0043198 dendritic shaft cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0004190 aspartic-type endopeptidase activity molecular_function
GO:0045296 cadherin binding molecular_function

KEGG:

id description
K04505 PSEN1, PS1; presenilin 1

RNA

RNA id representative length rna type GC content exon number start site end site
XM_043263612.1 False 2352 mRNA 0.50 11 18347425 18355107
XM_043263613.1 True 2562 mRNA 0.49 11 18347425 18354998

Neighbor

gene id symbol gene type direction distance location
paplna papln,paplna coding downstream 5489 18313681 ~ 18341936 (-)
aqr aqr coding downstream 36304 18282076 ~ 18311121 (-)
LOC122361452 gjd2,LOC107752716,LOC107565221,LOC107687856 coding downstream 71299 18270871 ~ 18276126 (-)
fosaa fosaa,fos,LOC107723273,LOC107702235,LOC108423428,LOC107735358 coding downstream 388830 17952048 ~ 17958595 (-)
jdp2a jdp2,jdp2a,LOC107701522,LOC107589793,LOC107702236 coding downstream 398187 17939741 ~ 17949238 (-)
trappc12 trappc12,LOC107684236,LOC107687835,LOC107753354,LOC107723257,LOC107589762 coding upstream 18883 18373990 ~ 18389654 (-)
ccr6b LOC107558470,LOC107753366,LOC107687955,LOC107758715,LOC107687848,LOC107589789 coding upstream 244118 18599225 ~ 18602734 (-)
atp6v1c2 LOC107687954,LOC107753364,LOC107558472,LOC107687850,LOC107589777,LOC107758708 coding upstream 250034 18605141 ~ 18616059 (-)
exd2 LOC107687943,LOC107753346,LOC107758720,LOC107687840 coding upstream 319019 18674126 ~ 18684463 (-)
numb numb,LOC107687942,LOC107753345 coding upstream 330920 18686027 ~ 18726828 (-)
G122019 NA non-coding downstream 124011 18223122 ~ 18223414 (-)
G121986 NA non-coding downstream 135009 18173717 ~ 18212416 (-)
G122013 NA non-coding downstream 139043 18202054 ~ 18208382 (-)
G122015 NA non-coding downstream 139074 18205506 ~ 18208351 (-)
G121987 NA non-coding downstream 176399 18166757 ~ 18171026 (-)
G122079 NA non-coding upstream 3635 18358742 ~ 18359108 (-)
G122081 NA non-coding upstream 14277 18369384 ~ 18369874 (-)
G122104 NA non-coding upstream 66507 18421614 ~ 18425369 (-)
G122114 NA non-coding upstream 71206 18426313 ~ 18426728 (-)
G122115 NA non-coding upstream 72848 18427955 ~ 18428405 (-)
LOC122361613 NA other downstream 65853 18279458 ~ 18281572 (-)
LOC122361562 otofb,LOC107752720,LOC107701524,LOC107723281,LOC108423539 other downstream 343211 17982051 ~ 18004214 (-)
acyp1 acyp1 other downstream 383444 17962289 ~ 17963981 (-)
LOC122362005 crim1,LOC107582940,LOC107679775,LOC107662656 other downstream 2395987 15829484 ~ 15951438 (-)
LOC122362003 LOC107664362,LOC107560152,LOC107752022,LOC107658150 other downstream 2580410 15760343 ~ 15767015 (-)
LOC122361943 NA other upstream 276150 18631257 ~ 18644992 (-)
G122247 NA other upstream 431775 18786882 ~ 18790880 (-)
LOC122362226 vps39,LOC107707670,LOC107572021,LOC107687842,LOC107558491,LOC107687939,LOC107758712 other upstream 464556 18819663 ~ 18836620 (-)
ralgapa2 ralgapa2,LOC107687934 other upstream 792224 19147331 ~ 19282456 (-)
LOC122362030 cldn20,tfb1m,LOC101886267,LOC107571061,LOC107675320,LOC107573130,LOC107728965,LOC108443299,LOC108269830,LOC107680107,LOC107728964,LOC107675319 other upstream 1469352 19824459 ~ 20053139 (-)

Expression


Co-expression Network