LOC103036425 (pax6,LOC103036425,LOC108444445)


Basic Information

Item Value
gene id LOC103036425
gene name pax6,LOC103036425,LOC108444445
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035901.1
NCBI id CM008304.1
chromosome length 40584741
location 618157 ~ 637895 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007239785.3
cctctcagtctctctctctacagtgtGTGGATGTTTGTGTCGTTTTTGCTCCTCCGATGCCGCAAAAGGAGTTCCATAATCAGACCTCATGGGAAACCGGAGTGGCCTCTATAATGCAAAACAGTCACAGTGGGGTAAATCAGCTGGGTGGTGTGTTTGTAAACGGTCGGCCGCTGCCGGACACGACAAGGCAGAAGATTGTAGAGCTTGCTCACAGTGGAGCTCGACCCTGCGACATCTCCCGCATACtgcaggtgtcGAACGGCTGTGTGAGTAAAATCCTGGGCAGGTATTATGAAACCGGTTCTATTCGTCCGCGAGCGATTGGGGGCAGTAAACCGCGGGTAGCGACTCCTGAAGTGGTCGGTAAAATCGCCCAGTATAAACACGAGTGTCCGTCCATCTTCGCCTGGGAGATCAGGGACAGGCTGCTCAGCGAGGGAATCTGCTCCAATGACAACATCCCCAGCGTTTCCTCCATAAACCGAGTTCTGCGTAACCTGGCCAGTGAGAAGCAGCAGGTGGGGGTGGATGGTGTGTATGATAAGCTGAGGATGTTGAACGGTCAAATTGGCACATGGGGGGCACGGCCTGGGTGGTACCCTGGAACTGCAGCACCTGGTCATCCAAACCAAGATGGTTGCCAGCAGCAGGAGaacagtagtgaaaacacaaatTCCATCAGCTCCAATGGAGAGGACTTGGACGAAACCCAGATACGGCTGCAGCTGAAAagaaaattacaaagaaatCGCACATCTTTCACTCAGGAACAGATTGAAGCCCTGGAAAAAGAGTTTGAAAGAACTCACTATCCTGACGTGTTTGCAAGAGAAAGACTTGCAGCCAAAATCGATCTCCCAGAGGCAAGAATACAGGTTTGGTTCTCCAACAGAAGAGCCAAATGGAGGAGAGAAGAAAAGCTGAGGAATCAGAGGCGACAAGTCAGCAGCAACTCCAGTCATGTTCCAGTCAGCAGCAACTTCAGCACCAGCATTTACCAGCACATTCCCCAGCCCAGCACTCCTGTAACTTTTACATCAGGCTCTATGCTGGCCAGGTCGGACGGCGCTTTGACGAACTCTTATAGTGGCCTGCCGCCCATGCCCACCTTCACCATGGCTAATAACCTCCCTATGCAGCCTAGCCAGGCCTCCTACTCCTGCATGCTGCCCACCAGTACGCCAGTGAATGGGCGGAGCTACGACACATTTCCATCCCCTCATATGCAGGCACACATGAACAGCCAATCAATGTCAACCTCTGGTACCACCTCTACAGgACTCATTTCCCCTGGAGTTTCAGTCCCGGTGCAGATCCCCGGAGCAGAGTCGGATATTTCTCAGTTCTGGTCACGACTgcagtaaagaaaaacactactTTACCCTCTGACCTACCAGCagtatttaacacacacacagatgagcAGAAGAAATGAGTGTTTCTTCAgtgctgtgttgtgttctgTGGAATAAAtggaggaaaaaggaaaaaagtgcCACATGGTAAAATTctagaacaaaacaaaaggaaagttttctgtctttattacgtttgtgtttaaaaactctgaGAAAGTTGTGCAGGAGGACGAGGACGGCAGGGCTGGACACACAGAGACTCTGCTGGCCTTTATTTCAAAAAGAAAACTTTGCCCTCACTGTGCGATGCTGTGCTCTGGATTCTCTGCTCACCAGCAACCAGTTTATTCCAGACTGACCCACATCAGGATCATATCAAACCAACACTGTCCGAAAGACCCACCTGCAGCCGTGTGGACTGGAGCTATAGAGAGTTAAAGCTGTGCTCTTCTCGACCAGAATGAATGTATCTTTAAACCAAAGGAGCAGCAATGTTTTGGCAGAAATGCTCACAGACTTTAATTCAGTTTATGTGATGTTTGGGTTTAAGTTCATATTgtccagaatatttttttaaataaaacttctgttttatctgattttacccaataataattaatatacaaaTTATGCATATTTCAGCTCCCTTTCTTCAGGGTGGGATGCTGTTGTCATAGCCATTGCTGTTATATTCTGTCCTACAATCACTTCATTTGTGATCCATTAGCAATATTTATCCacaaattgataaaaataagATGCATAGTTATAGAACATATCAGAACTGAATTGCTGATCGTTAAAAAAGACCAAAGCCTTTTTAtatctacttttcttttttccttgtTCGTGAAGTTTTGTTTAAGACTGTCACTTCCCTGCTTGTTGACTGACCACACTAATCAGCTTTTATTTATGAGAAGtgtgcttaatttaatttaatttgagtGTATATCTGTAAAGAAATAATTCAATCTATCtaattgtatttaaacattttgttaaCTGATTTTATGAAAGCTATAAAAATCATTTTCACTTC
>XM_022669472.1
tcctctcagtctctctctctacagtgtGTGGATGTTTGTGTCGTTTTTGCTCCTCCGATGCCGCAAAAGGAGTTCCATAATCAGACCTCATGGGAAACCGGAGTGGCCTCTATAATGCAAAACAGTCACAGTGGGGTAAATCAGCTGGGTGGTGTGTTTGTAAACGGTCGGCCGCTGCCGGACACGACAAGGCAGAAGATTGTAGAGCTTGCTCACAGTGGAGCTCGACCCTGCGACATCTCCCGCATACtgcagCTctatatgtgtatttgtgtgtatttgtgtgtgcaggtgtcGAACGGCTGTGTGAGTAAAATCCTGGGCAGGTATTATGAAACCGGTTCTATTCGTCCGCGAGCGATTGGGGGCAGTAAACCGCGGGTAGCGACTCCTGAAGTGGTCGGTAAAATCGCCCAGTATAAACACGAGTGTCCGTCCATCTTCGCCTGGGAGATCAGGGACAGGCTGCTCAGCGAGGGAATCTGCTCCAATGACAACATCCCCAGCGTTTCCTCCATAAACCGAGTTCTGCGTAACCTGGCCAGTGAGAAGCAGCAGGTGGGGGTGGATGGTGTGTATGATAAGCTGAGGATGTTGAACGGTCAAATTGGCACATGGGGGGCACGGCCTGGGTGGTACCCTGGAACTGCAGCACCTGGTCATCCAAACCAAGATGGTTGCCAGCAGCAGGAGaacagtagtgaaaacacaaatTCCATCAGCTCCAATGGAGAGGACTTGGACGAAACCCAGATACGGCTGCAGCTGAAAagaaaattacaaagaaatCGCACATCTTTCACTCAGGAACAGATTGAAGCCCTGGAAAAAGAGTTTGAAAGAACTCACTATCCTGACGTGTTTGCAAGAGAAAGACTTGCAGCCAAAATCGATCTCCCAGAGGCAAGAATACAGGTTTGGTTCTCCAACAGAAGAGCCAAATGGAGGAGAGAAGAAAAGCTGAGGAATCAGAGGCGACAAGTCAGCAGCAACTCCAGTCATGTTCCAGTCAGCAGCAACTTCAGCACCAGCATTTACCAGCACATTCCCCAGCCCAGCACTCCTGTAACTTTTACATCAGGCTCTATGCTGGCCAGGTCGGACGGCGCTTTGACGAACTCTTATAGTGGCCTGCCGCCCATGCCCACCTTCACCATGGCTAATAACCTCCCTATGCAGCCTAGCCAGGCCTCCTACTCCTGCATGCTGCCCACCAGTACGCCAGTGAATGGGCGGAGCTACGACACATTTCCATCCCCTCATATGCAGGCACACATGAACAGCCAATCAATGTCAACCTCTGGTACCACCTCTACAGgACTCATTTCCCCTGGAGTTTCAGTCCCGGTGCAGATCCCCGGAGCAGAGTCGGATATTTCTCAGTTCTGGTCACGACTgcagtaaagaaaaacactactTTACCCTCTGACCTACCAGCagtatttaacacacacacagatgagcAGAAGAAATGAGTGTTTCTTCAgtgctgtgttgtgttctgTGGAATAAAtggaggaaaaaggaaaaaagtgcCACATGGTAAAATTctagaacaaaacaaaaggaaagttttctgtctttattacgtttgtgtttaaaaactctgaGAAAGTTGTGCAGGAGGACGAGGACGGCAGGGCTGGACACACAGAGACTCTGCTGGCCTTTATTTCAAAAAGAAAACTTTGCCCTCACTGTGCGATGCTGTGCTCTGGATTCTCTGCTCACCAGCAACCAGTTTATTCCAGACTGACCCACATCAGGATCATATCAAACCAACACTGTCCGAAAGACCCACCTGCAGCCGTGTGGACTGGAGCTATAGAGAGTTAAAGCTGTGCTCTTCTCGACCAGAATGAATGTATCTTTAAACCAAAGGAGCAGCAATGTTTTGGCAGAAATGCTCACAGACTTTAATTCAGTTTATGTGATGTTTGGGTTTAAGTTCATATTgtccagaatatttttttaaataaaacttctgttttatctgattttacccaataataattaatatacaaaTTATGCATATTTCAGCTCCCTTTCTTCAGGGTGGGATGCTGTTGTCATAGCCATTGCTGTTATATTCTGTCCTACAATCACTTCATTTGTGATCCATTAGCAATATTTATCCacaaattgataaaaataagATGCATAGTTATAGAACATATCAGAACTGAATTGCTGATCGTTAAAAAAGACCAAAGCCTTTTTAtatctacttttcttttttccttgtTCGTGAAGTTTTGTTTAAGACTGTCACTTCCCTGCTTGTTGACTGACCACACTAATCAGCTTTTATTTATGAGAAGtgtgcttaatttaatttaatttgagtGTATATCTGTAAAGAAATAATTCAATCTATCtaattgtatttaaacattttgttaaCTGATTTTATGAAAGCTATAAAAATCATTTTCACTTC

Function

symbol description
pax6 Enables DNA-binding transcription factor activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; pancreatic A cell development; and positive regulation of macromolecule metabolic process. Located in chromatin; cytosol; and nucleoplasm. Implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Biomarker of pancreatic ductal carcinoma.

NR:

description
paired box protein Pax-6 isoform X1

GO:

id name namespace
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0002089 lens morphogenesis in camera-type eye biological_process
GO:0090104 pancreatic epsilon cell differentiation biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0030900 forebrain development biological_process
GO:0030902 hindbrain development biological_process
GO:0003309 type B pancreatic cell differentiation biological_process
GO:0003310 pancreatic A cell differentiation biological_process
GO:0003311 pancreatic D cell differentiation biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG:

id description
K08031 PAX6; paired box protein 6

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007239785.3 False 2403 mRNA 0.45 11 618158 637895
XM_022669472.1 True 2440 mRNA 0.45 11 618157 637895

Neighbor

gene id symbol gene type direction distance location
cp cp,LOC100533122 coding upstream 84530 479272 ~ 533627 (+)
LOC103032607 LOC108439442 coding upstream 146953 461480 ~ 471204 (+)
LOC103032290 LOC108439433,LOC108271171 coding upstream 170842 417368 ~ 447315 (+)
wwtr1 wwtr1 coding upstream 237612 297267 ~ 380545 (+)
LOC103034506 kcnh1b,LOC108411957,LOC108270513,LOC107689936,LOC107753489,LOC106564801,LOC105026838 coding upstream 379161 159102 ~ 238996 (+)
immp1l immp1l,LOC107594745 coding downstream 33986 671881 ~ 681622 (+)
ankdd1a ankdd1a,LOC107685207 coding downstream 337042 974937 ~ 1000284 (+)
clpx clpx,clpxa,LOC107733949,LOC107737000,LOC107594724,LOC107600713 coding downstream 373744 1011639 ~ 1036934 (+)
ubap1l ubap1l,LOC107096871,LOC103363109,LOC105018181 coding downstream 410349 1048244 ~ 1071616 (+)
rasl12 rasl12,LOC107600716,LOC107685213,LOC107737003,LOC107594763 coding downstream 444656 1082551 ~ 1092167 (+)
LOC111192489 NA non-coding upstream 14230 601856 ~ 603927 (+)
G39459 NA non-coding upstream 70344 547609 ~ 547813 (+)
G39457 NA non-coding upstream 70805 547081 ~ 547352 (+)
G39452 NA non-coding upstream 78329 539498 ~ 539828 (+)
G39372 NA non-coding upstream 79825 537105 ~ 538332 (+)
G39504 NA non-coding downstream 74938 712833 ~ 715218 (+)
G39506 NA non-coding downstream 107673 745568 ~ 750620 (+)
G39511 snrpa1,LOC106587741 non-coding downstream 112927 750822 ~ 753837 (+)
G39512 NA non-coding downstream 129443 767338 ~ 767614 (+)
G39529 NA non-coding downstream 241790 879685 ~ 879896 (+)
commd2 commd2 other upstream 327135 281585 ~ 291022 (+)
plekho2 NA other downstream 284862 922757 ~ 963284 (+)
pdcd7 NA other downstream 400678 1038573 ~ 1045347 (+)
G39619 mrpl21 other downstream 568892 1206787 ~ 1209096 (+)
G39626 NA other downstream 581911 1219806 ~ 1220486 (+)
LOC111192492 NA other downstream 627962 1265857 ~ 1268385 (+)

Expression


Co-expression Network