crbn (crbn,LOC107711034,LOC107748399)


Basic Information

Item Value
gene id crbn
gene name crbn,LOC107711034,LOC107748399
gene type coding
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056704.1
NCBI id CM032073.1
chromosome length 27473687
location 19795103 ~ 19800569 (-)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>XM_043242335.1
GCTGTGTGTTTTCCCCCGCGTGTCTCTTCAAGGCAGTGCTGCGCTTGTTGAGAGCTGATTGTAAACACACGGCTATGGCTGCTGAGAGGGGCGGAGGCGACAACAACAACCTTAACGACGAAATGGGCAACCAACTACAACTCCTGCCAGaaaatgaagaggaagaagaggatgaCATGGAGACAGAGGATCGAGATGGTGAGGATGCAGAAAAGCCAAGTATTATAAACTTTGACACGAGTCTGCCAACTTCACACGCTTACCTGGGCTCAGACATGGAGGAGTTTCACGGCCGTACCCTGCATGATGAGGACAGTGTGCAGAATCTGCCGGTTCTTCCTCACGTCACACTCATTCTGATCCCAGGTCAGACGCTACCCTTGCAGCTTTTCCGACCACAGGAGGTCAGCATGTTCCGCAACCTCATAAGCCAGGACCGCACGTTTGCAGTGCTTGCACACAGTCCTGATGCGAGTGGAGCGGAGATAAAAGCAGAGTTTGGGACGACTGCGGAGATCTATGCTTTTCGTGAGGAACAGGAGTACGGCATAGAGACAGTTAAGATCAAAGCTGTTGGACGGCAGCGCTTCAGAGTGCATGAAATACGCACACAAGCAGACGGGATTCGTCAGGCAAAAGTACAGATTTTACCTGAGAGGATTCTGCCAGACCCTTTATGTGCGCTGCAGTTCCTGCCccgcttacacacacacacaccacagatcaAACACTCACAAACCACACCGCAGGACCGGTGCAGACAGACCTATAGACAGaagaagTTTCATTGTGCTAGTATGACCTCATGGCCTCCTTGGGTGTATGCCTTATATGACTCTAAAACTCTCATGAGCAGAGTAAAGAAACAGCTCCACGAATGGGATGAAAACCTCAAAGACGAGTCCCTGCCTACAAATCCCACAGATTTCTCATACAGGGTAGCCGCATGTCTACCAATAGATGATGCTCTGAGACTCCAGCTACTGAAGATCGGCAGTGCCATCCAGAGACTGCGTTGTGAGTTGGACATCATGGACAGGTGCACCTCTCTTTGCTGTAAACAGTGCCAGGATACAGAGATAACTAGCAAGAACGAGATCTTCAGCCTGTCTCTGTATGGGCCAATGGCAGCGTATGTGAATCCGCATGGCTATGTTCACGAGACACTTACAGTCTACAAGGCCAACAACCTCAACCTGATTGGACGACCTTCCACACTGCATAGTTGGTTTCCAGGGTATGCGTGGACAATTGCTCAGTGCAGAACCTGCGGCTCTCATATGGGCTGGAAGTTCTCAGCAGTAAAAAAGGATCTGAGTCCACCTCGGTTCTGGGGTTTGACTCGTTCTGCCCTGCTACCGACAATCCCACAGGGCGAGGAGGGTGTCGAGGGGTCACGCTTGCTGTGCCTGTAATGTGATCAGAGCATTACTTGTGACCTTTAACCCTTCTGCCCACAAGCATATGCTCTCCCAGGGGTCTCTTCTGTAACCCCAAAAACATAAGACCCCAAAACCTCACccggagagagtgagagaaagtgtgtttgtgagtttatATGTGTAGATGTGTGCATGAACagggagaggaaaagaaaaaggggACAGGGTAGCATACAGGAGTAGAAAGAACAACAGAATGCAAGTTGTTGCCTTCACACACCTTGTGCTGTGTAAATTACAGCCTGATACGTGCAATATCATACCAGATGGGCTCTTTAAGATATTACAGTCTGTTGTAATGCACTTAATTTTTTCGTTTAGCAGTCTTTTCGTCATTATTACTGCCTAGGTAACAGTTAAGCAAGATGTCATCTTGTTTGGATGTTTATGAGTATTGTGTTAAAATAGGGTCAAATCTCTAACACCAAAGTGTGATGATCTCATTTAGTCCGACAGAAAGTCTTTTCATGCCCACGTTTAGCAACATAATCAACACTCATGTAGAATACCTCAACCAGATAAACGCTCTTGGACATCTTTCTCAAATGAAGATCGAAACTGCTTGAATTGAATCATTCCCCATACCTTGTGTCCCATGTGCTTGTGTCGGGGTACATCTGGCACACAAATCCTGGCTAAAAGTGTCAGTTGGTGAATAATAAAGGAAATATCAGGGAGTTACCTTTTATGTAATTAAGACTCAATATCCAGAGCAGTTCTTAAAGGGTGTTTTGTATTTCTCAGTCTCACTGTTTTGCTTCgtcttttatatttgttttgtttggataCCGTTTAATTGAATGAAGATATGATGTATATGTGGAGTTGAGAGCCAAAAACGTGCATCCTGAATggaatagtttttttcccccgaAAAACTATAGTCTGCATTGAGAAACTTCCTAAAGTATAAAGATCCTGATCACGTGTTCATTAAATGAGTGCAGAATACACACTTTAAGCAGAAAATTGGCACACAATCATGCTCATTCTTCACTATCATTTACATAGCTgtaataagaaaacataaacGTGATACACGCTGACTTGCATATCTGTAATGATCAAGAGGTtaaatactgttcagtgctgATCAATTCTCGCCAATAAACTGCTTCTGAAATGTTG
>XM_043242336.1
CCCGCGTGTCTCTTCAAGGCAGTGCTGCGCTTGTTGAGAGCTGATTGTAAACACACGGCTATGGCTGCTGAGAGGGGCGGAGGCGACAACAACAACCTTAACGACGAAATGGGCAACCAACTACAACTCCTGCCAGaaaatgaagaggaagaagaggatgaCATGGAGACAGAGGATCGAGATGTACCTGGGCTCAGACATGGAGGAGTTTCACGGCCGTACCCTGCATGATGAGGACAGTGTGCAGAATCTGCCGGTTCTTCCTCACGTCACACTCATTCTGATCCCAGGTCAGACGCTACCCTTGCAGCTTTTCCGACCACAGGAGGTCAGCATGTTCCGCAACCTCATAAGCCAGGACCGCACGTTTGCAGTGCTTGCACACAGTCCTGATGCGAGTGGAGCGGAGATAAAAGCAGAGTTTGGGACGACTGCGGAGATCTATGCTTTTCGTGAGGAACAGGAGTACGGCATAGAGACAGTTAAGATCAAAGCTGTTGGACGGCAGCGCTTCAGAGTGCATGAAATACGCACACAAGCAGACGGGATTCGTCAGGCAAAAGTACAGATTTTACCTGAGAGGATTCTGCCAGACCCTTTATGTGCGCTGCAGTTCCTGCCccgcttacacacacacacaccacagatcaAACACTCACAAACCACACCGCAGGACCGGTGCAGACAGACCTATAGACAGaagaagTTTCATTGTGCTAGTATGACCTCATGGCCTCCTTGGGTGTATGCCTTATATGACTCTAAAACTCTCATGAGCAGAGTAAAGAAACAGCTCCACGAATGGGATGAAAACCTCAAAGACGAGTCCCTGCCTACAAATCCCACAGATTTCTCATACAGGGTAGCCGCATGTCTACCAATAGATGATGCTCTGAGACTCCAGCTACTGAAGATCGGCAGTGCCATCCAGAGACTGCGTTGTGAGTTGGACATCATGGACAGGTGCACCTCTCTTTGCTGTAAACAGTGCCAGGATACAGAGATAACTAGCAAGAACGAGATCTTCAGCCTGTCTCTGTATGGGCCAATGGCAGCGTATGTGAATCCGCATGGCTATGTTCACGAGACACTTACAGTCTACAAGGCCAACAACCTCAACCTGATTGGACGACCTTCCACACTGCATAGTTGGTTTCCAGGGTATGCGTGGACAATTGCTCAGTGCAGAACCTGCGGCTCTCATATGGGCTGGAAGTTCTCAGCAGTAAAAAAGGATCTGAGTCCACCTCGGTTCTGGGGTTTGACTCGTTCTGCCCTGCTACCGACAATCCCACAGGGCGAGGAGGGTGTCGAGGGGTCACGCTTGCTGTGCCTGTAATGTGATCAGAGCATTACTTGTGACCTTTAACCCTTCTGCCCACAAGCATATGCTCTCCCAGGGGTCTCTTCTGTAACCCCAAAAACATAAGACCCCAAAACCTCACccggagagagtgagagaaagtgtgtttgtgagtttatATGTGTAGATGTGTGCATGAACagggagaggaaaagaaaaaggggACAGGGTAGCATACAGGAGTAGAAAGAACAACAGAATGCAAGTTGTTGCCTTCACACACCTTGTGCTGTGTAAATTACAGCCTGATACGTGCAATATCATACCAGATGGGCTCTTTAAGATATTACAGTCTGTTGTAATGCACTTAATTTTTTCGTTTAGCAGTCTTTTCGTCATTATTACTGCCTAGGTAACAGTTAAGCAAGATGTCATCTTGTTTGGATGTTTATGAGTATTGTGTTAAAATAGGGTCAAATCTCTAACACCAAAGTGTGATGATCTCATTTAGTCCGACAGAAAGTCTTTTCATGCCCACGTTTAGCAACATAATCAACACTCATGTAGAATACCTCAACCAGATAAACGCTCTTGGACATCTTTCTCAAATGAAGATCGAAACTGCTTGAATTGAATCATTCCCCATACCTTGTGTCCCATGTGCTTGTGTCGGGGTACATCTGGCACACAAATCCTGGCTAAAAGTGTCAGTTGGTGAATAATAAAGGAAATATCAGGGAGTTACCTTTTATGTAATTAAGACTCAATATCCAGAGCAGTTCTTAAAGGGTGTTTTGTATTTCTCAGTCTCACTGTTTTGCTTCgtcttttatatttgttttgtttggataCCGTTTAATTGAATGAAGATATGATGTATATGTGGAGTTGAGAGCCAAAAACGTGCATCCTGAATggaatagtttttttcccccgaAAAACTATAGTCTGCATTGAGAAACTTCCTAAAGTATAAAGATCCTGATCACGTGTTCATTAAATGAGTGCAGAATACACACTTTAAGCAGAAAATTGGCACACAATCATGCTCATTCTTCACTATCATTTACATAGCTgtaataagaaaacataaacGTGATACACGCTGACTTGCATATCTGTAATGATCAAGAGGTtaaatactgttcagtgctgATCAATTCTCGCCAATAAACTGCTTCTGAAATGTTG

Function

symbol description
crbn Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon).

NR:

description
protein cereblon

GO:

id name namespace
GO:0071600 otic vesicle morphogenesis biological_process
GO:0060173 limb development biological_process
GO:0016567 protein ubiquitination biological_process
GO:0035118 embryonic pectoral fin morphogenesis biological_process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004176 ATP-dependent peptidase activity molecular_function

KEGG:

id description
K11793 CRBN; cereblon

RNA

RNA id representative length rna type GC content exon number start site end site
XM_043242335.1 True 2570 mRNA 0.45 11 19795103 19800569
XM_043242336.1 False 2494 mRNA 0.45 11 19795103 19800555

Neighbor

gene id symbol gene type direction distance location
vhl LOC107711035,LOC107673464,LOC107585106,LOC107667384,LOC107748400,LOC107582681 coding downstream 477 19792750 ~ 19794626 (-)
tatdn2 LOC107673616,LOC107585107,LOC107711037 coding downstream 3653 19786424 ~ 19791450 (-)
ccdc174 ccdc174,LOC107673461,LOC107711012,LOC107585200,LOC107667317,LOC107582683,LOC107748410 coding downstream 10497 19780907 ~ 19784606 (-)
si:dkey-28n18.9 LOC107711013,LOC107585201,LOC107673478,LOC107582684,LOC107748409,LOC107667326 coding downstream 14348 19776312 ~ 19780755 (-)
ttll3 ttll3,LOC107711014,LOC107673469,LOC107585175,LOC107748395,LOC107667364,LOC107582793 coding downstream 47652 19740237 ~ 19747451 (-)
ppil1 ppil1,LOC107673584,LOC107667353 coding upstream 73404 19873973 ~ 19875768 (-)
LOC122347195 LOC107584484,LOC107673448,LOC107712069,LOC107721173 coding upstream 105282 19905851 ~ 19908068 (-)
c6h1orf159 LOC107673608,LOC107712089,LOC107584440 coding upstream 110425 19910994 ~ 19913842 (-)
kbtbd12 kbtbd12,LOC107673613,LOC107712091,LOC107584421,LOC107721181,LOC107667403,LOC107568198 coding upstream 117484 19918053 ~ 19921278 (-)
p4htmb p4htm,LOC107673589,LOC107712096,LOC107584428,LOC107721183,LOC107667396 coding upstream 127786 19928355 ~ 19934425 (-)
G46658 NA non-coding downstream 2775 19791642 ~ 19792328 (-)
LOC122347383 LOC107711016,LOC107673510 non-coding downstream 188047 19606362 ~ 19607056 (-)
G46540 mettl7a,LOC107711020,LOC107585130,LOC107740572,LOC107667380,LOC107673452,LOC107711000,LOC107582798 non-coding downstream 397373 19393477 ~ 19397730 (-)
G46509 NA non-coding downstream 552292 19212639 ~ 19242811 (-)
LOC122347223 NA non-coding downstream 643409 19149746 ~ 19151694 (-)
G46647 LOC107585105,LOC107711036,LOC107673557 non-coding upstream 674 19801243 ~ 19802266 (-)
G46673 LOC107712079,LOC107584413,LOC107673502,LOC107667352,LOC107721177,LOC107578835 non-coding upstream 33501 19834070 ~ 19838047 (-)
LOC122347207 NA non-coding upstream 76743 19877312 ~ 19880588 (-)
G46803 NA non-coding upstream 167677 19968246 ~ 19968460 (-)
G46816 fkbp5,LOC107584436,LOC107712109,LOC107673486,LOC107721196,LOC107667344 non-coding upstream 254297 20054866 ~ 20115259 (-)
tsfm tsfm,LOC107711018,LOC107585120 other downstream 239161 19553317 ~ 19555942 (-)
vdrb vdrb,LOC107585146,LOC107673565,LOC107711077,LOC107582718,LOC107667372,LOC107733590 other downstream 645372 19115061 ~ 19149731 (-)
G46478 NA other downstream 738972 19055146 ~ 19056131 (-)
G46423 sec23b,LOC107753900,LOC107752097,LOC107551934,LOC107659946 other downstream 1077615 18714174 ~ 18717488 (-)
LOC122347235 NA other downstream 1087507 18706623 ~ 18707596 (-)
tomm6 NA other upstream 40910 19841479 ~ 19842994 (-)
tspo tspo,LOC107721166,LOC107568174,LOC107584504,LOC107667354,LOC107673503 other upstream 42475 19843044 ~ 19847432 (-)
LOC122347177 LOC107584418 other upstream 99103 19899672 ~ 19956730 (-)
mustn1a mustn1a other upstream 198063 19998632 ~ 20000638 (-)
srsf3a LOC107712108,LOC107584442,LOC107673487,LOC107721197,LOC107667402 other upstream 295455 20096024 ~ 20102459 (-)

Expression


Co-expression Network