rpe65 (rpe65,rpe65a,LOC108436856,LOC107705134,LOC107708597,LOC107693590)


Basic Information

Item Value
gene id rpe65
gene name rpe65,rpe65a,LOC108436856,LOC107705134,LOC107708597,LOC107693590
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035912.1
NCBI id CM008315.1
chromosome length 41032606
location 16994339 ~ 17004804 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007254601.2
AAGCTCCAGTGAGGAACACAatacacacggacacacacacacctgcggGGTTTATCACACAGGTTGTCTGCACCAGGAGGAAAGATGTCCAGCCGTTTCGAGCATCCCGCTGGAGACTACAAGAAGATCTTTGAGACTGTGGAGGAGCTGAATGAGCCTCTCCCAGCCACAGTCACAGGCCGAATCCCCTCCTTTATCAGGGGCAGTCTTCTCCGGCTGGGCCCTGGACTCTTCGAGGTTGGAGCCGAACCCTTCTACCATCTCTTCGATGGCCAGGCCCTGATGCACAAGTTCGATTTTAGCAACGGCCAGGTCACCTATTTCCGCAAGTTTGTCAAGACAGATGCTTATGTGCGCGCCATCACAGAAAAGCGTGTGGTGATCACTGAGTTTGGAACCTGTGCTTATCCAGACCCCTGCAAGAACATCTTCTCCAGGTTCTTCACATACTTTAAAGGAGTTGAGGTAACAGATAACTGCCTGGTGAATGTTTACCCTATTGGAGAAGACTTCTACGCTGTCACAGAGACCAACTACATAACTAAAGTGAACACGGACACTCTGGAAACCCTGAAAAAGGTGGATATGTGTGACTATGTGAACATTAATGGAGTAACAGCACACCCCCAAATTGAAAGAGATGGCACCGTCTACAACATCGGAAACTGCATGGGCAAAGGAGCCACGCTGGCTTACAACATCGTCAAAATCCCACCAACCCAGAAAGATAAGTCAGACCCCATCGAGAAATCCAAGGTTGTGGTCCAGTTCCCAAGTGCTGAGAGGTTCAAGCCATCCTACGTACACAGCTTCGGGATGACGGAGAACTACTTTGTCTTTGTTGAGACGCCCGTCAAAATCAACCTGCTGAAGTTCTTGGGTGCCTGGGCTATTCGTGGGTCCAACTACATGGACTGCTTTGAGGCTGATGAGACAAAAGGAACGTGGATCCACATTGCTAAGAAGGACCCAGGAGAGTACATTGACTACAAGTTCAGAGCTGCTGCAATGGGCCTTTTCCACCACATCAATGCCTATGAAGACTCAGGTTTCGTCGTTTTTGATCTGTGCACCTGGAAAGGATTCGAGTTTGTGTACAACTATCTGTGGCTGGCAAACTTGCGTGAGAACTGGGACGAGGTGAAGAAGAACGCCATGATCGCCCCTCAGCCAGAAGTTAGGAGGTTTGTGCTCCCCCTGGACCCCTACAGGGAGGAGCAGGGGAAGAACCTGATCTCTCTGCCCTACACCACGGCCACGGCTACCATGCGCGAGGATGGGACCATCTGGCTGGAGCCTGAGGTGCTGTTCTCTGGCCCTCGGCAAGCTTTCGAGTTCCCTCAGATCAACTACAAAATGAACAACGGGAAGAACTACACCTACGCCTACGCCCTCGGCCTGAACCACTTCATTCCTGACAGGATTTGCAAGCTAAATGTGAGGACTAAGGAGACCTGGGTGTGGCAGGAGCCTGACTCATACCCCTCAGAGCCCCTGTTCGTACAGAACCCTGAAGGAGTTGATGAGGATGATGGTGTCCTGCTGACGATCGTGGTGTGTCCCGGAGCTCAGAGACCAACATACTGCCTGATACTGAACGCTAAAGACCTGTCCGAGATCGCCAGGGCCGAGGTGGACATCATGACGCCCGTCACTTTCCACGGCATGTACAAACCATAGAGCAGACAGAGCGCTCCAGAACATTACTATAACACTCCAATCTCCAGGATTAAATGTGTTAGGAAccctttaaatcatttattattttttgggtttttttgtaTGTTGAATGTTTTGAGTGTTTATGAGAGTATTAATGATTGTTGTTTGAATGAACCCAGATGTATAGCTAACAATAAATACCAGTGACCTTCCTTAACTATTATCCAATATGTCTTCTTCTTGAGGAAATATAGAAATACGCTATACTGTTTTGCCATTAATTTAACATACCAGTCTTATTTCTTATTGCTCAGGTTTTAGAAGAAATCTCTCAAGAAATGTATTTTGCTTGTAACACCATATTTAAAGTAGCGTAACGTTGAGACtcaataaagttattttaaaata

Function

symbol description
rpe65a Predicted to enable all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity and retinol isomerase activity. Predicted to be involved in retinoid metabolic process and zeaxanthin biosynthetic process. Predicted to act upstream of or within visual perception. Predicted to be located in endoplasmic reticulum membrane. Is expressed in head and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65).
rpe65 Enables all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity and isomerase activity. Involved in detection of light stimulus involved in visual perception; retina homeostasis; and terpenoid metabolic process. Located in endoplasmic reticulum membrane. Implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Biomarker of basal cell carcinoma and squamous cell carcinoma.

NR:

description
PREDICTED: retinoid isomerohydrolase

GO:

id name namespace
GO:0050896 response to stimulus biological_process
GO:0007601 visual perception biological_process
GO:0005886 plasma membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0052884 all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity molecular_function
GO:0052885 all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity molecular_function
GO:0046872 metal ion binding molecular_function

KEGG:

id description
K11158 RPE65; retinoid isomerohydrolase / lutein isomerase

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007254601.2 True 2070 mRNA 0.48 14 16994339 17004804

Neighbor

gene id symbol gene type direction distance location
efcab14 efcab14,LOC106569140 coding upstream 53971 16927428 ~ 16940368 (+)
LOC103044680 NA coding upstream 1494834 15481787 ~ 15499505 (+)
LOC103044992 kcnj10,LOC108440277,LOC107703868,LOC107728032,LOC107692845,LOC102205965 coding upstream 1518124 15443821 ~ 15476215 (+)
trnae-uuc_20 NA coding upstream 1580492 15413776 ~ 15413847 (+)
LOC103043450 LOC103043450 coding upstream 1609433 15379678 ~ 15384906 (+)
LOC111194332 NA coding downstream 230395 17235199 ~ 17304091 (+)
LOC103034870 NA coding downstream 1749003 18753807 ~ 18785358 (+)
LOC103034112 LOC103034112,LOC108411205,LOC108267323,LOC106599750,LOC105019307,LOC103396312,LOC101066292 coding downstream 1790099 18794903 ~ 18816397 (+)
exosc4 exosc4,exos4 coding downstream 1816614 18821418 ~ 18826143 (+)
LOC111188235 NA coding downstream 1926075 18930879 ~ 18932145 (+)
G142072 NA non-coding upstream 30825 16963192 ~ 16963514 (+)
G142065 NA non-coding upstream 96032 16897864 ~ 16898307 (+)
G142060 NA non-coding upstream 107932 16885916 ~ 16886407 (+)
G142047 NA non-coding upstream 178652 16815486 ~ 16815687 (+)
G142046 NA non-coding upstream 184187 16809465 ~ 16810152 (+)
G142079 NA non-coding downstream 2091 17006895 ~ 17061552 (+)
G142082 NA non-coding downstream 8297 17013101 ~ 17014834 (+)
G142091 abcf3 non-coding downstream 43646 17048450 ~ 17049952 (+)
G142119 NA non-coding downstream 139838 17144642 ~ 17145074 (+)
G142168 NA non-coding downstream 201655 17206459 ~ 17208182 (+)
G142067 LOC108436873,LOC108267642,LOC105898987 other upstream 9044 16972202 ~ 16985295 (+)
LOC103022185 ankrd13c,LOC108436872,LOC105898977 other upstream 26389 16948382 ~ 16967950 (+)
G141754 pnp5a,LOC108440276,LOC103368940,LOC107747996,LOC107692836,LOC107728028,LOC108267282,LOC107570765,LOC107703870 other upstream 1592435 15385616 ~ 15401904 (+)
G141791 NA other upstream 1708882 15228710 ~ 15285457 (+)
G141740 LOC108440267 other upstream 1937366 15054657 ~ 15056973 (+)
G142093 abcf3 other downstream 53490 17058294 ~ 17073484 (+)
G142166 LOC108436878 other downstream 198418 17203222 ~ 17204493 (+)
G142378 gpaa1 other downstream 1851432 18856236 ~ 18893509 (+)
G142384 gpaa1,LOC102780288 other downstream 1860646 18865450 ~ 18870317 (+)
G142620 NA other downstream 2731502 19736306 ~ 19868292 (+)

Expression


Co-expression Network